Gene Symbol: C1s
Description: complement C1s
Alias: r-gsp, complement C1s subcomponent, C1 esterase, complement component 1 subcomponent s, complement component 1, s subcomponent
Sakai H, Nakashima S, Yoshimura S, Nishimura Y, Sakai N, Nozawa Y. Molecular cloning of a cDNA encoding a serine protease homologous to complement C1s precursor from rat C6 glial cells and its expression during glial differentiation. Gene. 1998;209:87-94 pubmed
..by mRNA fingerprinting using arbitrarily primed polymerase chain reaction, and was homologous to complement C1s precursors of hamster and human...
Nakagawa M, Nakashima S, Banno Y, Yamada J, Sawada M, Yoshimura S, et al
. Increased expression and secretion of r-Gsp protein, rat counterpart of complement C1s precursor, during cyclic AMP-induced differentiation in rat C6 glioma cells. Brain Res Mol Brain Res. 2002;106:12-21 pubmed
..The deduced amino acid sequence of r-gsp was homologous to those of complement C1s precursors of hamsters and humans...
Gregory L, Thielens N, Arlaud G, Fontecilla Camps J, Gaboriaud C. X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement. J Biol Chem. 2003;278:32157-64 pubmed
C1, the complex that triggers the classical pathway of complement, is assembled from two modular proteases C1r and C1s and a recognition protein C1q...
Thielens N, Aude C, Lacroix M, Gagnon J, Arlaud G. Ca2+ binding properties and Ca2(+)-dependent interactions of the isolated NH2-terminal alpha fragments of human complement proteases C1-r and C1-s. J Biol Chem. 1990;265:14469-75 pubmed
..This 1:1 stoichiometry is maintained upon heterologous (C1-r-C1-s) interaction, whereas the homologous (C1-s-C1-s) interaction provides one additional binding site. ..
Rossi V, Cseh S, Bally I, Thielens N, Jensenius J, Arlaud G. Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2. J Biol Chem. 2001;276:40880-7 pubmed
..Recombinant MASP-2 displayed a rather wide, C1s-like esterolytic activity, and specifically cleaved complement proteins C2 and C4, with relative efficiencies 3- ..