Arc

Summary

Gene Symbol: Arc
Description: activity-regulated cytoskeleton-associated protein
Alias: rg3.1, activity-regulated cytoskeleton-associated protein, ARC/ARG3.1, activity regulated cytoskeletal-associated protein, activity-regulated gene 3.1 protein, arg3.1
Species: rat
Products:     Arc

Top Publications

  1. Singer W, Zuccotti A, Jaumann M, Lee S, Panford Walsh R, Xiong H, et al. Noise-induced inner hair cell ribbon loss disturbs central arc mobilization: a novel molecular paradigm for understanding tinnitus. Mol Neurobiol. 2013;47:261-79 pubmed publisher
    ..in stimulus-evoked neuronal activity, (4) the expression of the activity-regulated cytoskeletal protein, Arc, to identify long-lasting changes in network activity within the basolateral amygdala (BLA), hippocampal CA1, and ..
  2. Wu J, Petralia R, Kurushima H, Patel H, Jung M, Volk L, et al. Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent ?-amyloid generation. Cell. 2011;147:615-28 pubmed publisher
    ..Here, we report that the immediate early gene Arc is required for activity-dependent generation of A?...
  3. Vazdarjanova A, Ramirez Amaya V, Insel N, Plummer T, Rosi S, Chowdhury S, et al. Spatial exploration induces ARC, a plasticity-related immediate-early gene, only in calcium/calmodulin-dependent protein kinase II-positive principal excitatory and inhibitory neurons of the rat forebrain. J Comp Neurol. 2006;498:317-29 pubmed
    Active behavior, such as exploring a novel environment, induces the expression of the immediate-early gene Arc (activity-regulated cytoskeletal associated protein, or Arg 3...
  4. Soule J, Alme M, Myrum C, Schubert M, Kanhema T, Bramham C. Balancing Arc synthesis, mRNA decay, and proteasomal degradation: maximal protein expression triggered by rapid eye movement sleep-like bursts of muscarinic cholinergic receptor stimulation. J Biol Chem. 2012;287:22354-66 pubmed publisher
    Cholinergic signaling induces Arc/Arg3.1, an immediate early gene crucial for synaptic plasticity. However, the molecular mechanisms that dictate Arc mRNA and protein dynamics during and after cholinergic epochs are little understood...
  5. Ramirez Amaya V, Vazdarjanova A, Mikhael D, Rosi S, Worley P, Barnes C. Spatial exploration-induced Arc mRNA and protein expression: evidence for selective, network-specific reactivation. J Neurosci. 2005;25:1761-8 pubmed
    The immediate-early gene Arc is transcribed in neurons that are part of stable neural networks activated during spatial exploratory behaviors...
  6. Rial Verde E, Lee Osbourne J, Worley P, Malinow R, Cline H. Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission. Neuron. 2006;52:461-74 pubmed
    b>Arc/Arg3.1 is an immediate-early gene whose expression levels are increased by strong synaptic activation, including synapse-strengthening activity patterns. Arc/Arg3...
  7. Messaoudi E, Kanhema T, Soule J, Tiron A, Dagyte G, da Silva B, et al. Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo. J Neurosci. 2007;27:10445-55 pubmed
    ..Here we probed the dynamic function of activity-induced Arc (activity-regulated cytoskeletal-associated protein)/Arg3.1 (activity-regulated gene 3...
  8. Rodriguez J, Davies H, Silva A, De Souza I, Peddie C, Colyer F, et al. Long-term potentiation in the rat dentate gyrus is associated with enhanced Arc/Arg3.1 protein expression in spines, dendrites and glia. Eur J Neurosci. 2005;21:2384-96 pubmed
    ..to determine the localization, subcellular distribution and expression of activity-regulated cytoskeletal protein (Arc/Arg3...
  9. Gao Y, Tatavarty V, Korza G, Levin M, Carson J. Multiplexed dendritic targeting of alpha calcium calmodulin-dependent protein kinase II, neurogranin, and activity-regulated cytoskeleton-associated protein RNAs by the A2 pathway. Mol Biol Cell. 2008;19:2311-27 pubmed publisher
    ..Multiplexed dendritic targeting of different RNAs by the same pathway represents a new organizing principle for coordinating gene expression at the synapse. ..

More Information

Publications88

  1. Guzowski J, Lyford G, Stevenson G, Houston F, McGaugh J, Worley P, et al. Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. J Neurosci. 2000;20:3993-4001 pubmed
    ..Here, we investigated the role of the IEG Arc (also termed Arg3.1) in hippocampal plasticity...
  2. Chowdhury S, Shepherd J, Okuno H, Lyford G, Petralia R, Plath N, et al. Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron. 2006;52:445-59 pubmed
    b>Arc/Arg3.1 is an immediate-early gene whose mRNA is rapidly transcribed and targeted to dendrites of neurons as they engage in information processing and storage. Moreover, Arc/Arg3...
  3. Lyford G, Yamagata K, Kaufmann W, Barnes C, Sanders L, Copeland N, et al. Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. Neuron. 1995;14:433-45 pubmed
    ..Accordingly, we have termed the gene and encoded protein Arc (activity-regulated cytoskeleton-associated protein)...
  4. Link W, Konietzko U, Kauselmann G, Krug M, Schwanke B, Frey U, et al. Somatodendritic expression of an immediate early gene is regulated by synaptic activity. Proc Natl Acad Sci U S A. 1995;92:5734-8 pubmed
    ..The dendritic localization of the transcripts offers the potential for local synthesis of the protein at activated postsynaptic sites and may underlie synapse-specific modifications during long-term plastic events. ..
  5. Okuno H, Akashi K, Ishii Y, Yagishita Kyo N, Suzuki K, Nonaka M, et al. Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKII?. Cell. 2012;149:886-98 pubmed publisher
    The Arc/Arg3.1 gene product is rapidly upregulated by strong synaptic activity and critically contributes to weakening synapses by promoting AMPA-R endocytosis...
  6. Kelly M, Deadwyler S. Experience-dependent regulation of the immediate-early gene arc differs across brain regions. J Neurosci. 2003;23:6443-51 pubmed
    ..acquisition of a lever-press task resulted in higher levels of activity-regulated cytoskeleton-associated protein (Arc) mRNA induction than did overtrained performance (Kelly and Deadwyler, 2002)...
  7. Li M, Hou Y, Lu B, Chen J, Chi Z, Liu J. Expression pattern of neural synaptic plasticity marker-Arc in different brain regions induced by conditioned drug withdrawal from acute morphine-dependent rats. Acta Pharmacol Sin. 2009;30:282-90 pubmed publisher
    The immediate early gene Arc (activity-regulated cytoskeletal-associated protein) mRNA and protein are induced by strong synaptic activation and rapidly transported into dendrites, where they localize at active synaptic sites...
  8. Liu Y, Zhou Q, Hou Y, Lu B, Yu C, Chen J, et al. Actin polymerization-dependent increase in synaptic Arc/Arg3.1 expression in the amygdala is crucial for the expression of aversive memory associated with drug withdrawal. J Neurosci. 2012;32:12005-17 pubmed publisher
    ..polymerization within the amygdala triggered transportation of activity-regulated cytoskeletal-associated protein (Arc/Arg3.1) into amygdalar synapses. Increased synaptic Arc/Arg3...
  9. Shepherd J, Rumbaugh G, Wu J, Chowdhury S, Plath N, Kuhl D, et al. Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors. Neuron. 2006;52:475-84 pubmed
    ..Here, we demonstrate that Arc/Arg3...
  10. Lv X, Sun L, Cui C, Han J. NAc Shell Arc/Arg3.1 Protein Mediates Reconsolidation of Morphine CPP by Increased GluR1 Cell Surface Expression: Activation of ERK-Coupled CREB is Required. Int J Neuropsychopharmacol. 2015;18: pubmed publisher
    ..Morphine conditioned place preference (CPP) was used to assess activity-regulated cytoskeleton-associated protein (Arc/Arg3...
  11. Schmidt B, Satvat E, Argraves M, Markus E, Marrone D. Cognitive demands induce selective hippocampal reorganization: Arc expression in a place and response task. Hippocampus. 2012;22:2114-26 pubmed publisher
    ..b>Arc expression was used to measure the recruitment of ensembles across different hippocampal subregions in rats trained ..
  12. Gröger N, Bock J, Goehler D, Blume N, Lisson N, Poeggel G, et al. Stress in utero alters neonatal stress-induced regulation of the synaptic plasticity proteins Arc and Egr1 in a sex-specific manner. Brain Struct Funct. 2016;221:679-85 pubmed publisher
    ..impact of prenatal stress exposure ("first hit") on the regulation of the synaptic plasticity immediate early genes Arc and Egr1 in response to a second neonatal stressor ("second hit") in a sex-specific manner...
  13. Gardner R, Suarez D, Robinson Burton N, Rudnicky C, Gulati A, Ascoli G, et al. Differential Arc expression in the hippocampus and striatum during the transition from attentive to automatic navigation on a plus maze. Neurobiol Learn Mem. 2016;131:36-45 pubmed publisher
    ..In addition, dorsal hippocampal expression of the immediate early gene Arc was considerably reduced in rats that used a response strategy late in training (as compared with hippocampal ..
  14. Hearing M, Schwendt M, McGinty J. Suppression of activity-regulated cytoskeleton-associated gene expression in the dorsal striatum attenuates extinction of cocaine-seeking. Int J Neuropsychopharmacol. 2011;14:784-95 pubmed publisher
    ..previously associated with cocaine, but not yoked-saline, increases activity-regulated cytoskeleton-associated (Arc) gene mRNA expression within the dorsolateral (dl) CPu following prolonged abstinence...
  15. Ons S, Martí O, Armario A. Stress-induced activation of the immediate early gene Arc (activity-regulated cytoskeleton-associated protein) is restricted to telencephalic areas in the rat brain: relationship to c-fos mRNA. J Neurochem. 2004;89:1111-8 pubmed
    b>Arc is an effector immediate early gene whose expression is induced in situations of increased neuronal activity. However, there is no report on the influence of stress on Arc expression...
  16. Gil Bea F, Solas M, Mateos L, Winblad B, Ramirez M, Cedazo Minguez A. Cholinergic hypofunction impairs memory acquisition possibly through hippocampal Arc and BDNF downregulation. Hippocampus. 2011;21:999-1009 pubmed publisher
    Recent evidence suggests that activity-regulated cytoskeleton associated protein (Arc) and brain-derived neurotrophic factor (BDNF) are key players in the cellular mechanisms that trigger synaptic changes and memory consolidation...
  17. Kuipers S, Trentani A, Tiron A, Mao X, Kuhl D, Bramham C. BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis. Sci Rep. 2016;6:21222 pubmed publisher
    ..Importantly, inhibition of activity-regulated cytoskeleton-associated protein (Arc/Arg3...
  18. Molteni R, Calabrese F, Maj P, Olivier J, Racagni G, Ellenbroek B, et al. Altered expression and modulation of activity-regulated cytoskeletal associated protein (Arc) in serotonin transporter knockout rats. Eur Neuropsychopharmacol. 2009;19:898-904 pubmed publisher
    ..and SERT(-/-)) to investigate abnormalities in the expression and function of the activity-regulated gene Arc (Activity-regulated cytoskeletal associated protein) and the early inducible gene Zif-268, (zinc finger binding ..
  19. Wall V, Fischer E, Bland S. Isolation rearing attenuates social interaction-induced expression of immediate early gene protein products in the medial prefrontal cortex of male and female rats. Physiol Behav. 2012;107:440-50 pubmed publisher
    ..The protein products of the IEGs c-fos and Arc, as well as the neurotrophic factor BDNF were assessed in medial prefrontal cortex (mPFC) subregions (anterior ..
  20. Li M, Liu W, Lu B, Wang Y, Liu J. Differential expression of Arc in the mesocorticolimbic system is involved in drug and natural rewarding behavior in rats. Acta Pharmacol Sin. 2013;34:1013-24 pubmed publisher
    ..Immunohistochemical assay was used to quantify Arc protein expression in the medial prefrontal cortex (mPFC), the nucleus accumbens (NAc), the dorsomedial striatum (..
  21. Flanagan Cato L, Calizo L, Griffin G, Lee B, Whisner S. Sexual behaviour induces the expression of activity-regulated cytoskeletal protein and modifies neuronal morphology in the female rat ventromedial hypothalamus. J Neuroendocrinol. 2006;18:857-64 pubmed
    ..First, the expression of activity-regulated cytoskeletal protein (Arc), an IEG associated with neural plasticity, was assayed immunohistochemically in females after approximately 1 h of ..
  22. Hartzell A, Burke S, Hoang L, Lister J, Rodriguez C, Barnes C. Transcription of the immediate-early gene Arc in CA1 of the hippocampus reveals activity differences along the proximodistal axis that are attenuated by advanced age. J Neurosci. 2013;33:3424-33 pubmed publisher
    ..experiment investigated this possibility by monitoring behavior-induced cell activity across the CA1 axis using Arc mRNA imaging methods that compared adult and old rats in two conditions: (1) exploration of the same environment ..
  23. Wibrand K, Messaoudi E, Håvik B, Steenslid V, Løvlie R, Steen V, et al. Identification of genes co-upregulated with Arc during BDNF-induced long-term potentiation in adult rat dentate gyrus in vivo. Eur J Neurosci. 2006;23:1501-11 pubmed
    ..perforant path-granule synapses that is transcription-dependent and requires induction of the immediate early gene Arc. Rather than acting alone, Arc is likely to be part of a larger BDNF-induced transcriptional program...
  24. Song B, Li Y, Han D. Delayed electrical stimulation and BDNF application following induced deafness in rats. Acta Otolaryngol. 2009;129:142-54 pubmed publisher
    ..Moreover, the combination of ES and BDNF has a synergistic protective effect rather than an additive effect. Both SGC body and peripheral process influence the auditory sensitivity, and the latter appears to be more important...
  25. Wang D, Lin Y, Chen T, Lin H. Motor skill learning enhances the expression of activity-regulated cytoskeleton-associated protein in the rat cerebellum. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2014;200:959-66 pubmed publisher
    ..Because the induction of immediate-early genes activity-regulated cytoskeleton-associated protein (Arc) and zinc finger binding protein clone 268 (Zif268) has been regarded as a marker for recent neuronal activity, ..
  26. Nikbakht N, Zarei B, Shirani E, Moshtaghian J, Esmaeili A, Habibian S. Experience-dependent expression of rat hippocampal Arc and Homer 1a after spatial learning on 8-arm and 12-arm radial mazes. Neuroscience. 2012;218:49-55 pubmed publisher
    The expression of Arc and Homer 1a (H1a) depends on neural activity. This study was designed to determine hippocampal Arc and H1a mRNA expression levels after spatial learning with differing behavioral task demands...
  27. Hu S, Mei L, Chen J, Huang Z, Wu H. Expression of immediate-early genes in the inferior colliculus and auditory cortex in salicylate-induced tinnitus in rat. Eur J Histochem. 2014;58:2294 pubmed publisher
    ..Some IEGs, especially the activity-dependent cytoskeletal protein (Arc) and the early growth response gene-1 (Egr-1), appear to be highly correlated with sensory-evoked neuronal activity...
  28. Pastuzyn E, Chapman D, Wilcox K, Keefe K. Altered learning and Arc-regulated consolidation of learning in striatum by methamphetamine-induced neurotoxicity. Neuropsychopharmacology. 2012;37:885-95 pubmed publisher
    ..previously shown and now further show that the positive correlation between expression of the immediate-early gene Arc (activity-regulated, cytoskeleton-associated) in the dorsomedial (DM) striatum and learning on a response reversal ..
  29. Lonergan M, Gafford G, Jarome T, Helmstetter F. Time-dependent expression of Arc and zif268 after acquisition of fear conditioning. Neural Plast. 2010;2010:139891 pubmed publisher
    Memory consolidation requires transcription and translation of new protein. Arc, an effector immediate early gene, and zif268, a regulatory transcription factor, have been implicated in synaptic plasticity underlying learning and memory...
  30. Teber I, Köhling R, Speckmann E, Barnekow A, Kremerskothen J. Muscarinic acetylcholine receptor stimulation induces expression of the activity-regulated cytoskeleton-associated gene (ARC). Brain Res Mol Brain Res. 2004;121:131-6 pubmed
    ..transduction pathway coupling mAChR activation to induction of the activity-regulated cytoskeleton-associated gene (ARC) was examined...
  31. Kim S, Thompson R. c-Fos, Arc, and stargazin expression in rat eyeblink conditioning. Behav Neurosci. 2011;125:117-23 pubmed publisher
    ..A significant increase in Stargazin expression was also identified in the whole cerebellum. These preliminary findings document possible molecular mechanisms underlying the establishment of memory in the mammalian cerebellum. ..
  32. Lv X, Xu Y, Han J, Cui C. Expression of activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) in the nucleus accumbens is critical for the acquisition, expression and reinstatement of morphine-induced conditioned place preference. Behav Brain Res. 2011;223:182-91 pubmed publisher
    Activity-regulated cytoskeleton-associated protein (Arc), also known as activity-regulated gene 3.1 (Arg3...
  33. Zheng F, Luo Y, Wang H. Regulation of brain-derived neurotrophic factor-mediated transcription of the immediate early gene Arc by intracellular calcium and calmodulin. J Neurosci Res. 2009;87:380-92 pubmed publisher
    The induction of the immediate early gene Arc is strongly implicated in synaptic plasticity. Although the role of ERK has been demonstrated, the regulation of Arc expression is largely unknown...
  34. Holloway C, McIntyre C. Post-training disruption of Arc protein expression in the anterior cingulate cortex impairs long-term memory for inhibitory avoidance training. Neurobiol Learn Mem. 2011;95:425-32 pubmed publisher
    The activity-regulated-cytoskeletal-associated protein (Arc) has a well established role in memory consolidation and synaptic plasticity in the hippocampus and amygdala...
  35. Pei Q, Zetterström T, Sprakes M, Tordera R, Sharp T. Antidepressant drug treatment induces Arc gene expression in the rat brain. Neuroscience. 2003;121:975-82 pubmed
    ..b>Arc (Activity-regulated, cytoskeletal-associated protein) is an effector immediate early gene implicated in LTP and ..
  36. Gine E, Echeverry Alzate V, Lopez Moreno J, López Jiménez A, Torres Romero D, Perez Castillo A, et al. Developmentally-induced hypothyroidism alters the expression of Egr-1 and Arc genes and the sensitivity to cannabinoid agonists in the hippocampus. Possible implications for memory and learning. Mol Cell Endocrinol. 2013;365:119-28 pubmed publisher
    ..All these data suggest that the hippocampal deregulation of early genes expression could play an important role in the basal cognitive deficits of hypothyroid rats. ..
  37. Figge D, Rahman I, Dougherty P, Rademacher D. Retrieval of contextual memories increases activity-regulated cytoskeleton-associated protein in the amygdala and hippocampus. Brain Struct Funct. 2013;218:1177-96 pubmed publisher
    Activity-regulated cytoskeleton-associated protein (Arc) integrates information from multiple intracellular signaling cascades and, in turn, regulates cytoskeletal proteins involved in structural synaptic modifications...
  38. Chamniansawat S, Chongthammakun S. Estrogen stimulates activity-regulated cytoskeleton associated protein (Arc) expression via the MAPK- and PI-3K-dependent pathways in SH-SY5Y cells. Neurosci Lett. 2009;452:130-5 pubmed publisher
    Activity-regulated cytoskeleton associated protein (Arc) is known to be induced by synaptic plasticity following memory consolidation...
  39. Daberkow D, Riedy M, Kesner R, Keefe K. Arc mRNA induction in striatal efferent neurons associated with response learning. Eur J Neurosci. 2007;26:228-41 pubmed
    ..Activity-regulated, cytoskeleton-associated (Arc) protein is an effector immediate-early gene implicated in synaptic plasticity...
  40. Fletcher B, Baxter M, Guzowski J, Shapiro M, Rapp P. Selective cholinergic depletion of the hippocampus spares both behaviorally induced Arc transcription and spatial learning and memory. Hippocampus. 2007;17:227-34 pubmed
    ..and plasticity are compromised by fornix lesions, behaviorally induced expression of the immediate early gene, Arc, is correspondingly low...
  41. Pastuzyn E, Day C, Kearns R, Kyrke Smith M, Taibi A, McCormick J, et al. The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer. Cell. 2018;172:275-288.e18 pubmed publisher
    The neuronal gene Arc is essential for long-lasting information storage in the mammalian brain, mediates various forms of synaptic plasticity, and has been implicated in neurodevelopmental disorders...
  42. Haugan F, Wibrand K, Fiska A, Bramham C, Tjølsen A. Stability of long term facilitation and expression of zif268 and Arc in the spinal cord dorsal horn is modulated by conditioning stimulation within the physiological frequency range of primary afferent fibers. Neuroscience. 2008;154:1568-75 pubmed publisher
    ..responses of wide dynamic range neurons and the expression of immediate early genes (c-fos, zif268, and Arc) in anesthetized rats...
  43. Maddox S, Schafe G. The activity-regulated cytoskeletal-associated protein (Arc/Arg3.1) is required for reconsolidation of a Pavlovian fear memory. J Neurosci. 2011;31:7073-82 pubmed publisher
    The activity-regulated cytoskeletal-associated protein (Arc/Arg3...
  44. Lacor P, Buniel M, Chang L, Fernandez S, Gong Y, Viola K, et al. Synaptic targeting by Alzheimer's-related amyloid beta oligomers. J Neurosci. 2004;24:10191-200 pubmed
    ..Synaptic binding was accompanied by ectopic induction of Arc, a synaptic immediate-early gene, the overexpression of which has been linked to dysfunctional learning...
  45. Banerjee P, Aston J, Khundakar A, Zetterstrom T. Differential regulation of psychostimulant-induced gene expression of brain derived neurotrophic factor and the immediate-early gene Arc in the juvenile and adult brain. Eur J Neurosci. 2009;29:465-76 pubmed publisher
    ..factor (bdnf) and the effector immediate early gene activity-regulated, cytoskeletal-associated protein (Arc), was examined in both juvenile and adult rats. Both MPH [2 mg/kg, intraperitoneal (i.p.)] and AMPH (0.5 mg/kg, i.p...
  46. Caffino L, Giannotti G, Malpighi C, Racagni G, Filip M, Fumagalli F. Long-term abstinence from developmental cocaine exposure alters Arc/Arg3.1 modulation in the rat medial prefrontal cortex. Neurotox Res. 2014;26:299-306 pubmed publisher
    ..developmental exposure to cocaine results in increased Activity-Regulated Cytoskeletal-associated protein (Arc/Arg3.1) expression in the crude synaptosomal fraction (Giannotti et al...
  47. Marrone D, Satvat E, Shaner M, Worley P, Barnes C. Attenuated long-term Arc expression in the aged fascia dentata. Neurobiol Aging. 2012;33:979-90 pubmed publisher
    ..The immediate early gene Arc, which is implicated in both durable memory and synaptic plasticity, is expressed in the fascia dentata (FD) for ..
  48. Rosi S, Ramirez Amaya V, Vazdarjanova A, Worley P, Barnes C, Wenk G. Neuroinflammation alters the hippocampal pattern of behaviorally induced Arc expression. J Neurosci. 2005;25:723-31 pubmed
    ..associated with learning and memory, we studied the expression of the activity-induced immediate early gene Arc in the hippocampus of rats with experimental neuroinflammation...
  49. Panford Walsh R, Singer W, Ruttiger L, Hadjab S, Tan J, Geisler H, et al. Midazolam reverses salicylate-induced changes in brain-derived neurotrophic factor and arg3.1 expression: implications for tinnitus perception and auditory plasticity. Mol Pharmacol. 2008;74:595-604 pubmed publisher
    ..Brain-derived neurotrophic factor (BDNF), the activity-dependent cytoskeletal protein (Arg3.1, also known as Arc), and c-Fos are known to be affected by changes in excitability and plasticity...
  50. Farris S, Lewandowski G, Cox C, Steward O. Selective localization of arc mRNA in dendrites involves activity- and translation-dependent mRNA degradation. J Neurosci. 2014;34:4481-93 pubmed publisher
    b>Arc is an immediate early gene that is unique among neuronal mRNAs because its transcripts are transported into dendrites and accumulate near activated synapses, presumably to be translated locally...
  51. Peng F, Yao H, Bai X, Zhu X, Reiner B, Beazely M, et al. Platelet-derived growth factor-mediated induction of the synaptic plasticity gene Arc/Arg3.1. J Biol Chem. 2010;285:21615-24 pubmed publisher
    ..In the present study we demonstrated that in the rat hippocampal neurons PDGF regulated the expression of Arc/Arg3.1 gene that has been implicated in both synapse plasticity and long term potentiation...
  52. Liu D, Bei D, Parmar H, Matus A. Activity-regulated, cytoskeleton-associated protein (Arc) is essential for visceral endoderm organization during early embryogenesis. Mech Dev. 2000;92:207-15 pubmed
    Activity-regulated, cytoskeleton-associated protein (Arc) was first identified as an immediate-early gene regulated by synaptic activity. We have studied its functional role in vivo using a gene-targeting approach...
  53. El Sayed M, Hofman Bang J, Mikkelsen J. Effect of brain-derived neurotrophic factor on activity-regulated cytoskeleton-associated protein gene expression in primary frontal cortical neurons. Comparison with NMDA and AMPA. Eur J Pharmacol. 2011;660:351-7 pubmed publisher
    The effect of brain-derived neurotrophic factor (BDNF) on activity-regulated cytoskeleton-associated protein (Arc) mRNA levels in primary neuronal cultures of rat frontal cortex was characterized pharmacologically and compared to the ..
  54. Martinez M, Alen N, Ballarini F, Moncada D, Viola H. Memory traces compete under regimes of limited Arc protein synthesis: implications for memory interference. Neurobiol Learn Mem. 2012;98:165-73 pubmed publisher
    ..Furthermore, infusing Arc antisense oligonucleotide into the dorsal hippocampus, we found that Arc is necessary for LTM formation of these ..
  55. Fukuchi M, Nakashima F, Tabuchi A, Shimotori M, Tatsumi S, Okuno H, et al. Class I histone deacetylase-mediated repression of the proximal promoter of the activity-regulated cytoskeleton-associated protein gene regulates its response to brain-derived neurotrophic factor. J Biol Chem. 2015;290:6825-36 pubmed publisher
    We examined the transcriptional regulation of the activity-regulated cytoskeleton-associated protein gene (Arc), focusing on BDNF-induced Arc expression in cultured rat cortical cells...
  56. Matsuoka M, Yoshida Matsuoka J, Sugiura H, Yamagata K, Ichikawa M, Norita M. Mating behavior induces differential Arc expression in the main and accessory olfactory bulbs of adult rats. Neurosci Lett. 2002;335:111-4 pubmed
    The expression of activity-related cytoskeleton-associated protein, Arc, could be useful as a marker for neuronal activity...
  57. Khodadad A, Adelson P, Lifshitz J, Thomas T. The time course of activity-regulated cytoskeletal (ARC) gene and protein expression in the whisker-barrel circuit using two paradigms of whisker stimulation. Behav Brain Res. 2015;284:249-56 pubmed publisher
    ..To this end, we investigated the dynamics of ARC transcription in adult male rats during whisker somatosensation throughout the whisker barrel circuit...
  58. Na Y, Park S, Lee C, Kim D, Park J, Sockanathan S, et al. Real-Time Imaging Reveals Properties of Glutamate-Induced Arc/Arg 3.1 Translation in Neuronal Dendrites. Neuron. 2016;91:561-73 pubmed publisher
    The immediate early gene Arc (also Arg3.1) produces rapid changes in synaptic properties that are linked to de novo translation...
  59. Irie Y, Yamagata K, Gan Y, Miyamoto K, Do E, Kuo C, et al. Molecular cloning and characterization of Amida, a novel protein which interacts with a neuron-specific immediate early gene product arc, contains novel nuclear localization signals, and causes cell death in cultured cells. J Biol Chem. 2000;275:2647-53 pubmed
    Amida was isolated by the yeast two-hybrid system as a novel protein which associated with Arc, a non-transcriptional immediate early gene specific to the brain. Amida was confirmed to be associated with Arc in vitro and in vivo...
  60. Hosp J, Mann S, Wegenast Braun B, Calhoun M, Luft A. Region and task-specific activation of Arc in primary motor cortex of rats following motor skill learning. Neuroscience. 2013;250:557-64 pubmed publisher
    ..Here, we show that the immediate early gene Arc/Arg3.1 is specifically induced in M1 by learning a motor skill...
  61. Caffino L, Racagni G, Fumagalli F. Stress and cocaine interact to modulate Arc/Arg3.1 expression in rat brain. Psychopharmacology (Berl). 2011;218:241-8 pubmed publisher
    ..b>arc/arg3...
  62. Zhang P, Wang F, Liu Q, Xu W, Qi J, Liu Z, et al. [mRNA expression of activity-regulated cytoskeletal-associated protein in hippocampus induced by insular-kindled rats]. Zhonghua Yi Xue Za Zhi. 2010;90:2782-6 pubmed
    To investigate the expression of Arc mRNA in insular electrical kindled and single electrical stimulated rats and its significance...
  63. Dynes J, Steward O. Arc mRNA docks precisely at the base of individual dendritic spines indicating the existence of a specialized microdomain for synapse-specific mRNA translation. J Comp Neurol. 2012;520:3105-19 pubmed
    b>Arc (aka Arg 3.1) is induced by neural activity and learning experience. Arc mRNA is rapidly exported into dendrites where it localizes near activated synapses...
  64. Quinn R, Brown A, Goldie B, Levi E, Dickson P, Smith D, et al. Distinct miRNA expression in dorsal striatal subregions is associated with risk for addiction in rats. Transl Psychiatry. 2015;5:e503 pubmed publisher
    ..Notable was the strong reduction in expression for activity-regulated cytoskeleton-associated protein (Arc) considered a master regulator of synaptic plasticity...
  65. Pandey S, Zhang H, Ugale R, Prakash A, Xu T, Misra K. Effector immediate-early gene arc in the amygdala plays a critical role in alcoholism. J Neurosci. 2008;28:2589-600 pubmed publisher
    The immediate early gene, activity-regulated cytoskeleton-associated protein (Arc), has been implicated in synaptic plasticity. However, the role of Arc in alcoholism is unknown...
  66. Kumar V, Fahey P, Jong Y, Ramanan N, O Malley K. Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein. J Biol Chem. 2012;287:5412-25 pubmed publisher
    ..up-regulates genes involved in synaptic plasticity including activity-regulated cytoskeletal-associated protein (Arc/Arg3.1)...
  67. Stoss O, Schwaiger F, Cooper T, Stamm S. Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c. J Biol Chem. 1999;274:10951-62 pubmed
    ..Overexpression of Nop30 changes alternative exon usage in preprotachykinin and SRp20 reporter genes, suggesting that Nop30 influences alternative splice site selection in vivo. ..
  68. You C, Zhang H, Sakharkar A, Teppen T, Pandey S. Reversal of deficits in dendritic spines, BDNF and Arc expression in the amygdala during alcohol dependence by HDAC inhibitor treatment. Int J Neuropsychopharmacol. 2014;17:313-22 pubmed publisher
    ..and decreased brain-derived neurotrophic factor (BDNF) and activity-regulated cytoskeleton-associated protein (Arc) gene expression in the amygdala...
  69. Dyrvig M, Hansen H, Christiansen S, Woldbye D, Mikkelsen J, Lichota J. Epigenetic regulation of Arc and c-Fos in the hippocampus after acute electroconvulsive stimulation in the rat. Brain Res Bull. 2012;88:507-13 pubmed publisher
    ..looked at epigenetic regulation of two important immediate early genes that are both induced after ECS: c-Fos and Arc. We examined Arc and c-Fos protein expression and found Arc present over 4 h, in contrast to c-Fos presence lasting ..
  70. Li P, Li J, Müller E, Otto A, Dietz R, von Harsdorf R. Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC. Mol Cell. 2002;10:247-58 pubmed
    ..Here we report that the function of ARC is regulated by protein kinase CK2. ARC at threonine 149 is phosphorylated by CK2...
  71. Kuipers S, Tiron A, Soule J, Messaoudi E, Trentani A, Bramham C. Selective survival and maturation of adult-born dentate granule cells expressing the immediate early gene Arc/Arg3.1. PLoS ONE. 2009;4:e4885 pubmed publisher
    ..high-frequency stimulation (HFS) of the perforant path input elicits robust expression of the immediate early gene Arc/Arg3...
  72. Wang W, Ju Y, Zhou Q, Tang J, Li M, Zhang L, et al. The Small GTPase Rac1 Contributes to Extinction of Aversive Memories of Drug Withdrawal by Facilitating GABAA Receptor Endocytosis in the vmPFC. J Neurosci. 2017;37:7096-7110 pubmed publisher
    ..endocytosis via triggering synaptic translocation of activity-regulated cytoskeleton-associated protein (Arc) through facilitating actin polymerization...
  73. Fujiyama K, Kajii Y, Hiraoka S, Nishikawa T. Differential regulation by stimulants of neocortical expression of mrt1, arc, and homer1a mRNA in the rats treated with repeated methamphetamine. Synapse. 2003;49:143-9 pubmed
    ..In contrast, the basal expression of other stimulant-inducible and plasticity-related genes arc and homer1a and the ability of MAP or cocaine challenge to augment the amounts of their transcripts were not ..
  74. Fujimoto T, Tanaka H, Kumamaru E, Okamura K, Miki N. Arc interacts with microtubules/microtubule-associated protein 2 and attenuates microtubule-associated protein 2 immunoreactivity in the dendrites. J Neurosci Res. 2004;76:51-63 pubmed
    b>Arc, activity-regulated cytoskeleton-associated gene, is an immediate early gene, and its expression is regulated by a variety of stimuli, such as electric stimulation and methamphetamine. The function of Arc, however, is unknown...
  75. Gusev P, Cui C, Alkon D, Gubin A. Topography of Arc/Arg3.1 mRNA expression in the dorsal and ventral hippocampus induced by recent and remote spatial memory recall: dissociation of CA3 and CA1 activation. J Neurosci. 2005;25:9384-97 pubmed
    ..To address these questions, we mapped the expression of Arc/Arg 3...
  76. Szyndler J, Maciejak P, Wisłowska Stanek A, Lehner M, Płaźnik A. Changes in the Egr1 and Arc expression in brain structures of pentylenetetrazole-kindled rats. Pharmacol Rep. 2013;65:368-78 pubmed
    ..Some of immediate early genes (IEGs) as egr1 (zif268) or arc (arg3.1) are believed to play an important role in the process of epileptogenesis...
  77. Inberg S, Elkobi A, Edri E, Rosenblum K. Taste familiarity is inversely correlated with Arc/Arg3.1 hemispheric lateralization. J Neurosci. 2013;33:11734-43 pubmed publisher
    ..Here, we compared activity regulated cytoskeleton associated protein (Arc)/Arg3...
  78. Akiyama K, Ishikawa M, Saito A. mRNA expression of activity-regulated cytoskeleton-associated protein (arc) in the amygdala-kindled rats. Brain Res. 2008;1189:236-46 pubmed
    Activity-regulated cytoskeleton-associated protein (arc) is an immediate early gene (IEG) whose mRNA is targeted to dendrites of activated synapses...
  79. Wibrand K, Pai B, Siripornmongcolchai T, Bittins M, Berentsen B, Ofte M, et al. MicroRNA regulation of the synaptic plasticity-related gene Arc. PLoS ONE. 2012;7:e41688 pubmed publisher
    Expression of activity-regulated cytoskeleton associated protein (Arc) is crucial for diverse types of experience-dependent synaptic plasticity and long-term memory in mammals...