Bccip

Summary

Gene Symbol: Bccip
Description: BRCA2 and CDKN1A interacting protein
Alias: BRCA2 and CDKN1A-interacting protein
Species: rat
Products:     Bccip

Top Publications

  1. Ono T, Kitaura H, Ugai H, Murata T, Yokoyama K, Iguchi Ariga S, et al. TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase. J Biol Chem. 2000;275:31145-54 pubmed
    ..Furthermore, the results of three different types of experiments showed that TOK-1alpha enhanced the inhibitory activity of p21 toward histone H1 kinase activity of CDK2. TOK-1alpha is thus thought to be a new type of CDK2 modulator. ..
  2. Ash S, Yang D, Britt D. LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells. Biochem Biophys Res Commun. 2008;371:333-8 pubmed publisher
    ..We performed yeast two-hybrid screening to detect LYRIC/AEG-1 associated proteins, and identified BCCIP, a CDKN1A and BRCA2-associated protein involved in cell cycle regulation and DNA repair...
  3. Lu H, Huang Y, Mehrotra S, Droz Rosario R, Liu J, Bhaumik M, et al. Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes. PLoS Genet. 2011;7:e1002291 pubmed publisher
    b>BCCIP is a BRCA2- and CDKN1A(p21)-interacting protein that has been implicated in the maintenance of genomic integrity...
  4. Huhn S, Liu J, Ye C, Lu H, Jiang X, Feng X, et al. Regulation of spindle integrity and mitotic fidelity by BCCIP. Oncogene. 2017;36:4750-4766 pubmed publisher
    ..In this work, we demonstrate BCCIP, especially BCCIPα, as a previously unidentified component of the mitotic spindle pole and the centrosome...