Gene Symbol: Bccip
Description: BRCA2 and CDKN1A interacting protein
Alias: BRCA2 and CDKN1A-interacting protein
Ono T, Kitaura H, Ugai H, Murata T, Yokoyama K, Iguchi Ariga S, et al
. TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase. J Biol Chem. 2000;275:31145-54 pubmed
..Furthermore, the results of three different types of experiments showed that TOK-1alpha enhanced the inhibitory activity of p21 toward histone H1 kinase activity of CDK2. TOK-1alpha is thus thought to be a new type of CDK2 modulator. ..
Ash S, Yang D, Britt D. LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells. Biochem Biophys Res Commun. 2008;371:333-8 pubmed publisher
..We performed yeast two-hybrid screening to detect LYRIC/AEG-1 associated proteins, and identified BCCIP, a CDKN1A and BRCA2-associated protein involved in cell cycle regulation and DNA repair...
Lu H, Huang Y, Mehrotra S, Droz Rosario R, Liu J, Bhaumik M, et al
. Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes. PLoS Genet. 2011;7:e1002291 pubmed publisher
b>BCCIP is a BRCA2- and CDKN1A(p21)-interacting protein that has been implicated in the maintenance of genomic integrity...
Huhn S, Liu J, Ye C, Lu H, Jiang X, Feng X, et al
. Regulation of spindle integrity and mitotic fidelity by BCCIP. Oncogene. 2017;36:4750-4766 pubmed publisher
..In this work, we demonstrate BCCIP, especially BCCIPÎ±, as a previously unidentified component of the mitotic spindle pole and the centrosome...