Gene Symbol: Atp1b2
Description: ATPase Na+/K+ transporting subunit beta 2
Alias: ATPB2, ATPB2S, Amog, RATATPB2S, sodium/potassium-transporting ATPase subunit beta-2, ATPase, Na+/K+ transporting, beta 2 polypeptide, ATPase, Na+K+ transporting, beta polypeptide 2, sodium/potassium-dependent ATPase subunit beta-2
Species: rat
Products:     Atp1b2

Top Publications

  1. Crambert G, Hasler U, Beggah A, Yu C, Modyanov N, Horisberger J, et al. Transport and pharmacological properties of nine different human Na, K-ATPase isozymes. J Biol Chem. 2000;275:1976-86 pubmed
    ..In conclusion, our study reveals several new functional characteristics of human Na,K-ATPase isozymes which help to better understand their role in ion homeostasis in different tissues and in digitalis action and toxicity. ..
  2. Ruiz A, Bhat S, Bok D. Expression and synthesis of the Na,K-ATPase beta 2 subunit in human retinal pigment epithelium. Gene. 1996;176:237-42 pubmed
    ..It is therefore reasonable to suggest that both alpha 1 beta 1 and alpha 1 beta 2 heterodimers are present in these cells. ..
  3. Liu Y, Zuo S, Li X, Fan J, Cao X, Yu X, et al. Interaction between V-ATPase B2 and (Pro) renin Receptors in Promoting the progression of Renal Tubulointerstitial Fibrosis. Sci Rep. 2016;6:25035 pubmed publisher
    ..From the data we can assume that activation of (P) RR and V-ATPase may play an important role in tubulointerstitial fibrosis with possible involvement of interaction of V-ATPase B2 subunit and (P)RR. ..
  4. Liu Q, Guntuku S, Cui X, Matsuoka S, Cortez D, Tamai K, et al. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev. 2000;14:1448-59 pubmed
    ..Taken together, these data indicate that Chk1 plays an essential role in the mammalian DNA damage checkpoint, embryonic development, and tumor suppression, and that Atr regulates Chk1. ..
  5. Kawakami K, Okamoto H, Yagawa Y, Nagano K. Regulation of Na+,K(+)-ATPase. II. Cloning and analysis of the 5'-flanking region of the rat NKAB2 gene encoding the beta 2 subunit. Gene. 1990;91:271-4 pubmed
    ..Conserved sequence elements which may serve for coordinated expression of the alpha and beta subunits were found in the nt sequence of the 5'-flanking region. ..
  6. Hernando N, Martin Vasallo P, Ghosh S, Ghosh P, Swaroop A, Coca Prados M. Nucleotide sequence of a cDNA for the beta 2 subunit isoform of Na+,K(+)-ATPase from human retina. Biochim Biophys Acta. 1994;1189:109-11 pubmed
    ..6 kb) is approx. 300 nucleotides larger than the major transcript size expressed in rat (3.3 kb). The larger human size mRNA for the human beta 2 Na+,K(+)-ATPase indicates species differences in gene processing. ..
  7. Figtree G, Liu C, Bibert S, Hamilton E, Garcia A, White C, et al. Reversible oxidative modification: a key mechanism of Na+-K+ pump regulation. Circ Res. 2009;105:185-93 pubmed publisher
    ..These findings have implications for pathophysiological conditions characterized by neurohormonal dysregulation, myocardial oxidative stress and raised myocyte Na(+) levels...
  8. Martin Vasallo P, Dackowski W, Emanuel J, Levenson R. Identification of a putative isoform of the Na,K-ATPase beta subunit. Primary structure and tissue-specific expression. J Biol Chem. 1989;264:4613-8 pubmed
    ..These results suggest that different members of the Na,K-ATPase beta subunit family may have specialized functions. ..
  9. Helwig B, Schreurs K, Hansen J, Hageman K, Zbreski M, McAllister R, et al. Training-induced changes in skeletal muscle Na+-K+ pump number and isoform expression in rats with chronic heart failure. J Appl Physiol (1985). 2003;94:2225-36 pubmed
    ..This study demonstrates that CHF-induced alterations in skeletal muscle Na(+)-K(+)-ATPase, including B(max) and isoform expression, can be partially reversed by ET. ..

More Information


  1. Kao L, Kurtz L, Shao X, Papadopoulos M, Liu L, Bok D, et al. Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene). J Biol Chem. 2011;286:32563-74 pubmed publisher
    ..Our findings are the first demonstration of the fundamental importance of NBCe2 in the biology of the nervous system. ..
  2. Liu L, Askari A. Beta-subunit of cardiac Na+-K+-ATPase dictates the concentration of the functional enzyme in caveolae. Am J Physiol Cell Physiol. 2006;291:C569-78 pubmed
    ..Uneven distributions of alpha(1) and beta(1) in early and late endosomes of myocytes suggested different internalization routes of two subunits as a source of selective localization of active Na(+)-K(+)-ATPase in cardiac caveolae. ..