Gene Symbol: Avpr1a
Description: arginine vasopressin receptor 1A
Alias: AVPR, V1a, V1aR, vasopressin V1a receptor, antidiuretic hormone receptor 1a, arginine vasopressin receptor V1a, vascular/hepatic-type arginine vasopressin receptor
Species: rat
Products:     Avpr1a

Top Publications

  1. Krauskopf A, Lhote P, Mutter M, Dufour J, Ruegg U, Buetler T. Vasopressin type 1A receptor up-regulation by cyclosporin A in vascular smooth muscle cells is mediated by superoxide. J Biol Chem. 2003;278:41685-90 pubmed
  2. Veitenheimer B, Osborn J. Role of spinal V1a receptors in regulation of arterial pressure during acute and chronic osmotic stress. Am J Physiol Regul Integr Comp Physiol. 2011;300:R460-9 pubmed publisher
    ..rats, if the increases in MAP during acute or chronic osmotic stimuli are due to activation of spinal vasopressin (V1a) receptors...
  3. Watters J, Wilkinson C, Dorsa D. Glucocorticoid regulation of vasopressin V1a receptors in rat forebrain. Brain Res Mol Brain Res. 1996;38:276-84 pubmed
    ..b>V1aR mRNA was evaluated using in situ hybridization, and V1aR binding site density was quantified using a specific ..
  4. Veenema A, Bredewold R, de Vries G. Vasopressin regulates social recognition in juvenile and adult rats of both sexes, but in sex- and age-specific ways. Horm Behav. 2012;61:50-6 pubmed publisher
    In adult male rats, vasopressin (AVP) facilitates social recognition via activation of V1a receptors within the lateral septum...
  5. Lukas M, Bredewold R, Neumann I, Veenema A. Maternal separation interferes with developmental changes in brain vasopressin and oxytocin receptor binding in male rats. Neuropharmacology. 2010;58:78-87 pubmed publisher
  6. Murasawa S, Matsubara H, Kijima K, Maruyama K, Mori Y, Inada M. Structure of the rat V1a vasopressin receptor gene and characterization of its promoter region and complete cDNA sequence of the 3'-end. J Biol Chem. 1995;270:20042-50 pubmed
    The gene encoding the rat V1a arginine vasopressin (AVP) receptor was isolated, and its structural organization and 5'-flanking region were characterized...
  7. Nephew B, Bridges R. Central actions of arginine vasopressin and a V1a receptor antagonist on maternal aggression, maternal behavior, and grooming in lactating rats. Pharmacol Biochem Behav. 2008;91:77-83 pubmed publisher
    ..In the current study, AVP and an AVP V1a receptor antagonist were centrally administered to primiparous rats on days 5 and 15 of lactation, and aggression, ..
  8. Stojicic S, Milutinović Smiljanić S, Sarenac O, Milosavljevic S, Paton J, Murphy D, et al. Blockade of central vasopressin receptors reduces the cardiovascular response to acute stress in freely moving rats. Neuropharmacology. 2008;54:824-36 pubmed publisher
    ..They support the view that the V(1b) receptor antagonist may be of potential therapeutic value in reducing arterial pressure induced by stress-related disorders. ..
  9. Rosso L, Peteri Brünback B, Mienville J. Putative physiological significance of vasopressin V1a receptor activation in rat pituicytes. J Neuroendocrinol. 2004;16:313-8 pubmed
    ..These results support the concept that, during specific physiological states, pituicyte V(1a) receptor activation modulates the release of neurohypophysial hormones. ..

Scientific Experts

More Information


  1. Antunes V, Yao S, Pickering A, Murphy D, Paton J. A spinal vasopressinergic mechanism mediates hyperosmolality-induced sympathoexcitation. J Physiol. 2006;576:569-83 pubmed
    ..Our findings demonstrate the importance of vasopressin acting on spinal V(1a) receptors for mediating sympathoexcitatory response to acute salt loading. ..
  2. Reed M, Price K, Archbold J, Moffa A, Febo M. Predator odor-evoked BOLD activation in the awake rat: modulation by oxytocin and V?a vasopressin receptor antagonists. Brain Res. 2013;1494:70-83 pubmed publisher
    ..The data suggest that although OT receptors modulate BOLD activation in response to a novel and repulsive odor such as BA, vasopressin V(1a) receptors exert a modulatory influence on the neural response to a predator odor. ..
  3. Pavan de Arruda Camargo G, Abrão Saad W, de Arruda Camargo L. Vasopressin and angiotensin receptors of the medial septal area in the control of mean arterial pressure induced by vasopressin. J Renin Angiotensin Aldosterone Syst. 2008;9:133-8 pubmed publisher
    ..These results indicate there is a synergism between the V(1a)- and V(2)-AVP and AT(1)and AT(2)-Ang II receptors in the MSA in the regulation of MAP. ..
  4. Askew A, Gonzalez F, Stahl J, Karom M. Food competition and social experience effects on V1a receptor binding in the forebrain of male Long-Evans hooded rats. Horm Behav. 2006;49:328-36 pubmed
    ..In the rat, V(1a)R binding in several forebrain areas seems to be affected by brief periods of social interactions, and, in the LS, it also appears to be related to dominance status. ..
  5. Neef M, Biecker E, Heller J, Schepke M, Nischalke H, Wolff M, et al. Portal hypertension is associated with increased mRNA levels of vasopressor G-protein-coupled receptors in human hepatic arteries. Eur J Clin Invest. 2003;33:249-55 pubmed
    ..adrenoceptor (AR) subtypes a, b and d, angiotensin II type 1 receptor (AT1), arginine vasopressin receptor type 1a (V1a), endothelin receptor type A (ETA) and B (ETB)...
  6. Rivarola V, Ford P, del Pilar Flamenco M, Galizia L, Capurro C. Arginine-vasopressin modulates intracellular pH via V1 and V2 receptors in renal collecting duct cells. Cell Physiol Biochem. 2007;20:549-58 pubmed
    ..Specific V1- or V2-receptor antagonists were also used. RT-PCR studies demonstrated that RCCD(1) cells express V1a and V2 receptors...
  7. Nakatani Y, Chin Y, Hara S, Kudo I. Immediate prostaglandin E2 synthesis in rat 3Y1 fibroblasts following vasopressin V1a receptor stimulation. Biochem Biophys Res Commun. 2007;354:676-80 pubmed
    ..The antagonist of vasopressin receptor V1a, and not that of V2, inhibited the AVP-induced PGE(2) synthesis, indicating that AVP activates cPLA(2)alpha through ..
  8. Jackiewicz E, Szczepanska Sadowska E, Dobruch J. Altered expression of angiotensin AT1a and vasopressin V1a receptors and nitric oxide synthase mRNA in the brain of rats with renovascular hypertension. J Physiol Pharmacol. 2004;55:725-37 pubmed
    ..was to determine whether expression of AT1a angiotensin receptors (AT1aR) mRNA, V1a vasopressin receptors (V1aR) mRNA and neuronal nitric oxide synthase (NOS1) mRNA is altered in the brain of rats with the renovascular ..
  9. Liu X, Tribollet E, Ogier R, Barberis C, Raggenbass M. Presence of functional vasopressin receptors in spinal ventral horn neurons of young rats: a morphological and electrophysiological study. Eur J Neurosci. 2003;17:1833-46 pubmed
    ..In newborns, vasopressin binding sites of the V1a type were present in all laminae of the central gray at all segmental levels, whereas oxytocin binding sites were ..
  10. Vagnes O, Hansen F, Feng J, Iversen B, Arendshorst W. Enhanced Ca2+ response to AVP in preglomerular vessels from rats with genetic hypertension during different hydration states. Am J Physiol Renal Physiol. 2005;288:F1249-56 pubmed
    ..characteristic in young spontaneously hypertensive rats (SHR) during euvolemia, are related to greater amounts of V1a receptor mRNA and V1a protein in preglomerular resistance arterioles...
  11. Qiu F, Qiu C, Cai H, Liu T, Qu Z, Yang Z, et al. Oxytocin inhibits the activity of acid-sensing ion channels through the vasopressin, V1A receptor in primary sensory neurons. Br J Pharmacol. 2014;171:3065-76 pubmed publisher
    ..Nociceptive behaviour was induced by acetic acid in rats and mice lacking vasopressin, V1A receptors. OT inhibited the functional activity of native ASICs...
  12. Ribeiro N, Panizza H, Santos K, Ferreira Neto H, Antunes V. Salt-induced sympathoexcitation involves vasopressin V1a receptor activation in the paraventricular nucleus of the hypothalamus. Am J Physiol Regul Integr Comp Physiol. 2015;309:R1369-79 pubmed publisher
    ..Furthermore, we wanted to determine whether V1a receptors on PVN neurons would be involved in salt-induced sympathoexcitation and hypertension...
  13. Zhao L, Brinton R. Vasopressin-induced cytoplasmic and nuclear calcium signaling in cultured cortical astrocytes. Brain Res. 2002;943:117-31 pubmed
    ..To our knowledge, this is the first documentation of a vasopressin receptor-induced calcium signaling cascade in cortical astrocytes and the first documentation of vasopressin receptor induction of nuclear calcium signaling. ..
  14. Orcel H, Tobin V, Alonso G, Rabié A. Immunocytochemical localization of vasopressin v1a receptors in the rat pituitary gonadotropes. Endocrinology. 2002;143:4385-8 pubmed
    Immunocytochemical labeling using a specific antibody against vasopressin V1a receptor allowed the localization of this receptor within a subset of cells from male rat anterior pituitary...
  15. Landgraf R, Frank E, Aldag J, Neumann I, Sharer C, Ren X, et al. Viral vector-mediated gene transfer of the vole V1a vasopressin receptor in the rat septum: improved social discrimination and active social behaviour. Eur J Neurosci. 2003;18:403-11 pubmed
    This study explores the effects of enhancing vasopressin V1a receptor expression in the septum using viral vector-mediated gene transfer on social discrimination and social interactions...
  16. Hollon T, Bek M, Lachowicz J, Ariano M, Mezey E, Ramachandran R, et al. Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive. J Neurosci. 2002;22:10801-10 pubmed
  17. Wigger A, Sanchez M, Mathys K, Ebner K, Frank E, Liu D, et al. Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin. Neuropsychopharmacology. 2004;29:1-14 pubmed
    ..but not OXT, mRNA expression as well as release of the neuropeptide, were higher in the PVN of HABs, whereas AVP V1a-receptor binding failed to show significant differences in any brain region studied...
  18. Chen Q, Schreiber S, Brinton R. Vasopressin and oxytocin receptor mRNA expression during rat telencephalon development. Neuropeptides. 2000;34:173-80 pubmed
    ..Temporal patterns of vasopressin receptor and vasopressin peptide mRNA expression along with oxytocin receptor mRNA suggest a temporal role for vasopressin- and oxytocin-mediated actions during rat telencephalon development. ..
  19. Innamorati G, Lolait S, Birnbaumer M. Sequence identity between the rat and human vasopressin V1a receptors. Biochem J. 1996;314 ( Pt 2):710-1 pubmed
  20. Mogil J, Sorge R, Lacroix Fralish M, Smith S, Fortin A, Sotocinal S, et al. Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction. Nat Neurosci. 2011;14:1569-73 pubmed publisher
    Quantitative trait locus mapping of chemical/inflammatory pain in the mouse identified the Avpr1a gene, which encodes the vasopressin-1A receptor (V1AR), as being responsible for strain-dependent pain sensitivity to formalin and capsaicin...
  21. Wheatley M, Howl J, Morel A, Davies A. Homology between neurohypophyseal hormone receptors. Biochem J. 1993;296 ( Pt 2):519 pubmed
  22. Lozić M, Tasić T, Martin A, Greenwood M, Sarenac O, Hindmarch C, et al. Over-expression of V1A receptors in PVN modulates autonomic cardiovascular control. Pharmacol Res. 2016;114:185-195 pubmed publisher
    ..It is also a major source of the neuropeptide hormone vasopressin (VP), and co-expresses V1a receptors (V1aR). We thus sought to investigate the role of V1aR in PVN in cardiovascular control in response to stress...
  23. Takeda M, Dubey R, Phillips J, Matsumoto S, Lipski J. Effects of vasopressin on isolated rat adrenal chromaffin cells. Regul Pept. 2002;106:55-65 pubmed
    ..This response pattern may be related to the expression of V(1) receptor subtypes. ..
  24. Izumi Y, Nakayama Y, Mori T, Miyazaki H, Inoue H, Kohda Y, et al. Downregulation of vasopressin V2 receptor promoter activity via V1a receptor pathway. Am J Physiol Renal Physiol. 2007;292:F1418-26 pubmed
    ..These opposite effects of PKC and PKA appear to be regulated by the same promoter region of CAAT and SP1. ..
  25. Pascale C, Szmydynger Chodobska J, Sarri J, Chodobski A. Traumatic brain injury results in a concomitant increase in neocortical expression of vasopressin and its V1a receptor. J Physiol Pharmacol. 2006;57 Suppl 11:161-7 pubmed
  26. Morales J, Moitinho E, Abraldes J, Fernandez M, Bosch J. Effects of the V1a vasopressin agonist F-180 on portal hypertension-related bleeding in portal hypertensive rats. Hepatology. 2003;38:1378-83 pubmed
    F-180 is a new, long-acting analog of vasopressin with a selective agonist effect on the vascular V1a receptors, with the advantage of having no effect on renal V2 receptors...
  27. Allaman Exertier G, Reymond Marron I, Tribollet E, Raggenbass M. Vasopressin modulates lateral septal network activity via two distinct electrophysiological mechanisms. Eur J Neurosci. 2007;26:2633-42 pubmed
    ..This modulation by vasopressin of the lateral septal circuitry may be part of the neuronal mechanism by which the peptide, acting via V(1A) receptors, promotes social recognition. ..
  28. Yang G, Xu J, Li T, Ming J, Chen W, Liu L. Role of V1a receptor in AVP-induced restoration of vascular hyporeactivity and its relationship to MLCP-MLC20 phosphorylation pathway. J Surg Res. 2010;161:312-20 pubmed publisher
    ..The mechanism is mainly through PKC-MLCP-MLC(20) phosphorylation calcium sensitivity pathway. ..
  29. Gozdz A, Szczepanska Sadowska E, Szczepanska K, Maslinski W, Luszczyk B. Vasopressin V1a, V1b and V2 receptors mRNA in the kidney and heart of the renin transgenic TGR(mRen2)27 and Sprague Dawley rats. J Physiol Pharmacol. 2002;53:349-57 pubmed
    ..In both strains expression of V1aR and V2R mRNA was significantly greater in the renal medulla than in the renal cortex...
  30. Syed N, Martens C, Hsu W. Arginine vasopressin increases glutamate release and intracellular Ca2+ concentration in hippocampal and cortical astrocytes through two distinct receptors. J Neurochem. 2007;103:229-37 pubmed
    ..In addition, the administration of a phospholipase A(2) inhibitor failed to alter AVP-induced [Ca(2+)](i) increase suggesting the lack of involvement of this enzyme. ..
  31. Schöneborn S, Vollmer C, Barthel F, Herminghaus A, Schulz J, Bauer I, et al. Vasopressin V1A receptors mediate the stabilization of intestinal mucosal oxygenation during hypercapnia in septic rats. Microvasc Res. 2016;106:24-30 pubmed publisher
    ..b>Vasopressin V1A receptor blockade prevents this positive effect under otherwise physiological conditions...
  32. Tahara A, Tsukada J, Tomura Y, Wada K, Kusayama T, Ishii N, et al. Alterations of renal vasopressin V1A and V2 receptors in spontaneously hypertensive rats. Pharmacology. 2003;67:106-12 pubmed
    ..These results indicate that increased amounts of renal cortex V(1A) and medulla V(2) receptors in SHR play an important role in the pathophysiology of hypertension. ..
  33. Tahara A, Tsukada J, Tomura Y, Kusayama T, Momose K, Taniguchi N, et al. Binding and signal transduction characteristics of the nonpeptide vasopressin V1A receptor-selective antagonist YM218 in cultured rat mesangial cells. Pharmacology. 2006;78:81-90 pubmed
    ..Therefore, YM218 is a useful pharmacologic tool for investigating the physiologic and pathophysiologic roles of AVP in kidney, and may have clinical application in the prevention or regression of mesangial cell growth. ..
  34. Cheng M, Chuang C, Lin J, Hwang J. Cardiopulmonary response to vasopressin-induced activation on V1A receptors in the lateral ventrolateral medulla in the rat. Chin J Physiol. 2004;47:31-42 pubmed
    ..pressor response with AVP microinjection into the lateral VLM were totally abolished after pretreatment with AVP V1A receptor antagonist...
  35. Morel A, O Carroll A, Brownstein M, Lolait S. Molecular cloning and expression of a rat V1a arginine vasopressin receptor. Nature. 1992;356:523-6 pubmed
    ..Arginine vasopressin receptors are G protein-coupled and have been divided into at least three types; the V1a (vascular/hepatic) and V1b (anterior pituitary) receptors which act through phosphatidylinositol hydrolysis to ..
  36. Lewis S, Hoque A, Sandock K, Robertson T, Bates J, Kooy N. Differential effects of peroxynitrite on the function of arginine vasopressin V(1a) receptors and alpha(1)-adrenoceptors in vivo. Vascul Pharmacol. 2007;46:24-34 pubmed
    ..The possibility that peroxynitrite impairs AVP V(1a) receptor function by transient oxidation events whereas peroxynitrite impairs alpha(1)-adrenoceptor function by transient oxidation and permanent nitration events will be discussed. ..
  37. Xing C, Teranishi Y. V1 receptor activation induced by hemorrhage and sympathoinhibition in the mesentery and hindquarters of spontaneously hypertensive rats. Hiroshima J Med Sci. 2005;54:93-9 pubmed
    ..On the other hand, subsequent intravenous administration of a peptide vasopressin V1 receptor antagonist (V1A; 10 microg/kg:[d(CH2)5(1)-O Methyl-Tyr(2)-Arg8]-vasopressin) significantly reduced mesenteric resistance in SHR/Izm ..
  38. Tahara A, Tsukada J, Tomura Y, Suzuki T, Yatsu T, Shibasaki M. Effect of YM218, a nonpeptide vasopressin V(1A) receptor-selective antagonist, on rat mesangial cell hyperplasia and hypertrophy. Vascul Pharmacol. 2007;46:463-9 pubmed
  39. Bayerl D, Hönig J, Bosch O. Vasopressin V1a, but not V1b, receptors within the PVN of lactating rats mediate maternal care and anxiety-related behaviour. Behav Brain Res. 2016;305:18-22 pubmed publisher
    The brain neuropeptide arginine-vasopressin (AVP) mediates a wide range of social behaviours via its V1a (V1aR) but also its V1b receptor (V1bR)...
  40. Hurbin A, Orcel H, Alonso G, Moos F, Rabié A. The vasopressin receptors colocalize with vasopressin in the magnocellular neurons of the rat supraoptic nucleus and are modulated by water balance. Endocrinology. 2002;143:456-66 pubmed
    ..Colocalization might explain how V(1) autoreceptors are controlled by cell activity and/or local concentration of vasopressin (released locally by the neurons themselves), allowing fine adjustment of magnocellular neuron activity. ..
  41. Hawtin S, Tobin A, Patel S, Wheatley M. Palmitoylation of the vasopressin V1a receptor reveals different conformational requirements for signaling, agonist-induced receptor phosphorylation, and sequestration. J Biol Chem. 2001;276:38139-46 pubmed
    In this study, we establish that the V1a vasopressin receptor (V1aR) is palmitoylated, and we show that this modification has an important functional role...
  42. Chuang C, Cheng M, Yang S, Hwang J. Activation of ventrolateral medulla neurons by arginine vasopressin via V1A receptors produces inhibition on respiratory-related hypoglossal nerve discharge in the rat. Chin J Physiol. 2005;48:144-54 pubmed
    ..PNA) and hypoglossal nerve activity (HNA) by central administration of AVP and to identify the involvement of AVP V1A receptors in this modulation. Animals were anesthetized with urethane (1.2 g/kg, i.p...
  43. Bishara B, Shiekh H, Karram T, Rubinstein I, Azzam Z, Abu Saleh N, et al. Effects of novel vasopressin receptor antagonists on renal function and cardiac hypertrophy in rats with experimental congestive heart failure. J Pharmacol Exp Ther. 2008;326:414-22 pubmed publisher
    ..These results suggest that V(2) and V(1a) antagonists improve water balance and cardiac hypertrophy in CHF and might be beneficial for the treatment of water retention and cardiac remodeling in CHF. ..
  44. Perico N, Zoja C, Corna D, Rottoli D, Gaspari F, Haskell L, et al. V1/V2 Vasopressin receptor antagonism potentiates the renoprotection of renin-angiotensin system inhibition in rats with renal mass reduction. Kidney Int. 2009;76:960-7 pubmed publisher
    ..Our findings suggest that vasopressin receptor antagonists could be of additional therapeutic value in the treatment of chronic proteinuric nephropathy. ..
  45. Morel A, Lolait S, Brownstein M. Molecular cloning and expression of rat V1a and V2 arginine vasopressin receptors. Regul Pept. 1993;45:53-9 pubmed
    ..This receptor family has been subtyped by pharmacological studies, as V1a receptor whose action is mediated by intracellular calcium mobilization, and V2 receptor which is linked to ..
  46. Ueno H, Kuno M, Shintani Y, Kamo I. Role of vasopressin V(?A) receptor in the urethral closure reflex in rats. Am J Physiol Renal Physiol. 2011;300:F976-82 pubmed publisher
  47. Izumi Y, Nakayama Y, Memetimin H, Inoue T, Kohda Y, Nonoguchi H, et al. Regulation of V2R transcription by hypertonicity and V1aR-V2R signal interaction. Am J Physiol Renal Physiol. 2008;295:F1170-6 pubmed publisher
    ..V2 receptor (rV2R) promoter activity was increased by vasopressin V2R stimulation and decreased by vasopressin V1a receptor (V1aR) stimulation in a LLC-PK1 cell line stably expressing rat V1aR (LLC-PK1/rV1aR)...
  48. Hawtin S. Charged residues of the conserved DRY triplet of the vasopressin V1a receptor provide molecular determinants for cell surface delivery and internalization. Mol Pharmacol. 2005;68:1172-82 pubmed
    ..This study highlights the importance of specific charged residues within this motif that provide important determinants for cell surface delivery, internalization and for normal V(1a)R function. ..
  49. Chini B, Mouillac B, Ala Y, Balestre M, Trumpp Kallmeyer S, Hoflack J, et al. Tyr115 is the key residue for determining agonist selectivity in the V1a vasopressin receptor. EMBO J. 1995;14:2176-82 pubmed
    ..GPCR), we have previously succeeded in docking the neurohypophysial hormone arginine-vasopressin (AVP) into the V1a receptor. According to this model, the hormone is completely embedded in the transmembrane part of the receptor...
  50. Engin E, Treit D. Dissociation of the anxiolytic-like effects of Avpr1a and Avpr1b receptor antagonists in the dorsal and ventral hippocampus. Neuropeptides. 2008;42:411-21 pubmed publisher
    ..AVP is thought to mediate anxiety-related behavior through two central receptor subtypes, Avpr1a and Avpr1b...
  51. Cudnoch Jedrzejewska A, Dobruch J, Puchalska L, Szczepanska Sadowska E. Interaction of AT1 receptors and V1a receptors-mediated effects in the central cardiovascular control during the post-infarct state. Regul Pept. 2007;142:86-94 pubmed
    ..Because myocardial infarct is associated with overactivation of brain angiotensin II (ANG II) and vasopressin (AVP) V1a receptors we decided to determine whether AT1 and V1a receptors-mediated effects of ANG II and AVP interact in ..
  52. Memetimin H, Izumi Y, Nakayama Y, Kohda Y, Inoue H, Nonoguchi H, et al. Low pH stimulates vasopressin V2 receptor promoter activity and enhances downregulation induced by V1a receptor stimulation. Am J Physiol Renal Physiol. 2009;297:F620-8 pubmed publisher
    ..It is well known that V2R is localized on the basolateral side and the V1a receptor (V1aR) is distributed on the luminal side of the collecting ducts...
  53. Shi W, Cui N, Shi Y, Zhang X, Yang Y, Jiang C. Arginine vasopressin inhibits Kir6.1/SUR2B channel and constricts the mesenteric artery via V1a receptor and protein kinase C. Am J Physiol Regul Integr Comp Physiol. 2007;293:R191-9 pubmed
    ..The Kir6.1/SUR2B channel was expressed together with V1a receptor in the HEK-293 cell line...