Bdnf

Summary

Gene Symbol: Bdnf
Description: brain-derived neurotrophic factor
Alias: brain-derived neurotrophic factor, brain derived neurothrophic factor
Species: rat
Products:     Bdnf

Top Publications

  1. Mayeur S, Silhol M, Moitrot E, Barbaux S, Breton C, Gabory A, et al. Placental BDNF/TrkB signaling system is modulated by fetal growth disturbances in rat and human. Placenta. 2010;31:785-91 pubmed publisher
    The brain-derived neurotrophic factor (BDNF) has been shown to exert an important role during implantation, placental development, and fetal growth control in mice...
  2. Uchida H, Matsushita Y, Ueda H. Epigenetic regulation of BDNF expression in the primary sensory neurons after peripheral nerve injury: implications in the development of neuropathic pain. Neuroscience. 2013;240:147-54 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) is known to be up-regulated in the dorsal root ganglion (DRG) after peripheral nerve injury, and to contribute to neuropathic pain...
  3. Jeanblanc J, He D, Carnicella S, Kharazia V, Janak P, Ron D. Endogenous BDNF in the dorsolateral striatum gates alcohol drinking. J Neurosci. 2009;29:13494-502 pubmed publisher
    We previously found that brain-derived neurotrophic factor (BDNF)-haplodeficient mice exhibit greater ethanol-induced place preference and psychomotor sensitization, and greater ethanol consumption after deprivation, than control mice...
  4. Kumamaru E, Numakawa T, Adachi N, Kunugi H. Glucocorticoid suppresses BDNF-stimulated MAPK/ERK pathway via inhibiting interaction of Shp2 with TrkB. FEBS Lett. 2011;585:3224-8 pubmed publisher
    ..We previously found that dexamethasone (DEX, a synthetic GC) repressed brain-derived neurotrophic factor (BDNF)-induced synaptic proteins via suppressing extracellular signal-regulated protein kinase (ERK) signaling...
  5. Massa S, Yang T, Xie Y, Shi J, Bilgen M, Joyce J, et al. Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J Clin Invest. 2010;120:1774-85 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) activates the receptor tropomyosin-related kinase B (TrkB) with high potency and specificity, promoting neuronal survival, differentiation, and synaptic function...
  6. Clark C, Hasser E, Kunze D, Katz D, Kline D. Endogenous brain-derived neurotrophic factor in the nucleus tractus solitarius tonically regulates synaptic and autonomic function. J Neurosci. 2011;31:12318-29 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, are highly expressed in the nucleus tractus solitarius (nTS), the principal target of cardiovascular primary afferent input to the brainstem...
  7. Madinier A, Bertrand N, Rodier M, Quirié A, Mossiat C, Prigent Tessier A, et al. Ipsilateral versus contralateral spontaneous post-stroke neuroplastic changes: involvement of BDNF?. Neuroscience. 2013;231:169-81 pubmed publisher
    ..therapies have been undertaken and many experimental studies have reported that brain-derived neurotrophic factor (BDNF) is central to many facets of neuroplastic processes...
  8. Larsen M, Mikkelsen J, Hay Schmidt A, Sandi C. Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment. J Psychiatr Res. 2010;44:808-16 pubmed publisher
    ..Present evidence suggests a role for brain-derived neurotrophic factor (BDNF) in depression. BDNF mRNA levels in the ventral and dorsal hippocampus were assessed by in situ hybridization...
  9. Yang J, Yu Y, Yu H, Zuo X, Liu C, Gao L, et al. The role of brain-derived neurotrophic factor in experimental inflammation of mouse gut. Eur J Pain. 2010;14:574-9 pubmed publisher
    Previous studies suggested that brain-derived neurotrophic factor (BDNF) might act as an important modulator in chronic pain states. However, no systematic study has used knock-out mice to clarify its effect on visceral sensitivity...

More Information

Publications86

  1. Taliaz D, Loya A, Gersner R, Haramati S, Chen A, Zangen A. Resilience to chronic stress is mediated by hippocampal brain-derived neurotrophic factor. J Neurosci. 2011;31:4475-83 pubmed publisher
    ..Alterations in secretion of stress hormones and levels of brain-derived neurotrophic factor (BDNF) in the hippocampus were implicated in depression and the effects of antidepressant medications...
  2. Ding Q, Ying Z, Gomez Pinilla F. Exercise influences hippocampal plasticity by modulating brain-derived neurotrophic factor processing. Neuroscience. 2011;192:773-80 pubmed publisher
    ..been shown to impact brain plasticity and function by involving the action of brain-derived neurotrophic factor (BDNF); however, mechanisms involved are poorly understood...
  3. Cruz Duarte P, St Jacques B, Ma W. Prostaglandin E2 contributes to the synthesis of brain-derived neurotrophic factor in primary sensory neuron in ganglion explant cultures and in a neuropathic pain model. Exp Neurol. 2012;234:466-81 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) exists in small to medium size neurons in adult rat dorsal root ganglion (DRG) and serves as a modulator at the first synapse of the pain transmission pathway in the spinal dorsal horn...
  4. Kuczewski N, Fuchs C, Ferrand N, Jovanovic J, Gaiarsa J, Porcher C. Mechanism of GABAB receptor-induced BDNF secretion and promotion of GABAA receptor membrane expression. J Neurochem. 2011;118:533-45 pubmed publisher
    ..study, we reported that GABA(B) receptor activation triggers secretion of brain-derived neurotrophic factor (BDNF) and promotes the functional maturation of GABAergic synapses in the developing rat hippocampus...
  5. Shi S, Shao S, Yuan B, Pan F, Li Z. Acute stress and chronic stress change brain-derived neurotrophic factor (BDNF) and tyrosine kinase-coupled receptor (TrkB) expression in both young and aged rat hippocampus. Yonsei Med J. 2010;51:661-71 pubmed publisher
    The purpose of this study is to explore the dynamic change of brainderived neurotrophic factor (BDNF) mRNA, protein, and tyrosine kinase-coupled receptor (TrkB) mRNA of the rat hippocampus under different stress conditions and to explore ..
  6. Chan S, Wu C, Chang A, Hsu K, Chan J. Transcriptional upregulation of brain-derived neurotrophic factor in rostral ventrolateral medulla by angiotensin II: significance in superoxide homeostasis and neural regulation of arterial pressure. Circ Res. 2010;107:1127-39 pubmed publisher
    ..Emerging evidence suggests that brain-derived neurotrophic factor (BDNF) manifests "nontrophic" actions.
  7. Bejot Y, Prigent Tessier A, Cachia C, Giroud M, Mossiat C, Bertrand N, et al. Time-dependent contribution of non neuronal cells to BDNF production after ischemic stroke in rats. Neurochem Int. 2011;58:102-11 pubmed publisher
    Although brain-derived neurotrophic factor (BDNF) plays a central role in recovery after cerebral ischemia, little is known about cells involved in BDNF production after stroke...
  8. He D, Neasta J, Ron D. Epigenetic regulation of BDNF expression via the scaffolding protein RACK1. J Biol Chem. 2010;285:19043-50 pubmed publisher
    ..of chromatin remodeling, resulting in an exon-specific expression of the brain-derived neurotrophic factor (BDNF) gene...
  9. Cao X, Chen S, Li L, Pan H. Nerve injury increases brain-derived neurotrophic factor levels to suppress BK channel activity in primary sensory neurons. J Neurochem. 2012;121:944-53 pubmed publisher
    ..in DRG neurons in a rat model of neuropathic pain and the contribution of brain-derived neurotrophic factor (BDNF) to reduced BK channel activity...
  10. Frias B, Allen S, Dawbarn D, Charrua A, Cruz F, Cruz C. Brain-derived neurotrophic factor, acting at the spinal cord level, participates in bladder hyperactivity and referred pain during chronic bladder inflammation. Neuroscience. 2013;234:88-102 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) is a neurotrophin (NT) known to participate in chronic somatic pain. A recent study has indicated that BDNF may participate in chronic cystitis at the peripheral level...
  11. Ma C, Bampton E, Evans M, Taylor J. Synergistic effects of osteonectin and brain-derived neurotrophic factor on axotomized retinal ganglion cells neurite outgrowth via the mitogen-activated protein kinase-extracellular signal-regulated kinase 1/2 pathways. Neuroscience. 2010;165:463-74 pubmed publisher
    ..We also showed the synergistic effects of ON and brain-derived neurotrophic factor (BDNF) in promoting RGCs growth and the involvement of ON in two major neurotrophin-mediated signaling pathways, PI-3K-..
  12. Finsterwald C, Fiumelli H, Cardinaux J, Martin J. Regulation of dendritic development by BDNF requires activation of CRTC1 by glutamate. J Biol Chem. 2010;285:28587-95 pubmed publisher
    ..Among extrinsic signals that control dendritic development, substantial evidence indicates that BDNF regulates dendritic morphology...
  13. Lin Y, Ro L, Wang H, Chen J. Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study. J Neuroinflammation. 2011;8:126 pubmed publisher
    ..Brain-derived neurotrophic factor (BDNF) plays a neuromodulatory role in spinal cord dorsal horn via the post-synaptic tyrosine protein kinase B (trkB) ..
  14. Verpelli C, Piccoli G, Zibetti C, Zanchi A, Gardoni F, Huang K, et al. Synaptic activity controls dendritic spine morphology by modulating eEF2-dependent BDNF synthesis. J Neurosci. 2010;30:5830-42 pubmed publisher
    ..2 (eEF2K) regulates dendritic spine stability and synaptic structure by modulating activity-dependent dendritic BDNF synthesis...
  15. Saruta J, Kondo Y, Sato C, Shiiki N, Tsukinoki K, Sato S. Salivary glands as the source of plasma brain-derived neurotrophic factor in stressed rats engaged in biting behavior. Stress. 2010;13:238-47 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) is crucial for the survival and differentiation of the central and peripheral nervous systems. Recently, BDNF has been reported to exert broader biological activity on non-neural cells...
  16. Huang Y, Ko H, Cheung Z, Yung K, Yao T, Wang J, et al. Dual actions of brain-derived neurotrophic factor on GABAergic transmission in cerebellar Purkinje neurons. Exp Neurol. 2012;233:791-8 pubmed publisher
    ..feature of the nervous system and a growing body of evidence indicates that brain-derived neurotrophic factor (BDNF) acutely modulates the efficacy of GABA synaptic transmission...
  17. Bałkowiec Iskra E, Vermehren Schmaedick A, Balkowiec A. Tumor necrosis factor-? increases brain-derived neurotrophic factor expression in trigeminal ganglion neurons in an activity-dependent manner. Neuroscience. 2011;180:322-33 pubmed publisher
    ..In the present study, we examined the effects of TNF? on neuronal expression of brain-derived neurotrophic factor (BDNF), whose role in synaptic plasticity and sensitization of nociceptive pathways is well documented...
  18. Matsuda N, Lu H, Fukata Y, Noritake J, Gao H, Mukherjee S, et al. Differential activity-dependent secretion of brain-derived neurotrophic factor from axon and dendrite. J Neurosci. 2009;29:14185-98 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) is essential for neuronal survival and differentiation during development and for synaptic function and plasticity in the mature brain...
  19. Joseph M, Tillakaratne N, De Leon R. Treadmill training stimulates brain-derived neurotrophic factor mRNA expression in motor neurons of the lumbar spinal cord in spinally transected rats. Neuroscience. 2012;224:135-44 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) induces plasticity within the lumbar spinal circuits thereby improving locomotor recovery in spinal cord-injured animals...
  20. Tanaka J, Horiike Y, Matsuzaki M, Miyazaki T, Ellis Davies G, Kasai H. Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines. Science. 2008;319:1683-7 pubmed publisher
    ..The gradual enlargement was strongly dependent on protein synthesis and brain-derived neurotrophic factor (BDNF) action, often associated with spine twitching, and was induced specifically at the spines that were immediately ..
  21. Matsuoka Y, Yokoyama M, Kobayashi H, Omori M, Itano Y, Morita K, et al. Expression profiles of BDNF splice variants in cultured DRG neurons stimulated with NGF. Biochem Biophys Res Commun. 2007;362:682-8 pubmed
    Expression of brain-derived neurotrophic factor (BDNF) mRNA is increased in the dorsal root ganglion (DRG) in response to peripheral inflammation. Nerve growth factor (NGF) from inflammatory tissue is thought to induce expression of BDNF...
  22. Santi S, Cappello S, Riccio M, Bergami M, Aicardi G, Schenk U, et al. Hippocampal neurons recycle BDNF for activity-dependent secretion and LTP maintenance. EMBO J. 2006;25:4372-80 pubmed
    Regulation of brain-derived neurotrophic factor (BDNF) secretion plays a critical role in long-term potentiation (LTP). It is generally thought that the supply for this secretion is newly synthesized BDNF targeted to the synapse...
  23. Yajima Y, Narita M, Narita M, Matsumoto N, Suzuki T. Involvement of a spinal brain-derived neurotrophic factor/full-length TrkB pathway in the development of nerve injury-induced thermal hyperalgesia in mice. Brain Res. 2002;958:338-46 pubmed
    ..was abolished by repeated intrathecal pretreatment with a specific antibody to brain-derived neurotrophic factor (BDNF), but not neurotrophin-4, just before and after the nerve ligation...
  24. Ng B, Chen L, Mandemakers W, Cosgaya J, Chan J. Anterograde transport and secretion of brain-derived neurotrophic factor along sensory axons promote Schwann cell myelination. J Neurosci. 2007;27:7597-603 pubmed
    The neurotrophin brain-derived neurotrophic factor (BDNF) inhibits Schwann cell (SC) migration and promotes myelination via the p75 neurotrophin receptor (NTR)...
  25. Lubin F, Roth T, Sweatt J. Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory. J Neurosci. 2008;28:10576-86 pubmed publisher
    ..the contribution of chromatin remodeling to learning-induced changes in brain-derived neurotrophic factor (bdnf) gene expression in the adult hippocampus...
  26. Fauchais A, Boumediene A, Lalloue F, Gondran G, Loustaud Ratti V, Vidal E, et al. Brain-derived neurotrophic factor and nerve growth factor correlate with T-cell activation in primary Sjogren's syndrome. Scand J Rheumatol. 2009;38:50-7 pubmed publisher
    ..subjects were studied to determine serum levels of nerve-growth factor (NGF) and brain-derived neurotrophic factor (BDNF), and their relationships with T- and B-cell activation and disease activity...
  27. Bergami M, Santi S, Formaggio E, Cagnoli C, Verderio C, Blum R, et al. Uptake and recycling of pro-BDNF for transmitter-induced secretion by cortical astrocytes. J Cell Biol. 2008;183:213-21 pubmed publisher
    Activity-dependent secretion of brain-derived neurotrophic factor (BDNF) is thought to enhance synaptic plasticity, but the mechanisms controlling extracellular availability and clearance of secreted BDNF are poorly understood...
  28. Rasmusson A, Shi L, Duman R. Downregulation of BDNF mRNA in the hippocampal dentate gyrus after re-exposure to cues previously associated with footshock. Neuropsychopharmacology. 2002;27:133-42 pubmed
    ..and re-exposure to cues previously associated with footshock on expression of brain-derived neurotrophic factor (BDNF) mRNA in the hippocampus of male rats. Exposure to twenty 0.5-s 0...
  29. Ou L, Gean P. Transcriptional regulation of brain-derived neurotrophic factor in the amygdala during consolidation of fear memory. Mol Pharmacol. 2007;72:350-8 pubmed
    We have demonstrated previously that brain-derived neurotrophic factor (BDNF) signaling in the amygdala is required for the consolidation of fear memory...
  30. Takei N, Inamura N, Kawamura M, Namba H, Hara K, Yonezawa K, et al. Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites. J Neurosci. 2004;24:9760-9 pubmed
    ..synthesis and translational activation in neuronal dendrites are upregulated by brain-derived neurotrophic factor (BDNF) in a rapamycin and small interfering RNA specific for mammalian target of rapamycin (mTOR)-sensitive manner...
  31. Ohba S, Ikeda T, Ikegaya Y, Nishiyama N, Matsuki N, Yamada M. BDNF locally potentiates GABAergic presynaptic machineries: target-selective circuit inhibition. Cereb Cortex. 2005;15:291-8 pubmed
    ..receives target-selective modulation in the long term, we expressed the cDNA of brain-derived neurotrophic factor (BDNF), which has been shown to induce the augmentation of GABAergic synapses in vivo and in vitro, in a small population ..
  32. Roth T, Lubin F, Funk A, Sweatt J. Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol Psychiatry. 2009;65:760-9 pubmed publisher
    ..investigated whether early-life adversity leaves lasting epigenetic marks at the brain-derived neurotrophic factor (BDNF) gene in the central nervous system...
  33. Chaldakov G, Fiore M, Stankulov I, Hristova M, Antonelli A, Manni L, et al. NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome. Arch Physiol Biochem. 2001;109:357-60 pubmed
    ..in cardiovascular tissue development and in lipid and glucose metabolism, the role of the neurotrophins NGF and BDNF and also the adipokine leptin in human coronary atherosclerosis and related disorders, such as metabolic syndrome, ..
  34. Balkowiec A, Katz D. Activity-dependent release of endogenous brain-derived neurotrophic factor from primary sensory neurons detected by ELISA in situ. J Neurosci. 2000;20:7417-23 pubmed
    To define activity-dependent release of endogenous brain-derived neurotrophic factor (BDNF), we developed an in vitro model using primary sensory neurons and a modified ELISA, termed ELISA in situ...
  35. Qiao L, Gulick M, Bowers J, Kuemmerle J, Grider J. Differential changes in brain-derived neurotrophic factor and extracellular signal-regulated kinase in rat primary afferent pathways with colitis. Neurogastroenterol Motil. 2008;20:928-38 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) has been postulated to participate in inflammation-induced visceral hypersensitivity by modulating the sensitivity of visceral afferents through the activation of intracellular signalling pathways ..
  36. Elfving B, Plougmann P, Müller H, Mathe A, Rosenberg R, Wegener G. Inverse correlation of brain and blood BDNF levels in a genetic rat model of depression. Int J Neuropsychopharmacol. 2010;13:563-72 pubmed publisher
    There is accumulating evidence that brain-derived neurotrophic factor (BDNF) plays a critical role in the pathophysiology of depression...
  37. Lee R, Kermani P, Teng K, Hempstead B. Regulation of cell survival by secreted proneurotrophins. Science. 2001;294:1945-8 pubmed
    ..inactive precursors, we show here that the proforms of nerve growth factor (NGF) and the proforms of brain derived neurotrophic factor (BDNF) are secreted and cleaved extracellularly by the serine protease plasmin and by selective ..
  38. Aliaga E, Silhol M, Bonneau N, Maurice T, Arancibia S, Tapia Arancibia L. Dual response of BDNF to sublethal concentrations of beta-amyloid peptides in cultured cortical neurons. Neurobiol Dis. 2010;37:208-17 pubmed publisher
    ..We examined the time-course effect of sublethal concentrations of Abeta on total BDNF (panBDNF), BDNF transcripts (I, II, IV and VI), trkB.FL, trkB...
  39. Macias M, Dwornik A, Ziemlinska E, Fehr S, Schachner M, Czarkowska Bauch J, et al. Locomotor exercise alters expression of pro-brain-derived neurotrophic factor, brain-derived neurotrophic factor and its receptor TrkB in the spinal cord of adult rats. Eur J Neurosci. 2007;25:2425-44 pubmed
    ..evidence indicates that locomotor exercise is a powerful means of increasing brain-derived neurotrophic factor (BDNF) and its signal transduction receptor TrkB mRNA levels, immunolabeling intensity and number of BDNF- and TrkB-..
  40. Bekinschtein P, Cammarota M, Igaz L, Bevilaqua L, Izquierdo I, Medina J. Persistence of long-term memory storage requires a late protein synthesis- and BDNF- dependent phase in the hippocampus. Neuron. 2007;53:261-77 pubmed
    ..that LTM formation is dependent upon hippocampal de novo protein synthesis and Brain-Derived Neurotrophic Factor (BDNF) signaling during or early after acquisition...
  41. Tabuchi A, Sakaya H, Kisukeda T, Fushiki H, Tsuda M. Involvement of an upstream stimulatory factor as well as cAMP-responsive element-binding protein in the activation of brain-derived neurotrophic factor gene promoter I. J Biol Chem. 2002;277:35920-31 pubmed
    The use of different brain-derived neurotrophic factor (BDNF) gene promoters results in the differential production of 5'-alternative transcripts, suggesting versatile functions of BDNF in neurons...
  42. Zhang Y, Chi X, Nicol G. Brain-derived neurotrophic factor enhances the excitability of rat sensory neurons through activation of the p75 neurotrophin receptor and the sphingomyelin pathway. J Physiol. 2008;586:3113-27 pubmed publisher
    ..of small diameter sensory neurons through activation of p75(NTR), then brain-derived neurotrophic factor (BDNF) should produce the same sensitizing action as did NGF...
  43. Danzer S, Crooks K, Lo D, McNamara J. Increased expression of brain-derived neurotrophic factor induces formation of basal dendrites and axonal branching in dentate granule cells in hippocampal explant cultures. J Neurosci. 2002;22:9754-63 pubmed
    ..in vivo the dentate granule cells (DGCs) exhibit increased expression of brain-derived neurotrophic factor (BDNF), followed by striking morphologic plasticities, namely the formation of basal dendrites and the sprouting of mossy ..
  44. Aid T, Kazantseva A, Piirsoo M, Palm K, Timmusk T. Mouse and rat BDNF gene structure and expression revisited. J Neurosci Res. 2007;85:525-35 pubmed
    Brain-derived neurotrophic factor (BDNF) has important functions in the development of the nervous system and in brain plasticity-related processes such as memory, learning, and drug addiction...
  45. Tartaglia N, Du J, Tyler W, Neale E, Pozzo Miller L, Lu B. Protein synthesis-dependent and -independent regulation of hippocampal synapses by brain-derived neurotrophic factor. J Biol Chem. 2001;276:37585-93 pubmed
    ..hippocampal slices, we have investigated whether the modulation of synapses by brain-derived neurotrophic factor (BDNF) also requires protein synthesis...
  46. Larimore J, Chapleau C, Kudo S, Theibert A, Percy A, Pozzo Miller L. Bdnf overexpression in hippocampal neurons prevents dendritic atrophy caused by Rett-associated MECP2 mutations. Neurobiol Dis. 2009;34:199-211 pubmed publisher
    ..One of the targets of MeCP2 transcriptional control is the Bdnf gene...
  47. Coull J, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, et al. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature. 2005;438:1017-21 pubmed
    ..Applying brain-derived neurotrophic factor (BDNF) mimics the alteration in E(anion)...
  48. Tabuchi A, Yamada T, Sasagawa S, Naruse Y, Mori N, Tsuda M. REST4-mediated modulation of REST/NRSF-silencing function during BDNF gene promoter activation. Biochem Biophys Res Commun. 2002;290:415-20 pubmed
    ..To address this, we investigated the effect of REST/NRSF and REST4 on the activity-dependent activation of BDNF gene promoter I (BDNFp-I) using cultured rat cortical neurons...
  49. Maisonpierre P, Le Beau M, Espinosa R, Ip N, Belluscio L, de la Monte S, et al. Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. Genomics. 1991;10:558-68 pubmed
    ..Nerve growth factor (NGF) remains the best characterized neurotrophic molecule. Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are two recently cloned neurotrophic factors that are homologous to NGF...
  50. Gilmore J, Jarskog L, Vadlamudi S. Maternal infection regulates BDNF and NGF expression in fetal and neonatal brain and maternal-fetal unit of the rat. J Neuroimmunol. 2003;138:49-55 pubmed
    ..or saline was administered to rats to model maternal infection, and levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in maternal plasma, placenta, amniotic fluid, fetal liver/spleen, fetal brain, and ..
  51. Silhol M, Arancibia S, Perrin D, Maurice T, Alliot J, Tapia Arancibia L. Effect of aging on brain-derived neurotrophic factor, proBDNF, and their receptors in the hippocampus of Lou/C rats. Rejuvenation Res. 2008;11:1031-40 pubmed publisher
    ..e., brain-derived neurotrophic factor (BDNF), its precursor proBDNF, and its receptors (i.e., TrkB.FL, TrkB.T1, TrkB.T2, and p75)...
  52. Tessarollo L, Coppola V, Fritzsch B. NT-3 replacement with brain-derived neurotrophic factor redirects vestibular nerve fibers to the cochlea. J Neurosci. 2004;24:2575-84 pubmed
    Survival of inner ear sensory neurons depends on two neurotrophins, BDNF and NT-3, and their respective receptors, TrkB and TrkC...
  53. Noga O, Englmann C, Hanf G, Grützkau A, Seybold J, Kunkel G. The production, storage and release of the neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 by human peripheral eosinophils in allergics and non-allergics. Clin Exp Allergy. 2003;33:649-54 pubmed
    ..whether eosinophils of allergic and non-allergic donors produce, store and release the neurotrophic factors NGF, BDNF and NT-3...
  54. Monteggia L, Barrot M, Powell C, Berton O, Galanis V, Gemelli T, et al. Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci U S A. 2004;101:10827-32 pubmed
    Brain-derived neurotrophic factor (BDNF) regulates neuronal development and function. However, it has been difficult to discern its role in the adult brain in influencing complex behavior...
  55. Park J, Cawley N, Loh Y. A bi-directional carboxypeptidase E-driven transport mechanism controls BDNF vesicle homeostasis in hippocampal neurons. Mol Cell Neurosci. 2008;39:63-73 pubmed publisher
    Anterograde transport of brain-derived neurotrophic factor (BDNF) vesicles from the soma to neurite terminals is necessary for activity-dependent secretion of BDNF to mediate synaptic plasticity, memory and learning, and retrograde BDNF ..
  56. Lee T, Saruta J, Sasaguri K, Sato S, Tsukinoki K. Allowing animals to bite reverses the effects of immobilization stress on hippocampal neurotrophin expression. Brain Res. 2008;1195:43-9 pubmed publisher
    Acute immobilization stress alters the expression of neurotrophins, including brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), in rat hippocampus...
  57. Kanhema T, Dagestad G, Panja D, Tiron A, Messaoudi E, Håvik B, et al. Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation control. J Neurochem. 2006;99:1328-37 pubmed
    ..eEF2), during long-term potentiation (LTP) induced by local infusion of brain-derived neurotrophic factor (BDNF) into the dentate gyrus of anesthetized rats...
  58. Cellerino A, Arango Gonzalez B, Pinzon Duarte G, Kohler K. Brain-derived neurotrophic factor regulates expression of vasoactive intestinal polypeptide in retinal amacrine cells. J Comp Neurol. 2003;467:97-104 pubmed
    Brain-derived neurotrophic-factor (BDNF) is expressed in the retina and controls the development of subtypes of amacrine cells...
  59. Baker Herman T, Fuller D, Bavis R, Zabka A, Golder F, Doperalski N, et al. BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia. Nat Neurosci. 2004;7:48-55 pubmed
    ..Here we show that increased synthesis of brain-derived neurotrophic factor (BDNF) in the spinal cord is necessary and sufficient for pLTF in adult rats...
  60. Chen W, Chang Q, Lin Y, Meissner A, West A, Griffith E, et al. Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science. 2003;302:885-9 pubmed
    ..We find that MeCP2 binds selectively to BDNF promoter III and functions to repress expression of the BDNF gene...
  61. Parain K, Murer M, Yan Q, Faucheux B, Agid Y, Hirsch E, et al. Reduced expression of brain-derived neurotrophic factor protein in Parkinson's disease substantia nigra. Neuroreport. 1999;10:557-61 pubmed
    Several in vitro and in vivo studies have shown that brain-derived neurotrophic factor (BDNF) promotes survival of damaged mesencephalic dopaminergic neurons...
  62. Berglind W, See R, Fuchs R, Ghee S, Whitfield T, Miller S, et al. A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in rats. Eur J Neurosci. 2007;26:757-66 pubmed
    ..is critical for reinstatement of cocaine seeking and is the main source of brain-derived neurotrophic factor (BDNF) to striatal regions of the brain relapse circuitry...
  63. Bardoni R, Ghirri A, Salio C, Prandini M, Merighi A. BDNF-mediated modulation of GABA and glycine release in dorsal horn lamina II from postnatal rats. Dev Neurobiol. 2007;67:960-75 pubmed
    Recent studies show that excitatory glutamatergic transmission is potentiated by BDNF in superficial dorsal horn, both at the pre- and the postsynaptic site...
  64. Gomez Pinilla F, Ying Z, Roy R, Hodgson J, Edgerton V. Afferent input modulates neurotrophins and synaptic plasticity in the spinal cord. J Neurophysiol. 2004;92:3423-32 pubmed
    ..region but maintains the motoneuron-muscle connectivity, decreased the levels of brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3) mRNA and protein in the isolated segments...
  65. Timmusk T, Palm K, Metsis M, Reintam T, Paalme V, Saarma M, et al. Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron. 1993;10:475-89 pubmed
    Brain-derived neurotrophic factor (BDNF) supports the survival of a specific set of neurons in the vertebrate nervous system...
  66. Ottem E, Beck L, Jordan C, Breedlove S. Androgen-dependent regulation of brain-derived neurotrophic factor and tyrosine kinase B in the sexually dimorphic spinal nucleus of the bulbocavernosus. Endocrinology. 2007;148:3655-65 pubmed
    ..Brain-derived neurotrophic factor (BDNF), via activation of tyrosine receptor kinase B (trkB), has been implicated in mediating androgen effects on SNB ..
  67. Bishop J, Mueller G, Mouradian M. Alternate 5' exons in the rat brain-derived neurotrophic factor gene: differential patterns of expression across brain regions. Brain Res Mol Brain Res. 1994;26:225-32 pubmed
    Brain-derived neurotrophic factor (BDNF) enhances the survival of dopaminergic neurons and protects them from neurotoxins in vitro. This trophic factor might thus be of therapeutic value for the treatment of Parkinsonian syndromes...
  68. Groth R, Aanonsen L. Spinal brain-derived neurotrophic factor (BDNF) produces hyperalgesia in normal mice while antisense directed against either BDNF or trkB, prevent inflammation-induced hyperalgesia. Pain. 2002;100:171-81 pubmed
    Although known primarily for its role in neuronal development, brain-derived neurotrophic factor (BDNF) has also recently been implicated in processes mediated by the adult nervous system, such as spinal nociception...
  69. Balkowiec A, Katz D. Cellular mechanisms regulating activity-dependent release of native brain-derived neurotrophic factor from hippocampal neurons. J Neurosci. 2002;22:10399-407 pubmed
    Brain-derived neurotrophic factor (BDNF) plays a critical role in activity-dependent modifications of neuronal connectivity and synaptic strength, including establishment of hippocampal long-term potentiation (LTP)...
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    ..studies using molecular and genetic methods in humans and rodents suggest that brain-derived neurotrophic factor (BDNF) is involved in the behavioral effects of abused drugs, making understanding of its genomic structure and ..
  71. Kolarow R, Brigadski T, Lessmann V. Postsynaptic secretion of BDNF and NT-3 from hippocampal neurons depends on calcium calmodulin kinase II signaling and proceeds via delayed fusion pore opening. J Neurosci. 2007;27:10350-64 pubmed
    The mammalian neurotrophins (NTs) NGF, BDNF, NT-3, and NT-4 constitute a family of secreted neuronal growth factors. In addition, NTs are implicated in several forms of activity-dependent synaptic plasticity...
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    ..We used a combination of model cell lines and primary culture systems to study the polarity of BDNF sorting and the regulation of its release from hippocampal neurons...
  73. Ploughman M, Windle V, MacLellan C, White N, Doré J, Corbett D. Brain-derived neurotrophic factor contributes to recovery of skilled reaching after focal ischemia in rats. Stroke. 2009;40:1490-5 pubmed publisher
    Brain-derived neurotrophic factor (BDNF) is involved in neuronal survival, synaptic plasticity, learning and memory, and neuroplasticity...
  74. Slipczuk L, Bekinschtein P, Katche C, Cammarota M, Izquierdo I, Medina J. BDNF activates mTOR to regulate GluR1 expression required for memory formation. PLoS ONE. 2009;4:e6007 pubmed publisher
    ..In addition, we found that pre- or post-training administration of function-blocking anti-BDNF antibodies into dorsal CA1 hampered IA LTM retention, abolished the learning-induced biphasic activation of mTOR ..
  75. Slack S, Pezet S, McMahon S, Thompson S, Malcangio M. Brain-derived neurotrophic factor induces NMDA receptor subunit one phosphorylation via ERK and PKC in the rat spinal cord. Eur J Neurosci. 2004;20:1769-78 pubmed
    Brain-derived neurotrophic factor (BDNF) is involved in the modulation of synaptic transmission in the spinal cord, and several circumstantial lines of evidence suggest that it has the ability to modulate the activity of the NMDA receptor...
  76. Alonso M, Vianna M, Depino A, Mello e Souza T, Pereira P, Szapiro G, et al. BDNF-triggered events in the rat hippocampus are required for both short- and long-term memory formation. Hippocampus. 2002;12:551-60 pubmed
    ..Because brain-derived neutrophic factor (BDNF) modulates both short-term synaptic function and activity-dependent synaptic plasticity in the adult hippocampus, ..
  77. Wardle R, Poo M. Brain-derived neurotrophic factor modulation of GABAergic synapses by postsynaptic regulation of chloride transport. J Neurosci. 2003;23:8722-32 pubmed
    Brain-derived neurotrophic factor (BDNF) potentiates excitatory synapses in a variety of systems by promoting presynaptic transmitter release...