Gene Symbol: Atp1b1
Description: ATPase Na+/K+ transporting subunit beta 1
Alias: ATPBS, sodium/potassium-transporting ATPase subunit beta-1, ATPase, Na+/K+ transporting, beta 1 polypeptide, Na,K-ATPase beta 1 subunit, sodium/potassium-dependent ATPase subunit beta-1
Species: rat
Products:     Atp1b1

Top Publications

  1. Tokhtaeva E, Sachs G, Vagin O. Assembly with the Na,K-ATPase alpha(1) subunit is required for export of beta(1) and beta(2) subunits from the endoplasmic reticulum. Biochemistry. 2009;48:11421-31 pubmed publisher
  2. Yan X, Xun M, Li J, Wu L, Dou X, Zheng J. Activation of Na+/K+-ATPase attenuates high glucose-induced H9c2 cell apoptosis via suppressing ROS accumulation and MAPKs activities by DRm217. Acta Biochim Biophys Sin (Shanghai). 2016;48:883-893 pubmed
    ..Prevention of high glucose-induced myocardial cell injury by specific Na+/K+-ATPase activator may be an attractive therapeutic option. ..
  3. Kao L, Kurtz L, Shao X, Papadopoulos M, Liu L, Bok D, et al. Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene). J Biol Chem. 2011;286:32563-74 pubmed publisher
    ..Our findings are the first demonstration of the fundamental importance of NBCe2 in the biology of the nervous system. ..
  4. Hao H, Wendt C, Sandhu G, Ingbar D. Dexamethasone stimulates transcription of the Na+-K+-ATPase beta1 gene in adult rat lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2003;285:L593-601 pubmed
    ..We conclude that GC directly stimulate transcription of Na+-K+-ATPase beta1 gene expression in adult rat lung epithelial cells through a GR-dependent mechanism that can act at multiple sites. ..
  5. Molinas S, Trumper L, Serra E, Elías M. Evolution of renal function and Na+, K +-ATPase expression during ischaemia-reperfusion injury in rat kidney. Mol Cell Biochem. 2006;287:33-42 pubmed
    ..Although ATP and Na+, K+-ATPase activity returned to control values, postischemic kidney showed an abnormal function after 48 h of reflow. ..
  6. Liu B, Gick G. Characterization of the 5' flanking region of the rat Na+/K(+)-ATPase beta 1 subunit gene. Biochim Biophys Acta. 1992;1130:336-8 pubmed
    ..Potential binding sites for thyroid and glucocorticoid receptors were identified together with multiple sequence motifs which exhibit homology to calcium and serum responsive elements. ..
  7. Crambert G, Hasler U, Beggah A, Yu C, Modyanov N, Horisberger J, et al. Transport and pharmacological properties of nine different human Na, K-ATPase isozymes. J Biol Chem. 2000;275:1976-86 pubmed
    ..In conclusion, our study reveals several new functional characteristics of human Na,K-ATPase isozymes which help to better understand their role in ion homeostasis in different tissues and in digitalis action and toxicity. ..
  8. Beguin P, Crambert G, Monnet Tschudi F, Uldry M, Horisberger J, Garty H, et al. FXYD7 is a brain-specific regulator of Na,K-ATPase alpha 1-beta isozymes. EMBO J. 2002;21:3264-73 pubmed
    ..These data suggest that FXYD7 is a novel, tissue- and isoform-specific Na,K-ATPase regulator which could play an important role in neuronal excitability. ..
  9. Tokhtaeva E, Sachs G, Sun H, Dada L, Sznajder J, Vagin O. Identification of the amino acid region involved in the intercellular interaction between the ?1 subunits of Na+/K+ -ATPase. J Cell Sci. 2012;125:1605-16 pubmed publisher
    ..Therefore, the amino acid region 198-207 is crucial for both trans-dimerization of the Na(+)/K(+)-ATPase ?(1) subunits and cell-cell adhesion. ..

More Information


  1. Barwe S, Jordan M, Skay A, Inge L, Rajasekaran S, Wolle D, et al. Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit. J Mol Cell Cardiol. 2009;47:552-60 pubmed publisher
    ..In conclusion, our results demonstrate that Na,K-beta(1) plays an essential role in regulating cardiac contractility and that its loss is associated with significant pathophysiology of the heart. ..
  2. Mercer R, Schneider J, Savitz A, Emanuel J, Benz E, Levenson R. Rat-brain Na,K-ATPase beta-chain gene: primary structure, tissue-specific expression, and amplification in ouabain-resistant HeLa C+ cells. Mol Cell Biol. 1986;6:3884-90 pubmed
    ..These results suggest that the beta-subunit plays an important role in Na,K-ATPase structure-function and in the mechanism underlying cellular resistance to the cardiac glycosides. ..
  3. Hu L, Kontrogianni Konstantopoulos A. The kinase domains of obscurin interact with intercellular adhesion proteins. FASEB J. 2013;27:2001-12 pubmed publisher
    ..Collectively, our studies demonstrate that the obscurin kinase domains are enzymatically active and may be involved in the regulation of cell adhesion. ..
  4. Young R, Shull G, Lingrel J. Multiple mRNAs from rat kidney and brain encode a single Na+,K+-ATPase beta subunit protein. J Biol Chem. 1987;262:4905-10 pubmed
    ..In the 3' untranslated region, comparison of the nucleotide sequence of the rat beta subunit cDNAs to those from other species reveals regions of high sequence similarity. ..
  5. Gorokhova S, Bibert S, Geering K, Heintz N. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. Hum Mol Genet. 2007;16:2394-410 pubmed
    ..The neuronal expression of NKAIN proteins, their membrane localization and the temperature-sensitive paralysis of NKAIN Drosophila mutants strongly suggest that this novel protein family may be critical for neuronal function. ..
  6. Macphee D, Jones D, Barr K, Betts D, Watson A, Kidder G. Differential involvement of Na(+),K(+)-ATPase isozymes in preimplantation development of the mouse. Dev Biol. 2000;222:486-98 pubmed
    ..Our findings imply that the regulation of sodium transport within the preimplantation mouse embryo is more complex than had been appreciated. ..
  7. Helwig B, Schreurs K, Hansen J, Hageman K, Zbreski M, McAllister R, et al. Training-induced changes in skeletal muscle Na+-K+ pump number and isoform expression in rats with chronic heart failure. J Appl Physiol (1985). 2003;94:2225-36 pubmed
    ..This study demonstrates that CHF-induced alterations in skeletal muscle Na(+)-K(+)-ATPase, including B(max) and isoform expression, can be partially reversed by ET. ..
  8. Li J, Codina J, Petroske E, Werle M, Willingham M, Dubose T. The effect of beta-subunit assembly on function and localization of the colonic H+,K+-ATPase alpha-subunit. Kidney Int. 2004;66:1068-75 pubmed
    ..Taken together, these and previous results from our laboratory indicate that beta(1)-Na(+),K(+)-ATPase is likely to represent the most physiologic and efficient subunit for HKalpha(2) assembly in distal colon. ..
  9. Shao Y, Ismail Beigi F. Control of Na+-K+-ATPase beta 1-subunit expression: role of 3'-untranslated region. Am J Physiol Cell Physiol. 2004;286:C580-5 pubmed
    ..The above results suggest that the 143-nt segment in the distal segment of the 3'-UTR of beta1 mRNA may play an important role in the control of beta1-subunit expression. ..
  10. Liu L, Askari A. Beta-subunit of cardiac Na+-K+-ATPase dictates the concentration of the functional enzyme in caveolae. Am J Physiol Cell Physiol. 2006;291:C569-78 pubmed
    ..Uneven distributions of alpha(1) and beta(1) in early and late endosomes of myocytes suggested different internalization routes of two subunits as a source of selective localization of active Na(+)-K(+)-ATPase in cardiac caveolae. ..
  11. Tokhtaeva E, Sachs G, Souda P, Bassilian S, Whitelegge J, Shoshani L, et al. Epithelial junctions depend on intercellular trans-interactions between the Na,K-ATPase ?? subunits. J Biol Chem. 2011;286:25801-12 pubmed publisher
    ..Therefore, interactions between the ?? subunits of neighboring cells maintain integrity of intercellular junctions, and alterations in the ?? subunit N-glycan structure can regulate stability and tightness of intercellular junctions. ..
  12. Padilla Benavides T, Roldán M, Larre I, Flores Benitez D, Villegas Sepúlveda N, Contreras R, et al. The polarized distribution of Na+,K+-ATPase: role of the interaction between {beta} subunits. Mol Biol Cell. 2010;21:2217-25 pubmed publisher
  13. Swarts H, Weigand K, Venselaar H, van den Maagdenberg A, Russel F, Koenderink J. Familial hemiplegic migraine mutations affect Na,K-ATPase domain interactions. Biochim Biophys Acta. 2013;1832:2173-9 pubmed publisher
    ..Functional consequences were not observed for ATP1A2 mutations found in two sporadic hemiplegic migraine cases (Y9N and R879Q) and in migraine without aura (R51H and C702Y). ..
  14. Tokhtaeva E, Sachs G, Vagin O. Diverse pathways for maturation of the Na,K-ATPase ?1 and ?2 subunits in the endoplasmic reticulum of Madin-Darby canine kidney cells. J Biol Chem. 2010;285:39289-302 pubmed publisher
    ..Folded ?(1) and ?(2) either assemble with ?(1) or bind BiP. The ?(1)-bound ? subunits traffic to the Golgi, whereas BiP-bound ? subunits are retained and degraded in the ER. ..
  15. Wild G, Searles L, Koski K, Drozdowski L, Begum Hasan J, Thomson A. Oral polyamine administration modifies the ontogeny of hexose transporter gene expression in the postnatal rat intestine. Am J Physiol Gastrointest Liver Physiol. 2007;293:G453-60 pubmed
    ..Thus, 3 days of oral polyamine administration induces the precocious maturation of glucose transporters in the postnatal rat small intestine, which may be mediated by alterations in ODC expression. ..
  16. Kasai K, Yamashita T, Yamaguchi A, Yoshiya K, Kawakita A, Tanaka H, et al. Induction of mRNAs and proteins for Na/K ATPase alpha1 and beta1 subunits following hypoxia/reoxygenation in astrocytes. Brain Res Mol Brain Res. 2003;110:38-44 pubmed
    ..These findings suggest that Na/K ATPases may contribute to maintain the cellular environment of astrocytes subjected to hypoxia/reoxygenation. ..
  17. Figtree G, Liu C, Bibert S, Hamilton E, Garcia A, White C, et al. Reversible oxidative modification: a key mechanism of Na+-K+ pump regulation. Circ Res. 2009;105:185-93 pubmed publisher
    ..These findings have implications for pathophysiological conditions characterized by neurohormonal dysregulation, myocardial oxidative stress and raised myocyte Na(+) levels...
  18. Yoshimura S, Iwasaka S, Schwarz W, Takeyasu K. Fast degradation of the auxiliary subunit of Na+/K+-ATPase in the plasma membrane of HeLa cells. J Cell Sci. 2008;121:2159-68 pubmed publisher
    ..All these results indicate that the alpha- and beta-subunits of Na(+)/K(+)-ATPase are assembled in the endoplasmic reticulum, but are disassembled in the plasma membrane and undergo different degradation processes. ..
  19. Takiguchi Y, Sun G, Ogawa K, Matsunaga T. Long-lasting changes in the cochlear K+ recycling structures after acute energy failure. Neurosci Res. 2013;77:33-41 pubmed publisher
    ..These results indicate long-lasting changes in the cochlear lateral wall and spiral limbus, which may compensate for damaged K(+) recycling and protect cells from ATP shortage. ..
  20. Li C, Crambert G, Thuillard D, Roy S, Schaer D, Geering K. Role of the transmembrane domain of FXYD7 in structural and functional interactions with Na,K-ATPase. J Biol Chem. 2005;280:42738-43 pubmed
    ..These amino acids act in a synergistic way. These results highlight the important structural and functional role of the TM domain of FXYD7 and delineate the determinants that mediate the complex interactions of FXYD7 with Na,K-ATPase. ..