Avp

Summary

Gene Symbol: Avp
Description: arginine vasopressin
Alias: Vas, vasopressin-neurophysin 2-copeptin, AVP-NPII, arginine vasopressin (Diabetes insipidus), same as Di (conflicting physical mapping), prepropressophysin, preprovasopressin-neurophysin, vasopressin, vasopressin-neurophysin prepropeptide
Species: rat
Products:     Avp

Top Publications

  1. Schmale H, Richter D. Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats. Nature. 1984;308:705-9 pubmed
    In rats with hereditary hypothalamic diabetes insipidus (Brattleboro rats) the gene for the vasopressin precursor lacks a single G residue in the protein-coding region...
  2. Khegai I. [Interaction of the diabetes insipidus locus alleles with the renal 120 kDa protein-encoding gene in rat development]. Genetika. 2003;39:397-401 pubmed
    Age-dependant dynamics of the kidney inner medullary 120-kDa protein content in vasopressin-deficient Brattleboro rats with di/di mutant genotype was studied in comparison with WAG rats with genotype and normal vasopressin expression...
  3. Tahara A, Tsukada J, Tomura Y, Suzuki T, Yatsu T, Shibasaki M. Effect of YM218, a nonpeptide vasopressin V(1A) receptor-selective antagonist, on rat mesangial cell hyperplasia and hypertrophy. Vascul Pharmacol. 2007;46:463-9 pubmed
    Mesangial cell growth constitutes a key feature of progressive glomerular injury. Vasopressin (AVP), a potent peptide vasoconstrictor, acts on mesangial cells through the V(1A) receptors, inducing contraction and cell proliferation...
  4. Schank J. Early locomotor and social effects in vasopressin deficient neonatal rats. Behav Brain Res. 2009;197:166-77 pubmed publisher
    This study investigated behavioral differences between neonatal rats with vasopressin AVP deficiency (di/di) and those with little (+/di) or no deficiency (+/+) using a number of open field metrics...
  5. Palin K, Moreau M, Sauvant J, Orcel H, Nadjar A, Duvoid Guillou A, et al. Interleukin-6 activates arginine vasopressin neurons in the supraoptic nucleus during immune challenge in rats. Am J Physiol Endocrinol Metab. 2009;296:E1289-99 pubmed publisher
    The increase of plasma arginin-vasopressin (AVP) release, which translates hypothalamic AVP neuron activation in response to immune challenge, appears to occur independently of plasma osmolality or blood pressure changes...
  6. Ge Y, Ahn D, Stricklett P, Hughes A, Yanagisawa M, Verbalis J, et al. Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality. Am J Physiol Renal Physiol. 2005;288:F912-20 pubmed
    In vitro studies suggest that endothelin-1 (ET-1) inhibits vasopressin (AVP)-stimulated water permeability in the collecting duct (CD)...
  7. Greenwood M, Bordieri L, Greenwood M, Rosso Melo M, Colombari D, Colombari E, et al. Transcription factor CREB3L1 regulates vasopressin gene expression in the rat hypothalamus. J Neurosci. 2014;34:3810-20 pubmed publisher
    Arginine vasopressin (AVP) is a neurohypophysial hormone regulating hydromineral homeostasis...
  8. De Mota N, Reaux Le Goazigo A, El Messari S, Chartrel N, Roesch D, Dujardin C, et al. Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release. Proc Natl Acad Sci U S A. 2004;101:10464-9 pubmed
    ..Here, we investigated whether apelin interacts with arginine vasopressin (AVP) to maintain body fluid homeostasis...
  9. Reaux Le Goazigo A, Morinville A, Burlet A, Llorens Cortes C, Beaudet A. Dehydration-induced cross-regulation of apelin and vasopressin immunoreactivity levels in magnocellular hypothalamic neurons. Endocrinology. 2004;145:4392-400 pubmed
    ..of apelin in the regulation of water balance, we sought to determine whether apelin colocalized with arginine vasopressin (AVP) in the rat SON and PVN...

More Information

Publications100

  1. Ciosek J. Vasopressin and oxytocin release as influenced by thyrotropin-releasing hormone in euhydrated and dehydrated rats. J Physiol Pharmacol. 2002;53:423-37 pubmed
    Since the thyrotropin-releasing hormone (TRH) can modulate the processes of vasopressin (AVP) and oxytocin (OT) biosynthesis and release mainly at the hypothalamo-neurohypophysial level, the present experiments were undertaken to ..
  2. Ebner K, Wotjak C, Landgraf R, Engelmann M. Forced swimming triggers vasopressin release within the amygdala to modulate stress-coping strategies in rats. Eur J Neurosci. 2002;15:384-8 pubmed
    Previously, we have demonstrated that forced swimming triggers the release of arginine vasopressin (AVP) within the septum of rats, where AVP modulates stress-coping strategies...
  3. Jochem J. Involvement of arginine vasopressin in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats. Inflamm Res. 2004;53:269-76 pubmed
    Histamine is a potent stimulator of arginine vasopressin (AVP) release and therefore, the role of AVP was studied in the reversal of critical haemorrhagic hypotension induced by endogenous central histamine after inhibition of histamine ..
  4. Pak T, Chung W, Hinds L, Handa R. Arginine vasopressin regulation in pre- and postpubertal male rats by the androgen metabolite 3beta-diol. Am J Physiol Endocrinol Metab. 2009;296:E1409-13 pubmed publisher
    Arginine vasopressin (AVP) is a nonapeptide expressed in several brain regions. In addition to its well-characterized role in osmoregulation, AVP regulates paternal behavior, aggression,circadian rhythms, and the stress response...
  5. Watts A, Tanimura S, Sanchez Watts G. Corticotropin-releasing hormone and arginine vasopressin gene transcription in the hypothalamic paraventricular nucleus of unstressed rats: daily rhythms and their interactions with corticosterone. Endocrinology. 2004;145:529-40 pubmed
    ..anterior pituitary corticotropes signals from the circadian clock schedule CRH and, to lesser extent, arginine vasopressin (AVP) release from neuroendocrine terminals...
  6. dos Santos J, de Oliveira Pelegrin G, Athayde L, da Rocha M. An inhibitor of leukotriene synthesis affects vasopressin secretion following osmotic stimulus in rats. Regul Pept. 2012;179:6-9 pubmed publisher
    ..Our aim was to study the effect of an inhibitor of LT synthesis in the release of arginine vasopressin (AVP) following an osmotic stimulus in rats...
  7. Li D, Cai W, Li X, Niu D, Duan J. [Changes of encephalic contents of neuropeptides in rats with vascular dementia]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2008;37:468-71 pubmed
    To investigate the changes of encephalic contents of somatostatin (SS) and arginine vasopressin (AVP) in rats with vascular dementia...
  8. Moon B, Hong C, Kim S, Kim H, Shin S, Kang S, et al. A single administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin that produces reduced food and water intake induces long-lasting expression of corticotropin-releasing factor, arginine vasopressin, and proopiomelanocortin in rat brain. Toxicol Appl Pharmacol. 2008;233:314-22 pubmed publisher
    ..intake-reducing single administration of TCDD induced changes in corticotropin-releasing factor (CRF), arginine vasopressin (AVP), and proopiomelanocortin (POMC) expression in rat brain...
  9. Williamson M, Viau V. Selective contributions of the medial preoptic nucleus to testosterone-dependant regulation of the paraventricular nucleus of the hypothalamus and the HPA axis. Am J Physiol Regul Integr Comp Physiol. 2008;295:R1020-30 pubmed publisher
    ..indexes of HPA function, and the relative levels of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA in the amygdala...
  10. Zelena D, Filaretova L. Age-dependent role of vasopressin in susceptibility of gastric mucosa to indomethacin-induced injury. Regul Pept. 2010;161:15-21 pubmed publisher
    ..Based upon its multifactorial role vasopressin (VP) is supposed to be one of the contributory factors, however the data are contradictory...
  11. Alonso G, Galibert E, Boulay V, Guillou A, Jean A, Compan V, et al. Sustained elevated levels of circulating vasopressin selectively stimulate the proliferation of kidney tubular cells via the activation of V2 receptors. Endocrinology. 2009;150:239-50 pubmed publisher
    The hypothalamic hormone vasopressin (AVP) has known mitogenic effects on various cell types...
  12. Burbach J, Seidah N, Chretien M. Isolation and primary structure of novel neurointermediate pituitary peptides derived from the C-terminal of the rat vasopressin-neurophysin precursor (propressophysin). Eur J Biochem. 1986;156:137-42 pubmed
    ..Processing of CPP 1-39 could thus produce the four isolated peptides by specific post-Arg or post-Leu cleavages. ..
  13. Fortaleza E, Scopinho A, Correa F. Cardiovascular responses to microinjection of noradrenaline into the medial amygdaloid nucleus of conscious rats result from ??-receptor activation and vasopressin release. Eur J Neurosci. 2011;33:1677-84 pubmed publisher
    ..with the ganglion blocker pentolinium (5 mg/kg), and blocked by intravenous pretreatment with the selective V?-vasopressin antagonist dTyr(CH?)? (Me)AVP (50 ?g/kg)...
  14. Makara G, Varga J, Barna I, Pintér O, Klausz B, Zelena D. The vasopressin-deficient Brattleboro rat: lessons for the hypothalamo-pituitary-adrenal axis regulation. Cell Mol Neurobiol. 2012;32:759-66 pubmed publisher
    ..The hypothalamic component consists of corticotropin-releasing hormone and arginine vasopressin, with a questionable contribution of the latter...
  15. Jasnic N, Djordjevic J, Vujovic P, Lakic I, Djurasevic S, Cvijic G. The effect of vasopressin 1b receptor (V1bR) blockade on HPA axis activity in rats exposed to acute heat stress. J Exp Biol. 2013;216:2302-7 pubmed publisher
    ..of neuroendocrine responses including activation of the hypothalamo-pituitary-adrenal (HPA) axis and arginine vasopressin (AVP) release...
  16. Xu L, Tang G, Yang J, Liu H, Li J, Jiang Z. AVP modulation of the vestibular nucleus via V1b receptors potentially contributes to the development of motion sickness in rat. Mol Brain. 2015;8:86 pubmed publisher
    Arginine vasopressin (AVP) is considered to be an etiologic hormone in motion sickness (MS)...
  17. Lukas M, Bredewold R, Neumann I, Veenema A. Maternal separation interferes with developmental changes in brain vasopressin and oxytocin receptor binding in male rats. Neuropharmacology. 2010;58:78-87 pubmed publisher
    Brain vasopressin V(1A) receptors (V(1A)-R) and oxytocin receptors (OT-R) are important modulators of social behaviors...
  18. Du W, Stern J, Filosa J. Neuronal-derived nitric oxide and somatodendritically released vasopressin regulate neurovascular coupling in the rat hypothalamic supraoptic nucleus. J Neurosci. 2015;35:5330-41 pubmed publisher
    ..system (MNS) of the supraoptic nucleus (SON), in which dendritic release of neuropeptides, including vasopressin (VP), constitutes a key signaling modality influencing neuronal and network activity...
  19. Isobe Y, Nishino H. Signal transmission from the suprachiasmatic nucleus to the pineal gland via the paraventricular nucleus: analysed from arg-vasopressin peptide, rPer2 mRNA and AVP mRNA changes and pineal AA-NAT mRNA after the melatonin injection during light and dar. Brain Res. 2004;1013:204-11 pubmed
    Arg-vasopressin (AVP) containing neurons are one of the output paths from the suprachiasmatic nucleus (SCN), the center of the biological clock. AVP mRNA transcription is controlled by a negative feedback loop of clock genes...
  20. Holmes C, Landry D, Granton J. Science review: Vasopressin and the cardiovascular system part 1--receptor physiology. Crit Care. 2003;7:427-34 pubmed
    b>Vasopressin is emerging as a rational therapy for vasodilatory shock states. Unlike other vasoconstrictor agents, vasopressin also has vasodilatory properties...
  21. Tobin V, Hashimoto H, Wacker D, Takayanagi Y, Langnaese K, Caquineau C, et al. An intrinsic vasopressin system in the olfactory bulb is involved in social recognition. Nature. 2010;464:413-7 pubmed publisher
    ..Most strikingly, vasopressin and oxytocin, once thought of as circulating hormones whose actions were confined to peripheral organs, are now ..
  22. Chen J, Volpi S, Aguilera G. Anti-apoptotic actions of vasopressin in H32 neurons involve MAP kinase transactivation and Bad phosphorylation. Exp Neurol. 2008;211:529-38 pubmed publisher
    b>Vasopressin (VP) secreted within the brain modulates neuronal function acting as a neurotransmitter...
  23. da Silva M, Merino R, Mecawi A, Moraes D, Varanda W. In vitro differentiation between oxytocin- and vasopressin-secreting magnocellular neurons requires more than one experimental criterion. Mol Cell Endocrinol. 2015;400:102-11 pubmed publisher
    The phenotypic differentiation between oxytocin (OT)- and vasopressin (VP)-secreting magnocellular neurosecretory cells (MNCs) from the supraoptic nucleus is relevant to understanding how several physiological and pharmacological ..
  24. Hirasawa M, Mouginot D, Kozoriz M, Kombian S, Pittman Q. Vasopressin differentially modulates non-NMDA receptors in vasopressin and oxytocin neurons in the supraoptic nucleus. J Neurosci. 2003;23:4270-7 pubmed
    Magnocellular neurons of the supraoptic nucleus release the neuropeptides oxytocin and vasopressin from their dendrites to regulate their synaptic inputs...
  25. Oliveira Pelegrin G, Ravanelli M, Branco L, Rocha M. Thermoregulation and vasopressin secretion during polymicrobial sepsis. Neuroimmunomodulation. 2009;16:45-53 pubmed publisher
    ..nitric oxide (NO) formation and hydroelectrolytic alterations, as well as mean arterial pressure and arginine vasopressin (AVP) secretion, in experimental sepsis induced by cecal ligation and puncture (CLP)...
  26. Martin P, Bianchi M, Roger F, Niksic L, Feraille E. Arginine vasopressin modulates expression of neuronal NOS in rat renal medulla. Am J Physiol Renal Physiol. 2002;283:F559-68 pubmed
    Arginine vasopressin (AVP) plays a central role in water balance. In principal cells of the collecting duct system, AVP controls the expression of several genes, including aquaporin-2...
  27. Kessler M, Murgatroyd C, Bunck M, Czibere L, Frank E, Jacob W, et al. Diabetes insipidus and, partially, low anxiety-related behaviour are linked to a SNP-associated vasopressin deficit in LAB mice. Eur J Neurosci. 2007;26:2857-64 pubmed
    Following secretion from the posterior pituitary, the neuropeptide vasopressin (AVP) stimulates the kidney to retain water, and when released centrally it can contribute to anxiety- and depression-like behaviours...
  28. Zelena D, Barna I, Csabai K, Orlando G, Makara G, Engelmann M. Response of the adrenomedullary system to early postnatal stress in the Brattleboro rat. Ann N Y Acad Sci. 2008;1148:456-61 pubmed publisher
    ..Here we addressed the question of whether the neuropeptide arginine vasopressin (AVP) is involved in this type of information transfer during early postnatal development...
  29. Veenema A, Beiderbeck D, Lukas M, Neumann I. Distinct correlations of vasopressin release within the lateral septum and the bed nucleus of the stria terminalis with the display of intermale aggression. Horm Behav. 2010;58:273-81 pubmed publisher
    Arginine vasopressin (AVP) has been implicated in a wide variety of social behaviors ranging from affiliation to aggression. However, the precise functional involvement of AVP in intermale aggression is still a matter of debate...
  30. Sato K, Numata T, Saito T, Ueta Y, Okada Y. V? receptor-mediated autocrine role of somatodendritic release of AVP in rat vasopressin neurons under hypo-osmotic conditions. Sci Signal. 2011;4:ra5 pubmed publisher
    Arginine vasopressin (AVP) neurons in the hypothalamus are osmosensory neurons that respond to increased or decreased plasma osmolarity by releasing more or less AVP, respectively, from their axon terminals...
  31. Lipari E, Lipari D, Valentino B. Modifications of atrial natriuretic peptide and vasopressin peptides in the rat hypothalamic supraoptic nucleus during resistance training. Ital J Anat Embryol. 2010;115:211-7 pubmed
    Many studies have demonstrated the involvement of atrial natriuretic peptide (ANP) and vasopressin (VP) in the homeostasis of body fluids, but few studies have regarded the hypothalamic magnocellular neurosecretory system during physical ..
  32. Olias G, Richter D, Schmale H. Heterologous expression of human vasopressin-neurophysin precursors in a pituitary cell line: defective transport of a mutant protein from patients with familial diabetes insipidus. DNA Cell Biol. 1996;15:929-35 pubmed
    Familial hypothalamic diabetes insipidus is an autosomal dominant disorder characterized by deficient vasopressin synthesis...
  33. da Silveira L, Junta C, Monesi N, de Oliveira Pelegrin G, Passos G, Rocha M. Time course of c-fos, vasopressin and oxytocin mRNA expression in the hypothalamus following long-term dehydration. Cell Mol Neurobiol. 2007;27:575-84 pubmed
    1. This study presents a time course analysis of the messenger RNA (mRNA) levels of c-fos, vasopressin (VP), and oxytocin (OT) in the paraventricular (PVN) and supraoptic nucleus (SON), following acute and chronic dehydration by water ..
  34. Khegai I. [Phenotypic expression of the mutant gene diabetes insipidus in rats and criteria of genotyping by phenotype]. Genetika. 2003;39:70-4 pubmed
    ..Segregation analysis of F1 animals yielded by various crosses showed that genotyping of di/di homozygotes is absolutely reliable at 30% and higher level of the water consumption per day. ..
  35. Alonso G, Gallibert E, Lafont C, Guillon G. Intrahypothalamic angiogenesis induced by osmotic stimuli correlates with local hypoxia: a potential role of confined vasoconstriction induced by dendritic secretion of vasopressin. Endocrinology. 2008;149:4279-88 pubmed publisher
    ..is known to stimulate the metabolic activity of hypothalamic magnocellular neurons producing arginine vasopressin (AVP) and to increase the secretion of AVP, both by axon terminals into the circulation and by dendrites into ..
  36. Chauvet J, Chauvet M, Acher R. [Evolution of neurohypophyseal hormones: isolation of active principles from rabbits and rats]. Biochimie. 1971;53:1099-104 pubmed
  37. Bosch O, Neumann I. Both oxytocin and vasopressin are mediators of maternal care and aggression in rodents: from central release to sites of action. Horm Behav. 2012;61:293-303 pubmed publisher
    In the mammalian peripartum period, the activity of both the brain oxytocin and vasopressin system is elevated as part of the physiological adaptations occurring in the mother...
  38. Chuang C, Cheng M, Yang S, Hwang J. Activation of ventrolateral medulla neurons by arginine vasopressin via V1A receptors produces inhibition on respiratory-related hypoglossal nerve discharge in the rat. Chin J Physiol. 2005;48:144-54 pubmed
    Arginine vasopressin (AVP) is an important neurohormone in the regulation of many aspects of central nervous system, yet its modulation on the respiratory function remains largely unknown...
  39. Montero S, Mendoza H, Valles V, Lemus M, Alvarez Buylla R, de Alvarez Buylla E. Arginine-vasopressin mediates central and peripheral glucose regulation in response to carotid body receptor stimulation with Na-cyanide. J Appl Physiol (1985). 2006;100:1902-9 pubmed
    ..Here, we show that systemic arginine vasopressin (AVP) induced a transient, but significant, increase in blood glucose levels and increased brain glucose ..
  40. Mozid A, Tringali G, Forsling M, Hendricks M, Ajodha S, Edwards R, et al. Ghrelin is released from rat hypothalamic explants and stimulates corticotrophin-releasing hormone and arginine-vasopressin. Horm Metab Res. 2003;35:455-9 pubmed
    ..We previously studied the effect of synthetic growth hormone secretagogues on CRH and AVP release from rat hypothalami in vitro, and now report on the effects of ghrelin on CRH and AVP release...
  41. Yang J, Yuan H, Liu W, Song C, Xu H, Wang G, et al. Arginine vasopressin in hypothalamic paraventricular nucleus is transferred to the nucleus raphe magnus to participate in pain modulation. Peptides. 2009;30:1679-82 pubmed publisher
    Hypothalamic paraventricular nucleus (PVN) is one of the main sources of arginine vasopressin (AVP) synthesis and secretion. AVP is the most important bioactive substance in PVN regulating pain process...
  42. Chuang C, Cheng M, Lin J, Hsien H, Hung H, Hwang J. Arginine vasopressin produces inhibition upon respiration without pressor effect in the rat. Chin J Physiol. 2003;46:71-81 pubmed
    The purpose of the current study was to examine where arginine vasopressin (AVP) inhibits respiration by direct action on the areas of the ventrolateral medulla (VLM) in the rat. The animal was anesthetized by urethane (1.2 g/kg, i.p...
  43. Zemo D, McCabe J. Salt-loading increases vasopressin and vasopressin 1b receptor mRNA in the hypothalamus and choroid plexus. Neuropeptides. 2001;35:181-8 pubmed
    ..Messenger RNA (mRNA) transcripts encoding arginine vasopressin (AVP) and the vasopressin 1b receptor (V(1b)R) are found in various structures of the central nervous system, ..
  44. Chitturi S, Harris M, Thomsett M, Bowling F, McGown I, Cowley D, et al. Utility of AVP gene testing in familial neurohypophyseal diabetes insipidus. Clin Endocrinol (Oxf). 2008;69:926-30 pubmed publisher
    Familial neurohypophyseal diabetes insipidus (FNDI) is a rare disorder resulting from arginine vasopressin (AVP) gene mutations...
  45. Kohno D, Nakata M, Maejima Y, Shimizu H, Sedbazar U, Yoshida N, et al. Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding. Endocrinology. 2008;149:1295-301 pubmed
    ..In the PVN, 24% of nesfatin-1 neurons overlapped with oxytocin, 18% with vasopressin, 13% with CRH, and 12% with TRH neurons...
  46. Welker P, Böhlick A, Mutig K, Salanova M, Kahl T, Schluter H, et al. Renal Na+-K+-Cl- cotransporter activity and vasopressin-induced trafficking are lipid raft-dependent. Am J Physiol Renal Physiol. 2008;295:F789-802 pubmed publisher
    ..The role of NKCC2 is essential for renal volume regulation. Vasopressin (AVP) controls NKCC2 surface expression in cells of the thick ascending limb of the loop of Henle (TAL)...
  47. Schmale H, Ivell R, Breindl M, Darmer D, Richter D. The mutant vasopressin gene from diabetes insipidus (Brattleboro) rats is transcribed but the message is not efficiently translated. EMBO J. 1984;3:3289-93 pubmed
    The vasopressin gene from normal and diabetes insipidus (Brattleboro) rats has been isolated and sequenced...
  48. Kawasaki M, Ponzio T, Yue C, Fields R, Gainer H. Neurotransmitter regulation of c-fos and vasopressin gene expression in the rat supraoptic nucleus. Exp Neurol. 2009;219:212-22 pubmed publisher
    ..supraoptic nucleus (SON) and the paraventricular nucleus (PVN) in the hypothalamus inducing the secretion of vasopressin (VP) into the general circulation...
  49. Mori T, Dickhout J, Cowley A. Vasopressin increases intracellular NO concentration via Ca(2+) signaling in inner medullary collecting duct. Hypertension. 2002;39:465-9 pubmed
    The present study was designed to determine whether arginine vasopressin (AVP) stimulates NO production in the epithelial collecting duct cells of the inner medulla (IMCDs) and if this is mediated through Ca(2+) signaling...
  50. Iwanaga M, Ohno M, Katoh A, Ohbuchi T, Ishikura T, Fujihara H, et al. Upregulation of arginine vasopressin synthesis in the rat hypothalamus after kainic acid-induced seizures. Brain Res. 2011;1424:1-8 pubmed publisher
    We examined the effects of kainic acid (KA)-induced seizures on arginine vasopressin (AVP) gene expression in the paraventricular (PVN) and the supraoptic nuclei (SON) of normal rats using in situ hybridization histochemistry...
  51. Valentino B, Peri G, Lipari L, Valentino A, Cappello F, Lipari E. Presence and interaction in tissues of atrial natriuretic peptide, oxytocin and vasopressin: new insights. Ital J Anat Embryol. 2010;115:159-65 pubmed
    Atrial natriuretic peptide, oxytocin and vasopressin are three well known and widely studied molecules since many years...
  52. Sauvant J, Delpech J, Palin K, De Mota N, Dudit J, Aubert A, et al. Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging. PLoS ONE. 2014;9:e87421 pubmed publisher
    Normal aging is associated with vasopressin neuron adaptation, but little is known about its effects on the release of apelin, an aquaretic peptide colocalized with vasopressin...
  53. Ahumada C, Bahamondes C, Cerda C, Silva R, Cruz G, Moya P, et al. Amphetamine treatment affects the extra-hypothalamic vasopressinergic system in a sex- and nucleus-dependent manner. J Neuroendocrinol. 2017;29: pubmed publisher
    ..The present study aimed to investigate the modulatory effects of amphetamine (AMPH) on the expression of vasopressin (AVP) in the vasopressinergic extra-hypothalamic system in sensitised male and female rats...
  54. Bosch O, Neumann I. Brain vasopressin is an important regulator of maternal behavior independent of dams' trait anxiety. Proc Natl Acad Sci U S A. 2008;105:17139-44 pubmed publisher
    The neuropeptide arginine vasopressin (AVP) is arguably among the most potent regulators of social behaviors in mammals identified to date. However, only the related neuropeptide oxytocin (OXT) has been shown to promote maternal behavior...
  55. Wigger A, Sanchez M, Mathys K, Ebner K, Frank E, Liu D, et al. Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin. Neuropsychopharmacology. 2004;29:1-14 pubmed
    ..Thus, CRH, arginine-8-vasopressin (AVP), and oxytocin (OXT) were studied in brains of HAB and LAB males both under basal conditions and after ..
  56. Dibenedictis B, Nussbaum E, Cheung H, Veenema A. Quantitative mapping reveals age and sex differences in vasopressin, but not oxytocin, immunoreactivity in the rat social behavior neural network. J Comp Neurol. 2017;525:2549-2570 pubmed publisher
    The neuropeptides vasopressin (AVP) and oxytocin (OT) have been implicated in the regulation of numerous social behaviors in adult and juvenile animals...
  57. Perucca J, Bichet D, Bardoux P, Bouby N, Bankir L. Sodium excretion in response to vasopressin and selective vasopressin receptor antagonists. J Am Soc Nephrol. 2008;19:1721-31 pubmed publisher
    The mechanisms by which arginine vasopressin (AVP) exerts its antidiuretic and pressor effects, via activation of V2 and V1a receptors, respectively, are relatively well understood, but the possible associated effects on sodium handling ..
  58. Greenwood M, Greenwood M, Mecawi A, Loh S, Rodrigues J, Paton J, et al. Transcription factor CREB3L1 mediates cAMP and glucocorticoid regulation of arginine vasopressin gene transcription in the rat hypothalamus. Mol Brain. 2015;8:68 pubmed publisher
    Arginine vasopressin (AVP), a neuropeptide hormone that functions in the regulation of water homeostasis by controlling water re-absorption at kidneys, is synthesised in supraoptic nucleus and paraventricular nucleus of the hypothalamus...
  59. Suzuki H, Onaka T, Kasai M, Kawasaki M, Ohnishi H, Otsubo H, et al. Response of arginine vasopressin-enhanced green fluorescent protein fusion gene in the hypothalamus of adjuvant-induced arthritic rats. J Neuroendocrinol. 2009;21:183-90 pubmed publisher
    Arginine vasopressin (AVP) and corticotrophin-releasing hormone (CRH) in the parvocellular neurosecretory cells of the paraventricular nucleus (PVN) play a major role in activating the hypothalamic-pituitary-adrenal axis, which is the ..
  60. Fodor A, Kovács K, Balázsfi D, Klausz B, Pintér O, Demeter K, et al. Depressive- and anxiety-like behaviors and stress-related neuronal activation in vasopressin-deficient female Brattleboro rats. Physiol Behav. 2016;158:100-11 pubmed publisher
    b>Vasopressin can contribute to the development of stress-related psychiatric disorders, anxiety and depression. Although these disturbances are more common in females, most of the preclinical studies have been done in males...
  61. Handa R, Zoeller R, McGivern R. Changes in vasoactive intestinal peptide and arginine vasopressin expression in the suprachiasmatic nucleus of the rat brain following footshock stress. Neurosci Lett. 2007;425:99-104 pubmed
    The neuropeptides, arginine vasopressin (AVP) and vasoactive intestinal polypeptide (VIP) are synthesized by neurons of the suprachiasmatic nucleus (SCN) of the hypothalamus and are important regulators of SCN function...
  62. Paul M, Peters N, Holder M, Kim A, Whylings J, Terranova J, et al. Atypical Social Development in Vasopressin-Deficient Brattleboro Rats. Eneuro. 2016;3: pubmed publisher
    Over the past 3 decades, a large body of evidence has accumulated demonstrating that the neuropeptide arginine vasopressin (AVP) plays a critical role in regulating social behavior...
  63. Bowen M, Dass S, Booth J, Suraev A, Vyas A, McGregor I. Active coping toward predatory stress is associated with lower corticosterone and progesterone plasma levels and decreased methylation in the medial amygdala vasopressin system. Horm Behav. 2014;66:561-6 pubmed publisher
    ..Active responders had markedly less methylation of the AVP CGCG promoter region located at base 4970 in the posterodorsal region of the medial amygdala but did not differ in ..
  64. Zelena D, Langnaese K, Domokos A, Pintér O, Landgraf R, Makara G, et al. Vasopressin administration into the paraventricular nucleus normalizes plasma oxytocin and corticosterone levels in Brattleboro rats. Endocrinology. 2009;150:2791-8 pubmed publisher
    Adult male rats of the Brattleboro strain were used to investigate the impact of the congenital absence of vasopressin on plasma adrenocorticotropin, corticosterone, and oxytocin concentrations as well as the release pattern of oxytocin ..
  65. Jing W, Guo F, Cheng L, Zhang J, Qi J. Arginine vasopressin prevents amyloid beta protein-induced impairment of long-term potentiation in rat hippocampus in vivo. Neurosci Lett. 2009;450:306-10 pubmed publisher
    ..A significant decrease in [Arg(8)]-vasopressin (AVP) in the AD brain has been found...
  66. Chauvet M, Chauvet J, Acher R. Identification of rat neurophysins: complete amino acid sequences of MSEL- and VLDV-neurophysins. Biochem Biophys Res Commun. 1981;103:595-603 pubmed
  67. Majzoub J, Rich A, van Boom J, Habener J. Vasopressin and oxytocin mRNA regulation in the rat assessed by hybridization with synthetic oligonucleotides. J Biol Chem. 1983;258:14061-4 pubmed
    b>Vasopressin and oxytocin are nonapeptide hormones that regulate water metabolism and lactation, respectively...
  68. Zelena D, Stocker B, Barna I, Tóth Z, Makara G. Vasopressin deficiency diminishes acute and long-term consequences of maternal deprivation in male rat pups. Psychoneuroendocrinology. 2015;51:378-91 pubmed publisher
    ..As the role of vasopressin in hypothalamic-pituitary-adrenal axis regulation as well as in affective disorders seem to be important we ..
  69. Mueller P. Influence of sedentary versus physically active conditions on regulation of plasma renin activity and vasopressin. Am J Physiol Regul Integr Comp Physiol. 2008;295:R727-32 pubmed publisher
    ..We hypothesized that sedentary conditions may enhance release of the vasoactive hormones AVP and ANG II...
  70. Yue C, Mutsuga N, Scordalakes E, Gainer H. Studies of oxytocin and vasopressin gene expression in the rat hypothalamus using exon- and intron-specific probes. Am J Physiol Regul Integr Comp Physiol. 2006;290:R1233-41 pubmed
    To develop a comprehensive approach for the study of oxytocin (OT) and vasopressin (VP) gene expression in the rat hypothalamus, we first developed an intronic riboprobe to measure OT heteronuclear RNA (hnRNA) levels by in situ ..
  71. Li L, Galligan J, Fink G, Chen A. Vasopressin induces vascular superoxide via endothelin-1 in mineralocorticoid hypertension. Hypertension. 2003;41:663-8 pubmed
    ..b>Vasopressin is known to upregulate vascular preproET-1 gene expression in DOCA-salt rats, an effect that is absent in ..
  72. Cowley A, Skelton M, Kurth T. Effects of long-term vasopressin receptor stimulation on medullary blood flow and arterial pressure. Am J Physiol. 1998;275:R1420-4 pubmed
    Studies were carried out using instrumented unanesthetized rats to determine the long-term effects of arginine vasopressin (AVP) and a specific vasopressin V1 receptor agonist (V1AG; [Phe2, Ile3, Orn8]- vasopressin) on the renal ..
  73. Revsin Y, van Wijk D, Saravia F, Oitzl M, De Nicola A, de Kloet E. Adrenal hypersensitivity precedes chronic hypercorticism in streptozotocin-induced diabetes mice. Endocrinology. 2008;149:3531-9 pubmed publisher
    ..In response to ACTH (but not vasopressin), cultures of adrenal gland cells from 11-d diabetic mice secreted higher amounts of corticosterone than ..
  74. Li X, Jiang Z, Wang G, Shen H. [Relationship among sexual differences of susceptibility to motion sickness, AVP levels of plasma and pituitary and V1b receptor expression of pituitary in rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2007;23:35-40 pubmed
    To investigate the relationship among sexual differences of motion sickness (MS), AVP levels of plasma and pituitary and the expression of pituitary V1b receptors for further understanding of the MS mechanisms...
  75. Yang J, Yang Y, Chen J, Xu H, Liu W, Wang C, et al. Arginine vasopressin is an important regulator in antinociceptive modulation of hypothalamic paraventricular nucleus in the rat. Neuropeptides. 2007;41:165-76 pubmed
    ..The results showed that (1) intraventricular injection (icv) of anti-arginine vasopressin (AVP) serum completely reversed pain threshold increase induced by l-glutamate sodium (Glu) injection into the ..
  76. Lauand F, Ruginsk S, Rodrigues H, Reis W, de Castro M, Elias L, et al. Glucocorticoid modulation of atrial natriuretic peptide, oxytocin, vasopressin and Fos expression in response to osmotic, angiotensinergic and cholinergic stimulation. Neuroscience. 2007;147:247-57 pubmed
    ..present study, we evaluated the effect of dexamethasone on atrial natriuretic peptide (ANP), oxytocin (OT) and vasopressin (AVP) responses to i.c.v. microinjections of 0.15 M and 0.30 M NaCl, angiotensin-II (ANG-II) and carbachol...
  77. Yatagai T, Kusaka I, Nakamura T, Nagasaka S, Honda K, Ishibashi S, et al. Close association of severe hyponatremia with exaggerated release of arginine vasopressin in elderly subjects with secondary adrenal insufficiency. Eur J Endocrinol. 2003;148:221-6 pubmed
    Hyponatremia occurs not infrequently in hypopituitarism. Arginine vasopressin (AVP)-induced impaired water excretion is found in patients with hypopituitarism and experimental models of glucocorticoid deficiency...
  78. Jirikowski G, Herbert Z, Petrusz P, Sendemir E, Caldwell J. Co-expression of vasopressin and androgen-binding protein in the rat hypothalamus. J Chem Neuroanat. 2005;29:233-7 pubmed
    ..In the present study we used antibodies to the anti-diuretic hormone arginine vasopressin (AVP) for co-localization with ABP in the rat hypothalamus...
  79. Rossi N, Black S, Telemaque Potts S, Chen H. Neuronal nitric oxide synthase activity in the paraventricular nucleus buffers central endothelin-1- induced pressor response and vasopressin secretion. J Cardiovasc Pharmacol. 2004;44 Suppl 1:S283-8 pubmed
    ..ET-1) injected into the lateral cerebral ventricle increases sympathetic output, arterial pressure and plasma vasopressin (AVP)...
  80. Veenema A, Blume A, Niederle D, Buwalda B, Neumann I. Effects of early life stress on adult male aggression and hypothalamic vasopressin and serotonin. Eur J Neurosci. 2006;24:1711-20 pubmed
    ..the effects of maternal separation on adult intermale aggression in Wistar rats and on hypothalamic arginine vasopressin (AVP) mRNA expression, and AVP and serotonin (5-HT) immunoreactivity, as both AVP and 5-HT have been implicated ..
  81. Yu G, Chen H, Zhao W, Matta S, Sharp B. Nicotine self-administration differentially regulates hypothalamic corticotropin-releasing factor and arginine vasopressin mRNAs and facilitates stress-induced neuronal activation. J Neurosci. 2008;28:2773-82 pubmed publisher
    ..1) the effects of chronic nicotine SA on the coexpression of corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) mRNAs, the primary hypothalamic neuropeptides regulating ACTH release, in the parvocellular division of ..
  82. Pedersen C, Boccia M. Vasopressin interactions with oxytocin in the control of female sexual behavior. Neuroscience. 2006;139:843-51 pubmed
    Previous studies have found that central administration of arginine vasopressin and arginine vasopressin receptor V1a antagonists respectively inhibited and stimulated receptivity but did not examine effects on other aspects of female ..
  83. Ataka K, Nagaishi K, Asakawa A, Inui A, Fujimiya M. Alteration of antral and proximal colonic motility induced by chronic psychological stress involves central urocortin 3 and vasopressin in rats. Am J Physiol Gastrointest Liver Physiol. 2012;303:G519-28 pubmed publisher
    ..mRNA expression of AVP, oxytocin, and urocortin 3 was increased by chronic psychological stress...
  84. Murgatroyd C, Wigger A, Frank E, Singewald N, Bunck M, Holsboer F, et al. Impaired repression at a vasopressin promoter polymorphism underlies overexpression of vasopressin in a rat model of trait anxiety. J Neurosci. 2004;24:7762-70 pubmed
    ..The behavioral phenotype correlates with arginine vasopressin (AVP) expression at the level of the hypothalamic paraventricular nucleus (PVN), but not supraoptic nucleus, ..
  85. Jentsch J. Genetic vasopressin deficiency facilitates performance of a lateralized reaction-time task: altered attention and motor processes. J Neurosci. 2003;23:1066-71 pubmed
    ..of the outbred Long-Evans strain that possess a single nucleotide deletion in the second exon of the arginine vasopressin gene, resulting in the synthesis of an altered protein that does not enter the normal secretory pathway...
  86. Mucio Ramírez S, Sánchez Islas E, Sánchez Jaramillo E, Currás Collazo M, Juárez González V, Álvarez González M, et al. Perinatal exposure to organohalogen pollutants decreases vasopressin content and its mRNA expression in magnocellular neuroendocrine cells activated by osmotic stress in adult rats. Toxicol Appl Pharmacol. 2017;329:173-189 pubmed publisher
    ..exposed to Aroclor-1254 (A1254) and DE-71 (commercial mixtures of PCBs and PBDEs) decrease somatodendritic vasopressin (AVP) release while increasing plasma AVP responses to osmotic activation, potentially emptying AVP reserves ..
  87. Valesky E, Burda H, Kaufmann R, Oelschläger H. Distribution of oxytocin- and vasopressin-immunoreactive neurons in the brain of the eusocial mole rat (Fukomys anselli). Anat Rec (Hoboken). 2012;295:474-80 pubmed publisher
    ..Research on other mammals suggests that oxytocin (OT) and vasopressin (VP) as well as the distribution of OT- and VP-receptors may influence social behavior and pair bonding...
  88. Samson W, Yosten G, Chang J, Ferguson A, White M. Obestatin inhibits vasopressin secretion: evidence for a physiological action in the control of fluid homeostasis. J Endocrinol. 2008;196:559-64 pubmed publisher
    ..on water drinking by examining the effects of obestatin on hypovolemia-induced water and saline drinking and vasopressin release in male rats...
  89. Busnardo C, Tavares R, Correa F. Role of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors in the cardiovascular effects of L-glutamate microinjection into the hypothalamic paraventricular nucleus of unanesthetized rats. J Neurosci Res. 2009;87:2066-77 pubmed publisher
    ..potentiated or blocked the response to L-glu, suggesting that L-glu responses observed after LY235959 are vasopressin mediated. The increased pressor and bradycardiac responses observed after LY + PE was blocked by subsequent i.v...
  90. Cuadra A, Custer E, Bosworth E, Lemos J. P2X7 receptors in neurohypophysial terminals: evidence for their role in arginine-vasopressin secretion. J Cell Physiol. 2014;229:333-42 pubmed publisher
    Arginine-vasopressin (AVP) plays a major role in maintaining cardiovascular function and related pathologies. The mechanism involved in its release into the circulation is complex and highly regulated...
  91. Zelena D, Domokos A, Jain S, Jankord R, Filaretova L. The stimuli-specific role of vasopressin in the hypothalamus-pituitary-adrenal axis response to stress. J Endocrinol. 2009;202:263-78 pubmed publisher
    ..The present study tests the hypothesis that vasopressin (AVP) is required for the HPA response to acute stimuli...