Bcl11a

Summary

Gene Symbol: Bcl11a
Description: B-cell CLL/lymphoma 11A
Alias: B-cell lymphoma/leukemia 11A, B-cell CLL/lymphoma 11A (zinc finger protein)
Species: rat
Products:     Bcl11a

Top Publications

  1. Kuo T, Hsueh Y. Expression of zinc finger transcription factor Bcl11A/Evi9/CTIP1 in rat brain. J Neurosci Res. 2007;85:1628-36 pubmed
    b>Bcl11A/Evi9/CTIP1, a Kruppel-like zinc finger gene, plays an important role in B-cell development...
  2. Satterwhite E, Sonoki T, Willis T, Harder L, Nowak R, Arriola E, et al. The BCL11 gene family: involvement of BCL11A in lymphoid malignancies. Blood. 2001;98:3413-20 pubmed
    ..This CpG island was associated with a Krüppel zinc finger gene (BCL11A), which is normally expressed at high levels only in fetal brain and in germinal center B-cells...
  3. Chen Z, Luo H, Steinberg M, Chui D. BCL11A represses HBG transcription in K562 cells. Blood Cells Mol Dis. 2009;42:144-9 pubmed publisher
    b>BCL11A on chromosome 2p16 was recently shown to be a major quantitative trait locus for Hb F level and F-cell number in several populations with or without beta-hemoglobinopathy...
  4. Sankaran V, Xu J, Ragoczy T, Ippolito G, Walkley C, Maika S, et al. Developmental and species-divergent globin switching are driven by BCL11A. Nature. 2009;460:1093-7 pubmed publisher
    ..We show that the expression of BCL11A, a repressor of human gamma-globin expression identified by genome-wide association studies, differs between mouse ..
  5. Liu P, Keller J, Ortiz M, Tessarollo L, Rachel R, Nakamura T, et al. Bcl11a is essential for normal lymphoid development. Nat Immunol. 2003;4:525-32 pubmed
    b>Bcl11a (also called Evi9) functions as a myeloid or B cell proto-oncogene in mice and humans, respectively. Here we show that Bcl11a is essential for postnatal development and normal lymphopoiesis...
  6. Chu N, Wu Z, Zhang X, Fang S, Wang W, Cheng Y. Molecular mechanism of yisui shengxue granule, a complex chinese medicine, on thalassemia patients suffering from hemolysis and anemia of erythrocytes. Evid Based Complement Alternat Med. 2014;2014:213782 pubmed publisher
    ..disease, the relative expression level of (A) γ-globin to α-globin had an increasing trend and the level of BCL11A mRNA expression obviously increased...
  7. Flanagan J, Steward S, Howard T, Mortier N, Kimble A, Aygun B, et al. Hydroxycarbamide alters erythroid gene expression in children with sickle cell anaemia. Br J Haematol. 2012;157:240-8 pubmed publisher
    ..Hydroxycarbamide also affected expression of numerous genes associated with HbF including BCL11A, a key regulator of baseline HbF levels...
  8. Lettre G, Sankaran V, Bezerra M, Araújo A, Uda M, Sanna S, et al. DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proc Natl Acad Sci U S A. 2008;105:11869-74 pubmed publisher
    ..Common single nucleotide polymorphisms (SNPs) at the BCL11A and HBS1L-MYB loci have been implicated previously in HbF level variation in nonanemic European populations...
  9. Kuwata T, Nakamura T. BCL11A is a SUMOylated protein and recruits SUMO-conjugation enzymes in its nuclear body. Genes Cells. 2008;13:931-40 pubmed publisher
    b>BCL11A/EVI9 is a zinc-finger protein predominantly expressed in brain and hematopoietic cells. Previous studies show that BCL11A is involved in acute myelomonocytic leukemia and chronic lymphoid leukemia in mouse and human, respectively...

More Information

Publications20

  1. Kuo T, Hong C, Hsueh Y. Bcl11A/CTIP1 regulates expression of DCC and MAP1b in control of axon branching and dendrite outgrowth. Mol Cell Neurosci. 2009;42:195-207 pubmed publisher
    ..Here, we report that Bcl11A/CTIP1/Evi9, a zinc finger transcription factor, downregulates axon branching...
  2. Al Allawi N, Puehringer H, Raheem R, Oberkanins C. Genetic Modifiers in β-Thalassemia Intermedia: A Study on 102 Iraqi Arab Patients. Genet Test Mol Biomarkers. 2015;19:242-7 pubmed publisher
    ..The β and α genotypes as well as HBG2 g. 158 C>T (rs7482144), BCL11A (rs1427407 and rs10189857), and HBS1L-MYB (rs28384513 and rs9399137) by multiplex polymerase chain reaction and ..
  3. Jiang B, Zhang X, Su J, Meng W, Yang X, Yang J, et al. BCL11A overexpression predicts survival and relapse in non-small cell lung cancer and is modulated by microRNA-30a and gene amplification. Mol Cancer. 2013;12:61 pubmed publisher
    Aberrant activation of the proto-oncogene B-cell lymphoma/leukemia 11A (BCL11A) has been implicated in the pathogenesis of leukemia and lymphoma...
  4. Basak A, Hancarova M, Ulirsch J, Balci T, Trkova M, Pelisek M, et al. BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations. J Clin Invest. 2015;125:2363-8 pubmed publisher
    ..The transcription factor BCL11A silences HbF and has been an attractive therapeutic target for increasing HbF levels; however, it is not clear to ..
  5. Avram D, Fields A, Pretty On Top K, Nevrivy D, Ishmael J, Leid M. Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. J Biol Chem. 2000;275:10315-22 pubmed
  6. De Rubeis S, He X, Goldberg A, Poultney C, Samocha K, Cicek A, et al. Synaptic, transcriptional and chromatin genes disrupted in autism. Nature. 2014;515:209-15 pubmed publisher
  7. Neishabury M, Zamani F, Keyhani E, Azarkeivan A, Abedini S, Eslami M, et al. The influence of the BCL11A polymorphism on the phenotype of patients with beta thalassemia could be affected by the beta globin locus control region and/or the Xmn1-HBG2 genotypic background. Blood Cells Mol Dis. 2013;51:80-4 pubmed publisher
    ..the influence of the ? globin locus control region (LCR) genotypic background on the phenotype modifying role of BCL11A polymorphisms, 100 cases of thalassemia, 48 homozygous for the A allele and 52 homozygous for the G allele at the ..
  8. He Y, Chen P, Lin W, Luo J. Analysis of rs4671393 polymorphism in hemoglobin E/?-thalassemia major in Guangxi Province of China. J Pediatr Hematol Oncol. 2012;34:323-4 pubmed publisher
  9. Xu J, Peng C, Sankaran V, Shao Z, Esrick E, Chong B, et al. Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Science. 2011;334:993-6 pubmed publisher
    ..Here, we show that the repressor BCL11A is required in vivo for silencing of ?-globin expression in adult animals, yet dispensable for red cell production...
  10. Kuo T, Hong C, Chien H, Hsueh Y. X-linked mental retardation gene CASK interacts with Bcl11A/CTIP1 and regulates axon branching and outgrowth. J Neurosci Res. 2010;88:2364-73 pubmed publisher
    ..From a yeast two-hybrid screen, Krüppel-like zinc finger protein B cell lymphoma/COUP-TF-interacting protein 1 (Bcl11A/CTIP1) was identified as a CASK binding protein...
  11. Kuo T, Chen C, Hsueh Y. Bcl11A/CTIP1 mediates the effect of the glutamate receptor on axon branching and dendrite outgrowth. J Neurochem. 2010;114:1381-92 pubmed publisher
    ..A previous study demonstrated that knockdown of the zinc finger transcription factor B cell lymphoma 11A-long (Bcl11A-L) reduces deleted in colorectal cancer (DCC) and microtubule-associated protein (MAP) 1b expression, thereby ..