Gene Symbol: Bcl11b
Description: B-cell CLL/lymphoma 11B
Alias: Ctip2, B-cell lymphoma/leukemia 11B, B-cell CLL/lymphoma 11B (zinc finger protein), B-cell leukemia/lymphoma 11B, COUP-TF-interacting protein 2 long form
Species: rat
Products:     Bcl11b

Top Publications

  1. Wakabayashi Y, Inoue J, Takahashi Y, Matsuki A, Kosugi Okano H, Shinbo T, et al. Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas. Biochem Biophys Res Commun. 2003;301:598-603 pubmed
    ..analysis were conducted for gamma-ray induced mouse thymic lymphomas and a novel tumor suppressor gene, Rit1/Bcl11b, on chromosome 12 was isolated...
  2. Wakabayashi Y, Watanabe H, Inoue J, Takeda N, Sakata J, Mishima Y, et al. Bcl11b is required for differentiation and survival of alphabeta T lymphocytes. Nat Immunol. 2003;4:533-9 pubmed
    The gene Bcl11b, which encodes zinc finger proteins, and its paralog, Bcl11a, are associated with immune-system malignancies...
  3. Inoue J, Kanefuji T, Okazuka K, Watanabe H, Mishima Y, Kominami R. Expression of TCR alpha beta partly rescues developmental arrest and apoptosis of alpha beta T cells in Bcl11b-/- mice. J Immunol. 2006;176:5871-9 pubmed
    b>Bcl11b(-/-) mice show developmental arrest at the CD44(-)CD25(+) double-negative 3 (DN3) or immature CD8(+)single-positive stage of alphabeta T cell...
  4. Cismasiu V, Ghanta S, Duque J, Albu D, Chen H, Kasturi R, et al. BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes. Blood. 2006;108:2695-702 pubmed
    BCL11A and BCL11B are transcriptional regulators important for lymphopoiesis and previously associated with hematopoietic malignancies...
  5. Arlotta P, Molyneaux B, Chen J, Inoue J, Kominami R, Macklis J. Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo. Neuron. 2005;45:207-21 pubmed
    ..Loss-of-function experiments in null mutant mice for Ctip2 (also known as Bcl11b), one of the newly characterized genes, demonstrate that it plays a critical role in the development of CSMN ..
  6. Albu D, Feng D, Bhattacharya D, Jenkins N, Copeland N, Liu P, et al. BCL11B is required for positive selection and survival of double-positive thymocytes. J Exp Med. 2007;204:3003-15 pubmed
    ..We show that the transcription factor BCL11B plays a critical role in DP thymocytes by controlling positive selection of both CD4 and CD8 lineages...
  7. Lai T, Jabaudon D, Molyneaux B, Azim E, Arlotta P, Menezes J, et al. SOX5 controls the sequential generation of distinct corticofugal neuron subtypes. Neuron. 2008;57:232-47 pubmed publisher
    ..These data indicate that SOX5 controls the timing of critical fate decisions during corticofugal neuron production and thus subtype-specific differentiation and neocortical neuron diversity. ..
  8. Britanova O, de Juan Romero C, Cheung A, Kwan K, Schwark M, Gyorgy A, et al. Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex. Neuron. 2008;57:378-92 pubmed publisher
    ..b>Ctip2, a gene required for the formation of the corticospinal tract, is ectopically expressed in all UL1 neurons in the ..
  9. Desplats P, Lambert J, Thomas E. Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease. Neurobiol Dis. 2008;31:298-308 pubmed publisher
    ..Here we demonstrate that expression of Bcl11b (a.k.a...

More Information


  1. Golonzhka O, Metzger D, Bornert J, Bay B, Gross M, Kioussi C, et al. Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis. Proc Natl Acad Sci U S A. 2009;106:4278-83 pubmed publisher
    The transcription factor Ctip2/Bcl11b plays essential roles in developmental processes of the immune and central nervous systems and skin. Here we show that Ctip2 also plays a key role in tooth development...
  2. Srinivasan K, Leone D, Bateson R, Dobreva G, KOHWI Y, Kohwi Shigematsu T, et al. A network of genetic repression and derepression specifies projection fates in the developing neocortex. Proc Natl Acad Sci U S A. 2012;109:19071-8 pubmed publisher
    Neurons within each layer in the mammalian cortex have stereotypic projections. Four genes-Fezf2, Ctip2, Tbr1, and Satb2-regulate these projection identities...
  3. Adiningrat A, Tanimura A, Miyoshi K, Yanuaryska R, Hagita H, Horiguchi T, et al. Ctip2-mediated Sp6 transcriptional regulation in dental epithelium-derived cells. J Med Invest. 2014;61:126-36 pubmed
    ..specificity proteins 6 (Sp6) and chicken ovalbumin upstream promoter transcription factor-interacting protein 2 (Ctip2) were identified in loss-of-function studies as key transcription factors required for tooth development...
  4. Gil Sanz C, Landeira B, Ramos C, Costa M, M ller U. Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon. J Neurosci. 2014;34:10475-87 pubmed publisher
    ..Our findings suggest that defects in adherens junctions components in mice massively affects progenitor cell proliferation and leads to a double cortex-like phenotype...
  5. Liao C, Fang K, Chai K, Wu C, Ho C, Yang C, et al. Depletion of B cell CLL/Lymphoma 11B Gene Expression Represses Glioma Cell Growth. Mol Neurobiol. 2016;53:3528-3539 pubmed publisher
    B cell CLL/lymphoma 11B (Bcl11b), a C2H2 zinc finger transcription factor, not only serves as a critical regulator in development but also plays the controversial role in T cell acute lymphoblastic leukemia (T-ALL)...
  6. Li Z, Chen G, Yang Y, Guo W, Tian W. Bcl11b regulates enamel matrix protein expression and dental epithelial cell differentiation during rat tooth development. Mol Med Rep. 2017;15:297-304 pubmed publisher
    ..During early tooth development, the transcription factor B?cell CLL/lymphoma 11B (Bcl11b) participates in dental epithelial cell proliferation and differentiation...
  7. Punwani D, Zhang Y, Yu J, Cowan M, Rana S, Kwan A, et al. Multisystem Anomalies in Severe Combined Immunodeficiency with Mutant BCL11B. N Engl J Med. 2016;375:2165-2176 pubmed
    ..Exome sequencing revealed a heterozygous de novo missense mutation, p.N441K, in BCL11B. The resulting BCL11B protein had dominant negative activity, which abrogated the ability of wild-type BCL11B to ..