Gene Symbol: Bche
Description: butyrylcholinesterase
Alias: cholinesterase
Species: rat
Products:     Bche

Top Publications

  1. Da Silva C, Wolkmer P, Da Silva A, Paim F, Tonin A, Castro V, et al. Cholinesterases as markers of the inflammatory process in rats infected with Leptospira interrogans serovar Icterohaemorrhagiae. J Med Microbiol. 2012;61:278-84 pubmed publisher
    The aim of this study was evaluate changes in the cholinesterase activity in blood, lymphocytes and serum of rats infected with Leptospira interrogans serovar Icterohaemorrhagiae ('L. icterohaemorrhagiae')...
  2. Li B, Stribley J, Ticu A, Xie W, Schopfer L, Hammond P, et al. Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse. J Neurochem. 2000;75:1320-31 pubmed
    ..findings contradict the dogma, based mainly on observations in Triton X-100 extracts, that BChE is a minor cholinesterase in animal tissues...
  3. Wolkmer P, Lopes S, Franciscato C, Da Silva A, Traesel C, Siqueira L, et al. Trypanosoma evansi: cholinesterase activity in acutely infected Wistar rats. Exp Parasitol. 2010;125:251-5 pubmed publisher
    The aim of this study was to evaluate cholinesterase activity during the early acute phase of Trypanosoma evansi infection in rats...
  4. Ben Assayag E, Shenhar Tsarfaty S, Ofek K, Soreq L, Bova I, Shopin L, et al. Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality. Mol Med. 2010;16:278-86 pubmed publisher
    ..For this purpose, serum cholinesterase activities, butyrylcholinesterase-K genotype and inflammatory biomarkers were determined in 264 ischemic ..
  5. Darvesh S, LeBlanc A, Macdonald I, Reid G, Bhan V, Macaulay R, et al. Butyrylcholinesterase activity in multiple sclerosis neuropathology. Chem Biol Interact. 2010;187:425-31 pubmed publisher
    ..This suggests that BuChE could be a potential target for novel disease-modifying strategies for MS. ..
  6. Matte C, Durigon E, Stefanello F, Cipriani F, Wajner M, Wyse A. Folic acid pretreatment prevents the reduction of Na(+),K(+)-ATPase and butyrylcholinesterase activities in rats subjected to acute hyperhomocysteinemia. Int J Dev Neurosci. 2006;24:3-8 pubmed
  7. Gresner P, Dolnik M, Waczulikova I, Bryszewska M, Sikurova L, Watala C. Increased blood plasma hydrolysis of acetylsalicylic acid in type 2 diabetic patients: a role of plasma esterases. Biochim Biophys Acta. 2006;1760:207-15 pubmed
    ..01). No direct effects of plasma pH or albumin were observed. In conclusion, higher aspirin esterase activity contributes to the lowered response of diabetic platelets to ASA-mediated antiplatelet therapy. ..
  8. Srivastava A, Shivanandappa T. Differential cholinesterase inhibition in the rat brain regions by dichlorvos and protective effect of Decalepis hamiltonii roots. Neurotoxicology. 2011;32:931-4 pubmed publisher
    Dichlorvos (DDVP) causes neurotoxicity primarily by inhibiting cholinesterase (ChE) which is the characteristic feature of organophosphate pesticides...
  9. Huang Y, Huang Y, Baldassarre H, Wang B, Lazaris A, Leduc M, et al. Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning. Proc Natl Acad Sci U S A. 2007;104:13603-8 pubmed
    ..Because exposure to OP could create a danger for humans in the future, butyrylcholinesterase (BChE) has been developed for prophylaxis to these chemicals...

More Information


  1. Geyer B, Kannan L, Garnaud P, Broomfield C, Cadieux C, Cherni I, et al. Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents. Proc Natl Acad Sci U S A. 2010;107:20251-6 pubmed publisher
    The concept of using cholinesterase bioscavengers for prophylaxis against organophosphorous nerve agents and pesticides has progressed from the bench to clinical trial. However, the supply of the native human proteins is either limited (e...
  2. Iwasaki T, Yoneda M, Nakajima A, Terauchi Y. Serum butyrylcholinesterase is strongly associated with adiposity, the serum lipid profile and insulin resistance. Intern Med. 2007;46:1633-9 pubmed
    We investigated the association between the serum butyrylcholinesterase (BChE) activity and parameters of adiposity, insulin resistance and the serum lipid profile, including the serum levels of triglyceride (TG), HDL-cholesterol (HDL-C) ..
  3. Oguri M, Kato K, Hibino T, Yokoi K, Segawa T, Matsuo H, et al. Genetic risk for restenosis after coronary stenting. Atherosclerosis. 2007;194:e172-8 pubmed
    ..analysis with adjustment for the prevalence of diabetes mellitus revealed that the 1615G-->A polymorphism of BCHE, the 7,067,365C-->A polymorphism of INSR, the C-->T polymorphism of GPX1, the G-->A polymorphism of ROS1, ..
  4. Bodur E, Layer P. Counter-regulation of cholinesterases: differential activation of PKC and ERK signaling in retinal cells through BChE knockdown. Biochimie. 2011;93:469-76 pubmed publisher
    The ubiquitous cholinesterase (ChE) enzymes, functioning in the termination of acetylcholine mediated neural transmission, are also reported to have additional functions...
  5. Tonin A, Da Silva A, Thorstenberg M, Castilhos L, França R, Leal D, et al. Influence of Toxoplasma gondii acute infection on cholinesterase activities of Wistar rats. Korean J Parasitol. 2013;51:421-6 pubmed publisher
    ..the acetylcholinesterase (AChE) activity in blood and lymphocytes and the activity of butyrylcholinesterase (BChE) in serum of rats experimentally infected with T. gondii during the acute phase of infection...
  6. Hartmann J, Kiewert C, Duysen E, Lockridge O, Greig N, Klein J. Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity. J Neurochem. 2007;100:1421-9 pubmed
    ..dysfunction is treated with inhibitors of acetylcholinesterase (AChE) while the role of butyrylcholinesterase (BChE) for brain cholinergic function is unclear...
  7. Brazzolotto X, Wandhammer M, Ronco C, Trovaslet M, Jean L, Lockridge O, et al. Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure. FEBS J. 2012;279:2905-16 pubmed publisher
    Butyrylcholinesterase (BChE) is a serine hydrolase that is present in all mammalian tissues...
  8. Al Fakhri N, Bogusch G. Activity of acetylcholinesterase and unspecific cholinesterase during differentiation of somites in mouse embryos. Anat Embryol (Berl). 1995;192:257-64 pubmed
    During the development of somites in mouse embryos, widespread activity of unspecific cholinesterase (BuChE) was demonstrated after prolonged incubation...
  9. Kalman J, Juhász A, Rakonczay Z, Abraham G, Zana M, Boda K, et al. Increased serum butyrylcholinesterase activity in type IIb hyperlipidaemic patients. Life Sci. 2004;75:1195-204 pubmed
    ..The APOE4 allele was significantly overrepresented among the hyperlipidaemic probands, but neither serum cholinesterase activity was affected by the dosage of the APOE4 gene...
  10. Dave K, Katyare S. Effect of alloxan-induced diabetes on serum and cardiac butyrylcholinesterases in the rat. J Endocrinol. 2002;175:241-50 pubmed
    Elevated serum butyrylcholinesterase (BChE) activity in the diabetic rat, mouse and human is very evident. The source of the increased level of BChE in the diabetic condition is not known...
  11. Mabrouk H, Mechria H, Mechri A, Rahali H, Douki W, Gaha L, et al. [Butyrylcholinesterase activity in schizophrenic patients]. Ann Biol Clin (Paris). 2011;69:647-52 pubmed publisher
    Butyrylcholinesterase (BChE) is an enzyme that has been investigated for its putative role in neurodegenerative and neuropsychiatric disorders...
  12. Sánchez Chávez G, Salceda R. Acetyl- and butyrylcholinesterase in normal and diabetic rat retina. Neurochem Res. 2001;26:153-9 pubmed
    ..Less than 5% of the cholinesterase activity was due to BChE...
  13. Ofek K, Krabbe K, Evron T, Debecco M, Nielsen A, Brunnsgaad H, et al. Cholinergic status modulations in human volunteers under acute inflammation. J Mol Med (Berl). 2007;85:1239-51 pubmed
    ..Enhancers showed significant co-increases in plasma butyrylcholinesterase (BChE) and paraoxonase (PON1) activities, accompanied by rapid recovery of lymphocyte counts...
  14. Sakamoto N, Hidaka K, Fujisawa T, Maeda M, Iuchi I. Identification of a point mutation associated with a silent phenotype of human serum butyrylcholinesterase--a case of familial cholinesterasemia. Clin Chim Acta. 1998;274:159-66 pubmed
    A point mutation which caused a silent phenotype of human serum butyrylcholinesterase (BChE) was identified in the DNA of a 47-year-old Japanese woman who visited our hospital complaining of hypertension...
  15. Amitay M, Shurki A. The structure of G117H mutant of butyrylcholinesterase: nerve agents scavenger. Proteins. 2009;77:370-7 pubmed publisher
    ..G117H mutant of human Butyrylcholinesterase (BChE) was found to be capable of hydrolyzing certain OPs and protect against their toxicity...
  16. Koohestani F, Brown C, Meisami E. Differential effects of developmental hypo- and hyperthyroidism on acetylcholinesterase and butyrylcholinesterase activity in the spinal cord of developing postnatal rat pups. Int J Dev Neurosci. 2012;30:570-7 pubmed publisher
    ..ages, using SC homogenates with acetylthiocholine-chloride as the substrate, together with specific cholinesterase inhibitors, which specifically target AChE and BuChE...
  17. Delwing de Lima D, Wollinger L, Casagrande A, Delwing F, da Cruz J, Wyse A, et al. Guanidino compounds inhibit acetylcholinesterase and butyrylcholinesterase activities: effect neuroprotector of vitamins E plus C. Int J Dev Neurosci. 2010;28:465-73 pubmed publisher
    ..It is presumed that these results might be associated, at least in part, with the neuronal dysfunction of patients affected by hyperargininemia. ..
  18. Ramkumar K, Latha M, Ashokkumar N, Pari L, Ananthan R. Modulation of impaired cholinesterase activity in experimental diabetes: effect of Gymnema montanum leaf extract. J Basic Clin Physiol Pharmacol. 2005;16:17-35 pubmed
    ..of the extract on the activity of reduced brain and retinal acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in streptozotocin (STZ)-induced diabetic male Wistar rats...
  19. Ruberg M, Villageois A, Bonnet A, Pillon B, Rieger F, Agid Y. Acetylcholinesterase and butyrylcholinesterase activity in the cerebrospinal fluid of patients with neurodegenerative diseases involving cholinergic systems. J Neurol Neurosurg Psychiatry. 1987;50:538-43 pubmed
    Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were assayed in the cerebrospinal fluid (CSF) of subjects with neurodegenerative diseases (dementing and non-dementing, with and without known cholinergic lesions), to determine ..
  20. Mis K. Colocalization of acetylcholinesterase, butyrylcholinesterase and choline acetyltransferase in rat spinal cord. Hum Exp Toxicol. 2005;24:543-5 pubmed
    ..All neurons expressing mRNAs for AChE and BuChE were found to be ChAT positive. This finding supports the previous proposal that BuChE modulates cholinergic transmission in AChE knockout mice. ..
  21. Basu P, Batabyal S, Bhattacharya A, Datta T. Cholinesterase activities in cerebrospinal fluid of patients with idiopathic convulsive disorders. Clin Chim Acta. 1995;235:107-12 pubmed
  22. Hrabovska A, Debouzy J, Froment M, Devínsky F, Paulíková I, Masson P. Rat butyrylcholinesterase-catalysed hydrolysis of N-alkyl homologues of benzoylcholine. FEBS J. 2006;273:1185-97 pubmed
    ..substrate concentration showed a premature plateau far below V(max). This was due to the loss of substrate availability. The best substrates for rat butyrylcholinesterase were short alkyl homologues, BzCh - BCH4...
  23. Greig N, Utsuki T, Ingram D, Wang Y, Pepeu G, Scali C, et al. Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proc Natl Acad Sci U S A. 2005;102:17213-8 pubmed
    Like acetylcholinesterase, butyrylcholinesterase (BChE) inactivates the neurotransmitter acetylcholine (ACh) and is hence a viable therapeutic target in Alzheimer's disease, which is characterized by a cholinergic deficit...
  24. Randell E, Mathews M, Zhang H, Seraj J, Sun G. Relationship between serum butyrylcholinesterase and the metabolic syndrome. Clin Biochem. 2005;38:799-805 pubmed
    ..These results suggest the involvement of BuChE in the pathophysiological process constituting the metabolic syndrome. Whether increased BuChE activity precedes or follows the development of risk factors is not known. ..
  25. Berg R, Ofek K, Qvist T, Tofteng F, Soreq H, Møller K. Cholinesterase modulations in patients with acute bacterial meningitis. Scand J Clin Lab Invest. 2011;71:350-2 pubmed publisher
    ..Arterial and jugular venous enzyme activities were similar both in patients and controls, suggesting that no cerebral release was present. ..
  26. Bradamante V, Krnić Z, Zrinski R, Konjevoda P, Reiner Z. Changes in butyrylcholinesterase activity and serum lipids after oxprenolol and glibenclamide treatments in non-diabetic rats. Arzneimittelforschung. 2006;56:64-9 pubmed
    ..These results showed that the increase in BuChE activity might be the first sign of altered triglyceride and lipoprotein metabolism. ..
  27. Darreh Shori T, Brimijoin S, Kadir A, Almkvist O, Nordberg A. Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE epsilon4 allele, in relation to cognitive function and cerebral glucose metabolism. Neurobiol Dis. 2006;24:326-33 pubmed
    ..Thus, low BuChE in a patient's CSF may predict extensive incorporation in neuritic plaques, increased neurotoxicity and greater central neurodegeneration. ..
  28. Alcântara V, Chautard Freire Maia E, Scartezini M, Cerci M, Braun Prado K, Picheth G. Butyrylcholinesterase activity and risk factors for coronary artery disease. Scand J Clin Lab Invest. 2002;62:399-404 pubmed
    ..which risk factors for coronary artery disease (CAD) are independently correlated with butyrylcholinesterase (BChE) activity. We studied 88 White individuals (43 males) aged 47.3+/-15.7 years (mean+/-SD; range: 14.0-80...
  29. Lepienski L, Souza R, Chautard Freire Maia E, Alcântara V, Rea R. Variant K of butyrylcholinesterase and risk of early-onset type 1 diabetes mellitus in Euro-Brazilians. Diabetes Obes Metab. 2006;8:709-11 pubmed
  30. Flumerfelt B, Lewis P. Cholinesterase activity in the hypoglossal nucleus of the rat and the changes produced by axotomy: a light and electron microscopic study. J Anat. 1975;119:309-31 pubmed
    ..BuChE activity returns only erratically and never completely. The similarity in normal distribution, and in response to axotomy, of the two cholinesterases suggests that their functions are related. ..
  31. Svoboda Z, Kvetina J, Kunesova G, Herink J, Bajgar J, Bartosova L, et al. Effect of galantamine on acetylcholinesterase and butyrylcholinesterase activities in the presence of L-carnitine in rat selected brain and peripheral tissues. Neuro Endocrinol Lett. 2006;27 Suppl 2:183-6 pubmed
    ..Premedication by CAR led to a slight change in the values of the activities monitored. CAR in terms of positive modulation of GAL targeting to the central nervous system had no statistically significant effect. ..
  32. Yoo D, Woo Y, Kim W, Nam S, Lee B, Yeun G, et al. Effects of a new synthetic butyrylcholinesterase inhibitor, HBU-39, on cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus in a scopolamine-induced amnesia animal model. Neurochem Int. 2011;59:722-8 pubmed publisher
    ..These results suggest that the BuChE inhibitor, HBU-39, can ameliorate the scopolamine-induced reductions of cell proliferation and neuroblast differentiation, and HBU-39 may be applicable to amnesia patients to promote memory functions...
  33. Wyse A, Stefanello F, Chiarani F, Delwing D, Wannmacher C, Wajner M. Arginine administration decreases cerebral cortex acetylcholinesterase and serum butyrylcholinesterase probably by oxidative stress induction. Neurochem Res. 2004;29:385-9 pubmed
  34. Nakahara T, Kubota Y, Sakamoto K, Ishii K. The role of cholinesterases in rat urinary bladder contractility. Urol Res. 2003;31:223-6 pubmed
    ..05) higher than those of BuChE. These results indicated that AChE, rather than BuChE, plays an important role in controlling ACh-induced contractions of rat urinary bladder. ..
  35. Darreh Shori T, Siawesh M, Mousavi M, Andreasen N, Nordberg A. Apolipoprotein ?4 modulates phenotype of butyrylcholinesterase in CSF of patients with Alzheimer's disease. J Alzheimers Dis. 2012;28:443-58 pubmed publisher
    Butyrylcholinesterase K (BCHE-K) is associated with increased risk of developing Alzheimer's disease (AD) in apolipoprotein ? (APOE4) carriers, while among APOE4 non-carriers BCHE-K appears to be protective...
  36. Hashim Y, Shepherd D, Wiltshire S, Holman R, Levy J, Clark A, et al. Butyrylcholinesterase K variant on chromosome 3 q is associated with Type II diabetes in white Caucasian subjects. Diabetologia. 2001;44:2227-30 pubmed
    To determine the association of three genes associated with Alzheimer's disease--butyrylcholinesterase (BcHE) on chromosome 3 q, alpha2 macroglobulin (alpha2M) on chromosome 12 p and apolipoprotein E (ApoE) on chromosome 19 q--with Type ..
  37. McGuire M, Nogueira C, Bartels C, Lightstone H, Hajra A, van der Spek A, et al. Identification of the structural mutation responsible for the dibucaine-resistant (atypical) variant form of human serum cholinesterase. Proc Natl Acad Sci U S A. 1989;86:953-7 pubmed
    A point mutation in the gene for human serum cholinesterase was identified that changes Asp-70 to Gly in the atypical form of serum cholinesterase...
  38. Lucić Vrdoljak A, Bradamante V, Radic B, Peraica M, Fuchs R, Reiner Z. Butyrylcholinesterase activity and plasma lipids in dexamethasone treated rats. Acta Pharm. 2005;55:177-85 pubmed
    ..Neither positive correlation between BuChE and triglycerides nor negative correlation between BuChE and HDL was found. Changes in lipid profile during DM treatment were not sex- and time-dependent. ..
  39. Godfrey D, Matschinsky F. Enzymes of the cholinergic system in islets of Langerhans. J Histochem Cytochem. 1975;23:645-51 pubmed
    ..Since the islets of diabetic rats are probably much smaller than those of control rats, it is suggested that cholinergic elements associated with pancreatic islets are lost following induction of streptozotocin diabetes. ..
  40. Vaisi Raygani A, Rahimi Z, Entezami H, Kharrazi H, Bahrhemand F, Tavilani H, et al. Butyrylcholinesterase K variants increase the risk of coronary artery disease in the population of western Iran. Scand J Clin Lab Invest. 2008;68:123-9 pubmed
    ..results of several studies suggest that there is an association between the butyrylcholinesterase-K variant (BCHE-K, G1615A/Ala539Thr) and the risk of developing coronary artery disease (CAD) in diabetes and non-diabetic subjects...
  41. Muñoz Delgado E, Montenegro M, Campoy F, Moral Naranjo M, Cabezas Herrera J, Kovacs G, et al. Expression of cholinesterases in human kidney and its variation in renal cell carcinoma types. FEBS J. 2010;277:4519-29 pubmed publisher
    ..expressed in renal tumours, paired pieces of normal kidney and renal cell carcinomas (RCCs) were compared for cholinesterase activity and mRNA levels...
  42. Moral Naranjo M, Cabezas Herrera J, Vidal C, Campoy F. Muscular dystrophy with laminin deficiency decreases the content of butyrylcholinesterase tetramers in sciatic nerves of Lama2dy mice. Neurosci Lett. 2002;331:155-8 pubmed
    ..The anomalous synthesis of BuChE forms in dystrophic nerve may be related with peripheral neuropathy of MCMD. ..
  43. Darvesh S, Cash M, Reid G, Martin E, Mitnitski A, Geula C. Butyrylcholinesterase is associated with ?-amyloid plaques in the transgenic APPSWE/PSEN1dE9 mouse model of Alzheimer disease. J Neuropathol Exp Neurol. 2012;71:2-14 pubmed publisher
    ..These observations suggest that BuChE is associated with a subpopulation of A? plaques and may play a role in AD plaque maturation. A further study of this animal model could clarify the role of BuChE in AD pathology. ..
  44. Abbott C, Mackness M, Kumar S, Olukoga A, Gordon C, Arrol S, et al. Relationship between serum butyrylcholinesterase activity, hypertriglyceridaemia and insulin sensitivity in diabetes mellitus. Clin Sci (Lond). 1993;85:77-81 pubmed
    ..6. These results are consistent with the view that butyrylcholinesterase may have a role in the altered lipoprotein metabolism in hypertriglyceridaemia associated with insulin insensitivity or insulin deficiency in diabetes mellitus. ..
  45. Alves Amaral G, Pires Oliveira M, Andrade Lopes A, Chiavegatti T, Godinho R. Gender-related differences in circadian rhythm of rat plasma acetyl- and butyrylcholinesterase: effects of sex hormone withdrawal. Chem Biol Interact. 2010;186:9-15 pubmed publisher
    ..Plasma and liver cholinesterase activities were evaluated in control or 2-30-day castrated adult male and female rats...
  46. Koohestani F, Brown C, Meisami E. Postnatal growth hormone deficiency in growing rats causes marked decline in the activity of spinal cord acetylcholinesterase but not butyrylcholinesterase. Int J Dev Neurosci. 2012;30:578-83 pubmed publisher
    The effects of growth hormone (GH) deficiency on the developmental changes in the abundance and activity of cholinesterase enzymes were studied in the developing spinal cord (SC) of postnatal rats by measuring the specific activity of ..
  47. Stefanello F, Franzon R, Tagliari B, Wannmacher C, Wajner M, Wyse A. Reduction of butyrylcholinesterase activity in rat serum subjected to hyperhomocysteinemia. Metab Brain Dis. 2005;20:97-103 pubmed
    ..The data suggest that the inhibitory effect of Hcy on BuChE activity is probably mediated by free radicals, since vitamins E and C administration prevented such effect. ..
  48. Bartosova L, Bielavska M, Bajgar J. Detection of sarin in plasma of rats after inhalation intoxication. J Enzyme Inhib Med Chem. 2006;21:509-14 pubmed