Gene Symbol: B4galnt2
Description: beta-1,4-N-acetyl-galactosaminyl transferase 2
Alias: beta-1,4 N-acetylgalactosaminyltransferase 2
Mohlke K, Purkayastha A, Westrick R, Smith P, Petryniak B, Lowe J, et al
. Mvwf, a dominant modifier of murine von Willebrand factor, results from altered lineage-specific expression of a glycosyltransferase. Cell. 1999;96:111-20 pubmed
..These findings identify alterations in glycosyltransferase function as a potential general mechanism for the genetic modification of plasma protein levels. ..
Montiel M, Krzewinski Recchi M, Delannoy P, Harduin Lepers A. Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytopl. Biochem J. 2003;373:369-79 pubmed
Ponder B, Festing M, Wilkinson M. An allelic difference determines reciprocal patterns of expression of binding sites for Dolichos biflorus lectin in inbred strains of mice. J Embryol Exp Morphol. 1985;87:229-39 pubmed
..If so, elucidation of the genetic basis of the polymorphism might provide an insight into the mechanisms of developmental regulation of glycosyltransferase activity. ..
Brooks R, Gooderham N, Zhao K, Edwards R, Howard L, Boobis A, et al
. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is a potent mutagen in the mouse small intestine. Cancer Res. 1994;54:1665-71 pubmed
Lo Presti L, Cabuy E, Chiricolo M, Dall Olio F. Molecular cloning of the human beta1,4 N-acetylgalactosaminyltransferase responsible for the biosynthesis of the Sd(a) histo-blood group antigen: the sequence predicts a very long cytoplasmic domain. J Biochem. 2003;134:675-82 pubmed
..The mRNA is expressed at a high level in differentiated Caco2 cells and in colonic mucosa and at a much lower level in lymphocytes and other colon cancer cell lines. ..
Kawamura Y, Kawashima R, Fukunaga R, Hirai K, Toyama Sorimachi N, Tokuhara M, et al
. Introduction of Sd(a) carbohydrate antigen in gastrointestinal cancer cells eliminates selectin ligands and inhibits metastasis. Cancer Res. 2005;65:6220-7 pubmed
..In summary, forced expression of Sd(a) carbohydrate determinant caused remarkable elimination of carbohydrate ligands for selectin and reduced metastasis of human gastrointestinal tract cancer cells. ..