Gene Symbol: Astl
Description: astacin like metalloendopeptidase
Alias: RGD1562279, astacin-like metalloendopeptidase, astacin-like metalloendopeptidase (M12 family)
Species: rat

Top Publications

  1. Quesada V, Sanchez L, Alvarez J, Lopez Otin C. Identification and characterization of human and mouse ovastacin: a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish. J Biol Chem. 2004;279:26627-34 pubmed
    ..On the basis of these results, we suggest that ovastacin could play in mammals a physiological function similar to that performed by hatching proteases in evolutionary distant species from arthropods to fish. ..
  2. Sachdev M, Mandal A, Mulders S, Digilio L, Panneerdoss S, Suryavathi V, et al. Oocyte specific oolemmal SAS1B involved in sperm binding through intra-acrosomal SLLP1 during fertilization. Dev Biol. 2012;363:40-51 pubmed publisher
    ..SAS1B knockout female mice showed a 34% reduction in fertility. The study identified SAS1B-SLLP1 as a pair of novel sperm-egg binding partners involving the oolemma and intra-acrosomal compartment during fertilization...
  3. Burkart A, Xiong B, Baibakov B, Jim nez Movilla M, Dean J. Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy. J Cell Biol. 2012;197:37-44 pubmed publisher
    ..Based on the cleavage site of ZP2, ovastacin was selected as a candidate protease. Encoded by the single-copy Astl gene, ovastacin is an oocyte-specific member of the astacin family of metalloendoproteases...