Gene Symbol: Atf1
Description: activating transcription factor 1
Alias: Atf-1, cyclic AMP-dependent transcription factor ATF-1
Species: rat
Products:     Atf1

Top Publications

  1. Napolitano G, Montani V, Giuliani C, Di Vincenzo S, Bucci I, Todisco V, et al. Transforming growth factor-beta1 down-regulation of major histocompatibility complex class I in thyrocytes: coordinate regulation of two separate elements by thyroid-specific as well as ubiquitous transcription factors. Mol Endocrinol. 2000;14:486-505 pubmed
    ..TGF-beta1 effects on c-jun may be a pivotal fulcrum in the hitherto unrecognized coordinate regulation of Enhancer A and the DRE. ..
  2. Ghosh S, Gadiparthi L, Zeng Z, Bhanoori M, Tellez C, Bar Eli M, et al. ATF-1 mediates protease-activated receptor-1 but not receptor tyrosine kinase-induced DNA synthesis in vascular smooth muscle cells. J Biol Chem. 2002;277:21325-31 pubmed
  3. Ciani B, Bjelic S, Honnappa S, Jawhari H, Jaussi R, Payapilly A, et al. Molecular basis of coiled-coil oligomerization-state specificity. Proc Natl Acad Sci U S A. 2010;107:19850-5 pubmed publisher
    ..We successfully confirmed our results in two other, unrelated coiled-coil dimers, ATF1 and cortexillin-1...
  4. Katsuyama M, Ozgur Cevik M, Arakawa N, Kakehi T, Nishinaka T, Iwata K, et al. Myocyte enhancer factor 2B is involved in the inducible expression of NOX1/NADPH oxidase, a vascular superoxide-producing enzyme. FEBS J. 2007;274:5128-36 pubmed
    ..These results indicate that superoxide production in vascular smooth muscle cells is regulated by the ATF-1-MEF2B cascade by induction of the expression of the NOX1 gene. ..
  5. Ziel K, Campbell C, Wilson G, Gillespie M. Ref-1/Ape is critical for formation of the hypoxia-inducible transcriptional complex on the hypoxic response element of the rat pulmonary artery endothelial cell VEGF gene. FASEB J. 2004;18:986-8 pubmed
  6. Luo S, Baumeister P, Yang S, Abcouwer S, Lee A. Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements. J Biol Chem. 2003;278:37375-85 pubmed
    ..Here we have identified the closely related ATF1 and CREB1 as nuclear co-factors that form in vivo complexes with endogenous ATF4...
  7. Rehfuss R, Walton K, Loriaux M, Goodman R. The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A. J Biol Chem. 1991;266:18431-4 pubmed
    ..These findings indicate that CREB is not unique in its ability to mediate cAMP-dependent transcriptional regulation. ..
  8. Iijima K, Yoshizumi M, Hashimoto M, Kim S, Eto M, Ako J, et al. Red wine polyphenols inhibit proliferation of vascular smooth muscle cells and downregulate expression of cyclin A gene. Circulation. 2000;101:805-11 pubmed
    ..These results suggest that the downregulation of cyclin A gene expression may contribute to the antiproliferative effect of red wine polyphenols on RASMCs through the inhibition of transcription factor expression. ..
  9. Zaman K, Ryu H, Hall D, O Donovan K, Lin K, Miller M, et al. Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), an. J Neurosci. 1999;19:9821-30 pubmed

More Information


  1. Ji L, Mochon E, Arcinas M, Boxer L. CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas. J Biol Chem. 1996;271:22687-91 pubmed
    ..We conclude that the CRE site functions as a positive regulatory site for the translocated bcl-2 allele in t(14;18) lymphomas. ..
  2. Umesh H, Ganesh B, Reddy C. Secalonic acid D alters the expression and phosphorylation of the transcription factors and their binding to cAMP response element in developing murine secondary palate. J Craniofac Genet Dev Biol. 2000;20:173-82 pubmed
    ..leading to altered expression of genes involved in cell proliferation, an event critical for normal palate development. ..
  3. Takahashi M, Mutoh M, Shoji Y, Kamanaka Y, Naka M, Maruyama T, et al. Transfection of K-rasAsp12 cDNA markedly elevates IL-1beta- and lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells. Oncogene. 2003;22:7667-76 pubmed
  4. Jones L, Scammell J. The cAMP-response element mediates induction of secretogranin II by CHX and FSK in GH4C1 cells. Am J Physiol. 1998;274:E656-64 pubmed
  5. Fan C, Katsuyama M, Nishinaka T, Yabe Nishimura C. Transactivation of the EGF receptor and a PI3 kinase-ATF-1 pathway is involved in the upregulation of NOX1, a catalytic subunit of NADPH oxidase. FEBS Lett. 2005;579:1301-5 pubmed
    ..Accordingly, the transactivation of the EGF receptor and the activation of ERK1/2, PI3 kinase, and ATF-1 constitute the signaling pathways involved in the upregulation of NOX1. ..
  6. Matsuo N, Tanaka S, Gordon M, Koch M, Yoshioka H, Ramirez F. CREB-AP1 protein complexes regulate transcription of the collagen XXIV gene (Col24a1) in osteoblasts. J Biol Chem. 2006;281:5445-52 pubmed
    ..cis-acting element, which is shared by both transcripts and is recognized by specific combinations of c-Jun, CREB1, ATF1, and ATF2 dimers...
  7. Shimomura A, Okamoto Y, Hirata Y, Kobayashi M, Kawakami K, Kiuchi K, et al. Dominant negative ATF1 blocks cyclic AMP-induced neurite outgrowth in PC12D cells. J Neurochem. 1998;70:1029-34 pubmed
    ..As CREB preferentially forms heterodimers with ATF1 in PC12D cells, we examined the roles of the CREB/ATF1 heterodimer on cyclic AMP (cAMP)-induced neurite extension, ..
  8. Wang X, Ward C, Harris P, Torres V. Cyclic nucleotide signaling in polycystic kidney disease. Kidney Int. 2010;77:129-40 pubmed publisher
    ..This may account, in part, for increased cyclic nucleotide signaling in polycystic kidney disease and contribute substantially to disease progression...