Gene Symbol: Bpi
Description: bactericidal/permeability-increasing protein
Alias: Bpifd1, bactericidal permeability-increasing protein, BPI fold containing family D, member 1
Dentener M, von Asmuth E, Francot G, Marra M, Buurman W. Antagonistic effects of lipopolysaccharide binding protein and bactericidal/permeability-increasing protein on lipopolysaccharide-induced cytokine release by mononuclear phagocytes. Competition for binding to lipopolysaccharide. J Immunol. 1993;151:4258-65 pubmed
..responses to LPS, whereas the polymorphonuclear leukocyte product bactericidal/permeability-increasing protein (BPI) inhibits LPS-induced cell activation...
Fang W, Yao Y, Shi Z, Yu Y, Wu Y, Lu L, et al
. Effect of recombinant bactericidal/permeability-increasing protein on endotoxin translocation and lipopolysaccharide-binding protein/CD14 expression in rats after thermal injury. Crit Care Med. 2001;29:1452-9 pubmed
..rBPI21 (2 mg/kg body wt, BPI group) or a protein control preparation (burn group) in the same dose was administered in an intravenous bolus at ..
Takahashi M, Horiuchi Y, Tezuka T. Presence of bactericidal/permeability-increasing protein in human and rat skin. Exp Dermatol. 2004;13:55-60 pubmed
To examine the presence of bactericidal/permeability-increasing protein (BPI) in skin, which is an antibacterial protein, has cytotoxicity toward Gram-negative bacteria, and may have an important role against bacterial infection in the ..
Lennartsson A, Pieters K, Vidovic K, Gullberg U. A murine antibacterial ortholog to human bactericidal/permeability-increasing protein (BPI) is expressed in testis, epididymis, and bone marrow. J Leukoc Biol. 2005;77:369-77 pubmed
The bactericidal/permeability-increasing protein (BPI), stored in human neutrophil granulocytes, is cytotoxic against Gram-negative bacteria...
Klein W, Tromm A, Folwaczny C, Hagedorn M, Duerig N, Epplen J, et al
. A polymorphism of the bactericidal/permeability increasing protein (BPI) gene is associated with Crohn's disease. J Clin Gastroenterol. 2005;39:282-3 pubmed
The bactericidal/permeability increasing protein (BPI) is involved in the elimination of gram-negative bacteria. A functionally relevant single nucleotide polymorphism of the BPI gene causes an amino acid exchange (Glu216Lys)...