Gene Symbol: Arf4
Description: ADP-ribosylation factor 4
Alias: ADP-ribosylation factor 4
Species: rat
Products:     Arf4

Top Publications

  1. Suzuki I, Owada Y, Suzuki R, Yoshimoto T, Kondo H. Localization of mRNAs for six ARFs (ADP-ribosylation factors) in the brain of developing and adult rats and changes in the expression in the hypoglossal nucleus after its axotomy. Brain Res Mol Brain Res. 2001;88:124-34 pubmed
    ..The present findings suggest that ARFs are differentially involved in some processes essential to nerve regeneration as well as neuronal differentiation and maturation. ..
  2. Kim S, Hayashi M, Lo J, Yang Y, Yoo J, Lee J. ADP-ribosylation factor 4 small GTPase mediates epidermal growth factor receptor-dependent phospholipase D2 activation. J Biol Chem. 2003;278:2661-8 pubmed
    ..We found that ADP-ribosylation factor 4 (ARF4) interacts with the intracellular part of EGFR and mediates the EGF-dependent cellular activation of phospholipase ..
  3. Woo I, Eun S, Jang H, Kang E, Kim G, Kim H, et al. Identification of ADP-ribosylation factor 4 as a suppressor of N-(4-hydroxyphenyl)retinamide-induced cell death. Cancer Lett. 2009;276:53-60 pubmed publisher
    ..inhibitors of Bcl-2-associated X protein (Bax)-induced cell death in yeast identified ADP-ribosylation factor 4 (ARF4) as a novel anti-apoptotic gene in human glioblastoma-derived U373MG cells...
  4. Sadakata T, Shinoda Y, Sekine Y, Saruta C, Itakura M, Takahashi M, et al. Interaction of calcium-dependent activator protein for secretion 1 (CAPS1) with the class II ADP-ribosylation factor small GTPases is required for dense-core vesicle trafficking in the trans-Golgi network. J Biol Chem. 2010;285:38710-9 pubmed publisher
    ..Biochemical analyses of the protein-protein interaction showed that CAPS1 interacted specifically with the class II ARF4/ARF5, but not with other classes of ARFs, via the pleckstrin homology domain in a GDP-bound ARF form-specific ..
  5. Jain S, Yoon S, Zhu L, Brodbeck J, Dai J, Walker D, et al. Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development. PLoS ONE. 2012;7:e46340 pubmed publisher
    ..We report a novel role for the small GTPase ADP ribosylation factor 4 (Arf4) in controlling pattern separation by regulating dendritic spine development...
  6. Kahn R, Kern F, Clark J, Gelmann E, Rulka C. Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins. J Biol Chem. 1991;266:2606-14 pubmed
  7. Price S, Nightingale M, Tsuchiya M, Moss J, Vaughan M. Interspecies relationships among ADP-ribosylation factors (ARFs): evidence of evolutionary pressure to maintain individual identities. Mol Cell Biochem. 1996;159:15-23 pubmed
    ..sequences for rat ARFs 1, 2, 3, 5 and 6 were identical to those of the known cognate human and bovine ARFs; rat ARF4 was 96% identical to human ARF4...
  8. Yu J, Chia J, Canning C, Jones C, Bard F, Virshup D. WLS retrograde transport to the endoplasmic reticulum during Wnt secretion. Dev Cell. 2014;29:277-91 pubmed publisher
    ..ERGIC2 is required for efficient Wnt secretion. ER retrieval is an integral part of the WLS transport cycle. ..
  9. Mishima K, Price S, Nightingale M, Kousvelari E, Moss J, Vaughan M. Regulation of ADP-ribosylation factor (ARF) expression. Cross-species conservation of the developmental and tissue-specific alternative polyadenylation of ARF 4 mRNA. J Biol Chem. 1992;267:24109-16 pubmed
    ..1-kb mRNA was identified primarily in mature sperm, consistent with the developmental studies. Shorter mRNAs, thought to be more stable, may compensate for cessation of transcription at late stages of spermatogenesis. ..

More Information


  1. Hosaka M, Toda K, Takatsu H, Torii S, Murakami K, Nakayama K. Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6). J Biochem. 1996;120:813-9 pubmed
    ..These results suggest that although all the ARF proteins play fundamental and critical roles in cellular function, they are involved in different vesicular transport processes. ..
  2. Chen L, Johnson R, Milgram S. P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes. J Biol Chem. 1998;273:33524-32 pubmed
    ..The data suggest that P-CIP1 associates with vesicles in the recycling endosomal pathway, and may play a role in regulating the trafficking of integral membrane PAM. ..
  3. Jang S, Jang S, Ko J. Regulation of ADP-ribosylation factor 4 expression by small leucine zipper protein and involvement in breast cancer cell migration. Cancer Lett. 2012;314:185-97 pubmed publisher
    ADP-ribosylation factor 4 (ARF4) is a member of the Ras superfamily of small guanine nucleotide-binding proteins...
  4. Follit J, San Agustin J, Jonassen J, Huang T, Rivera Perez J, Tremblay K, et al. Arf4 is required for Mammalian development but dispensable for ciliary assembly. PLoS Genet. 2014;10:e1004170 pubmed publisher
    ..b>Arf4 has been proposed to sort cargo destined for the cilium at the Golgi complex and deemed a key regulator of ciliary ..