C1r

Summary

Gene Symbol: C1r
Description: complement C1r
Alias: complement C1r subcomponent, complement component 1, r subcomponent
Species: rat
Products:     C1r

Top Publications

  1. Zhang J, Wright W, Bernlohr D, Cushman S, Chen X. Alterations of the classic pathway of complement in adipose tissue of obesity and insulin resistance. Am J Physiol Endocrinol Metab. 2007;292:E1433-40 pubmed
    ..C1 complex comprising three distinct proteins, C1q, C1r, and C1s, involves the key initial activation of the classic pathway of complement and plays an important role in ..
  2. Budayova Spano M, Lacroix M, Thielens N, Arlaud G, Fontecilla Camps J, Gaboriaud C. The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex. EMBO J. 2002;21:231-9 pubmed
    b>C1r is the modular serine protease (SP) that mediates autolytic activation of C1, the macromolecular complex that triggers the classical pathway of complement...
  3. Major B, Kardos J, K├ękesi K, Lorincz Z, Zavodszky P, Gal P. Calcium-dependent conformational flexibility of a CUB domain controls activation of the complement serine protease C1r. J Biol Chem. 2010;285:11863-9 pubmed publisher
    ..of the complement system, is a Ca(2+)-dependent heteropentamer complex of C1q and two modular serine proteases, C1r and C1s. Current functional models assume significant flexibility of the subcomponents...