Gene Symbol: Arhgap21
Description: Rho GTPase activating protein 21
Alias: rho GTPase-activating protein 21
Species: rat
Products:     Arhgap21

Top Publications

  1. Hehnly H, Xu W, Chen J, Stamnes M. Cdc42 regulates microtubule-dependent Golgi positioning. Traffic. 2010;11:1067-78 pubmed publisher
    ..Here we show that reduced expression of the Cdc42-specific GTPase-activating protein, ARHGAP21, inhibits the ability of dispersed Golgi membranes to reposition at the centrosome following nocodazole treatment ..
  2. Borges L, Bigarella C, Baratti M, Crosara Alberto D, Joazeiro P, Franchini K, et al. ARHGAP21 associates with FAK and PKCzeta and is redistributed after cardiac pressure overload. Biochem Biophys Res Commun. 2008;374:641-6 pubmed publisher
    b>ARHGAP21 is highly expressed in the heart, which demonstrates activity over Cdc42 and interacts with proteins of the cytoskeleton and adherent junctions...
  3. Schultz M, Tecedor L, Stein C, STAMNES M, Davidson B. CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events. PLoS ONE. 2014;9:e96647 pubmed publisher
    ..We also demonstrate dramatically reduced plasma membrane recruitment of the Cdc42 GTPase activating protein, ARHGAP21. In line with this, GTP-loaded ARF1, an effector of ARHGAP21 recruitment, is depressed...