Gene Symbol: Blnk
Description: B-cell linker
Alias: B-cell linker protein, cytoplasmic adapter protein
Species: rat
Products:     Blnk

Top Publications

  1. Fu C, Turck C, Kurosaki T, Chan A. BLNK: a central linker protein in B cell activation. Immunity. 1998;9:93-103 pubmed
    ..We describe here the identification of a novel B cell linker protein, termed BLNK, that interfaces the B cell receptor-associated Syk tyrosine kinase with PLCgamma, the Vav ..
  2. Minegishi Y, Rohrer J, Coustan Smith E, Lederman H, Pappu R, Campana D, et al. An essential role for BLNK in human B cell development. Science. 1999;286:1954-7 pubmed
    ..In evaluating patients with absent B cells, a male with a homozygous splice defect in the cytoplasmic adapter protein BLNK (B cell linker protein) was identified...
  3. Fu C, Chan A. Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation. J Biol Chem. 1997;272:27362-8 pubmed
    ..Moreover, SLP-76 protein was not detected in a number of B cell lines or in normal mouse B cells. Hence, we propose that pp70 and pp68 likely represent B cell homologs of SLP-76 which facilitate and coordinate B cell activation. ..