Gene Symbol: Bloc1s1
Description: biogenesis of lysosomal organelles complex-1, subunit 1
Alias: biogenesis of lysosome-related organelles complex 1 subunit 1, BLOC-1 subunit 1
Starcevic M, Dell Angelica E. Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1). J Biol Chem. 2004;279:28393-401 pubmed
..Mutations in the human genes encoding Snapin and the BLOS proteins could underlie novel forms of HPS. ..
Pu J, Schindler C, Jia R, Jarnik M, Backlund P, Bonifacino J. BORC, a multisubunit complex that regulates lysosome positioning. Dev Cell. 2015;33:176-88 pubmed publisher
..In turn, this causes reduced cell spreading and migration, highlighting the importance of BORC-dependent centrifugal transport for non-degradative functions of lysosomes. ..
Lee H, Nemecek D, Schindler C, Smith W, Ghirlando R, Steven A, et al
. Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1). J Biol Chem. 2012;287:5882-90 pubmed publisher
..The two subcomplexes appear to constitute flexible units within the larger BLOC-1 chain, an arrangement conducive to simultaneous interactions with multiple BLOC-1 partners in the course of tubular endosome biogenesis and sorting. ..
Scott I, Webster B, Li J, Sack M. Identification of a molecular component of the mitochondrial acetyltransferase programme: a novel role for GCN5L1. Biochem J. 2012;443:655-61 pubmed publisher
..We show that GCN5L1 [GCN5 (general control of amino acid synthesis 5)-like 1; also known as Bloc1s1] counters the acetylation and respiratory effects of SIRT3...
Thapa D, Zhang M, Manning J, Guimaraes D, Stoner M, O Doherty R, et al
. Acetylation of mitochondrial proteins by GCN5L1 promotes enhanced fatty acid oxidation in the heart. Am J Physiol Heart Circ Physiol. 2017;313:H265-H274 pubmed publisher
..Here, we provide new evidence that acetylation of cardiac mitochondrial fatty acid oxidation enzymes by GCN5L1 significantly upregulates their activity in diet-induced obese mice. ..
Wong K, Zhang J, Awasthi S, Sharma A, Rogers L, Matlock E, et al
. Nerve growth factor receptor signaling induces histone acetyltransferase domain-dependent nuclear translocation of p300/CREB-binding protein-associated factor and hGCN5 acetyltransferases. J Biol Chem. 2004;279:55667-74 pubmed
Di Pietro S, Falcon Perez J, Tenza D, Setty S, Marks M, Raposo G, et al
. BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes. Mol Biol Cell. 2006;17:4027-38 pubmed
..These findings support the idea that BLOC-1 and -2 represent hitherto unknown components of the endosomal protein trafficking machinery. ..