Gene Symbol: Arhgef11
Description: Rho guanine nucleotide exchange factor 11
Alias: Gtrap48, rho guanine nucleotide exchange factor 11, Rho guanine nucleotide exchange factor (GEF) 11, RhoGEF glutamate transport modulator GTRAP48, glutamate transporter EAAT4 associated protein 48
Species: rat
Products:     Arhgef11

Top Publications

  1. Wuertz C, Lorincz A, Vettel C, Thomas M, Wieland T, Lutz S. p63RhoGEF--a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells. FASEB J. 2010;24:4865-76 pubmed publisher
  2. Siegert P, Schmidt G, Papatheodorou P, Wieland T, Aktories K, Orth J. Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the G?(q/11)--p63RhoGEF--RhoA axis. PLoS Pathog. 2013;9:e1003385 pubmed publisher
  3. Artamonov M, Momotani K, Stevenson A, Trentham D, Derewenda U, Derewenda Z, et al. Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study. J Biol Chem. 2013;288:34030-40 pubmed publisher
  4. Jia Z, Johnson A, Wang X, Guo Z, Dreisbach A, Lewin J, et al. Allelic Variants in Arhgef11 via the Rho-Rock Pathway Are Linked to Epithelial-Mesenchymal Transition and Contributes to Kidney Injury in the Dahl Salt-Sensitive Rat. PLoS ONE. 2015;10:e0132553 pubmed publisher
    Previously, genetic analyses identified that variants in Arhgef11 may influence kidney injury in the Dahl salt-sensitive (S) rat, a model of hypertensive chronic kidney disease...
  5. Fukuhara S, Murga C, Zohar M, Igishi T, Gutkind J. A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. J Biol Chem. 1999;274:5868-79 pubmed
  6. Yamada T, Ohoka Y, Kogo M, Inagaki S. Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs). J Biol Chem. 2005;280:19358-63 pubmed
    ..Taken together, these results indicate that formation of the LPA receptor/PDZ domain-containing RhoGEF complex plays a pivotal role in LPA-induced RhoA activation. ..
  7. Hilgers R, Todd J, Webb R. Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric arteries of angiotensin II-induced hypertensive rats. J Hypertens. 2007;25:1687-97 pubmed
    ..This enhanced signaling leads to increased MLCP phosphorylation, resulting in vascular hyper-reactivity. ..
  8. Park H, Kim J, Zuo Z, Do S. Ethanol increases the activity of rat excitatory amino acid transporter type 4 expressed in Xenopus oocytes: role of protein kinase C and phosphatidylinositol 3-kinase. Alcohol Clin Exp Res. 2008;32:348-54 pubmed publisher
    ..The effects of ethanol on EAAT4 may play a role in the cerebellar dysfunction caused by ethanol intoxication. ..
  9. Williams J, Johnson A, Stelloh C, Dreisbach A, Franceschini N, Regner K, et al. Genetic variants in Arhgef11 are associated with kidney injury in the Dahl salt-sensitive rat. Hypertension. 2012;60:1157-68 pubmed publisher
    ..Gene expression profiling indicated that only a few genes exhibited differential expression. Arhgef11, Pear1, and Sh2d2 were identified as important candidate genes that may be linked to kidney injury in the S rat...

More Information


  1. Jackson M, Song W, Liu M, Jin L, Dykes Hoberg M, Lin C, et al. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Nature. 2001;410:89-93 pubmed
    ..Here we report the identification and characterization of two proteins, GTRAP41 and GTRAP48 (for glutamate transporter EAAT4 associated protein) that specifically interact with the intracellular carboxy-..
  2. Chen Z, Singer W, Danesh S, Sternweis P, Sprang S. Recognition of the activated states of Galpha13 by the rgRGS domain of PDZRhoGEF. Structure. 2008;16:1532-43 pubmed publisher
    ..Replacement of key residues in this motif with their counterparts in p115RhoGEF confers GAP activity. ..