Gene Symbol: Bmpr1b
Description: bone morphogenetic protein receptor type 1B
Alias: CFK-43a, bone morphogenetic protein receptor type-1B, bone morphogenetic protein binding serine/threonine kinase receptor, bone morphogenetic protein receptor, type IB
Species: rat
Products:     Bmpr1b

Top Publications

  1. Lehmann K, Seemann P, Stricker S, Sammar M, Meyer B, Süring K, et al. Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2. Proc Natl Acad Sci U S A. 2003;100:12277-82 pubmed
    ..This interval includes the gene bone morphogenetic protein receptor 1B (BMPR1B), a type I transmembrane serinethreonine kinase...
  2. Tsujii M, Akeda K, Iino T, Uchida A. Are BMPs involved in normal nerve and following transection?: a pilot study. Clin Orthop Relat Res. 2009;467:3183-9 pubmed publisher
    ..BMPRs were also upregulated compared with the normal nerve. The upregulation in BMP expression after nerve transection suggests that BMPs may play a role in the healing response of the peripheral nerve. ..
  3. Aström A, Jin D, Imamura T, Roijer E, Rosenzweig B, Miyazono K, et al. Chromosomal localization of three human genes encoding bone morphogenetic protein receptors. Mamm Genome. 1999;10:299-302 pubmed
    ..Here we report the cDNA cloning of human BMPR1B and the chromosomal localization of all three BMPR genes...
  4. Baur S, Mai J, Dymecki S. Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity. Development. 2000;127:605-19 pubmed
  5. Faber S, Robinson M, Makarenkova H, Lang R. Bmp signaling is required for development of primary lens fiber cells. Development. 2002;129:3727-37 pubmed
    ..Second, we have expressed a dominant-negative form of the type 1 Bmp family receptor Alk6 (Bmpr1b -- Mouse Genome Informatics) in the lens in transgenic mice and shown that an inhibition of primary fiber cell ..
  6. Rosendahl A, Pardali E, Speletas M, Ten Dijke P, Heldin C, Sideras P. Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation. Am J Respir Cell Mol Biol. 2002;27:160-9 pubmed
  7. Dewachter L, Adnot S, Guignabert C, Tu L, Marcos E, Fadel E, et al. Bone morphogenetic protein signalling in heritable versus idiopathic pulmonary hypertension. Eur Respir J. 2009;34:1100-10 pubmed publisher
    ..Most heterogeneous BMPR-2 mutations are associated with defective Smad signalling compensated for by an activation of p38MAPK signalling, accounting for PASMC proliferation and deficient apoptosis. ..
  8. Demirhan O, Turkmen S, Schwabe G, Soyupak S, Akgul E, Tastemir D, et al. A homozygous BMPR1B mutation causes a new subtype of acromesomelic chondrodysplasia with genital anomalies. J Med Genet. 2005;42:314-7 pubmed
    ..a patient with acromesomelic chondrodysplasia and genital anomalies caused by a novel homozygous mutation in BMPR1B, the gene coding for bone morphogenetic protein receptor 1B...
  9. Kariyawasam H, Xanthou G, Barkans J, Aizen M, Kay A, Robinson D. Basal expression of bone morphogenetic protein receptor is reduced in mild asthma. Am J Respir Crit Care Med. 2008;177:1074-81 pubmed publisher
    ..Allergen provocation increases expression of the regulatory ligand BMP-7, activates BMP signaling, and increases receptor expression, all of which may contribute to repair and control of inflammation. ..

More Information


  1. Mazerbourg S, Sangkuhl K, Luo C, Sudo S, Klein C, Hsueh A. Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses. J Biol Chem. 2005;280:32122-32 pubmed
    ..Thus, the present approach provides a genomic paradigm for matching paralogous polypeptide ligands with a limited number of evolutionarily related receptors capable of activating specific downstream Smad proteins. ..
  2. Degenkolbe E, König J, Zimmer J, Walther M, Reißner C, Nickel J, et al. A GDF5 point mutation strikes twice--causing BDA1 and SYNS2. PLoS Genet. 2013;9:e1003846 pubmed publisher
    ..These novel insights into the biology of GDF5 might also provide further clues on the pathophysiology of OA. ..
  3. Miyagi M, Mikawa S, Hasegawa T, Kobayashi S, Sho K, Matsuyama Y, et al. Bone morphogenetic protein receptor expressions in the adult rat brain. Neuroscience. 2011;176:93-109 pubmed publisher
  4. Itoh S, Kanno S, Gai Z, Suemoto H, Kawakatsu M, Tanishima H, et al. Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells. Genes Cells. 2008;13:355-63 pubmed publisher
    ..In conclusion, Trps1 acts downstream of the Gdf5 signaling pathway and promotes the differentiation and apoptosis of ATDC5 cells. ..
  5. Murali D, Yoshikawa S, Corrigan R, Plas D, Crair M, Oliver G, et al. Distinct developmental programs require different levels of Bmp signaling during mouse retinal development. Development. 2005;132:913-23 pubmed
    ..Further reduction of Bmp receptor activity by removing one functional copy of another Bmp type I receptor gene, Bmpr1b, in the retina-specific Bmpr1a mutant background, results in abnormal retinal dorsoventral patterning...
  6. Inman G, Nicolás F, Callahan J, Harling J, Gaster L, Reith A, et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol. 2002;62:65-74 pubmed
    ..SB-431542 has no effect on components of the ERK, JNK, or p38 MAP kinase pathways or on components of the signaling pathways activated in response to serum. ..
  7. Yi S, LaPolt P, Yoon B, Chen J, Lu J, Lyons K. The type I BMP receptor BmprIB is essential for female reproductive function. Proc Natl Acad Sci U S A. 2001;98:7994-9 pubmed
  8. Babitt J, Huang F, Wrighting D, Xia Y, Sidis Y, Samad T, et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 2006;38:531-9 pubmed
    ..Our data suggest a mechanism by which HFE2 mutations cause hemochromatosis: hemojuvelin dysfunction decreases BMP signaling, thereby lowering hepcidin expression. ..
  9. Lavery K, Swain P, Falb D, Alaoui Ismaili M. BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. J Biol Chem. 2008;283:20948-58 pubmed publisher
    ..b>BMPR1B and ACVR2B were expressed at low levels and were not found to play a significant role in signaling by any of the ..
  10. Visser J, Olaso R, Verhoef Post M, Kramer P, Themmen A, Ingraham H. The serine/threonine transmembrane receptor ALK2 mediates Müllerian inhibiting substance signaling. Mol Endocrinol. 2001;15:936-45 pubmed
    ..The use of this ubiquitously expressed type I receptor underscores the role of the MIS ligand and the MIS type II receptor in establishing the specificity of the MIS signaling cascade. ..
  11. Graul Neumann L, Deichsel A, Wille U, Kakar N, Koll R, Bassir C, et al. Homozygous missense and nonsense mutations in BMPR1B cause acromesomelic chondrodysplasia-type Grebe. Eur J Hum Genet. 2014;22:726-33 pubmed publisher
    ..157T>C, p.(C53R)) or nonsense (c.657G>A, p.(W219*)) mutations in BMPR1B. Homozygous affected individuals show clinical and radiographic findings consistent with ACD-type Grebe...