Gene Symbol: Bst2
Description: bone marrow stromal cell antigen 2
Alias: DAMP-1, Damp1, bone marrow stromal antigen 2, BST-2, protein DAMP-1
Species: rat
Products:     Bst2

Top Publications

  1. Kupzig S, Korolchuk V, Rollason R, Sugden A, Wilde A, Banting G. Bst-2/HM1.24 is a raft-associated apical membrane protein with an unusual topology. Traffic. 2003;4:694-709 pubmed
    ..Data from several experiments are consistent with this localization. We present a model in which BST-2/HM1.24 serves to link adjacent lipid rafts within the plasma membrane. ..
  2. Jouvenet N, Neil S, Zhadina M, Zang T, Kratovac Z, Lee Y, et al. Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin. J Virol. 2009;83:1837-44 pubmed publisher
    ..Overall, tetherin is potentially active against many enveloped viruses and likely to be an important component of the antiviral innate immune defense. ..
  3. Perez Caballero D, Zang T, Ebrahimi A, McNatt M, Gregory D, Johnson M, et al. Tetherin inhibits HIV-1 release by directly tethering virions to cells. Cell. 2009;139:499-511 pubmed publisher
  4. Hinz A, Miguet N, Natrajan G, Usami Y, Yamanaka H, Renesto P, et al. Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain. Cell Host Microbe. 2010;7:314-23 pubmed publisher
    ..We propose that the irregular coiled coil provides conformational flexibility, ensuring that BST-2/tetherin anchoring both in the plasma membrane and in the newly formed virus membrane is maintained during virus budding. ..
  5. Weidner J, Jiang D, Pan X, Chang J, Block T, Guo J. Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms. J Virol. 2010;84:12646-57 pubmed publisher
    ..Collectively, our work sheds light on the mechanisms by which tetherin and IFITM3 restrict infection with rhabdoviruses and possibly other pathogenic viruses. ..
  6. Rollason R, Korolchuk V, Hamilton C, Jepson M, Banting G. A CD317/tetherin-RICH2 complex plays a critical role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. J Cell Biol. 2009;184:721-36 pubmed publisher
    ..Thus, CD317 provides a physical link between lipid rafts and the apical actin network in polarized epithelial cells and is crucial for the maintenance of microvilli in such cells. ..
  7. Cao W, Bover L, Cho M, Wen X, Hanabuchi S, Bao M, et al. Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J Exp Med. 2009;206:1603-14 pubmed publisher
    ..we discovered an ILT7 ligand expressed by human cell lines and identified it as bone marrow stromal cell antigen 2 (BST2; CD317)...
  8. Radoshitzky S, Dong L, Chi X, Clester J, Retterer C, Spurgers K, et al. Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin. J Virol. 2010;84:10569-80 pubmed publisher
    b>Bone marrow stromal antigen 2 (BST-2/tetherin) is a cellular membrane protein that inhibits the release of HIV-1...
  9. Schubert H, Zhai Q, Sandrin V, Eckert D, Garcia Maya M, Saul L, et al. Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations. Proc Natl Acad Sci U S A. 2010;107:17951-6 pubmed publisher
    HIV-1 and other enveloped viruses can be restricted by a host cellular protein called BST2/tetherin that prevents release of budded viruses from the cell surface...

More Information


  1. Yang H, Wang J, Jia X, McNatt M, Zang T, Pan B, et al. Structural insight into the mechanisms of enveloped virus tethering by tetherin. Proc Natl Acad Sci U S A. 2010;107:18428-32 pubmed publisher
    Tetherin/BST2 is a type-II membrane protein that inhibits the release of a range of enveloped viruses, including HIV-1...
  2. Sarojini S, Theofanis T, Reiss C. Interferon-induced tetherin restricts vesicular stomatitis virus release in neurons. DNA Cell Biol. 2011;30:965-74 pubmed publisher
  3. Gu G, Zhao D, Yin Z, Liu P. BST-2 binding with cellular MT1-MMP blocks cell growth and migration via decreasing MMP2 activity. J Cell Biochem. 2012;113:1013-21 pubmed publisher
    ..Taken together, BST-2, as a membrane protein and a tetherin of enveloped viruses, was a novel inhibitor of MT1-MMP and could be considerable as an inhibitor of cancer cell growth and migration on clinic. ..
  4. Caillet M, Janvier K, Pelchen Matthews A, Delcroix GenĂȘte D, Camus G, Marsh M, et al. Rab7A is required for efficient production of infectious HIV-1. PLoS Pathog. 2011;7:e1002347 pubmed publisher
    ..We also show that siRNA-mediated Rab7A depletion induces a BST2/Tetherin phenotype on HIV-1 release...
  5. Jones P, Mehta H, Maric M, Roller R, Okeoma C. Bone marrow stromal cell antigen 2 (BST-2) restricts mouse mammary tumor virus (MMTV) replication in vivo. Retrovirology. 2012;9:10 pubmed publisher
    ..Our data provide evidence that BST-2 restricts MMTV release from naturally infected cells and that BST-2 is an antiviral factor in vivo. ..