Gene Symbol: Atcay
Description: ATCAY, caytaxin
Alias: caytaxin, ataxia, cerebellar, Cayman type
Bomar J, Benke P, Slattery E, Puttagunta R, Taylor L, Seong E, et al
. Mutations in a novel gene encoding a CRAL-TRIO domain cause human Cayman ataxia and ataxia/dystonia in the jittery mouse. Nat Genet. 2003;35:264-9 pubmed
..The gene ATCAY or Atcay encodes a neuron-restricted protein called caytaxin. Caytaxin contains a CRAL-TRIO motif common to proteins that bind small lipophilic molecules...
Buschdorf J, Li Chew L, Zhang B, Cao Q, Liang F, Liou Y, et al
. Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels. J Cell Sci. 2006;119:3337-50 pubmed
..Cayman ataxia and mouse or rat dystonia are linked to mutations in the genes ATCAY (Atcay) that encode BNIP-H or Caytaxin, a brain-specific member of the BNIP-2 family...
Xiao J, Ledoux M. Caytaxin deficiency causes generalized dystonia in rats. Brain Res Mol Brain Res. 2005;141:181-92 pubmed
..repeat portion of an intracisternal A particle element inserted into Intron 1 of Atcay, the gene which encodes caytaxin. Northern and Western blotting and quantitative real-time RT-PCR defined the Atcay allele in dt rats (Atcay(dt)) ..
Xiao J, Gong S, LeDoux M. Caytaxin deficiency disrupts signaling pathways in cerebellar cortex. Neuroscience. 2007;144:439-61 pubmed
..As a result, dt rats are deficient in Atcay transcript and the neuronally-restricted protein caytaxin. Previous electrophysiological and biochemical studies have defined olivocerebellar pathways, particularly the ..
Hayakawa Y, Itoh M, Yamada A, Mitsuda T, Nakagawa T. Expression and localization of Cayman ataxia-related protein, Caytaxin, is regulated in a developmental- and spatial-dependent manner. Brain Res. 2007;1129:100-9 pubmed
Mutation of the gene encoding Caytaxin causes human Cayman ataxia by interfering with normal splicing and, in mutant rodents, by reducing normal transcription, which leads to ataxia, dystonia, and mental retardation: These observations ..
Buschdorf J, Chew L, Soh U, Liou Y, Low B. Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons. PLoS ONE. 2008;3:e2686 pubmed publisher
Mutations in ATCAY that encodes the brain-specific protein BNIP-H (or Caytaxin) lead to Cayman cerebellar ataxia. BNIP-H binds to glutaminase, a neurotransmitter-producing enzyme, and affects its activity and intracellular localization...
Aoyama T, Hata S, Nakao T, Tanigawa Y, Oka C, Kawaichi M. Cayman ataxia protein caytaxin is transported by kinesin along neurites through binding to kinesin light chains. J Cell Sci. 2009;122:4177-85 pubmed publisher
Deficiency of caytaxin results in hereditary ataxia or dystonia in humans, mice and rats. Our yeast two-hybrid screen identified kinesin light chains (KLCs) as caytaxin-binding proteins...
Sun J, Pan C, Chew T, Liang F, Burmeister M, Low B. BNIP-H Recruits the Cholinergic Machinery to Neurite Terminals to Promote Acetylcholine Signaling and Neuritogenesis. Dev Cell. 2015;34:555-68 pubmed publisher
..Here, we demonstrate that ataxia-related protein BNIP-H/Caytaxin links kinesin-1 (KLC1) to ATP citrate lyase (ACL), a key enzyme for ACh synthesis, and transports it toward ..