Atat1

Summary

Gene Symbol: Atat1
Description: alpha tubulin acetyltransferase 1
Alias: 3110080J08Rik, Mec17, RGD1303066, TAT, alpha-tubulin N-acetyltransferase 1, acetyltransferase mec-17 homolog, alpha-TAT, alpha-TAT1
Species: rat
Products:     Atat1

Top Publications

  1. Akella J, Wloga D, Kim J, Starostina N, Lyons Abbott S, Morrissette N, et al. MEC-17 is an alpha-tubulin acetyltransferase. Nature. 2010;467:218-22 pubmed publisher
    ..In summary, we identify MEC-17 as an enzyme that acetylates the K40 residue of alpha-tubulin, the only PTM known to occur on the luminal surface of microtubules...
  2. Li L, Wei D, Wang Q, Pan J, Liu R, Zhang X, et al. MEC-17 deficiency leads to reduced ?-tubulin acetylation and impaired migration of cortical neurons. J Neurosci. 2012;32:12673-83 pubmed publisher
    ..This finding reveals the importance of MEC-17 and ?-tubulin acetylation in cortical development. ..
  3. Yang W, Guo X, Thein S, Xu F, Sugii S, Baas P, et al. Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of ?-tubulin. Biochem J. 2013;449:605-12 pubmed publisher
  4. Kim G, Li L, Ghorbani M, You L, Yang X. Mice lacking ?-tubulin acetyltransferase 1 are viable but display ?-tubulin acetylation deficiency and dentate gyrus distortion. J Biol Chem. 2013;288:20334-50 pubmed publisher
    ..There is one such protein known as Atat1 (?-tubulin acetyltransferase 1) per higher organism...
  5. Kalebic N, Sorrentino S, Perlas E, Bolasco G, Martínez C, Heppenstall P. ?TAT1 is the major ?-tubulin acetyltransferase in mice. Nat Commun. 2013;4:1962 pubmed publisher
    ..elegans. Here we generate mice with a targeted deletion of Atat1 to determine its function in mammals...
  6. Friedmann D, Aguilar A, Fan J, Nachury M, Marmorstein R. Structure of the ?-tubulin acetyltransferase, ?TAT1, and implications for tubulin-specific acetylation. Proc Natl Acad Sci U S A. 2012;109:19655-60 pubmed publisher
  7. Misawa T, Takahama M, Kozaki T, Lee H, Zou J, Saitoh T, et al. Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat Immunol. 2013;14:454-60 pubmed publisher
    ..Therefore, in addition to direct activation of NLRP3, the creation of optimal sites for signal transduction by microtubules is required for activation of the entire NLRP3 inflammasome. ..
  8. Szyk A, Deaconescu A, Spector J, Goodman B, Valenstein M, Ziólkowska N, et al. Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase. Cell. 2014;157:1405-15 pubmed publisher
    Acetylation of α-tubulin Lys40 by tubulin acetyltransferase (TAT) is the only known posttranslational modification in the microtubule lumen...
  9. Nakakura T, Suzuki T, Nemoto T, Tanaka H, Asano Hoshino A, Arisawa K, et al. Intracellular localization of α-tubulin acetyltransferase ATAT1 in rat ciliated cells. Med Mol Morphol. 2016;49:133-43 pubmed publisher
    ..Tubulin N-acetyltransferase 1 (ATAT1) is an acetyltransferase specific to the K40 residue of α-tubulin; however, its intracellular distribution in ..

More Information

Publications11

  1. Nakakura T, Nemoto T, Suzuki T, Asano Hoshino A, Tanaka H, Arisawa K, et al. Adrenalectomy facilitates ATAT1 expression and ?-tubulin acetylation in ACTH-producing corticotrophs. Cell Tissue Res. 2016;366:363-370 pubmed publisher
    ..Tubulin N-acetyltransferase 1 (ATAT1), which acetylates the lysine residue at position 40 of ?-tubulin, functions not only in stabilizing microtubule ..
  2. Lin S, Sterling N, Junker I, Helm C, Smith G. Effects of ?TAT1 and HDAC5 on axonal regeneration in adult neurons. PLoS ONE. 2017;12:e0177496 pubmed publisher
    ..Thus, while ?TAT1 may be important for axonal growth in vitro, neither ?TAT1 nor HDAC5 had an effect in vivo on the regeneration of sciatic nerves. ..