Gene Symbol: Atp1b3
Description: ATPase Na+/K+ transporting subunit beta 3
Alias: NKAB3S, sodium/potassium-transporting ATPase subunit beta-3, ATPB-3, ATPase, Na+/K+ transporting, beta 3 polypeptide, ATPase, Na+K+ transporting, beta polypeptide 3, Na+/K+ -ATPase beta 3 subunit, sodium/potassium-dependent ATPase subunit beta-3
Crambert G, Hasler U, Beggah A, Yu C, Modyanov N, Horisberger J, et al
. Transport and pharmacological properties of nine different human Na, K-ATPase isozymes. J Biol Chem. 2000;275:1976-86 pubmed
..In conclusion, our study reveals several new functional characteristics of human Na,K-ATPase isozymes which help to better understand their role in ion homeostasis in different tissues and in digitalis action and toxicity. ..
Helwig B, Schreurs K, Hansen J, Hageman K, Zbreski M, McAllister R, et al
. Training-induced changes in skeletal muscle Na+-K+ pump number and isoform expression in rats with chronic heart failure. J Appl Physiol (1985). 2003;94:2225-36 pubmed
..This study demonstrates that CHF-induced alterations in skeletal muscle Na(+)-K(+)-ATPase, including B(max) and isoform expression, can be partially reversed by ET. ..
Scavone C, Munhoz C, Kawamoto E, Glezer I, de Sa Lima L, Marcourakis T, et al
. Age-related changes in cyclic GMP and PKG-stimulated cerebellar Na,K-ATPase activity. Neurobiol Aging. 2005;26:907-16 pubmed
..On the other hand, age-related reduction in glutamate positive modulation of cerebellar alpha(2/3)-Na,K-ATPase is linked to a defective PKG signaling pathway. ..
Yoshimura S, Iwasaka S, Schwarz W, Takeyasu K. Fast degradation of the auxiliary subunit of Na+/K+-ATPase in the plasma membrane of HeLa cells. J Cell Sci. 2008;121:2159-68 pubmed publisher
..All these results indicate that the alpha- and beta-subunits of Na(+)/K(+)-ATPase are assembled in the endoplasmic reticulum, but are disassembled in the plasma membrane and undergo different degradation processes. ..
Figtree G, Liu C, Bibert S, Hamilton E, Garcia A, White C, et al
. Reversible oxidative modification: a key mechanism of Na+-K+ pump regulation. Circ Res. 2009;105:185-93 pubmed publisher
..These findings have implications for pathophysiological conditions characterized by neurohormonal dysregulation, myocardial oxidative stress and raised myocyte Na(+) levels...
Liu L, Askari A. Beta-subunit of cardiac Na+-K+-ATPase dictates the concentration of the functional enzyme in caveolae. Am J Physiol Cell Physiol. 2006;291:C569-78 pubmed
..Uneven distributions of alpha(1) and beta(1) in early and late endosomes of myocytes suggested different internalization routes of two subunits as a source of selective localization of active Na(+)-K(+)-ATPase in cardiac caveolae. ..
Macphee D, Jones D, Barr K, Betts D, Watson A, Kidder G. Differential involvement of Na(+),K(+)-ATPase isozymes in preimplantation development of the mouse. Dev Biol. 2000;222:486-98 pubmed
..Our findings imply that the regulation of sodium transport within the preimplantation mouse embryo is more complex than had been appreciated. ..
Li J, Codina J, Petroske E, Werle M, Willingham M, Dubose T. The effect of beta-subunit assembly on function and localization of the colonic H+,K+-ATPase alpha-subunit. Kidney Int. 2004;66:1068-75 pubmed
..Taken together, these and previous results from our laboratory indicate that beta(1)-Na(+),K(+)-ATPase is likely to represent the most physiologic and efficient subunit for HKalpha(2) assembly in distal colon. ..