B3gnt2

Summary

Gene Symbol: B3gnt2
Description: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Alias: B3gnt1, N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
Species: rat
Products:     B3gnt2

Top Publications

  1. Shiraishi N, Natsume A, Togayachi A, Endo T, Akashima T, Yamada Y, et al. Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family. J Biol Chem. 2001;276:3498-507 pubmed
    ..Considering the differences in substrate specificity and distribution, each beta1,3-N-acetylglucosaminyltransferase may play different roles. ..
  2. Henion T, Raitcheva D, Grosholz R, Biellmann F, Skarnes W, Hennet T, et al. Beta1,3-N-acetylglucosaminyltransferase 1 glycosylation is required for axon pathfinding by olfactory sensory neurons. J Neurosci. 2005;25:1894-903 pubmed
    ..These results reveal an essential role for lactosamine in sensory axon pathfinding and in the formation of OB synaptic connections. ..
  3. Praissman J, Live D, Wang S, Ramiah A, Chinoy Z, Boons G, et al. B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of α-dystroglycan. elife. 2014;3: pubmed publisher
    Recent studies demonstrated that mutations in B3GNT1, an enzyme proposed to be involved in poly-N-acetyllactosamine synthesis, were causal for congenital muscular dystrophy with hypoglycosylation of α-dystroglycan (secondary ..
  4. Zhou D, Dinter A, Gutierrez Gallego R, Kamerling J, Vliegenthart J, Berger E, et al. A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases. Proc Natl Acad Sci U S A. 1999;96:406-11 pubmed
    ..This suggests that the conserved amino acid motifs likely represent residues required for the catalysis of the glycosidic (beta1-3) linkage. ..
  5. Henion T, Madany P, Faden A, Schwarting G. ?3GnT2 null mice exhibit defective accessory olfactory bulb innervation. Mol Cell Neurosci. 2013;52:73-86 pubmed publisher
    ..These results identify a novel function for ?3GnT2 glycosylation in maintaining expression of layer-specific vomeronasal receptors, as well as adhesion molecules required for proper AOB glomerular formation. ..