C3

Summary

Gene Symbol: C3
Description: complement C3
Alias: complement C3, complement component 3
Species: rat
Products:     C3

Top Publications

  1. Gullstrand B, Martensson U, Sturfelt G, Bengtsson A, Truedsson L. Complement classical pathway components are all important in clearance of apoptotic and secondary necrotic cells. Clin Exp Immunol. 2009;156:303-11 pubmed publisher
    ..macrophages in the presence of sera from individuals with complement deficiencies was studied, as well as C3 deposition on apoptotic cells using flow cytometry...
  2. Polack F, Teng M, Collins P, Prince G, Exner M, Regele H, et al. A role for immune complexes in enhanced respiratory syncytial virus disease. J Exp Med. 2002;196:859-65 pubmed
    ..Here, we demonstrate that enhanced RSV disease is mediated by immune complexes and abrogated in complement component C3 and B cell-deficient mice but not in controls...
  3. Barnes K, Grant A, Baltadzhieva D, Zhang S, Berg T, Shao L, et al. Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families. Genes Immun. 2006;7:27-35 pubmed
    Proinflammatory and immunoregulatory products from C3 play a major role in phagocytosis, respiratory burst, and airways inflammation...
  4. Hasegawa K, Tamari M, Shao C, Shimizu M, Takahashi N, Mao X, et al. Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma. Hum Genet. 2004;115:295-301 pubmed
    ..Recent studies have provided evidence that C3, C3a receptor, and C5 are linked to airway hyperresponsiveness...
  5. Pei X, Li X, Bao Y, Yu W, Yan Z, Qi H, et al. Association of c3 gene polymorphisms with neovascular age-related macular degeneration in a chinese population. Curr Eye Res. 2009;34:615-22 pubmed
    The purpose of this study was to determine whether the genetic polymorphisms of complement factor 3 (C3) are associated with neovascular age-related macular degeneration (AMD) in the Chinese population...
  6. Rutar M, Natoli R, Kozulin P, Valter K, Gatenby P, Provis J. Analysis of complement expression in light-induced retinal degeneration: synthesis and deposition of C3 by microglia/macrophages is associated with focal photoreceptor degeneration. Invest Ophthalmol Vis Sci. 2011;52:5347-58 pubmed publisher
    ..Photoreceptor apoptosis was assessed using TUNEL and C3 was further investigated by spatiotemporal analysis using in situ hybridization and immunohistochemistry...
  7. Bora P, Sohn J, Cruz J, Jha P, Nishihori H, Wang Y, et al. Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization. J Immunol. 2005;174:491-7 pubmed
    ..A murine model of laser-induced CNV in C57BL/6 mice revealed the deposition of C3 and membrane attack complex (MAC) in the neovascular complex...
  8. Jha P, Sohn J, Xu Q, Wang Y, Kaplan H, Bora P, et al. Suppression of complement regulatory proteins (CRPs) exacerbates experimental autoimmune anterior uveitis (EAAU). J Immunol. 2006;176:7221-31 pubmed
    ..Increased complement activation as determined by increased deposition of C3, C3 activation fragments, and membrane attack complex was observed in the eyes of Lewis rats when the function and/..
  9. Villaescusa Blanco R, Arce A, Santos R, Fernandez N. [Changes of the complement system in myelodysplastic syndromes]. Sangre (Barc). 1998;43:210-2 pubmed
    ..We determined factor B, alternate and classical hemolytic activity, as well as C3 and C4 quantification of the complement system...

More Information

Publications100

  1. Kerwar S, Bauman N, Oronsky A, Sloboda A. Studies on type II collagen induced polyarthritis in rats. Effect of complement depletion. J Immunopharmacol. 1981;3:323-37 pubmed
    ..In the established lesion, treatment with cobra venom factor has no effect, on either the inflammatory lesion or the various radiological parameters of joint destruction. ..
  2. Jacobs T, Andrä J, Gaworski I, Graefe S, Mellenthin K, Krömer M, et al. Complement C3 is required for the progression of cutaneous lesions and neutrophil attraction in Leishmania major infection. Med Microbiol Immunol. 2005;194:143-9 pubmed
    ..CVF expression in these mice leads to a continuous activation and subsequent consumption of complement C3 in the serum...
  3. Senbagavalli P, Geetha S, Venkatesan P, Ramanathan V. Defective solubilization of immune complexes and activation of the complement system in patients with pulmonary tuberculosis. J Clin Immunol. 2009;29:674-80 pubmed publisher
  4. Misumi Y, Sohda M, Ikehara Y. Nucleotide and deduced amino acid sequence of rat complement C3. Nucleic Acids Res. 1990;18:2178 pubmed
  5. Pickering M, de Jorge E, Martinez Barricarte R, Recalde S, Garcia Layana A, Rose K, et al. Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains. J Exp Med. 2007;204:1249-56 pubmed
    ..an abundant serum glycoprotein that regulates the alternative pathway of complement-preventing uncontrolled plasma C3 activation and nonspecific damage to host tissues...
  6. McKay G, Dasari S, Patterson C, Chakravarthy U, Silvestri G. Complement component 3: an assessment of association with AMD and analysis of gene-gene and gene-environment interactions in a Northern Irish cohort. Mol Vis. 2010;16:194-9 pubmed
    A non-synonymous single nucleotide polymorphism (SNP) in complement component 3 has been shown to increase the risk of age-related macular degeneration (AMD)...
  7. O Brien K, Morrison T, Dundore D, Heise M, Schultz Cherry S. A protective role for complement C3 protein during pandemic 2009 H1N1 and H5N1 influenza A virus infection. PLoS ONE. 2011;6:e17377 pubmed publisher
    ..b>C3, a member of the complement system of serum proteins, is a major component of the innate immune and inflammatory ..
  8. Stoop M, Rosenling T, Attali A, Meesters R, Stingl C, Dekker L, et al. Minocycline effects on the cerebrospinal fluid proteome of experimental autoimmune encephalomyelitis rats. J Proteome Res. 2012;11:4315-25 pubmed publisher
    ..Two of these proteins, complement C3 and carboxypeptidase B2, were validated by quantitative LC-MS/MS in the SRM mode...
  9. Abe K, Miyazaki M, Koji T, Furusu A, Shioshita K, Tsukasaki S, et al. Intraglomerular synthesis of complement C3 and its activation products in IgA nephropathy. Nephron. 2001;87:231-9 pubmed
    Complement activation is thought to be pathologically important in IgA nephropathy (IgAN). Although C3 deposition in the mesangium is found in IgAN, the origin of C3 is not clear...
  10. Chudwin D, Korenblit A, Kingzette M, Artrip S, Rao S. Increased activation of the alternative complement pathway in sickle cell disease. Clin Immunol Immunopathol. 1985;37:93-7 pubmed
    ..In all, 89% of SS sera had elevated concentrations of C3b,P complexes, indicative of increased alternative pathway activation. Chronic activation of the alternative pathway may contribute to impaired host defense in SS patients. ..
  11. Li J, Pircher P, Schulman I, Westin S. Regulation of complement C3 expression by the bile acid receptor FXR. J Biol Chem. 2005;280:7427-34 pubmed
    ..The analysis of the human complement C3 gene reveals the presence of functional FXR response elements in the proximal promoter of C3...
  12. Zou L, Feng Y, Li Y, Zhang M, Chen C, Cai J, et al. Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis. J Immunol. 2013;191:5625-35 pubmed publisher
    ..Cecal ligation and puncture also led to the alternative pathway activation, C3 fragment deposition in the kidney and heart, and cfB-dependent C3dg elevation...
  13. Guhad F, Jensen H, Aalbaek B, Rycroft A, Hau J. A murine model for the study of mycotic mastitis. J Comp Pathol. 1995;113:315-25 pubmed
  14. Rutar M, Natoli R, Provis J, Valter K. Complement activation in retinal degeneration. Adv Exp Med Biol. 2012;723:31-6 pubmed publisher
  15. Jefferson J, Suga S, Kim Y, Pippin J, Gordon K, Johnson R, et al. Intravenous immunoglobulin protects against experimental thrombotic microangiopathy. Kidney Int. 2001;60:1018-25 pubmed
    ..utilized in several forms of vasculitis and has many potential mechanisms of action, including the inhibition of C3 activation...
  16. Hoh Kam J, Lenassi E, Malik T, Pickering M, Jeffery G. Complement component C3 plays a critical role in protecting the aging retina in a murine model of age-related macular degeneration. Am J Pathol. 2013;183:480-92 pubmed publisher
    Complement component C3 is the central complement component and a key inflammatory protein activated in age-related macular degeneration (AMD)...
  17. Kuehn M, Kim C, Ostojic J, Bellin M, Alward W, Stone E, et al. Retinal synthesis and deposition of complement components induced by ocular hypertension. Exp Eye Res. 2006;83:620-8 pubmed
    ..Toward this goal the gene expression levels of complement components 1qb (C1qb) and 3 (C3) were determined in the retina by quantitative polymerase chain reaction in human eyes with elevated intraocular ..
  18. Roy R, Paes H, Nanjappa S, Sorkness R, Gasper D, Sterkel A, et al. Complement component 3C3 and C3a receptor are required in chitin-dependent allergic sensitization to Aspergillus fumigatus but dispensable in chitin-induced innate allergic inflammation. MBio. 2013;4: pubmed publisher
    ..b>C3(-/-) and C3aR(-/-) mice were protected from chitin-dependent sensitization to Aspergillus and had reduced lung ..
  19. Goicoechea de Jorge E, Caesar J, Malik T, Patel M, Colledge M, Johnson S, et al. Dimerization of complement factor H-related proteins modulates complement activation in vivo. Proc Natl Acad Sci U S A. 2013;110:4685-90 pubmed publisher
    ..Our data demonstrate that these CFHR proteins function as competitive antagonists of CFH to modulate complement activation in vivo and explain why variation in the CFHRs predisposes to disease. ..
  20. van Oostrom A, Alipour A, Plokker T, Sniderman A, Cabezas M. The metabolic syndrome in relation to complement component 3 and postprandial lipemia in patients from an outpatient lipid clinic and healthy volunteers. Atherosclerosis. 2007;190:167-73 pubmed
    We investigated the relationship between complement component 3 (C3), fasting and postprandial lipemia and the metabolic syndrome (MetabS)...
  21. Padilla N, van Vliet A, Schoots I, Valls Seron M, Maas M, Peltenburg E, et al. C-reactive protein and natural IgM antibodies are activators of complement in a rat model of intestinal ischemia and reperfusion. Surgery. 2007;142:722-33 pubmed
    ..A good correlation was observed in the intestinal homogenates between C4b/c and CRP levels. Clear depositions of C3, CRP, and IgM in intestinal tissue were demonstrated after II/R, and a strong correlation of both CRP and IgM with ..
  22. Zhang Y, Bao M, Dai M, Wang X, He W, Tan T, et al. Cardiospecific CD36 suppression by lentivirus-mediated RNA interference prevents cardiac hypertrophy and systolic dysfunction in high-fat-diet induced obese mice. Cardiovasc Diabetol. 2015;14:69 pubmed publisher
    ..Cardiospecific CD36 inhibition protects against the aggravation of cardiac functional and morphological changes associated with HFD induced obesity. CD36 represents a potential therapeutic target for obesity cardiomyopathy. ..
  23. Griffiths M, Wang J, Joe B, Dracheva S, Kawahito Y, Shepard J, et al. Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis. Arthritis Rheum. 2000;43:1278-89 pubmed
  24. Li F, Cheng Y, Lu J, Hu R, Wan Q, Feng H. Photodynamic therapy boosts anti-glioma immunity in mice: a dependence on the activities of T cells and complement C3. J Cell Biochem. 2011;112:3035-43 pubmed publisher
    ..The anti-glioma immunity fostered by PDT is inhibited in complement C3 knockout mice and the nude mice indicate the requirement of the activities of complement C3 and T cells...
  25. Cai X, Shedden K, Ao X, Davis M, Fu X, Lawrence T, et al. Plasma proteomic analysis may identify new markers for radiation-induced lung toxicity in patients with non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2010;77:867-76 pubmed publisher
    ..C4b-binding protein alpha chain, Complement C3, and Vitronectin had significantly higher expression levels in patients with RILT2 compared with patients ..
  26. Kalant D, MacLaren R, Cui W, Samanta R, Monk P, Laporte S, et al. C5L2 is a functional receptor for acylation-stimulating protein. J Biol Chem. 2005;280:23936-44 pubmed
    ..This is the first demonstration that C5L2 is a functional receptor, mediating ASP triglyceride stimulation. ..
  27. Cowell R, Plane J, Silverstein F. Complement activation contributes to hypoxic-ischemic brain injury in neonatal rats. J Neurosci. 2003;23:9459-68 pubmed
    ..With immunofluorescence assays and confocal microscopy, both C3 and C9 were localized to injured neurons 16 and 24 hr post-HI...
  28. Lundeen S, Zhang Z, Zhu Y, Carver J, Winneker R. Rat uterine complement C3 expression as a model for progesterone receptor modulators: characterization of the new progestin trimegestone. J Steroid Biochem Mol Biol. 2001;78:137-43 pubmed
    ..Here we report the development and characterization of the rat uterine complement component C3 mRNA as a molecular target for the evaluation of the antiestrogenic activity of progestins in the uterus...
  29. Tao Y, Cianflone K, Sniderman A, Colby Germinario S, Germinario R. Acylation-stimulating protein (ASP) regulates glucose transport in the rat L6 muscle cell line. Biochim Biophys Acta. 1997;1344:221-9 pubmed
    ..These results suggest that muscle is also responsive to ASP and that ASP may play a role in glucose metabolism in both muscle and adipose tissue. ..
  30. Saha K, Sharma V, Chakrabarty A, Sehgal V. Breakdown product of factor B as an index of complement activation in lepromatous leprosy and its relation with bacillary load. Scand J Immunol. 1983;17:37-43 pubmed
    ..profile studied in 50 lepromatous leprosy patients with various bacillary loads demonstrated significantly decreased C3 levels in patients with high bacteriological index (2+ to 4+) as compared with those with lesser bacterial load...
  31. Fischetti F, Durigutto P, Pellis V, Debeus A, Macor P, Bulla R, et al. Thrombus formation induced by antibodies to beta2-glycoprotein I is complement dependent and requires a priming factor. Blood. 2005;106:2340-6 pubmed
    ..Anti-beta2-glycoprotein I-depleted aPL IgG failed to induce PLAs and TOs. C3 and C9 colocalized with aPL IgG on the mesenteric vessels...
  32. Nie F, Wang J, Su D, Shi Y, Chen J, Wang H, et al. Abnormal activation of complement C3 in the spinal dorsal horn is closely associated with progression of neuropathic pain. Int J Mol Med. 2013;31:1333-42 pubmed publisher
    ..Moreover, mCCI induced a significant increase (+40%) in the expression of component 3 (C3) mRNA in the spinal dorsal horn, which was associated with hyperalgesia...
  33. Mondino B, Glovsky M, Ghekiere L. Activated complement in inflamed aqueous humor. Invest Ophthalmol Vis Sci. 1984;25:871-3 pubmed
    ..Radioimmunoassay was used to measure levels of C3a, an activated fragment of C3, in aqueous humor...
  34. Kapadia S, Levine B, Speck S, Virgin H. Critical role of complement and viral evasion of complement in acute, persistent, and latent gamma-herpesvirus infection. Immunity. 2002;17:143-55 pubmed
    ..We evaluated the role of complement factor C3 (C3) and the murine gamma-herpesvirus 68 (gammaHV68) RCA protein in viral pathogenesis...
  35. Richardson M, Segu Z, Price M, Lai X, Witzmann F, Mechref Y, et al. Alterations in the aqueous humor proteome in patients with Fuchs endothelial corneal dystrophy. Mol Vis. 2010;16:2376-83 pubmed
    ..The levels of five of these were significantly lower (afamin, complement C3, histidine-rich glycoprotein, immunoglobulin heavy [IgH], and protein family with sequence similarity 3, ..
  36. Lillegard K, Johnson A, Lojovich S, Bauer A, Marsh H, Gilbert J, et al. Complement activation is critical for placental ischemia-induced hypertension in the rat. Mol Immunol. 2013;56:91-7 pubmed publisher
    ..Circulating complement component 3 decreased and complement activation product C3a increased in RUPP vs. Sham (p<0...
  37. Inoue H, Mashimo Y, Funamizu M, Shimojo N, Hasegawa K, Hirota T, et al. Association study of the C3 gene with adult and childhood asthma. J Hum Genet. 2008;53:728-38 pubmed publisher
    ..It has been shown that complement-C3-deficient mice have reduced inflammation of asthmatic airways...
  38. Lajoie S, Lewkowich I, Suzuki Y, Clark J, Sproles A, Dienger K, et al. Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. Nat Immunol. 2010;11:928-35 pubmed publisher
    ..The opposing effects of C3a and C5a were mediated through their reciprocal regulation of IL-23 production. These data demonstrate a critical role for complement-mediated regulation of the IL-23-T(H)17 axis in severe asthma...
  39. Sun S, Wang H, Zhao G, An Y, Guo Y, Du L, et al. Complement inhibition alleviates paraquat-induced acute lung injury. Am J Respir Cell Mol Biol. 2011;45:834-42 pubmed publisher
    ..Within 24 hours of PQ-induced ALI, there was significantly increased expression of the complement proteins, C1q and C3, in the lung. Expression of the anaphylatoxin receptors, C3aR and C5aR, was also increased...
  40. Zhang X, Köhl J. A complex role for complement in allergic asthma. Expert Rev Clin Immunol. 2010;6:269-77 pubmed
    ..Different models of experimental allergic asthma suggest that the small complement fragments of C3 and C5, the anaphylatoxins C3a and C5a, not only promote proallergic effector functions during the allergic effector ..
  41. Kapp A, Schopf E. Involvement of complement in atopic dermatitis. Acta Derm Venereol Suppl (Stockh). 1985;114:152-4 pubmed
    ..35 patients had not received systemic or topical steroid therapy 6 weeks prior to blood collection. C3, C4 and C1 INA were determined in serum by radioimmunodiffusion...
  42. Ballow M, Donshik P, Mendelson L. Complement proteins and C3 anaphylatoxin in the tears of patients with conjunctivitis. J Allergy Clin Immunol. 1985;76:473-6 pubmed
    ..The tears of VC (15) and GPC (10) patients with active disease had elevated tear levels of both C3 and factor B...
  43. Sehgal V, Sharma V, Sharma V. Comprehensive evaluation of complement components in the course of type I (Lepra) and type II (ENL) reactions. Int J Dermatol. 1989;28:32-5 pubmed
    Complement components C1q and C4 of classic pathway; C3d, a breakdown product of C3, and factor B of alternate pathway: and C3, a component both of classic and alternate pathways, were studied in 35 patients, comprising 18 type I (Lepra) ..
  44. Yang H, Wu B, Tuzun E, Saini S, Li J, Allman W, et al. A new mouse model of autoimmune ocular myasthenia gravis. Invest Ophthalmol Vis Sci. 2007;48:5101-11 pubmed
    ..Mice with oMG had serum autoantibodies to the mouse extraocular AChR, pathologic deposits of IgG, C3, and C5b-C9 in their extraocular and limb neuromuscular junctions, and droopiness of eyelids...
  45. Nozaki M, Raisler B, Sakurai E, Sarma J, Barnum S, Lambris J, et al. Drusen complement components C3a and C5a promote choroidal neovascularization. Proc Natl Acad Sci U S A. 2006;103:2328-33 pubmed
    ..a recently described mouse model of AMD, early subretinal pigmented epithelium deposition of complement components C3 and C5 occurs, suggesting a contributing role for these inflammatory proteins in the development of AMD...
  46. Collier R, Wang Y, Smith S, Martin E, Ornberg R, Rhoades K, et al. Complement deposition and microglial activation in the outer retina in light-induced retinopathy: inhibition by a 5-HT1A agonist. Invest Ophthalmol Vis Sci. 2011;52:8108-16 pubmed publisher
    ..stained with antibody for a microglial marker (Iba1), a T-lymphocyte marker (CD3), and complement components C1q, C3, factor B, factor H, and membrane attack complex (MAC)...
  47. Trcka J, Moroi Y, Clynes R, Goldberg S, Bergtold A, Perales M, et al. Redundant and alternative roles for activating Fc receptors and complement in an antibody-dependent model of autoimmune vitiligo. Immunity. 2002;16:861-8 pubmed
    ..deficient in activating FcR containing the common gamma subunit (Fc gamma R gamma(-/-)) and in mice deficient in the C3 complement component...
  48. Coonrod J, Rylko Bauer B. Complement levels in pneumococcal pneumonia. Infect Immun. 1977;18:14-22 pubmed
    ..Mean levels of C3 and properdin and the functional activity of the alternate pathway in acute sera were significantly (P less than 0...
  49. Verschoor A, Brockman M, Knipe D, Carroll M. Cutting edge: myeloid complement C3 enhances the humoral response to peripheral viral infection. J Immunol. 2001;167:2446-51 pubmed
    ..The development of an efficient humoral response to the virus is dependent on innate immunity component complement C3. The liver is the major source of C3, but there are also extrahepatic origins of C3 such as lymphoid ..
  50. Amezcua Guerra L, Springall R, Arrieta Alvarado A, Rodriguez V, Rivera Martínez E, Castillo Martínez D, et al. C-reactive protein and complement components but not other acute-phase reactants discriminate between clinical subsets and organ damage in systemic lupus erythematosus. Clin Lab. 2011;57:607-13 pubmed
    ..Serum C-reactive protein (CRP), complement C3, C4 and CH50%, alpha-1-antitrypsin (AAT), transferrin (Tf), procalcitonin, erythrosedimentation rate (ESR), ..
  51. Chen D, Song M, Liu Y, Xue Y, Cheng P, Zheng H, et al. Inhibition of complement C3 might rescue vascular hyporeactivity in a conscious hemorrhagic shock rat model. Microvasc Res. 2016;105:23-9 pubmed publisher
    ..We use cobra venom factor (CVF) and the soluble form of CR1 (sCR1) which deplete or inhibit complement C3 respectively to examine its role in vascular hyporeactivity in a conscious hemorrhagic shock rat model...
  52. Rostami E, Davidsson J, Gyorgy A, Agoston D, Risling M, Bellander B. The terminal pathway of the complement system is activated in focal penetrating but not in mild diffuse traumatic brain injury. J Neurotrauma. 2013;30:1954-65 pubmed publisher
    ..We used in situ hybridization to examine the distribution of mRNA for C1q and C3 and immunohistochemistry to examine the presence of the C3 protein and C5b-9 complex at 1-5 days after injury...
  53. Ben David I, Price S, Bortz D, Greineder C, Cohen S, Bauer A, et al. Dynamics of intrapulmonary bacterial growth in a murine model of repeated microaspiration. Am J Respir Cell Mol Biol. 2005;33:476-82 pubmed
    ..When parallel experiments were performed in complement C3-deficient mice, no suppression of the second inoculum was noted, suggesting that early upregulation of ..
  54. Li S, Xian J, He L, Luo X, Tan B, Yang Y, et al. The protective effect of SCR(15-18) on cerebral ischemia-reperfusion injury. Neurol Res. 2011;33:866-74 pubmed publisher
    ..protect brain cells against cerebral ischemic/reperfusion (CI/R) injury due to its decay-accelerating activity for C3/C5 convertase and co-factor activity for C3b/C4b degradation...
  55. Furuya T, Salstrom J, McCall Vining S, Cannon G, Joe B, Remmers E, et al. Genetic dissection of a rat model for rheumatoid arthritis: significant gender influences on autosomal modifier loci. Hum Mol Genet. 2000;9:2241-50 pubmed
    ..Our data support the view that multiple autoimmune diseases may share genetic risk factors, and suggest that many of these loci are gender influenced. ..
  56. Sundstrom S, Komm B, Ponce de Leon H, Yi Z, Teuscher C, Lyttle C. Estrogen regulation of tissue-specific expression of complement C3. J Biol Chem. 1989;264:16941-7 pubmed
    ..This LE-1 cDNA was sequenced and shown to be homologous to complement component C3. The sequence was approximately 81 and 90% homologous to human and mouse C3, respectively...
  57. Lang J, Sun A, Fan J, Tian S, Jia R, Cao P. [MRNA expression of complement C3 and C4 in rat nasal mucosa with allergic rhinitis]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2006;41:928-31 pubmed
    To investigate the level of mRNA expression of complement C3 and C4 in rat nasal mucosa and to reveal the relationship with the pathogenesis of allergic rhinitis (AR) ...
  58. Yao E, Fukuda N, Ueno T, Tsunemi A, Endo M, Matsumoto K. Complement 3 activates the KLF5 gene in rat vascular smooth muscle cells. Biochem Biophys Res Commun. 2008;367:468-73 pubmed publisher
    ..smooth muscle cells (VSMCs) change to the synthetic phenotype and show increased expression of complement 3 (C3) and that C3 plays a role in the change to the synthetic phenotype...
  59. Ma Z, Feng X, Zheng S, Bie P, Wang S, Li K, et al. Ethanol preconditioning reduces hepatic I/R injury by inhibiting the complement system activation. J Surg Res. 2011;166:314-23 pubmed publisher
    ..Animal survival rate was compared. Liver function, hepatic MDA level, plasma complement C3 level, and serum hemolytic activity were determined...
  60. Woodruff T, Costantini K, Crane J, Atkin J, Monk P, Taylor S, et al. The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis. J Immunol. 2008;181:8727-34 pubmed
    ..With end-stage disease, SOD1(G93A) rats displayed marked deposition of C3/C3b, and a significant up-regulation of the C5aR in the lumbar spinal cord...
  61. Schlosser R, Mulligan R, Casey S, Varela J, Harvey R, Atkinson C. Alterations in gene expression of complement components in chronic rhinosinusitis. Am J Rhinol Allergy. 2010;24:21-5 pubmed publisher
    ..rhinosinusitis (AFRS), CRS without NPs (CRS-NPs), and controls were harvested and gene and protein expression of C3, factor B (fB), C5, and C7 complement proteins were analyzed using quantitative polymerase chain reaction and ..
  62. Najam F, Giasuddin A, Shembesh A. Complement components (C3, C4) in childhood asthma. Indian J Pediatr. 2005;72:745-9 pubmed
    To assess the involvement of complements (C3, C4) in the pathophysiology of bronchial asthma. Selection of patients (n = 64) were made according to the recommended international criteria for diagnosis and classification of asthma...
  63. Beatty D, Ryder C, Heese H. Complement abnormalities during an epidemic of group B meningococcal infection in children. Clin Exp Immunol. 1986;64:465-70 pubmed
    ..in classical pathway function (CH50), normal alternate pathway function (AP50), C4 and factor B levels, and raised C3 levels...
  64. Rosenling T, Stoop M, Attali A, van Aken H, Suidgeest E, Christin C, et al. Profiling and identification of cerebrospinal fluid proteins in a rat EAE model of multiple sclerosis. J Proteome Res. 2012;11:2048-60 pubmed publisher
    ..Lysozyme C1, fetuin B, T-kininogen, serum paraoxonase/arylesterase 1, glutathione peroxidase 3, complement C3, and afamin are among the proteins significantly elevated in this rat EAE model...
  65. Mizuno M, Harris C, Johnson P, Morgan B. Rat membrane cofactor protein (MCP; CD46) is expressed only in the acrosome of developing and mature spermatozoa and mediates binding to immobilized activated C3. Biol Reprod. 2004;71:1374-83 pubmed
    ..Acrosome-reacted but not unreacted spermatozoa bound methylamine-activated C3 immobilized on plastic...
  66. Li Q, Li Y, Stahl G, Thurman J, He Y, Tong H. Essential role of factor B of the alternative complement pathway in complement activation and opsonophagocytosis during acute pneumococcal otitis media in mice. Infect Immun. 2011;79:2578-85 pubmed publisher
    ..Using mice deficient in complement C1qa, factor B, and factor B/C2, we found that complement C3 activation and opsonophagocytosis of S...
  67. Maga T, Nishimura C, Weaver A, Frees K, Smith R. Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome. Hum Mutat. 2010;31:E1445-60 pubmed publisher
    ..complement factor H-related 5 (CFHR5), complement factor I (CFI), CD46 (MCP), complement factor B (CFB), complement component 3 (C3) and thrombomodulin (THBD). Since aHUS is rare, mutation rate data in large patient cohorts are scarce...
  68. Proctor L, Moore T, Monk P, Sanderson S, Taylor S, Woodruff T. Complement factors C3a and C5a have distinct hemodynamic effects in the rat. Int Immunopharmacol. 2009;9:800-6 pubmed publisher
    ..These results demonstrate that C3a and C5a mediate distinct effects on blood pressure and circulating polymorphonuclear leukocytes in the rat. ..
  69. Choucair Jaafar N, Laporte V, Levy R, Poindron P, Lombard Y, Gies J. Complement receptor 3 (CD11b/CD18) is implicated in the elimination of ?-amyloid peptides. Fundam Clin Pharmacol. 2011;25:115-22 pubmed publisher
    ..Moreover, a concomitant inhibition of LRP and CR3 completely blocked the ingestion of both kinds of particles suggesting that no other receptors participate to this mechanism. ..
  70. Lasbury M, Durant P, Tschang D, Wang S, Zhang C, Liao C, et al. Expression and activation of complement protein and alveolar damage during Pneumocystis pneumonia. J Eukaryot Microbiol. 2006;53 Suppl 1:S136-7 pubmed
  71. Shinosaki T, Kobayashi T, Kimura K, Kurihara H. Involvement of dipeptidyl peptidase IV in immune complex-mediated glomerulonephritis. Lab Invest. 2002;82:505-13 pubmed
    ..Treatment with F16 inhibited glomerular deposition of complement C3 and complement C4 after the binding of E30 to the mesangial cell surface...
  72. Goudriaan J, Dahlmans V, Teusink B, Ouwens D, Febbraio M, Maassen J, et al. CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice. J Lipid Res. 2003;44:2270-7 pubmed
    ..Moreover, hepatic activation of protein kinase B by insulin, measured by Western blot, was reduced by 54%. Our results show a dissociation between increased muscle and decreased liver insulin sensitivity in CD36-/- mice. ..
  73. Bao Y, Xiu D, Zhang L. Proteomic profiling of heterotopic heart-transplanted rats using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry: potential biomarkers and drug targets. J Int Med Res. 2013;41:628-35 pubmed publisher
    ..Two protein peaks, with mass-to-charge ratios of 1950 Da and 8577 Da, may have potential for use in post-transplant diagnosis of rejection. ..
  74. Yanagisawa S, Kondo N, Miki A, Matsumiya W, Kusuhara S, Tsukahara Y, et al. A common complement C3 variant is associated with protection against wet age-related macular degeneration in a Japanese population. PLoS ONE. 2011;6:e28847 pubmed publisher
    Genetic variants in the complement component 3 gene (C3) have been shown to be associated with age-related macular degeneration (AMD) in Caucasian populations of European descent...
  75. Silva E, Bourin S, Sabounchi Schütt F, Laurin Y, Barker E, Newman L, et al. A quantitative proteomic analysis of soluble bronchoalveolar fluid proteins from patients with sarcoidosis and chronic beryllium disease. Sarcoidosis Vasc Diffuse Lung Dis. 2007;24:24-32 pubmed
    ..The protein expression levels of peroxiredoxin 5, heat shock protein 70, complement C3, annexin A2 and transthyretin were significantly different in sarcoidosis versus control group...
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    ..expression of macrophage activators was dominated by the complement system factors including the central complement component 3. Additional studies confirmed increased complement component 3 protein levels in both cystic and non-..
  77. Aminudin N, Abdullah N, Misbah H, Karsani S, Husain R, Hoe S, et al. Treatment with captopril abrogates the altered expression of alpha1 macroglobulin and alpha1 antiproteinase in sera of spontaneously hypertensive rats. Proteome Sci. 2012;10:17 pubmed publisher
    ..Analysis by mass spectrometry and database search identified the proteins as retinol binding protein 4, complement C3, albumin (19...
  78. Kellermann W, Frentzel Beyme R, Welte M, Jochum M. Phospholipase A in acute lung injury after trauma and sepsis: its relation to the inflammatory mediators PMN-elastase, C3a, and neopterin. Klin Wochenschr. 1989;67:190-5 pubmed
    ..The relation between PLA and neopterin shown in the study is consistent with the possibility of macrophages being a source of the plasma PLA, as reported in experimental studies. ..
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    ..Complement activation is associated with the pathogenesis of age-related macular degeneration (AMD). We aimed to investigate whether 670-nm light treatment reduces the propagation of complement in a light-induced model of atrophic AMD...
  80. Proitsi P, Lupton M, Dudbridge F, Tsolaki M, Hamilton G, Daniilidou M, et al. Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation. Neurobiol Aging. 2012;33:1843.e9-17 pubmed publisher
    ..susceptibility protein 2 (ARMS2) the complement component 2 (C2), the complement factor B (CFB), and the complement component 3 (C3) genes...
  81. Sax H, Talamini M, Hasselgren P, Rosenblum L, Ogle C, Fischer J. Increased synthesis of secreted hepatic proteins during abdominal sepsis. J Surg Res. 1988;44:109-16 pubmed
    ..rates of the acute-phase secretory proteins alpha 1-acid glycoprotein, transferrin and complement component C3 were significantly increased 16 hr after CLP. However, the albumin synthetic rate was not increased during sepsis...
  82. Krantz S, Stelter F, Lober M, Rjasanowski I, Michaelis D, Buske B. Complement component 3 (C 3) and diabetes mellitus. Exp Clin Endocrinol. 1988;92:287-96 pubmed
    Complement factor 3 (C3) phenotype and allele frequencies were defined in 312 patients with Type 1 diabetes (IDDM), 256 patients with Type 2 diabetes mellitus (NIDDM), 114 apparently healthy first-degree relatives of Type 1 diabetics, in ..
  83. Rutar M, Valter K, Natoli R, Provis J. Synthesis and propagation of complement C3 by microglia/monocytes in the aging retina. PLoS ONE. 2014;9:e93343 pubmed publisher
    ..We aimed to investigate the expression and localization of C3, a crucial component of the complement system, in the retina during the course of aging...
  84. Dalle Lucca J, Chavko M, Dubick M, Adeeb S, Falabella M, Slack J, et al. Blast-induced moderate neurotrauma (BINT) elicits early complement activation and tumor necrosis factor ? (TNF?) release in a rat brain. J Neurol Sci. 2012;318:146-54 pubmed publisher
    ..Moderate blast triggers moderate brain injuries, elevated levels of local brain C3/C5b-9 and systemic C5b-9, increased leukocyte infiltration, unregulated tumor necrosis factor alpha (TNF?), and ..
  85. Dantas M, Costa R, Barbosa J, Graeff M, Sarti W, De Carvalho I. Intravenous immunoglobulin (IVIG) attenuates antibody binding in acute haemorrhagic immunopneumonitis in a rat model of complement-dependent lung injury. Clin Exp Immunol. 2000;121:139-45 pubmed
    ..Pulmonary damage was evaluated by light microscopy; C3 deposits and the binding of immunoglobulins to the alveolar septa were assayed by immunofluorescence...
  86. Lim J, Iyer A, Suen J, Seow V, Reid R, Brown L, et al. C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling. FASEB J. 2013;27:822-31 pubmed publisher
  87. Senaldi G, Lupoli S, Vergani D, Black C. Activation of the complement system in systemic sclerosis. Relationship to clinical severity. Arthritis Rheum. 1989;32:1262-7 pubmed
    ..05), demonstrating that complement activation occurs in SSc. Levels of C3d, C3d:C3, Ba, and Ba:factor B were higher in patients with diffuse cutaneous SSc patients than in controls (P less than 0.01)...
  88. Ruseva M, Hughes T, Donev R, Sivasankar B, Pickering M, Wu X, et al. Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury. Mol Immunol. 2009;46:803-11 pubmed publisher
    ..Gene deletion is 100% embryonically lethal; Crry-deficient (Crry(-/-)) mice were rescued by back-crossing onto C3 deficiency, confirming that embryo loss was complement mediated...
  89. Jordan J, Montalto M, Stahl G. Inhibition of mannose-binding lectin reduces postischemic myocardial reperfusion injury. Circulation. 2001;104:1413-8 pubmed
    ..In vivo, rats were subjected to 30 minutes of left coronary artery occlusion and 4 hours of reperfusion. Complement C3 deposition was greatly attenuated in hearts pretreated with P7E4 compared with 14C3.74-treated hearts...
  90. Sheth R, Hawkins E, Brewer E. Vascular C3 deposits on renal biopsy in pediatric patients with hematuria. Pediatr Nephrol. 2000;14:797-801 pubmed
    Isolated deposition of the third component of complement (C3) in the renal arterioles has been noted on biopsy specimens in patients with hematuria...
  91. Murray I, Kohl J, Cianflone K. Acylation-stimulating protein (ASP): structure-function determinants of cell surface binding and triacylglycerol synthetic activity. Biochem J. 1999;342 ( Pt 1):41-8 pubmed
    ..This contrasts markedly with the structure-function studies of C3a where both binding competency and function were dependent on the C-terminal Arg. Thus ASP demonstrates distinct bioactivity. ..