B3gnt5

Summary

Gene Symbol: B3gnt5
Description: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
Alias: lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase, BGnT-5, UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5, beta-1,3-Gn-T5, beta-1,3-N-acetylglucosaminyltransferase 5, beta3Gn-T5, lactotriaosylceramide synthase, lc(3)Cer synthase, lc3 synthase
Species: rat
Products:     B3gnt5

Top Publications

  1. Henion T, Zhou D, Wolfer D, Jungalwala F, Hennet T. Cloning of a mouse beta 1,3 N-acetylglucosaminyltransferase GlcNAc(beta 1,3)Gal(beta 1,4)Glc-ceramide synthase gene encoding the key regulator of lacto-series glycolipid biosynthesis. J Biol Chem. 2001;276:30261-9 pubmed
    ..The Lc3 synthase activity has been shown to be regulated during development, especially during brain morphogenesis...
  2. Togayachi A, Akashima T, Ookubo R, Kudo T, Nishihara S, Iwasaki H, et al. Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids. J Biol Chem. 2001;276:22032-40 pubmed
    ..4) The changes in beta3Gn-T5 transcript levels during the rat brain development were determined. Points 2, 3, and 4 were consistent with the Lc(3)Cer synthase activity reported previously. ..