Gene Symbol: Babam2
Description: BRISC and BRCA1 A complex member 2
Alias: BRISC and BRCA1-A complex member 2, BRCA1-A complex subunit BRE, BRCA1/BRCA2-containing complex subunit 45, brain and reproductive organ-expressed (TNFRSF1A modulator), brain and reproductive organ-expressed protein
Species: rat
Products:     Babam2

Top Publications

  1. Li L, Yoo H, Becker F, Ali Osman F, Chan J. Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid. Biochem Biophys Res Commun. 1995;206:764-74 pubmed
    ..These data indicate that BRE is a house-keeping gene and it may play a role in homeostatis or in certain pathways of differentiation in cells of neural, epithelial and germ line origins. ..
  2. Gu C, Castellino A, Chan J, Chao M. BRE: a modulator of TNF-alpha action. FASEB J. 1998;12:1101-8 pubmed
    ..Overexpression of BRE inhibited TNF-induced NFkappaB activation, indicating that the interaction of BRE protein with the cytoplasmic region of p55 TNF receptor may modulate signal transduction by TNF-alpha. ..
  3. Dong Y, Hakimi M, Chen X, Kumaraswamy E, Cooch N, Godwin A, et al. Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. Mol Cell. 2003;12:1087-99 pubmed
    ..BRCC36 shows aberrant expression in sporadic breast tumors. These findings identify BRCC as a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. ..
  4. Li Q, Ching A, Chan B, Chow S, Lim P, Ho T, et al. A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway. J Biol Chem. 2004;279:52106-16 pubmed
    ..We propose that BRE inhibits, by ubiquitination-like activity, components in or proximal to the death-inducing signaling complexes that are necessary for activation of the mitochondria. ..
  5. Sobhian B, Shao G, Lilli D, Culhane A, Moreau L, Xia B, et al. RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science. 2007;316:1198-202 pubmed
    ..These events are required for cell cycle checkpoint and repair responses to ionizing radiation, implicating ubiquitin chain recognition and turnover in the BRCA1-mediated repair of DSBs. ..
  6. Cooper E, Cutcliffe C, Kristiansen T, Pandey A, Pickart C, Cohen R. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1. EMBO J. 2009;28:621-31 pubmed publisher
    ..Our results suggest that specificity for K63-linked polyubiquitin is a common property of the JAMM/MPN+ family of DUBs. ..
  7. Shao G, Patterson Fortin J, Messick T, Feng D, Shanbhag N, Wang Y, et al. MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks. Genes Dev. 2009;23:740-54 pubmed publisher
    ..These findings provide new molecular insights into how BRCA1 associates with independently assembled core protein complexes to maintain genome integrity. ..
  8. Feng L, Huang J, Chen J. MERIT40 facilitates BRCA1 localization and DNA damage repair. Genes Dev. 2009;23:719-28 pubmed publisher
    ..Together, our study reveals that a stable complex containing MERIT40 acts early in DNA damage response and regulates damage-dependent BRCA1 localization. ..
  9. Wang B, Hurov K, Hofmann K, Elledge S. NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev. 2009;23:729-39 pubmed publisher
    ..These findings provide a new perspective from which to view the BRCA1 A complex. ..

More Information


  1. Zheng H, Gupta V, Patterson Fortin J, Bhattacharya S, Katlinski K, Wu J, et al. A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses. Cell Rep. 2013;5:180-93 pubmed publisher
    ..These studies reveal a mechanism of DUB regulation and suggest a therapeutic use of BRISC inhibitors for treating pathophysiological processes driven by elevated IFN responses. ..