C5ar1

Summary

Gene Symbol: C5ar1
Description: complement C5a receptor 1
Alias: C5r1, C5a anaphylatoxin chemotactic receptor 1, C5a-R, C5aR, complement component 5, receptor 1, complement component 5a receptor 1
Species: rat
Products:     C5ar1

Top Publications

  1. Woodruff T, Costantini K, Crane J, Atkin J, Monk P, Taylor S, et al. The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis. J Immunol. 2008;181:8727-34 pubmed
    ..end-stage disease, SOD1(G93A) rats displayed marked deposition of C3/C3b, and a significant up-regulation of the C5aR in the lumbar spinal cord. This was associated with increased numbers of C5aR-positive astrocytes...
  2. Farkas I, Takahashi M, Fukuda A, Yamamoto N, Akatsu H, Baranyi L, et al. Complement C5a receptor-mediated signaling may be involved in neurodegeneration in Alzheimer's disease. J Immunol. 2003;170:5764-71 pubmed
    In our earlier results, we demonstrated that cells expressing the complement C5aR are vulnerable since abnormal activation of C5aR caused apoptosis of these cells...
  3. Köhl J, Baelder R, Lewkowich I, Pandey M, Hawlisch H, Wang L, et al. A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. J Clin Invest. 2006;116:783-96 pubmed
    ..Here we report that local pharmacological targeting of the C5a receptor (C5aR) prior to initial allergen sensitization in murine models of inhalation tolerance or allergic asthma resulted in ..
  4. Benard M, Gonzalez B, Schouft M, Falluel Morel A, Vaudry D, Chan P, et al. Characterization of C3a and C5a receptors in rat cerebellar granule neurons during maturation. Neuroprotective effect of C5a against apoptotic cell death. J Biol Chem. 2004;279:43487-96 pubmed
    There is now clear evidence that the Complement anaphylatoxin C3a and C5a receptors (C3aR and C5aR) are expressed in glial cells, notably in astrocytes and microglia...
  5. Proctor L, Strachan A, Woodruff T, Mahadevan I, Williams H, Shiels I, et al. Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats. Int Immunopharmacol. 2006;6:1224-32 pubmed
  6. Lajoie S, Lewkowich I, Suzuki Y, Clark J, Sproles A, Dienger K, et al. Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. Nat Immunol. 2010;11:928-35 pubmed publisher
    ..production of anaphylatoxins, as mouse strains deficient in complement factor 5 (C5) or the complement receptor C5aR mounted robust IL-17A responses, whereas mice deficient in C3aR had fewer IL-17-producing helper T cells (T(H)17 ..
  7. Harkin D, Romaschin A, Taylor S, Rubin B, Lindsay T. Complement C5a receptor antagonist attenuates multiple organ injury in a model of ruptured abdominal aortic aneurysm. J Vasc Surg. 2004;39:196-206 pubmed
    ..We examined the role of a novel complement factor 5a (C5aR) receptor antagonist, the cyclic peptide AcF-(OpdChaWR), in attenuation of pathologic complement activation and ..
  8. Crane J, Buller K. Systemic blockade of complement C5a receptors reduces lipopolysacharride-induced responses in the paraventricular nucleus and the central amygdala. Neurosci Lett. 2007;424:10-5 pubmed
    ..Our findings demonstrate that C5a may have a role in the activation of the HPA axis in response to systemic LPS. ..
  9. Akatsu H, Miwa T, Sakurada C, Fukuoka Y, Ember J, Yamamoto T, et al. cDNA cloning and characterization of rat C5a anaphylatoxin receptor. Microbiol Immunol. 1997;41:575-80 pubmed
    ..To determine the pathological roles played by C5a and C5a receptor (C5aR) in rats, we cloned C5aR cDNA and analyzed distribution of its mRNA in various organs including lung from an LPS-..

More Information

Publications41

  1. Cao Q, McIsaac S, Stadnyk A. Human colonic epithelial cells detect and respond to C5a via apically expressed C5aR through the ERK pathway. Am J Physiol Cell Physiol. 2012;302:C1731-40 pubmed publisher
    ..The split component C5a is a potent proinflammatory molecule, and the C5a receptor (C5aR) CD88 has been reported on multiple cell types...
  2. Lim J, Iyer A, Suen J, Seow V, Reid R, Brown L, et al. C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling. FASEB J. 2013;27:822-31 pubmed publisher
    ..Here we identify surprising energy-conserving roles for complement proteins C5a and C3a and their receptors, C5aR and C3aR, roles that are contraindicated in complement biology...
  3. Fregonese L, Swan F, van Schadewijk A, Dolhnikoff M, Santos M, Daha M, et al. Expression of the anaphylatoxin receptors C3aR and C5aR is increased in fatal asthma. J Allergy Clin Immunol. 2005;115:1148-54 pubmed
    ..involvement of the anaphylatoxins C3a and C5a, generated during complement activation, and their receptors C3aR and C5aR in the pathogenesis of asthma...
  4. Tokodai K, Goto M, Inagaki A, Imura T, Nakanishi W, Satomi S. Expression of receptors for anaphylatoxins C3a and C5a on rat islet preparations. Transplant Proc. 2011;43:3179-80 pubmed publisher
    ..In the present study, we investigated this component in detail. C3aR, C5aR, and C5L2, together with CD11b and CD31, on freshly isolated islets (fresh group) and islets cultured with (..
  5. Caspi E, Herczeg E, Solomon F, Sompolinsky D. Amnionitis and T strain mycoplasmemia. Am J Obstet Gynecol. 1971;111:1102-6 pubmed
  6. van Werkhoven M, Damman J, Daha M, Krikke C, van Goor H, van Son W, et al. Novel insights in localization and expression levels of C5aR and C5L2 under native and post-transplant conditions in the kidney. Mol Immunol. 2013;53:237-45 pubmed publisher
    ..The two receptors for C5a are C5a receptor (C5aR) and C5a-like-receptor-2 (C5L2)...
  7. Sun S, Wang H, Zhao G, An Y, Guo Y, Du L, et al. Complement inhibition alleviates paraquat-induced acute lung injury. Am J Respir Cell Mol Biol. 2011;45:834-42 pubmed publisher
    ..Expression of the anaphylatoxin receptors, C3aR and C5aR, was also increased...
  8. Kondo C, Mizuno M, Nishikawa K, Yuzawa Y, Hotta N, Matsuo S. The role of C5a in the development of thrombotic glomerulonephritis in rats. Clin Exp Immunol. 2001;124:323-9 pubmed
    ..of complement, the soluble complement receptor type 1 (sCR1) (Group II) or the C5a receptor antagonist peptide (C5aR-AP) (Group III) was intravenously administered 30 min before RbAGBM injection...
  9. Iyer A, Woodruff T, Wu M, Stylianou C, Reid R, Fairlie D, et al. Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive rats. J Cardiovasc Pharmacol. 2011;58:479-86 pubmed publisher
    ..innate immunity complement system is a potent inflammatory peptide mediator through the G-protein-coupled receptor C5aR (CD88) present in immune-inflammatory cells, including monocytes, macrophages, neutrophils, T cells, and mast cells...
  10. Ignatius A, Ehrnthaller C, Brenner R, Kreja L, Schoengraf P, Lisson P, et al. The anaphylatoxin receptor C5aR is present during fracture healing in rats and mediates osteoblast migration in vitro. J Trauma. 2011;71:952-60 pubmed publisher
    ..We investigated the expression of the key anaphylatoxin receptor C5aR during fracture healing in rats by immunostaining after 1, 3, 7, 14, and 28 days...
  11. Andersson C, Mori M, Bjermer L, Löfdahl C, Erjefalt J. Alterations in lung mast cell populations in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2010;181:206-17 pubmed publisher
    ..In COPD lungs, these novel histopathological features were found to be correlated to lung function and they may thus have clinical consequences. ..
  12. Crane J, Baiquni G, Sullivan R, Lee J, Sah P, Taylor S, et al. The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres. J Neuroinflammation. 2009;6:34 pubmed publisher
    ..Although the role of CD88 on mossy fibres remains to be established, their involvement in synaptic/cellular plasticity, and in cognitive disorders such as Alzheimer's disease deserves investigation. ..
  13. Jun S, Kim T, Lee H, Lee S, Kim W, Park S, et al. Overexpression of the anaphylatoxin receptors, complement anaphylatoxin 3a receptor and complement anaphylatoxin 5a receptor, in the nasal mucosa of patients with mild and severe persistent allergic rhinitis. J Allergy Clin Immunol. 2008;122:119-25 pubmed publisher
    ..We investigated the expressional levels and distributional patterns of the C3a receptor (C3aR) and C5a receptor (C5aR) in normal, mild, and severe persistent allergic nasal mucosa...
  14. Dong Q, Sun L, Peng L, Yan B, Lv J, Wang G, et al. Expression of C5a and its receptor following spinal cord ischemia reperfusion injury in the rat. Spinal Cord. 2015;53:581-4 pubmed publisher
    ..Immunofluorescent staining was performed to detect the expression and cellular localization of C5aR in spinal cord following SIRI. Following SIRI, the motor behavior of the rats was significantly compromised...
  15. Rothermel E, Zwirner J, Vogt T, Rabini S, Gotze O. Molecular cloning and expression of the functional rat C5a receptor. Mol Immunol. 1997;34:877-86 pubmed
    ..16 +/- 0.65. No binding of huC5a to the ratC5aR could be observed although high concentrations of this ligand (> 60 nM) promoted chemotaxis of RBL cells transfected with the huC5aR. ..
  16. Daveau M, Benard M, Scotte M, Schouft M, Hiron M, Francois A, et al. Expression of a functional C5a receptor in regenerating hepatocytes and its involvement in a proliferative signaling pathway in rat. J Immunol. 2004;173:3418-24 pubmed
    ..system generates the anaphylatoxin C5a whose activities are mediated through its binding to the widely expressed C5aR. C5aR mRNA and protein expressions are known to be induced in rat hepatocytes under inflammatory conditions...
  17. Bhatia M, Saluja A, Singh V, Frossard J, Lee H, Bhagat L, et al. Complement factor C5a exerts an anti-inflammatory effect in acute pancreatitis and associated lung injury. Am J Physiol Gastrointest Liver Physiol. 2001;280:G974-8 pubmed
    Complement factor C5a acting via C5a receptors (C5aR) is recognized as an anaphylotoxin and chemoattractant that exerts proinflammatory effects in many pathological states...
  18. Nozaki M, Raisler B, Sakurai E, Sarma J, Barnum S, Lambris J, et al. Drusen complement components C3a and C5a promote choroidal neovascularization. Proc Natl Acad Sci U S A. 2006;103:2328-33 pubmed
    ..Collectively, these findings establish a mechanistic basis for the clinical observation that drusen predispose to CNV, revealing a role for immunological phenomena in angiogenesis and providing therapeutic targets for AMD...
  19. Benard M, Raoult E, Vaudry D, Leprince J, Falluel Morel A, Gonzalez B, et al. Role of complement anaphylatoxin receptors (C3aR, C5aR) in the development of the rat cerebellum. Mol Immunol. 2008;45:3767-74 pubmed publisher
    ..In particular, it has been recently reported that the anaphylatoxin receptors C3aR and C5aR are transiently expressed in the cerebellar cortex of newborn rat, suggesting that anaphylatoxins are involved in ..
  20. Perret J, Raspe E, Vassart G, Parmentier M. Cloning and functional expression of the canine anaphylatoxin C5a receptor. Evidence for high interspecies variability. Biochem J. 1992;288 ( Pt 3):911-7 pubmed
    ..The low similarity between C5a receptors from different mammalian species is quite unusual for a G-protein-coupled receptor. ..
  21. Francis K, Lewis B, Monk P, Ham J. Complement C5a receptors in the pituitary gland: expression and function. J Endocrinol. 2008;199:417-24 pubmed publisher
    ..These data show that functional C5a receptors (C5a and C5L2) are present in the anterior pituitary gland and they may play a role in dampening down inflammation by inhibiting the release of MIF and stimulating the release of ACTH. ..
  22. Tschernig T, Kiafard Z, Dibbert C, Neumann D, Zwirner J. Use of monoclonal antibodies to assess expression of anaphylatoxin receptors in rat and murine models of lung inflammation. Exp Toxicol Pathol. 2007;58:419-25 pubmed
    ..Besides their expression in leukocytes, receptors for C3a and C5a (C3aR and C5aR) have been noted in alveolar and bronchial epithelial cells, bronchial smooth muscle cells as well as in vascular ..
  23. Proctor L, Arumugam T, Shiels I, Reid R, Fairlie D, Taylor S. Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury. Br J Pharmacol. 2004;142:756-64 pubmed
    ..Instead, C3aRA-mediated global neutrophil tissue sequestration during ischaemia and early reperfusion may account for the protective effects observed. ..
  24. Arumugam T, Woodruff T, Stocks S, Proctor L, Pollitt S, Shiels I, et al. Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. J Hepatol. 2004;40:934-41 pubmed
    ..This study investigated the efficacy of a small molecule C5a receptor (C5aR) antagonist against hepatic I/R injury...
  25. Short A, Paczkowski N, Vogen S, Sanderson S, Taylor S. Response-selective C5a agonists: differential effects on neutropenia and hypotension in the rat. Br J Pharmacol. 1999;128:511-4 pubmed
    ..In vitro C5a receptor (C5aR) binding experiments showed that YSFKPMPLaR and YSFKD(NMeNle)PlaR had similar affinities for the macrophage C5aR (..
  26. Hirsch R, Clarke N. Has small-scale audio-visual dental health education a viable future?. Community Dent Oral Epidemiol. 1977;5:160-3 pubmed
  27. Riedemann N, Guo R, Sarma V, Laudes I, Huber Lang M, Warner R, et al. Expression and function of the C5a receptor in rat alveolar epithelial cells. J Immunol. 2002;168:1919-25 pubmed
    ..or TNF-alpha, the increased binding of C5a being associated with increased levels of mRNA for the C5a receptor (C5aR). Exposure of RAEC to C5a also caused increased expression of mRNA for C5aR...
  28. Mullaly S, Kubes P. The role of TLR2 in vivo following challenge with Staphylococcus aureus and prototypic ligands. J Immunol. 2006;177:8154-63 pubmed
    ..leukocyte recruitment was P-/E-selectin dependent but only partially TLR2 dependent, and also involved the C5aR. Concomitant inhibition of TLR2 and C5aR resulted in a further reduction in PGN-induced peritonitis...
  29. Guo R, Riedemann N, Bernacki K, Sarma V, Laudes I, Reuben J, et al. Neutrophil C5a receptor and the outcome in a rat model of sepsis. FASEB J. 2003;17:1889-91 pubmed
    Complement fragment 5a (C5a)-C5a receptor (C5aR) signaling plays an essential role in neutrophil innate immunity. Blockade of either the ligand or the receptor improves survival rates in experimental sepsis...
  30. Hillebrandt S, Wasmuth H, Weiskirchen R, Hellerbrand C, Keppeler H, Werth A, et al. Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Nat Genet. 2005;37:835-43 pubmed
    ..Thus, the mouse quantitative trait gene led to the identification of an unknown gene underlying human susceptibility to liver fibrosis, supporting the idea that C5 has a causal role in fibrogenesis across species. ..
  31. Flierl M, Rittirsch D, Chen A, Nadeau B, Day D, Sarma J, et al. The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis. PLoS ONE. 2008;3:e2560 pubmed publisher
    ..These effects could be reversed by dual-blockade of the C5a receptors, C5aR and C5L2...
  32. Gerard C, Bao L, Orozco O, Pearson M, Kunz D, Gerard N. Structural diversity in the extracellular faces of peptidergic G-protein-coupled receptors. Molecular cloning of the mouse C5a anaphylatoxin receptor. J Immunol. 1992;149:2600-6 pubmed
    ..Additionally, these data provide a reagent for immunologic and molecular genetic studies on the role of C5a receptors in inflammatory models. ..