Bnip3

Summary

Gene Symbol: Bnip3
Description: BCL2 interacting protein 3
Alias: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3, BCL2/adenovirus E1B 19 kDa-interacting protein 3, BCL2/adenovirus E1B interacting protein 3
Species: rat
Products:     Bnip3

Top Publications

  1. Zhang S, Zhang Z, Sandhu G, Ma X, Yang X, Geiger J, et al. Evidence of oxidative stress-induced BNIP3 expression in amyloid beta neurotoxicity. Brain Res. 2007;1138:221-30 pubmed
    ..Here we show that Abeta-induced oxidative stress activates the pro-death gene BNIP3. Abeta treatment results in mitochondrial dysfunction, accumulation of reactive oxygen species, and subsequent ..
  2. Quinsay M, Lee Y, Rikka S, Sayen M, Molkentin J, Gottlieb R, et al. Bnip3 mediates permeabilization of mitochondria and release of cytochrome c via a novel mechanism. J Mol Cell Cardiol. 2010;48:1146-56 pubmed publisher
    b>Bnip3 is a member of the BH3-only subfamily of pro-apoptotic Bcl-2 proteins and is associated with loss of cardiac myocytes after a myocardial infarction...
  3. Vande Velde C, Cizeau J, Dubik D, Alimonti J, Brown T, Israels S, et al. BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. Mol Cell Biol. 2000;20:5454-68 pubmed
    ..b>BNIP3 (formerly NIP3) is a member of the Bcl-2 family that is expressed in mitochondria and induces apoptosis without a ..
  4. Quinsay M, Thomas R, Lee Y, Gustafsson A. Bnip3-mediated mitochondrial autophagy is independent of the mitochondrial permeability transition pore. Autophagy. 2010;6:855-62 pubmed
    b>Bnip3 is a pro-apoptotic BH3-only protein which is associated with mitochondrial dysfunction and cell death. Bnip3 is also a potent inducer of autophagy in many cells...
  5. Kubli D, Quinsay M, Huang C, Lee Y, Gustafsson A. Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusion. Am J Physiol Heart Circ Physiol. 2008;295:H2025-31 pubmed publisher
    Bcl-2/adenovirus E1B 19-kDa protein-interacting protein 3 (Bnip3) is a member of the Bcl-2 homology domain 3-only subfamily of proapoptotic Bcl-2 proteins and is associated with cell death in the myocardium...
  6. Zhang H, Bosch Marce M, Shimoda L, Tan Y, Baek J, Wesley J, et al. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem. 2008;283:10892-903 pubmed publisher
    ..autophagy is induced by hypoxia, that this process requires the hypoxia-dependent factor-1-dependent expression of BNIP3 and the constitutive expression of Beclin-1 and Atg5, and that in cells subjected to prolonged hypoxia, ..
  7. Kubasiak L, Hernandez O, Bishopric N, Webster K. Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3. Proc Natl Acad Sci U S A. 2002;99:12825-30 pubmed
    ..We now report that hypoxia-acidosis-associated cell death is mediated by BNIP3, a member of the Bcl-2 family of apoptosis-regulating proteins...
  8. Gang H, Hai Y, Dhingra R, Gordon J, Yurkova N, Aviv Y, et al. A novel hypoxia-inducible spliced variant of mitochondrial death gene Bnip3 promotes survival of ventricular myocytes. Circ Res. 2011;108:1084-92 pubmed publisher
    ..Previously, we established hypoxia-inducible death factor Bnip3 as a critical component of the intrinsic death pathway...
  9. Nakamura Y, Kitamura N, Shinogi D, Yoshida M, Goda O, Murai R, et al. BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria. PLoS ONE. 2012;7:e30767 pubmed publisher
    ..Here, we report that an additional mitochondrial outer membrane protein, BNIP3, is also involved in MALM...

More Information

Publications70

  1. Lomonosova E, Chinnadurai G. BH3-only proteins in apoptosis and beyond: an overview. Oncogene. 2008;27 Suppl 1:S2-19 pubmed publisher
    ..The cell death activity of a subclass of BH3-only members (BNIP3 and BNIP3L) is linked to cardiomyocyte loss during heart failure...
  2. Regula K, Ens K, Kirshenbaum L. Inducible expression of BNIP3 provokes mitochondrial defects and hypoxia-mediated cell death of ventricular myocytes. Circ Res. 2002;91:226-31 pubmed
    In this study, we provide evidence for the operation of BNIP3 as a key regulator of mitochondrial function and cell death of ventricular myocytes during hypoxia. In contrast to normoxic cells, a 5.6-fold increase (P<0...
  3. Galvez A, Brunskill E, Marreez Y, Benner B, Regula K, Kirschenbaum L, et al. Distinct pathways regulate proapoptotic Nix and BNip3 in cardiac stress. J Biol Chem. 2006;281:1442-8 pubmed
    Up-regulation of myocardial Nix and BNip3 is associated with apoptosis in cardiac hypertrophy and ischemia, respectively...
  4. Zhang J, Ye J, Altafaj A, Cardona M, Bahi N, Llovera M, et al. EndoG links Bnip3-induced mitochondrial damage and caspase-independent DNA fragmentation in ischemic cardiomyocytes. PLoS ONE. 2011;6:e17998 pubmed publisher
    ..The atypical BH3-only protein Bnip3 is involved in the process leading to caspase-independent DNA fragmentation in cardiomyocytes...
  5. Zhang Z, Yang X, Zhang S, Ma X, Kong J. BNIP3 upregulation and EndoG translocation in delayed neuronal death in stroke and in hypoxia. Stroke. 2007;38:1606-13 pubmed
    ..Here we test the hypothesis that one of the caspase-independent apoptosis pathways is activated by BNIP3 and mediated by EndoG...
  6. Chen G, Ray R, Dubik D, Shi L, Cizeau J, Bleackley R, et al. The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis. J Exp Med. 1997;186:1975-83 pubmed
    ..Nip3 protein levels are much higher and persist longer in Bcl-2 expressing cells. In conclusion, Nip3 is an apoptosis-inducing dimeric mitochondrial protein that can overcome Bcl-2 suppression. ..
  7. Bellot G, Garcia Medina R, Gounon P, Chiche J, Roux D, Pouyssegur J, et al. Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol. 2009;29:2570-81 pubmed publisher
    ..Several studies implicate the HIF-induced putative BH3-only proapoptotic genes bnip3 and bnip3l in hypoxia-mediated cell death. We, like others, do not support this assertion...
  8. Hamacher Brady A, Brady N, Logue S, Sayen M, Jinno M, Kirshenbaum L, et al. Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy. Cell Death Differ. 2007;14:146-57 pubmed
    Ischemia and reperfusion (I/R) injury is associated with extensive loss of cardiac myocytes. Bnip3 is a mitochondrial pro-apoptotic Bcl-2 protein which is expressed in the adult myocardium...
  9. Li C, Guan T, Chen X, Li W, Cai Q, Niu J, et al. BNIP3 mediates pre-myelinating oligodendrocyte cell death in hypoxia and ischemia. J Neurochem. 2013;127:426-33 pubmed publisher
    ..Previously, we showed that Bcl-2?E1B-19K-interacting protein 3 (BNIP3), a proapoptotic member of the Bcl-2 family proteins, induced neuronal death in a caspase-independent manner in ..
  10. Boyd J, Malstrom S, Subramanian T, Venkatesh L, Schaeper U, Elangovan B, et al. Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. Cell. 1994;79:341-51 pubmed
    ..Our results suggest that two diverse proteins, the E1B 19 kDa and the Bcl-2 proteins, promote cell survival through interaction with a common set of cellular proteins. ..
  11. Zhao S, Chen M, Li S, Zhang M, Li B, Das M, et al. Mitochondrial BNIP3 upregulation precedes endonuclease G translocation in hippocampal neuronal death following oxygen-glucose deprivation. BMC Neurosci. 2009;10:113 pubmed publisher
    ..mitochondrial proteins, including endonuclease G (EndoG) and Bcl-2/adenovirus E1B 19 kDa-interacting protein (BNIP3), in the pathway of non-neuronal cells...
  12. Jian B, Yang S, Chen D, Zou L, Chatham J, Chaudry I, et al. Aging influences cardiac mitochondrial gene expression and cardiovascular function following hemorrhage injury. Mol Med. 2011;17:542-9 pubmed publisher
    ..The expression of c-Myc and cardiac death promoting gene Bnip3 were increased, and Pgc1-? and Ppar-? a decreased following T-H...
  13. Jannig P, Moreira J, Bechara L, Bozi L, Bacurau A, Monteiro A, et al. Autophagy signaling in skeletal muscle of infarcted rats. PLoS ONE. 2014;9:e85820 pubmed publisher
    ..The key findings of the present study were: a) upregulation of autophagy-related genes (GABARAPL1, ATG7, BNIP3, CTSL1 and LAMP2) was observed only in plantaris while muscle atrophy was observed in both soleus and plantaris ..
  14. Kubli D, Gustafsson A. Mitochondria and mitophagy: the yin and yang of cell death control. Circ Res. 2012;111:1208-21 pubmed publisher
    ..Herein, we discuss the importance of mitochondria and mitophagy in cardiovascular health and disease and provide a review of our current understanding of how these processes are regulated. ..
  15. Lee Y, Lee H, Hanna R, Gustafsson A. Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2011;301:H1924-31 pubmed publisher
    The Bcl2/adenovirus E1B 19-kDa interacting protein 3 (Bnip3) is an atypical BH3-only protein that is associated with mitochondrial dysfunction and cell death...
  16. Althaus J, Bernaudin M, Petit E, Toutain J, Touzani O, Rami A. Expression of the gene encoding the pro-apoptotic BNIP3 protein and stimulation of hypoxia-inducible factor-1alpha (HIF-1alpha) protein following focal cerebral ischemia in rats. Neurochem Int. 2006;48:687-95 pubmed
    ..Moreover, we demonstrated, for the first time a specific localization of the pro-apoptotic regulator BNIP3 in striatal and cortical neurons after transient focal ischemia in rats...
  17. Dong Y, Li Y, Sun Y, Mao J, Yao F, Tian Y, et al. Bufei Jianpi granules improve skeletal muscle and mitochondrial dysfunction in rats with chronic obstructive pulmonary disease. BMC Complement Altern Med. 2015;15:51 pubmed publisher
    ..and ultrastructural changes and expressions of mitochondrial Bcl-2 nineteen-kilodalton interacting protein 3 (Bnip3) and cytoplasm cytochrome C (Cyto C) in the four skeletal muscles were observed by using optical and electron ..
  18. Li R, Yan G, Li Q, Sun H, Hu Y, Sun J, et al. MicroRNA-145 protects cardiomyocytes against hydrogen peroxide (H?O?)-induced apoptosis through targeting the mitochondria apoptotic pathway. PLoS ONE. 2012;7:e44907 pubmed publisher
    ..These protective effects of miR-145 were abrogated by over-expression of Bnip3, an initiation factor of the mitochondrial apoptotic pathway in cardiomyocytes...
  19. Dhingra R, Gang H, Wang Y, Biala A, Aviv Y, Margulets V, et al. Bidirectional regulation of nuclear factor-?B and mammalian target of rapamycin signaling functionally links Bnip3 gene repression and cell survival of ventricular myocytes. Circ Heart Fail. 2013;6:335-43 pubmed publisher
    ..Our previous work has shown that NF-?B signaling suppresses transcription of the death gene Bnip3 resulting in ventricular myocyte survival...
  20. Frazier D, Wilson A, Graham R, Thompson J, Bishopric N, Webster K. Acidosis regulates the stability, hydrophobicity, and activity of the BH3-only protein Bnip3. Antioxid Redox Signal. 2006;8:1625-34 pubmed
    b>Bnip3 is a prodeath member of the so-called BH3-only subfamily of Bcl-2 proteins...
  21. Chaanine A, Gordon R, Kohlbrenner E, Benard L, Jeong D, Hajjar R. Potential role of BNIP3 in cardiac remodeling, myocardial stiffness, and endoplasmic reticulum: mitochondrial calcium homeostasis in diastolic and systolic heart failure. Circ Heart Fail. 2013;6:572-83 pubmed publisher
    We have shown that BNIP3 expression is significantly increased in heart failure (HF). In this study, we tested the effects of BNIP3 manipulation in HF...
  22. Zhang X, Bian X, Kong J. The proapoptotic protein BNIP3 interacts with VDAC to induce mitochondrial release of endonuclease G. PLoS ONE. 2014;9:e113642 pubmed publisher
    b>BNIP3 is a proapoptotic protein that induces cell death through a mitochondria-mediated pathway...
  23. Byun Y, Kim S, Kim Y, Chae G, Jeong S, Lee S. Hydrogen peroxide induces autophagic cell death in C6 glioma cells via BNIP3-mediated suppression of the mTOR pathway. Neurosci Lett. 2009;461:131-5 pubmed publisher
    ..at Ser 2481 and the p70 ribosomal protein S6 kinase (p70S6K) at Thr389 in a Bcl-2/E1B 19kDa interacting protein 3 (BNIP3)-dependent manner...
  24. Yasuda M, Han J, Dionne C, Boyd J, Chinnadurai G. BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3. Cancer Res. 1999;59:533-7 pubmed
    ..Cellular protein BNIP3 is a BCL-2 family proapoptotic protein that interacts with viral antiapoptosis proteins such as adenoviruses E1B-..
  25. An H, Maeng O, Kang K, Lee J, Kim Y, Paik S, et al. Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death. J Biol Chem. 2006;281:33939-48 pubmed
    ..We have shown previously that endogenously produced or exogenously added NO induces expression of BNIP3 (Bcl-2/adenovirus E1B 19 kDa-interacting protein 3), leading to death of macrophages (Yook, Y.-H., Kang, K.-H...
  26. Min J, Huo X, Xiang L, Qin Y, Chai K, Wu B, et al. Protective effect of Dl-3n-butylphthalide on learning and memory impairment induced by chronic intermittent hypoxia-hypercapnia exposure. Sci Rep. 2014;4:5555 pubmed publisher
    ..Moreover, NBP further induced the expression of HIF-1?, accompanied by the up-regulation of the autophagy proteins Bnip3, Beclin-1 and LC3-II...
  27. Wu C, Hu Q, Chen J, Yan F, Li J, Wang L, et al. Inhibiting HIF-1? by 2ME2 ameliorates early brain injury after experimental subarachnoid hemorrhage in rats. Biochem Biophys Res Commun. 2013;437:469-74 pubmed publisher
    ..We found that treatment with 2ME2 suppressed the expression of HIF-1?, BNIP3 and VEGF and reduced cell apoptosis, blood-brain barrier (BBB) permeability, brain edema, and neurologic scores...
  28. Yu D, Li M, Ni B, Kong J, Zhang Z. Induction of neuronal mitophagy in acute spinal cord injury in rats. Neurotox Res. 2013;24:512-22 pubmed publisher
    ..Bcl-2/E1B-19 K-interacting protein 3 (BNIP3) and Nip-like protein X (NIX, also known as BNIP3L) are mitochondrial BH3-only proteins that are implicated in ..
  29. Yurkova N, Shaw J, Blackie K, Weidman D, Jayas R, Flynn B, et al. The cell cycle factor E2F-1 activates Bnip3 and the intrinsic death pathway in ventricular myocytes. Circ Res. 2008;102:472-9 pubmed
    ..Furthermore, we show mechanistically that the hypoxia-inducible death factor Bnip3 is a direct transcriptional target of E2F-1 that is necessary and sufficient for E2F-1-induced cell death...
  30. Prabhakaran K, Li L, Zhang L, Borowitz J, Isom G. Upregulation of BNIP3 and translocation to mitochondria mediates cyanide-induced apoptosis in cortical cells. Neuroscience. 2007;150:159-67 pubmed
    Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 (BNIP3), a Bcl-2 homology domain 3 (BH3) domain only protein, has been identified as a mitochondrial mediator of hypoxia-induced cell death...
  31. Band M, Joel A, Hernandez A, Avivi A. Hypoxia-induced BNIP3 expression and mitophagy: in vivo comparison of the rat and the hypoxia-tolerant mole rat, Spalax ehrenbergi. FASEB J. 2009;23:2327-35 pubmed publisher
    ..b>BNIP3, an HIF-1 dependent hypoxia-response gene, has a proapoptotic function; however, expression is suppressed in many ..
  32. Zamora R, Vodovotz Y, Betten B, Wong C, Zuckerbraun B, Gibson K, et al. Intestinal and hepatic expression of BNIP3 in necrotizing enterocolitis: regulation by nitric oxide and peroxynitrite. Am J Physiol Gastrointest Liver Physiol. 2005;289:G822-30 pubmed
    ..We examined the expression and regulation of the Bcl-2/adenovirus EIB 19-kDa-interacting protein 3 (BNIP3), a pro-apoptotic gene regulated by nitric oxide (NO) in hepatocytes, in NEC...
  33. Liu J, Peng N, Zeng S, Lu Y, Wang J, Zhou Y. [Upregulation of Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 and translocation to mitochondria in nucleus pulposus cells induced by nutrition deprivation]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2012;26:166-71 pubmed
    To detect the expression of Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 (BNIP3) in cell death induced by nutrition deprivation in nucleus pulposus cells so as to further understand the mechanism of death in nucleus pulposus cells...
  34. Zhang Z, Shi R, Weng J, Xu X, Li X, Gao T, et al. The proapoptotic member of the Bcl-2 family Bcl-2?/?E1B-19K-interacting protein 3 is a mediator of caspase-independent neuronal death in excitotoxicity. FEBS J. 2011;278:134-42 pubmed publisher
    ..Here, we tested the hypothesis that the gene encoding Bcl-2/E1B-19K-interacting protein 3 (BNIP3) mediates caspase-independent neuronal death in excitotoxicity...
  35. Hoshino A, Matoba S, Iwai Kanai E, Nakamura H, Kimata M, Nakaoka M, et al. p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia. J Mol Cell Cardiol. 2012;52:175-84 pubmed publisher
    ..In p53(-/-) and TIGAR(-/-) ischemic myocardium, ROS production was elevated and followed by Bnip3 activation which is an initiator of mitophagy...
  36. Zhang Q, Chang Q, Cox R, Gong X, Gould L. Hyperbaric oxygen attenuates apoptosis and decreases inflammation in an ischemic wound model. J Invest Dermatol. 2008;128:2102-12 pubmed publisher
    ..Analysis of ischemic wound tissue extracts demonstrated significantly reduced expression of HIF-1alpha, p53, and BNip3. Additionally, HBO increased expression of Bcl-2 while decreasing cleaved caspase-3...
  37. Ishihara M, Urushido M, Hamada K, Matsumoto T, Shimamura Y, Ogata K, et al. Sestrin-2 and BNIP3 regulate autophagy and mitophagy in renal tubular cells in acute kidney injury. Am J Physiol Renal Physiol. 2013;305:F495-509 pubmed publisher
    ..The aim of this study was to investigate the roles of BNIP3 and sestrin-2 in oxidative stress-induced autophagy during AKI...
  38. Sandau U, Handa R. Localization and developmental ontogeny of the pro-apoptotic Bnip3 mRNA in the postnatal rat cortex and hippocampus. Brain Res. 2006;1100:55-63 pubmed
    ..b>Bnip3 is a pro-apoptotic member of the Bcl-2 family that induces cell death by opening the mitochondrial permeability ..
  39. Shaw J, Yurkova N, Zhang T, Gang H, Aguilar F, Weidman D, et al. Antagonism of E2F-1 regulated Bnip3 transcription by NF-kappaB is essential for basal cell survival. Proc Natl Acad Sci U S A. 2008;105:20734-9 pubmed publisher
    ..The hypoxia-inducible death factor Bnip3 is an E2F-1 target gene and integral component of the intrinsic mitochondrial death pathway...
  40. Sowter H, Ferguson M, Pym C, Watson P, Fox S, Han C, et al. Expression of the cell death genes BNip3 and NIX in ductal carcinoma in situ of the breast; correlation of BNip3 levels with necrosis and grade. J Pathol. 2003;201:573-80 pubmed
    ..Two cell death genes, BNip3 and NIX, are up-regulated in response to hypoxia in breast carcinoma cells, although any involvement of either ..
  41. Wei H, Liu L, Chen Q. Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses. Biochim Biophys Acta. 2015;1853:2784-90 pubmed publisher
    ..In mammals, different mitophagy effectors, including the mitophagy receptors NIX, BNIP3 and FUDNC1 and the PINK1/Parkin pathway, have been identified to participate in the selective clearance of ..
  42. Itoh T, Itoh A, Pleasure D. Bcl-2-related protein family gene expression during oligodendroglial differentiation. J Neurochem. 2003;85:1500-12 pubmed
    ..Among 'BH3 domain-only' members examined (Bim, Biklk, DP5/Hrk, Bad, Bid, Noxa, Puma/Bbc3, Bmf, BNip3 and BNip3L), BNip3 and Bmf mRNAs increase markedly during differentiation...
  43. Fordjour P, Wang L, Gao H, Li L, Wang Y, Nyagblordzro M, et al. Targeting BNIP3 in inflammation-mediated heart failure: a novel concept in heart failure therapy. Heart Fail Rev. 2016;21:489-97 pubmed publisher
    ..activates inflammatory mediators and provokes the integration of BCL-2/adenovirus E1B 19KD interacting protein 3 (BNIP3) into mitochondrial membranes...
  44. Shelby S, Angadi P, Zheng Q, Yao J, Jia L, Zacks D. Hypoxia inducible factor 1α contributes to regulation of autophagy in retinal detachment. Exp Eye Res. 2015;137:84-93 pubmed publisher
    ..observed increased levels of HIF-1α and HIF-2α within 1 day post-detachment, as well as increased levels of BNIP3, a downstream target of HIF-1α that contributes to autophagy activation...
  45. Wang P, Tang Y, Chen X, Du B. [Nuclear translocation of the pro-apoptotic protein BNIP3 in cultured spiral ganglion cells of rat with cisplatin insult]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011;46:214-9 pubmed
    To observe spiral ganglion cell (SGC) death pattern caused by cisplatin and investigate pro-apoptotic protein BNIP3 involvement in SGC death. Cochlear SGC were isolated from the neonatal rats and cultured in vitro...
  46. Cao W, Liu N, Tang S, Bao L, Shen L, Yuan H, et al. Acetyl-Coenzyme A acyltransferase 2 attenuates the apoptotic effects of BNIP3 in two human cell lines. Biochim Biophys Acta. 2008;1780:873-80 pubmed publisher
    b>BNIP3 is a unique pro-apoptotic protein which belongs to the BH3-only subset of the Bcl-2 family and localizes on mitochondrial membrane...
  47. Kliminski V, Uziel O, Kessler Icekson G. Popdc1/Bves Functions in the Preservation of Cardiomyocyte Viability While Affecting Rac1 Activity and Bnip3 Expression. J Cell Biochem. 2017;118:1505-1517 pubmed publisher
    ..injury and death, upregulation of the pro-apoptotic protein Bcl-2/adenovirus E1B 19-kDa interacting protein3 (Bnip3), as well as reduction in Rac1-GTPase activity and in Akt phosphorylation...
  48. Thompson J, Wei J, Appau K, Wang H, Yu H, Spiga M, et al. Bnip3 Binds and Activates p300: Possible Role in Cardiac Transcription and Myocyte Morphology. PLoS ONE. 2015;10:e0136847 pubmed publisher
    b>Bnip3 is a hypoxia-regulated member of the Bcl-2 family of proteins that is implicated in apoptosis, programmed necrosis, autophagy and mitophagy...
  49. Graham R, Thompson J, Webster K. BNIP3 promotes calcium and calpain-dependent cell death. Life Sci. 2015;142:26-35 pubmed publisher
    ..Hypoxia-acidosis was demonstrated to activate the pro-apoptotic Bcl-2 protein BNIP3 which initiated opening of the mitochondrial permeability transition pore and cell death in the absence of caspase ..
  50. Landes T, Emorine L, Courilleau D, Rojo M, Belenguer P, Arnauné Pelloquin L. The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms. EMBO Rep. 2010;11:459-65 pubmed publisher
    ..We show that Bnip3 interacts with Opa1, leading to mitochondrial fragmentation and apoptosis...
  51. Lee Y, Kubli D, Hanna R, Cortez M, Lee H, Miyamoto S, et al. Cellular redox status determines sensitivity to BNIP3-mediated cell death in cardiac myocytes. Am J Physiol Cell Physiol. 2015;308:C983-92 pubmed publisher
    The atypical BH3-only protein Bcl-2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3) is an important regulator of hypoxia-mediated cell death. Interestingly, the susceptibility to BNIP3-mediated cell death differs between cells...
  52. Shaw J, Zhang T, Rzeszutek M, Yurkova N, Baetz D, Davie J, et al. Transcriptional silencing of the death gene BNIP3 by cooperative action of NF-kappaB and histone deacetylase 1 in ventricular myocytes. Circ Res. 2006;99:1347-54 pubmed
    ..In this report we provide new mechanistic evidence that the hypoxia-inducible death factor BNIP3 is transcriptionally silenced by NF-kappaB through a mechanism that involves the cooperative actions of HDAC1...
  53. Dhingra R, Margulets V, Chowdhury S, Thliveris J, Jassal D, Fernyhough P, et al. Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling. Proc Natl Acad Sci U S A. 2014;111:E5537-44 pubmed publisher
    ..respiratory chain defects and necrotic cell death to the BH3-only protein Bcl-2-like 19 kDa-interacting protein 3 (Bnip3). Cellular defects, including vacuolization and disrupted mitochondria, were observed in DOX-treated mice hearts...
  54. Fedorova L, Tamirisa A, Kennedy D, Haller S, Budnyy G, Shapiro J, et al. Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach. BMC Nephrol. 2013;14:209 pubmed publisher
    ..b>BNIP3 protein, which can initiate both mitochondrial autophagy and cell death, was up-regulated considerably in kidneys ..
  55. Wang E, Gang H, Aviv Y, Dhingra R, Margulets V, Kirshenbaum L. p53 mediates autophagy and cell death by a mechanism contingent on Bnip3. Hypertension. 2013;62:70-7 pubmed publisher
    ..Previously, we showed that the Bcl-2 death gene Bnip3 is highly induced during ischemia, where it triggers mitochondrial perturbations resulting in autophagy and cell ..
  56. Baetz D, Regula K, Ens K, Shaw J, Kothari S, Yurkova N, et al. Nuclear factor-kappaB-mediated cell survival involves transcriptional silencing of the mitochondrial death gene BNIP3 in ventricular myocytes. Circulation. 2005;112:3777-85 pubmed
    ..mechanistic evidence that survival signals conferred by NF-kappaB impinge on the hypoxia-inducible death factor BNIP3. Activation of the NF-kappaB signaling pathway by IKKbeta in ventricular myocytes suppressed mitochondrial ..
  57. Ohi N, Tokunaga A, Tsunoda H, Nakano K, Haraguchi K, Oda K, et al. A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region. Cell Death Differ. 1999;6:314-25 pubmed
    ..However the deletion mutant B5Delta1-31 lacking the N-terminus does induce apoptosis, although weaker than does Nip3, suggesting that the N-terminal region is masking the apoptosis-inducing capacity of B5. ..
  58. Diao H, Liu B, Shi Y, Song C, Guo Z, Liu N, et al. MicroRNA-210 alleviates oxidative stress-associated cardiomyocyte apoptosis by regulating BNIP3. Biosci Biotechnol Biochem. 2017;81:1712-1720 pubmed publisher
    ..was upregulated in myocardial tissues of I/R rats, while that of Bcl-2 adenovirus E1B 19kDa-interacting protein 3 (BNIP3) was downregulated...
  59. Tea M, Fogarty R, Brereton H, Michael M, Van der Hoek M, Tsykin A, et al. Gene expression microarray analysis of early oxygen-induced retinopathy in the rat. J Ocul Biol Dis Infor. 2009;2:190-201 pubmed
    ..Quantitative real-time RT-PCR analysis of Egln3, Bnip3, Slc16a3, and Hk2 confirmed the microarray results...
  60. Metukuri M, Beer Stolz D, Namas R, Dhupar R, Torres A, Loughran P, et al. Expression and subcellular localization of BNIP3 in hypoxic hepatocytes and liver stress. Am J Physiol Gastrointest Liver Physiol. 2009;296:G499-509 pubmed publisher
    We have previously demonstrated that the Bcl-2/adenovirus EIB 19-kDa interacting protein 3 (BNIP3), a cell death-related member of the Bcl-2 family, is upregulated in vitro and in vivo in both experimental and clinical settings of redox ..
  61. Ułamek Kozioł M, Kocki J, Bogucka Kocka A, Petniak A, Gil Kulik P, Januszewski S, et al. Dysregulation of Autophagy, Mitophagy, and Apoptotic Genes in the Medial Temporal Lobe Cortex in an Ischemic Model of Alzheimer's Disease. J Alzheimers Dis. 2016;54:113-21 pubmed publisher