Gene Symbol: Atf5
Description: activating transcription factor 5
Alias: cyclic AMP-dependent transcription factor ATF-5, cAMP-dependent transcription factor ATF-5, transcription factor ATFx
Species: rat
Products:     Atf5

Top Publications

  1. Persengiev S, Devireddy L, Green M. Inhibition of apoptosis by ATFx: a novel role for a member of the ATF/CREB family of mammalian bZIP transcription factors. Genes Dev. 2002;16:1806-14 pubmed
    ..However, constitutive expression of ATFx renders cells resistant to 24p3-mediated apoptosis. Collectively, our results indicate that ATFx is an anti-apoptotic factor, a novel role for an ATF protein. ..
  2. Zhang Z, Li S, Zhang H, Wu Q, Gong J, Liang T, et al. Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates the interleukin-1β-stimulated C/EBP signaling pathway. Mol Cell Biol. 2015;35:778-88 pubmed publisher
    ..NLK interacted with activating transcription factor 5 (ATF5) and inhibited the proteasome-dependent degradation of ATF5 in a kinase-independent manner...
  3. Yamazaki T, Ohmi A, Kurumaya H, Kato K, Abe T, Yamamoto H, et al. Regulation of the human CHOP gene promoter by the stress response transcription factor ATF5 via the AARE1 site in human hepatoma HepG2 cells. Life Sci. 2010;87:294-301 pubmed publisher
    ..We have shown that ATF5 is a stress response transcription factor that responds to amino acid limitation, arsenite exposure, or cadmium ..
  4. Wei Y, Jiang J, Sun M, Chen X, Wang H, Gu J. ATF5 increases cisplatin-induced apoptosis through up-regulation of cyclin D3 transcription in HeLa cells. Biochem Biophys Res Commun. 2006;339:591-6 pubmed
    b>ATF5 transcription factor plays an essential role in hematopoietic and glioma cell survival and neuronal cell differentiation...
  5. Koyanagi S, Hamdan A, Horiguchi M, Kusunose N, Okamoto A, Matsunaga N, et al. cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene. J Biol Chem. 2011;286:32416-23 pubmed publisher
    ..These results suggest that ATF4 is a component responsible for sustaining circadian oscillation of CRE-mediated gene expression and also constitute a molecular link connecting cAMP-dependent signaling to the circadian clock. ..
  6. Liu X, Liu D, Qian D, Dai J, An Y, Jiang S, et al. Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells. J Biol Chem. 2012;287:19599-609 pubmed publisher
    Nucleophosmin (NPM1/B23) and the activating transcription factor 5 (ATF5) are both known to subject to cell type-dependent regulation...
  7. Angelastro J, Ignatova T, Kukekov V, Steindler D, Stengren G, Mendelsohn C, et al. Regulated expression of ATF5 is required for the progression of neural progenitor cells to neurons. J Neurosci. 2003;23:4590-600 pubmed
    ..We report that the bZIP transcription factor ATF5 plays a major regulatory role in this process...
  8. Li G, Xu Y, Guan D, Liu Z, Liu D. HSP70 protein promotes survival of C6 and U87 glioma cells by inhibition of ATF5 degradation. J Biol Chem. 2011;286:20251-9 pubmed publisher
    Although both the heat shock protein 70 (HSP70) and the activating transcription factor 5 (ATF5) have been shown to promote cell survival of transformed cells but not survival of non-transformed cells, the relationship of the two ..
  9. Wang H, Lin G, Zhang Z. ATF5 promotes cell survival through transcriptional activation of Hsp27 in H9c2 cells. Cell Biol Int. 2007;31:1309-15 pubmed
    ..Here we described that ATF5 could promote cell survival in heat shock stress and identified that heat shock protein 27 (Hsp27) as one of its ..

More Information


  1. Li G, Li W, Angelastro J, Greene L, Liu D. Identification of a novel DNA binding site and a transcriptional target for activating transcription factor 5 in c6 glioma and mcf-7 breast cancer cells. Mol Cancer Res. 2009;7:933-43 pubmed publisher
    Recent reports indicate that the activating transcription factor 5 (ATF5) is required for the survival of cancer cells but not for noncancer cells...
  2. Dluzen D, Li G, Tacelosky D, Moreau M, Liu D. BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner. J Biol Chem. 2011;286:7705-13 pubmed publisher
    b>ATF5 loss of function has been shown previously to cause apoptotic cell death in glioblastoma and breast cancer cells but not in non-transformed astrocytes and human breast epithelial cells...
  3. Zhao Y, Zhang Y, Zhang Y, Qian S, Zhang Z, Li S, et al. p300-dependent acetylation of activating transcription factor 5 enhances C/EBP? transactivation of C/EBP? during 3T3-L1 differentiation. Mol Cell Biol. 2014;34:315-24 pubmed publisher
    ..In this study, we found that activating transcription factor 5 (ATF5) can bind to the promoter of C/EBP? via its direct interaction with C/EBP? (which is mediated via the p300-..
  4. Madarampalli B, Yuan Y, Liu D, Lengel K, Xu Y, Li G, et al. ATF5 Connects the Pericentriolar Materials to the Proximal End of the Mother Centriole. Cell. 2015;162:580-92 pubmed publisher
    ..Here, we show that ATF5 forms a characteristic 9-fold symmetrical ring structure in the inner layer of the PCM outfitting the proximal end ..
  5. Angelastro J, Mason J, Ignatova T, Kukekov V, Stengren G, Goldman J, et al. Downregulation of activating transcription factor 5 is required for differentiation of neural progenitor cells into astrocytes. J Neurosci. 2005;25:3889-99 pubmed
    ..The transcription factor activating transcription factor 5 (ATF5) is expressed in neural progenitors of developing brain but is absent from mature astrocytes and neurons...
  6. Lemos D, Goodspeed L, Tonelli L, Antoch M, Ojeda S, Urbanski H. Evidence for circadian regulation of activating transcription factor 5 but not tyrosine hydroxylase by the chromaffin cell clock. Endocrinology. 2007;148:5811-21 pubmed
    ..several genes in a 24-h rhythmic pattern, including TH (the rate-limiting enzyme in catecholamine synthesis) and Atf5 (a transcription factor involved in apoptosis and neural cell differentiation) together with the core-clock genes...
  7. Forgacs E, Gupta S, Kerry J, Semmes O. The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription. J Virol. 2005;79:6932-9 pubmed
    ..We propose that recruitment of ATFx to the HTLV-1 LTR serves to link viral transcription with critical events in cellular homeostasis. ..
  8. Liu D, Qian D, Wang B, Yang J, Lu Z. p300-Dependent ATF5 acetylation is essential for Egr-1 gene activation and cell proliferation and survival. Mol Cell Biol. 2011;31:3906-16 pubmed publisher
    b>ATF5 has been shown to be a critical regulator of cell proliferation and survival; however, the underlying mechanism remains largely unknown...
  9. De Graeve F, Bahr A, Chatton B, Kedinger C. A murine ATFa-associated factor with transcriptional repressing activity. Oncogene. 2000;19:1807-19 pubmed
    ..Together, these findings suggest that mAM may be involved in the fine-tuning of ATFa-regulated gene expression, by interfering with the assembly or stability of specific preinitiation transcription complexes. ..
  10. Lee H, Angelastro J, Kenney A, Mason C, Greene L. Reciprocal actions of ATF5 and Shh in proliferation of cerebellar granule neuron progenitor cells. Dev Neurobiol. 2012;72:789-804 pubmed publisher
    ..The transcription factor ATF5 promotes proliferation of cerebral cortical neuroprogenitor cells and its down regulation permits their ..