Ar

Summary

Gene Symbol: Ar
Description: androgen receptor
Alias: Andr, Tfm, androgen receptor, androgen receptor (Testicular feminization), same as Tfm, dihydrotestosterone receptor, nuclear receptor subfamily 3 group C member 4
Species: rat

Top Publications

  1. ncbi Dominant expression of androgen receptors and their functional regulation of organic anion transporter 3 in rat brain capillary endothelial cells; comparison of gene expression between the blood-brain and -retinal barriers
    Sumio Ohtsuki
    Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Sendai, Japan
    J Cell Physiol 204:896-900. 2005
  2. ncbi Association of repeat polymorphisms in the estrogen receptors alpha, beta, and androgen receptor genes with knee osteoarthritis
    P Fytili
    Department of Orthopedics, Medical School, University of Thessaly, Universit Hospital of Larissa, Larissa, Greece
    Clin Genet 68:268-77. 2005
  3. pmc Deletion of the steroid-binding domain of the human androgen receptor gene in one family with complete androgen insensitivity syndrome: evidence for further genetic heterogeneity in this syndrome
    T R Brown
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 85:8151-5. 1988
  4. ncbi Androgen receptor antagonist suppresses exercise-induced hypertrophy of skeletal muscle
    K Inoue
    Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Japan
    Eur J Appl Physiol Occup Physiol 69:88-91. 1994
  5. ncbi A practical approach to the detection of androgen receptor gene mutations and pedigree analysis in families with x-linked androgen insensitivity
    C Ris-Stalpers
    Department of Endocrinology, Erasmus University Rotterdam, The Netherlands
    Pediatr Res 36:227-34. 1994
  6. pmc CREB-binding protein in androgen receptor-mediated signaling
    P Aarnisalo
    Department of Physiology, Institute of Biomedicine, University of Helsinki, P O Box 9, FIN 00014 Helsinki, Finland
    Proc Natl Acad Sci U S A 95:2122-7. 1998
  7. ncbi Dihydrotestosterone and estrogen regulation of rat brain androgen-receptor immunoreactivity
    C S Lynch
    Department of Psychology, University of Louisiana, P O Box 43131, Lafayette, LA 70504, USA
    Physiol Behav 69:445-53. 2000
  8. ncbi Abolition of hypertension-induced end-organ damage by androgen receptor blockade in transgenic rats harboring the mouse ren-2 gene
    Ovidiu Baltatu
    Max Delbrück Center for Molecular Medicine MDC, Berlin Buch, Germany
    J Am Soc Nephrol 13:2681-7. 2002
  9. ncbi BRCA2 mutations and androgen receptor expression as independent predictors of outcome of male breast cancer patients
    Eliza Kwiatkowska
    Department of Cancer Immunology, University of Medical Sciences, Great Poland Cancer Center, Poznan, Poland
    Clin Cancer Res 9:4452-9. 2003
  10. ncbi Bone anabolic effects of S-40503, a novel nonsteroidal selective androgen receptor modulator (SARM), in rat models of osteoporosis
    Keigo Hanada
    Central Research Laboratories, Kaken Pharmaceutical Co, Ltd, Shinomiya, Kyoto, Japan
    Biol Pharm Bull 26:1563-9. 2003

Research Grants

Scientific Experts

Detail Information

Publications122 found, 100 shown here

  1. ncbi Dominant expression of androgen receptors and their functional regulation of organic anion transporter 3 in rat brain capillary endothelial cells; comparison of gene expression between the blood-brain and -retinal barriers
    Sumio Ohtsuki
    Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Sendai, Japan
    J Cell Physiol 204:896-900. 2005
    ..selectively expressed at the blood-brain barrier (BBB) and to clarify the function of the selective gene, androgen receptor (AR)...
  2. ncbi Association of repeat polymorphisms in the estrogen receptors alpha, beta, and androgen receptor genes with knee osteoarthritis
    P Fytili
    Department of Orthopedics, Medical School, University of Thessaly, Universit Hospital of Larissa, Larissa, Greece
    Clin Genet 68:268-77. 2005
    ..the possible role of genetic variation in the estrogen receptors alpha and beta (ER-alpha, ER-beta) and androgen receptor (AR) genes with knee OA, the -1174(TA)(n), c.1092+3607(CA)(n), and c...
  3. pmc Deletion of the steroid-binding domain of the human androgen receptor gene in one family with complete androgen insensitivity syndrome: evidence for further genetic heterogeneity in this syndrome
    T R Brown
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 85:8151-5. 1988
    The cloning of a cDNA for the human androgen receptor gene has resulted in the availability of cDNA probes that span various parts of the gene, including the entire steroid-binding domain and part of the DNA-binding domain, as well as ..
  4. ncbi Androgen receptor antagonist suppresses exercise-induced hypertrophy of skeletal muscle
    K Inoue
    Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Japan
    Eur J Appl Physiol Occup Physiol 69:88-91. 1994
    ..gastrocnemius muscles by electrical stimulation every other day for 2 weeks, male rats were administered the androgen receptor antagonist, oxendolone...
  5. ncbi A practical approach to the detection of androgen receptor gene mutations and pedigree analysis in families with x-linked androgen insensitivity
    C Ris-Stalpers
    Department of Endocrinology, Erasmus University Rotterdam, The Netherlands
    Pediatr Res 36:227-34. 1994
    Androgen insensitivity syndrome (AIS) is an X-linked disorder in which defects in the androgen receptor gene have prevented the normal development of both internal and external male structures in 46,XY individuals...
  6. pmc CREB-binding protein in androgen receptor-mediated signaling
    P Aarnisalo
    Department of Physiology, Institute of Biomedicine, University of Helsinki, P O Box 9, FIN 00014 Helsinki, Finland
    Proc Natl Acad Sci U S A 95:2122-7. 1998
    ..CBP enhanced androgen receptor (AR)-dependent transcription under transient transfection conditions in CV-1 cells...
  7. ncbi Dihydrotestosterone and estrogen regulation of rat brain androgen-receptor immunoreactivity
    C S Lynch
    Department of Psychology, University of Louisiana, P O Box 43131, Lafayette, LA 70504, USA
    Physiol Behav 69:445-53. 2000
    ..As reported before, castration eliminated AR-ir (androgen-receptor immunoreactivity) and AAS upregulated AR-ir in the ventromedial hypothalamus (VMHVL), medial ..
  8. ncbi Abolition of hypertension-induced end-organ damage by androgen receptor blockade in transgenic rats harboring the mouse ren-2 gene
    Ovidiu Baltatu
    Max Delbrück Center for Molecular Medicine MDC, Berlin Buch, Germany
    J Am Soc Nephrol 13:2681-7. 2002
    ..Male TGR(mREN2)27 rats were treated with the androgen receptor antagonist Flutamide starting at 4 wk of age...
  9. ncbi BRCA2 mutations and androgen receptor expression as independent predictors of outcome of male breast cancer patients
    Eliza Kwiatkowska
    Department of Cancer Immunology, University of Medical Sciences, Great Poland Cancer Center, Poznan, Poland
    Clin Cancer Res 9:4452-9. 2003
    ..The purpose of the study was to investigate the prognostic value of BRCA2 status in male breast carcinoma (MBC)...
  10. ncbi Bone anabolic effects of S-40503, a novel nonsteroidal selective androgen receptor modulator (SARM), in rat models of osteoporosis
    Keigo Hanada
    Central Research Laboratories, Kaken Pharmaceutical Co, Ltd, Shinomiya, Kyoto, Japan
    Biol Pharm Bull 26:1563-9. 2003
    A novel nonsteroidal androgen receptor (AR) binder, S-40503, was successfully generated in order to develop selective androgen receptor modulators (SARMs)...
  11. ncbi A CAG repeat polymorphism in the androgen receptor gene is associated with reduced bone mass and increased risk of osteoporotic fractures
    B L Langdahl
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus Amtssygehus, DK 8000 Aarhus, Denmark
    Calcif Tissue Int 73:237-43. 2003
    ..The estrogen and androgen receptor genes are therefore strong candidates for mediating the genetic influence on bone mass and risk of ..
  12. pmc A selective androgen receptor modulator for hormonal male contraception
    Jiyun Chen
    College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    J Pharmacol Exp Ther 312:546-53. 2005
    The recent discovery of nonsteroidal selective androgen receptor modulators (SARMs) provides a promising alternative for testosterone replacement therapies, including hormonal male contraception...
  13. ncbi Gonadal effects of a mouse Denys-Drash syndrome mutation
    C E Patek
    Sir Alastair Currie Cancer Research UK Laboratories, Molecular Medicine Centre, Western General Hospital, Crewe Road, EH4 2XU Edinburgh, UK
    Transgenic Res 14:691-702. 2005
    ..Control XXY Sertoli cells showed immuno-expression of WT1 and androgen receptor (AR) indistinguishable from wild-type (40,XY), but expressed anti-Mullerian hormone (AMH)...
  14. ncbi Molecular chaperones throughout the life cycle of the androgen receptor
    Jennifer Prescott
    Department of Urology and Preventive Medicine, Norris Cancer Center, USC Keck School of Medicine, Los Angeles, CA 90089, USA
    Cancer Lett 231:12-9. 2006
    Aberrant signaling by the androgen receptor contributes to the initiation and progression of prostate cancer...
  15. ncbi [Study on the expression of androgen receptor in testis, epididymis and prostate of adult rats with diabetes]
    Su huan Liu
    Department of Cell Biology, School of Basic Medical Science, Jilin University, Changchun, Jilin 130021, China
    Zhonghua Nan Ke Xue 11:891-4. 2005
    To investigate if there is abnormal expression of androgen receptor (AR) in adult diabetic rats.
  16. doi Androgen receptor: a new player associated with apoptosis and proliferation of pancreatic beta-cell in type 1 diabetes mellitus
    Ru Jiang Li
    Department of Anatomy and Histo Embryology, Key Laboratory of Environment and Genes Related to Disease Ministry of Education, Medical School of Xi an Jiaotong University, No 76 Yanta West Road, Xi an, 710061, China
    Apoptosis 13:959-71. 2008
    b>Androgen receptor (AR) mediates a wide range of cellular processes, such as proliferation, differentiation and apoptosis...
  17. doi Alcoholism and coagulating gland: androgen and insulin like growth factor-1 receptor features
    Fábio Montico
    Department of Anatomy, Cellular Biology, Physiology and Biophysics, Institute of Biology, University of Campinas UNICAMP, Campinas, SP, Brazil
    Tissue Cell 42:203-10. 2010
    ..Intensed androgen receptor (AR) immunolocalization was verified in the epithelium and weak in the stroma of the control group in ..
  18. doi A novel Arg615Ser mutation of androgen receptor DNA-binding domain in three 46,XY sisters with complete androgen insensitivity syndrome and bilateral inguinal hernia
    Vikas Sharma
    Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Hyderabad, India
    Fertil Steril 95:804.e19-21. 2011
    ..To present clinical, genetic, biochemical, and molecular findings in a family with three sisters with complete androgen insensitivity syndrome (CAIS) and bilateral inguinal hernia...
  19. doi Blockade of androgen receptor in the medial amygdala inhibits noncontact erections in male rats
    Michal Bialy
    Department of Experimental and Clinical Physiology, Krakowskie Przedmiescie 26 28, The Medical University of Warsaw, 00 927 Warsaw, Poland
    Physiol Behav 103:295-301. 2011
    ..Furthermore, it is sensitive to relatively fast changes in the level of androgen receptors stimulation...
  20. doi Pharmacological doses of testosterone upregulated androgen receptor and 3-Beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase and impaired leydig cells steroidogenesis in adult rats
    Tatjana S Kostic
    Reproductive Endocrinology and Signaling Group, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, 21000 Novi Sad, Serbia
    Toxicol Sci 121:397-407. 2011
    ..Oppositely, the expression of Hsd3b (3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase), Ar (androgen receptor), and Pde4a/b (cyclic adenosine monophosphate-dependent phosphodiesterases) was increased...
  21. pmc Male rats with the testicular feminization mutation of the androgen receptor display elevated anxiety-related behavior and corticosterone response to mild stress
    Damian G Zuloaga
    Department of Psychology and Program in Neuroscience, 108 Giltner Hall, Michigan State University, East Lansing, MI 48824 1101, USA
    Horm Behav 60:380-8. 2011
    ..anxiety-related behavior, and sensorimotor gating in rodents, but little is known about the role of the androgen receptor (AR) in mediating these influences...
  22. doi Anti-androgenic effects of S-40542, a novel non-steroidal selective androgen receptor modulator (SARM) for the treatment of benign prostatic hyperplasia
    Hiroaki Nejishima
    Central Research Laboratories, Kaken Pharmaceutical Co, Ltd, Fujieda, Shizuoka, Japan
    Prostate 72:1580-7. 2012
    Selective androgen receptor modulators (SARMs) would provide alternative therapeutic agent for androgen-related diseases...
  23. doi Senescence and steroid hormone receptor reactivities in accessory sex glands of elderly rats (Sprague-Dawley) following exogenous hormonal therapy
    Eduardo Marcelo Cândido
    Department of Anatomy, Cellular Biology, Physiology and Biophysics, Institute of Biology, State University of Campinas UNICAMP, Campinas, PO Box 6109, Sao Paulo, Brazil
    Tissue Cell 44:227-37. 2012
    The aim of this study was to characterize the stromal and epithelial distribution of AR, ERα and ERβ reactivities in the different accessory sex glands of elderly rats and during strong hormonal changes...
  24. pmc Impact of lycopene on epididymal androgen and estrogen receptors' expression in polychlorinated biphenyls-exposed rat
    Manickavel Vinoth Raj
    1Department of Endocrinology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, Tamil Nadu, India
    Reprod Sci 21:89-101. 2014
    The aim of the study was to evaluate the androgen (AR) and estrogen receptors' (ER) expression in epididymis of polychlorinated biphenyls (PCBs)-exposed rats. The rats were assigned to groups...
  25. pmc The mutational landscape of prostate cancer
    Christopher E Barbieri
    Department of Urology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Eur Urol 64:567-76. 2013
    ..Molecular characterization has revealed striking mutational heterogeneity that may underlie the variable clinical course of the disease...
  26. doi Androgens increase survival of adult-born neurons in the dentate gyrus by an androgen receptor-dependent mechanism in male rats
    D K Hamson
    Department of Psychology, University of British Columbia, Vancouver V6T 1Z4, British Columbia, Canada
    Endocrinology 154:3294-304. 2013
    ..These results suggest androgens regulate hippocampal neurogenesis via the androgen receptor (AR)...
  27. doi A novel selective androgen receptor modulator, NEP28, is efficacious in muscle and brain without serious side effects on prostate
    Kazumasa Akita
    Environmental Health Science Laboratory, Sumitomo Chemical Co, Ltd, Osaka, Japan Electronic address
    Eur J Pharmacol 720:107-14. 2013
    ..However, androgen therapy is not used routinely for these indications, because of side effects. Selective androgen receptor modulators (SARMs) are a new class of compounds...
  28. doi Androgen insensitive male rats display increased anxiety-like behavior on the elevated plus maze
    Dwayne K Hamson
    Hormones and Behaviour Lab, Department of Psychology, Simon Fraser University, Canada Electronic address
    Behav Brain Res 259:158-63. 2014
    ..These data, in contrast to earlier reports, thus implicate androgen receptor-mediated functions in the expression of anxiety behaviors in male rats...
  29. ncbi A single low dose of cadmium exposure induces benign prostate hyperplasia like condition in rat: A novel benign prostate hyperplasia rodent model
    Akhilesh Prajapati
    Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat 390002, India
    Exp Biol Med (Maywood) 239:829-841. 2014
    ..and immunohistochemistry data suggest that Cd induces hyperplasia like condition by activating the androgen receptor and estrogen receptor-α and suppresses the action of estrogen receptor-β...
  30. pmc Androgen modulation of Foxp1 and Foxp2 in the developing rat brain: impact on sex specific vocalization
    J Michael Bowers
    Department of Pharmacology J M B, M P P, C R R, M M M, University of Maryland School of Medicine and Programs in Neuroscience M M M and Medicine T E R, University of Maryland School of Medicine, University of Maryland, Baltimore, Baltimore, Maryland 21201
    Endocrinology 155:4881-94. 2014
    ..Immunofluorescence microscopy and coimmunoprecipitation demonstrate Foxp2 and the androgen receptor protein interact...
  31. doi Blocking hyperactive androgen receptor signaling ameliorates cardiac and renal hypertrophy in Fabry mice
    Jin Song Shen
    Institute of Metabolic Disease, Baylor Research Institute, 3812 Elm Street, Dallas, TX 75226, USA
    Hum Mol Genet 24:3181-91. 2015
    ..We found increased activity of androgen receptor (AR) signaling in Fabry disease...
  32. doi Transient gestational and neonatal hypothyroidism-induced specific changes in androgen receptor expression in skeletal and cardiac muscles of adult rat
    K Annapoorna
    Department of Endocrinology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, TN, India
    Horm Metab Res 45:197-205. 2013
    ..Serum was collected for hormone assay. Androgen receptor status, Glu-4 expression, and enzyme activities were assessed in the skeletal and cardiac muscles...
  33. ncbi Association of the androgen receptor gene (AR) with ADHD and conduct disorder
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Neuroreport 10:1589-92. 1999
    ..Since the shorter alleles of the CAG and GGC polymorphisms of the AR gene are associated with increased gene expression we sought to determine whether they were also associated with ..
  34. pmc NF-kB overexpression and decreased immunoexpression of AR in the muscular layer is related to structural damages and apoptosis in cimetidine-treated rat vas deferens
    Juliana Y Koshimizu
    Department of Morphology, Laboratory of Histology and Embryology, Araraquara Dental School UNESP Univ, Estadual Paulista, Brazil
    Reprod Biol Endocrinol 11:29. 2013
    ..Either androgen or histamine H2 receptors have been detected in the mucosa and smooth muscular layer of vas deferens. Thus, the effect of cimetidine on this androgen and histamine-dependent muscular duct was morphologically evaluated...
  35. ncbi Cloning and functional characterization of a rat Daxx that functions as a corepressor for the androgen receptor
    Haruo Mizuta
    Department of Internal Medicine, Division of Neurology, Saga University, Faculty of Medicine, Saga 849 8501, Japan
    Cell Biol Int 28:609-14. 2004
    The androgen receptor (AR), a ligand-activated nuclear transcription factor, plays an important role in endocrine system development and homeostasis...
  36. ncbi Effects of prepubertal epididymal ligation on the androgen receptor distribution of the rat testis
    Fatih Mehmet Gur
    Sabiha Gokcen Airport Veterinary Border Inspection Post, Ministry of Food, Agriculture and Livestock, Pendik Istanbul
    Anal Quant Cytopathol Histpathol 34:317-24. 2012
    To investigate the effects of prepubertal epididymal obstruction on the androgen receptor (AR) distribution in the testis.
  37. ncbi A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat
    W G Yarbrough
    Laboratory for Reproductive Biology, University of North Carolina, Chapel Hill 27599
    J Biol Chem 265:8893-900. 1990
    ..syndrome in which genetic males fail to undergo masculinization in utero due to defective functioning of the androgen receptor (AR)...
  38. ncbi The rat androgen receptor: primary structure, autoregulation of its messenger ribonucleic acid, and immunocytochemical localization of the receptor protein
    J A Tan
    Laboratories for Reproductive Biology, University of North Carolina, Chapel Hill 27599
    Mol Endocrinol 2:1276-85. 1988
    A composite androgen receptor DNA sequence 4,181 base pairs in length was determined from three cDNA clones isolated from a rat epididymal bacteriophage lambda gt11 library...
  39. pmc Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription
    A M Moilanen
    Department of Physiology, Institute of Biomedicine, University of Helsinki, FIN 00014 Helsinki, Finland
    Mol Cell Biol 18:5128-39. 1998
    Using the DNA-binding domain of androgen receptor (AR) as a bait in a yeast two-hybrid screening, we have identified a small nuclear RING finger protein, termed SNURF, that interacts with AR in a hormone-dependent fashion in both yeast ..
  40. ncbi Developmental profiles of TSH, sex steroids, and their receptors in the thyroid and their relevance to thyroid growth in immature rats
    Sakhila K Banu
    Department of Endocrinology, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600 113, India
    Steroids 67:137-44. 2002
    ..This is the first report to show the availability of sex steroids and their receptors in the thyroid glands of immature rats under normal conditions...
  41. ncbi Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1
    Elin Holter
    Department of Biosciences at Novum, Karolinska Institute, S 14157 Huddinge, Sweden
    Mol Endocrinol 16:515-28. 2002
    ..In this study, we have identified the androgen receptor (AR) NR3C4 as a novel target for DAX-1...
  42. ncbi Liganded androgen receptor interaction with beta-catenin: nuclear co-localization and modulation of transcriptional activity in neuronal cells
    John E Pawlowski
    Research Service, Veterans Affairs Medical Center and Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80220, USA
    J Biol Chem 277:20702-10. 2002
    A yeast two-hybrid assay was employed to identify androgen receptor (AR) protein partners in gonadotropin-releasing hormone neuronal cells...
  43. ncbi DNA methylation in the androgen receptor gene promoter region in rat prostate cancers
    Satoru Takahashi
    First Department of Pathology, Nagoya City University Medical School, Mizuho cho, Mizuho ku, Nagoya, Japan
    Prostate 52:82-8. 2002
    ..DMAB) and testosterone propionate (TP) are biologically androgen-independent and lacking androgen receptor protein (AR) expression...
  44. pmc A novel steroid receptor co-activator protein (SRAP) as an alternative form of steroid receptor RNA-activator gene: expression in prostate cancer cells and enhancement of androgen receptor activity
    Hidenori Kawashima
    Department of Urology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abenoku, Osaka 545 8585, Japan
    Biochem J 369:163-71. 2003
    ..Glutathione S-transferase pull-down assays showed that SRAP associates with the partial androgen receptor (AR) protein composed of a DNA-binding domain and an activation function 2...
  45. ncbi Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila
    Ken ichi Takeyama
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, Japan
    Neuron 35:855-64. 2002
    ..only males and is caused by expanded polyglutamine (polyQ) stretches in the N-terminal A/B domain of human androgen receptor (hAR)...
  46. ncbi Androgen receptor length polymorphism associated with prostate cancer risk in Hispanic men
    Ivana Balic
    Department of Cellular and Structural Biology, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA
    J Urol 168:2245-8. 2002
    The transcriptional activation domain of the androgen receptor gene includes a CAG repeat length polymorphism. A smaller number of repeats is reported to increase the risk of prostate cancer...
  47. ncbi Testosterone and estradiol up-regulate androgen and estrogen receptors in immature and adult rat thyroid glands in vivo
    Sakhila K Banu
    Department of Endocrinology, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Chennai Taramani 600113, India
    Steroids 67:1007-14. 2002
    ..Gonadectomy significantly decreased serum and thyroidal testosterone and estradiol and concentrations of androgen receptor (AR) and estrogen receptor (ER) in the thyroid...
  48. ncbi Androgen receptor (AR) gene microsatellite polymorphism in postmenopausal women: correlation to bone mineral density and susceptibility to osteoporosis
    Huey Yi Chen
    Department of Obstetrics and Gynaecology, China Medical College Hospital, School of Medicine, Taichung, Taiwan
    Eur J Obstet Gynecol Reprod Biol 107:52-6. 2003
    To investigate the correlation of the androgen receptor gene microsatellite polymorphism (CAG trinucleotide repeat polymorphism on exon 1) with bone mineral density and their relationship to osteoporosis in postmenopausal women.
  49. pmc Isolation and identification of L-dopa decarboxylase as a protein that binds to and enhances transcriptional activity of the androgen receptor using the repressed transactivator yeast two-hybrid system
    Latif A Wafa
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
    Biochem J 375:373-83. 2003
    The AR (androgen receptor) is a ligand-regulated transcription factor, which belongs to the steroid receptor family and plays an essential role in growth and development of the prostate...
  50. ncbi Androgen receptor expression in the developing male and female rat visual and prefrontal cortex
    J L Nunez
    Neuroscience Program and Department of Psychology, University of Illinois, Champaign, Illinois 61820, USA
    J Neurobiol 56:293-302. 2003
    ..primary visual cortex (Oc1) and the anterior cingulate/frontal cortex (Cg1/Fr2); and to determine whether androgen receptor (AR) expression in these regions differs between developing males and females...
  51. ncbi Regulation of androgen receptor expression at the onset of functional overload in rat plantaris muscle
    Won Jun Lee
    Univ of South Carolina, Dept of Exercise Science, 1300 Wheat St, Columbia SC 29208, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1076-85. 2003
    Skeletal muscle androgen receptor (AR) expression at the onset of functional overload (OV) has not been well described. It is also not known if overload and/or anabolic steroid differentially regulate AR expression...
  52. ncbi Androgen receptor and calcitonin gene-related peptide in neurons of the genitofemoral nerve during testicular descent induced with human chorionic gonadotropin
    Rosa Maria Vigueras
    Departamento de Biologia Celular y Fisiologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    Arch Med Res 34:166-70. 2003
    ..Treatment with human chorionic gonadotrophin (hCG) induces testis descent by stimulating production of testosterone (T). Neurons of genitofemoral nerve (GFN), which innervate testicular gubernaculum, may play a role in testis descent...
  53. ncbi Nuclear factor-kappaB activates transcription of the androgen receptor gene in Sertoli cells isolated from testes of adult rats
    Liying Zhang
    Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Room W3606, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Endocrinology 145:781-9. 2004
    The androgen receptor (AR) in Sertoli cells mediates the actions of testosterone on spermatogenesis. However, the transcription factors responsible for AR gene regulation in Sertoli cells remain unknown...
  54. ncbi Agonist-antagonist induced coactivator and corepressor interplay on the human androgen receptor
    Helmut Dotzlaw
    Genetic Institute, Justus Liebig University, Heinrich Buff Ring 58 62, D 35392 Giessen, Germany
    Mol Cell Endocrinol 213:79-85. 2003
    The human androgen receptor (AR) is a member of the nuclear hormone receptor superfamily. However, in contrast to other members of this family the amino-(N)-terminus of AR harbors the major transactivation function...
  55. ncbi Androgen receptor gene cytosine, adenine, and guanine trinucleotide repeats in patients with endometriosis
    Debora Lattuada
    Molecular Biology Laboratory Istituto Auxologico Italiano, Milan, Italy
    J Soc Gynecol Investig 11:237-40. 2004
    A genetic variation in the androgen receptor (AR) has been associated with the risk of developing endometriosis...
  56. ncbi Targeted overexpression of androgen receptor in osteoblasts: unexpected complex bone phenotype in growing animals
    Kristine M Wiren
    Base and Mineral Research Unit, Portland Veterans Affairs Medical Center P3 R and D39, 3710 Southwest Veterans Hospital Road, Portland, Oregon 97239, USA
    Endocrinology 145:3507-22. 2004
    The androgen receptor (AR), as a classic steroid receptor, generally mediates biologic responses to androgens. In bone tissue, both AR and the estrogen receptor (ER) are expressed in a variety of cell types...
  57. ncbi Linkage between cryptorchidism, hypospadias, and GGN repeat length in the androgen receptor gene
    Elin L Aschim
    Andrology Laboratory, Department of Gynaecology and Obstetrics, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    J Clin Endocrinol Metab 89:5105-9. 2004
    Although sufficient androgen receptor (AR) function is crucial for normal male sexual differentiation, single-point mutations in the AR gene are infrequent in the two most common male congenital malformations, hypospadias and ..
  58. ncbi Absence of a correlation of androgen receptor gene CAG repeat length and prostate cancer risk in an African-American population
    Timothy Gilligan
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Clin Prostate Cancer 3:98-103. 2004
    Shorter androgen receptor gene CAG repeat length has been associated with an increased risk of prostate cancer, an earlier age of onset, and more advanced stage of disease...
  59. ncbi Ultrastructural evidence that androgen receptors are located at extranuclear sites in the rat hippocampal formation
    N E Tabori
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 411 East 69th Street, New York, NY 10021, USA
    Neuroscience 130:151-63. 2005
    ..By light microscopy, AR immunoreactivity (-ir) was found in CA1 pyramidal cell nuclei and in disperse, punctate processes that were most ..
  60. ncbi Androgen, estrogen, and progesterone receptor gene regulation during diabetic erectile dysfunction and insulin treatment
    Masato Shirai
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, School of Medicine, San Francisco, California 94121, USA
    Urology 64:1244-9. 2004
    ..Insulin treatment can restore erectile function through modulation of sex hormone receptor genes...
  61. pmc Androgen receptor trinucleotide polymorphism in leiomyoma
    Yao Yuan Hsieh
    Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan
    J Assist Reprod Genet 21:453-7. 2004
    b>Androgen receptor (AR) was detected in leiomyoma. AR gene has a polymorphic microsatellite encoding cytosine, adenine, and guanine (CAG) repeats. We aimed to investigate the association between the AR gene CAG repeats and leiomyoma.
  62. ncbi GGC and StuI polymorphism on the androgen receptor gene in endometrial cancer patients
    Masahiro Sasaki
    Department of Urology, University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, CA, USA
    Biochem Biophys Res Commun 329:100-4. 2005
    Androgens have an anti-proliferative effect on endometrial cells. Human androgen receptor (AR) gene contains two polymorphic short tandem repeats of GGC and CAG, and a single-nucleotide polymorphism on exon 1 that is recognized by the ..
  63. ncbi Spatial memory performance in androgen insensitive male rats
    Bryan A Jones
    Hormones and Behaviour Laboratory, Department of Psychology, Simon Fraser University, Burnaby, BC, Canada V5A 1S6
    Physiol Behav 85:135-41. 2005
    ..A novel way of examining this is through the study of male rats that express the tfm mutation of the androgen receptor (AR) gene; such males are fully androgen insensitive and manifest a female phenotype due to a failure of AR-..
  64. ncbi Androgen receptor gene CAG length polymorphism in women with polycystic ovary syndrome
    Jarmo Jääskeläinen
    Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland
    Fertil Steril 83:1724-8. 2005
    To determine whether the CAG repeat length of the androgen receptor (AR) gene contributes to individual differences in the susceptibility to the development of polycystic ovary syndrome (PCOS).
  65. ncbi Immunohistochemical study of androgen receptors in breast carcinoma. Evidence of their frequent expression in lobular carcinoma
    Cristina Riva
    Department of Human Morphology, Section of Pathology, University of Insubria, Varese, Italy
    Virchows Arch 447:695-700. 2005
    Androgens and androgen receptors (AR) are involved in the pathogenesis of breast cancer. Epidemiological studies have shown a significant association between the risk of breast cancer and androgens...
  66. ncbi The androgen receptor CAG repeat modifies the impact of testosterone on insulin resistance in women with polycystic ovary syndrome
    Matthias Mohlig
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Berlin, Germany
    Eur J Endocrinol 155:127-30. 2006
    ..Androgens act through the androgen receptor (AR)...
  67. ncbi Neuronal differentiation of PC12 cells abolishes the expression of membrane androgen receptors
    Vassilia Ismini Alexaki
    Laboratories of Experimental Endocrinology, University of Crete, School of Medicine, P O Box 2208, Heraklion 71003, Greece
    Exp Cell Res 312:2745-56. 2006
    ..In the present work, we have examined the expression and functional significance of membrane androgen receptor sites in normal rat adrenal chromaffin cells and in the PC12 rat pheochromocytoma cell line which can ..
  68. ncbi Expression of androgen receptor and 3beta-hydroxysteroid dehydrogenase in corpora lutea during pregnancy in the rat
    M Szołtys
    Laboratory of Endocrinology and Tissue Culture, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Reprod Fertil Dev 19:356-65. 2007
    Immunoexpression of androgen receptor (AR) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD) was investigated in three generations of corpora lutea (CLs), found in the ovaries of rats on Days 1, 2, 5, 9, 14 and 20 of pregnancy...
  69. ncbi Chronic testosterone treatment induces selective insulin resistance in subcutaneous adipocytes of women
    A Corbould
    Prince Henry s Institute of Medical Research, Monash Medical Centre, Block E, Level 4, Clayton Road, Clayton, Victoria 3168, Australia
    J Endocrinol 192:585-94. 2007
    ..of healthy women aged 37 +/- 5 years were differentiated in vitro, then treated with testosterone (T) and/or androgen receptor (AR) antagonists (cyproterone acetate, flutamide) for 48 h...
  70. ncbi Experimental arterial thrombosis regulated by androgen and its receptor via modulation of platelet activation
    Shijun Li
    Division of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People s Republic of China
    Thromb Res 121:127-34. 2007
    ..The aim of our study is to elucidate whether experimental arterial thrombosis is regulated by physiological doses of androgen and its receptor via modulation of platelet activation...
  71. ncbi FoxG1, a member of the forkhead family, is a corepressor of the androgen receptor
    Maik Obendorf
    Schering AG Jenapharm GmbH and Co KG, CRBA G and A, Otto Schott Str 15, D 07745 Jena, Germany
    J Steroid Biochem Mol Biol 104:195-207. 2007
    The androgen receptor (AR) is a ligand-dependent transcriptional regulator which belongs to the nuclear receptor superfamily...
  72. ncbi Expression of androgen receptor and two androgen-induced proteins (apolipoprotein D and pepsinogen C) in ductal carcinoma in situ of the breast
    L O Gonzalez
    Instituto Universitario de Oncologí, a del Principado de Asturias, Hospital de Jove, Gijon, Spain
    Histopathology 50:866-74. 2007
    To evaluate the expression of androgen receptors (AR) and two androgen-induced proteins [apolipoprotein D (ApoD) and pepsinogen C (PepC)] in ductal carcinoma in situ (DCIS) of the breast.
  73. ncbi Androgen signaling and its interactions with other signaling pathways in prostate cancer
    Mari Kaarbø
    Department of Molecular Biosciences, University of Oslo, Norway
    Bioessays 29:1227-38. 2007
    ..The androgen receptor (AR) is required for prostate cancer growth in all stages, including the relapsed, "androgen-independent" ..
  74. ncbi Differential expression of oestrogen receptor isoforms and androgen receptor in the normal vulva and vagina compared with vulval lichen sclerosus and chronic vaginitis
    A H Taylor
    Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, and Gynaecology Research Unit, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, UK
    Br J Dermatol 158:319-28. 2008
    Although the expression of the oestrogen receptor (ER) alpha isoform and androgen receptor (AR) has been examined in vulval lichen sclerosus (VLS), the distribution pattern of ERalpha, ERbeta and AR has not been described in chronic ..
  75. doi Alteration in [11C]vorozole binding to aromatase in neuronal cells of rat brain induced by anabolic androgenic steroids and flutamide
    Kayo Takahashi
    Molecular Probe Dynamics Laboratory, Molecular Imaging Research Program, RIKEN, Kobe, Japan
    Neuroreport 19:431-5. 2008
    ..Our findings suggest that aromatase is regulated through an androgen receptor-mediated system...
  76. doi Androgen receptors are required for full masculinization of nitric oxide synthase system in rat limbic-hypothalamic region
    M Martini
    Laboratory of Neuroendocrinology, Department of Anatomy, Pharmacology and Forensic Medicine, Neuroscience Institute of Turin NIT, University of Torino, Torino, Italy
    Horm Behav 54:557-64. 2008
    ..elucidate the role of AR on nNOS expression, we compared male and female rats with a non-functional mutation of AR (Tfm, testicular feminization mutation) to their control littermates...
  77. pmc Androgen and estrogen (alpha) receptor localization on periaqueductal gray neurons projecting to the rostral ventromedial medulla in the male and female rat
    Dayna R Loyd
    Neuroscience Institute, Center for Behavioral Neuroscience, Georgia State University, PO Box 4010, Atlanta, GA 30302 4010, United States
    J Chem Neuroanat 36:216-26. 2008
    ..The expression of androgen (AR) and estrogen (ERalpha) receptors in the PAG of female rats and within this descending inhibitory pathway in both ..
  78. pmc Sex differences and laterality in astrocyte number and complexity in the adult rat medial amygdala
    Ryan T Johnson
    Neuroscience Program, Michigan State University, East Lansing, Michigan 48824 1101, USA
    J Comp Neurol 511:599-609. 2008
    ..and process complexity of MePD astrocytes in adult wildtype male and female rats and testicular feminized mutant (TFM) male rats that lack functional androgen receptors (ARs) to determine whether MePD astrocytes are sexually ..
  79. pmc Loss of androgen receptor in aging and oxidative stress through Myb protooncoprotein-regulated reciprocal chromatin dynamics of p53 and poly(ADP-ribose) polymerase PARP-1
    Liheng Shi
    Department of Molecular Medicine Institute of Biotechnology, The University of Texas Health Science Center, San Antonio, Texas 78245, USA
    J Biol Chem 283:36474-85. 2008
    ..Herein we show that transcriptional down-regulation of androgen receptor (AR) in the aging rat liver and in oxidatively stressed hepatoma cells involves exchange of a PARP-1-..
  80. doi Inhibin A inhibits follicle-stimulating hormone (FSH) action by suppressing its receptor expression in cultured rat granulosa cells
    Cuiling Lu
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District, Beijing 100101, China
    Mol Cell Endocrinol 298:48-56. 2009
    ..Inhibin A was also capable of suppressing FSH-induced expression of steroidogenic factor 1 (SF-1) and androgen receptor, but stimulating DAX-1 expression in the culture...
  81. doi Androgen receptor is expressed in murine choroid plexus and downregulated by 5alpha-dihydrotestosterone in male and female mice
    C Henrique Alves
    Research Center in Health Sciences CICS, University of Beira Interior, Av Infante D Henrique, 6200 506, Covilha, Portugal
    J Mol Neurosci 38:41-9. 2009
    ..Androgens regulate the expression of neuroprotective peptides in several tissues where the androgen receptor (AR) is coexpressed, including the brain...
  82. pmc Age-related changes in hypothalamic androgen receptor and estrogen receptor alpha in male rats
    Di Wu
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
    J Comp Neurol 512:688-701. 2009
    ..We performed a stereologic analysis of immunoreactive androgen receptor (AR) and estrogen receptor alpha (ERalpha) cells in three POA nuclei of male Sprague-Dawley rats (..
  83. doi Dietary fatty acid quality affects AR and PPARgamma levels and prostate growth
    Esdras L O Escobar
    Department of Cell Biology, Institute of Biology, State University of Campinas UNICAMP, Campinas, SP, Brazil
    Prostate 69:548-58. 2009
    ..of this work was to evaluate the effect of quality of fatty acid on the rat ventral prostate growth, tissue organization, and expression of androgen receptor (AR) and peroxisome proliferation activator receptor gamma (PPARgamma).
  84. doi Sex-specific regulation of ENaC and androgen receptor in female rat kidney
    T Kienitz
    Clinical Endocrinology, Department of Internal Medicine, Gastroenterology, Hepatology and Endocrinology, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Berlin 10117, Germany
    Horm Metab Res 41:356-62. 2009
    ..Regulation of the androgen receptor (AR) is known to be tissue-specific and age-dependent, but not well studied in the kidney...
  85. pmc Sexual differentiation of the spinal nucleus of the bulbocavernosus is not mediated solely by androgen receptors in muscle fibers
    Lee Niel
    Department of Psychology, University of Toronto at Mississauga, 3359 Mississauga Road, Mississauga, Ontario, Canada
    Endocrinology 150:3207-13. 2009
    ..manipulations of developing rats as well as from evidence that male rats with the testicular feminization mutation (Tfm), which is a loss of function AR mutation, have a feminine SNB phenotype...
  86. pmc Androgen regulates the sexually dimorphic gastrin-releasing peptide system in the lumbar spinal cord that mediates male sexual function
    Hirotaka Sakamoto
    Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Endocrinology 150:3672-9. 2009
    ..Genetically male (XY) rats with the dysfunctional testicular feminization allele for the androgen receptor (AR) displayed GRP mRNA and protein levels in the spinal cord similar to those of females, indicating that ..
  87. pmc Estrogen-induced developmental disorders of the rat penis involve both estrogen receptor (ESR)- and androgen receptor (AR)-mediated pathways
    H O Goyal
    Department of Biomedical Sciences and Biology CBR RCMI, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, USA
    Biol Reprod 81:507-16. 2009
    This study tested the hypothesis that the estrogen receptor (ESR) pathway, androgen receptor (AR) pathway, or both mediate estrogen-induced developmental penile disorders...
  88. doi Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat
    Francisco M Zurvarra
    Department of Morphological Sciences and Center for Experimental Biology and Laboratory Animals Sciences, Faculty of Veterinary Sciences, Universidad Nacional del Litoral, Argentina
    Reprod Fertil Dev 21:827-39. 2009
    ..and tissue distribution of steroid receptors (oestrogen receptor-alpha and -beta (ERalpha, ERbeta), androgen receptor (AR) and progesterone receptor (PR)) and steroidogenic enzymes (P450 aromatase (P450arom), 3beta-..
  89. ncbi Autophagy and access: understanding the role of androgen receptor subcellular localization in SBMA
    Heather L Montie
    Thomas Jefferson University, Department of Biochemistry and Molecular Biology, Philadelphia, PA, USA
    Autophagy 5:1194-7. 2009
    ..We have recently reported that lack of access of nuclear polyglutamine-expanded androgen receptor (AR) to the autophagic degradation pathway is a critical point in pathogenesis...
  90. doi Immunolocalization of androgen receptor and steroidogenic enzymes in cumuli oophori of pre- and post-ovulatory rats
    Maria Szołtys
    Department of Endocrinology and Tissue Culture, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Acta Histochem 112:576-82. 2010
    Immunolocalization of 3β-hydroxysteroid dehydrogense (3β-HSD), cytochrome P450c17 (P450c17) and androgen receptor (AR) were investigated in rat cumuli oophori (COCs) of late pre-ovulatory follicles and in post-ovulatory COCs bearing ..
  91. pmc Expression of aromatase, androgen and estrogen receptors in peripheral target tissues in diabetes
    Anjali Prabhu
    Department of Medicine, Georgetown University Medical Center, 4000 Reservoir Road NW, Washington, DC 20057, United States
    Steroids 75:779-87. 2010
    ..Overall, our data provides evidence for the extra-testicular source of estradiol that in males, through an intracrine mechanism, may contribute to the development and/or progression of end-organ damage associated with diabetes...
  92. pmc Membrane androgen receptors may mediate androgen reinforcement
    Satoru M Sato
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Psychoneuroendocrinology 35:1063-73. 2010
    ..First, we tested androgen self-administration in rats with the testicular feminization mutation (Tfm), which interferes with androgen binding...
  93. pmc A simple technique for the prediction of interacting proteins reveals a direct Brn-3a-androgen receptor interaction
    Daniel C Berwick
    Medical Molecular Biology Unit, University College London Institute of Child Health, London, UK
    J Biol Chem 285:15286-95. 2010
    ..developmental transcription factor Brn-3a to predict and verify a novel interaction between Brn-3a and the androgen receptor (AR)...
  94. doi Androgen receptor blockade in the posterodorsal medial amygdala impairs sexual odor preference in male rats
    Nami Hosokawa
    Department of Materials and Life Sciences, Sophia University, Tokyo 102 8554, Japan
    Horm Behav 58:493-500. 2010
    ..Gonadally intact, sexually experienced male rats received bilateral administration of flutamide, an androgen receptor (AR) blocker, aimed at either the posterior dorsal part (MePD) or the anterior dorsal part (MeAD) of the MeA ..
  95. doi Is gender difference in postnatal thyroid growth associated with specific expression patterns of androgen and estrogen receptors?
    Jone A Stanley
    Department of Endocrinology, Dr ALM, Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, India
    Steroids 75:1058-66. 2010
    ..In the present study we tested androgen receptor (AR) and estrogen receptor (ER) concentrations by ligand binding assay, and expression of their genes by RT-..
  96. doi Distribution of aromatase and sex steroid receptors in the baculum during the rat life cycle: effects of estrogen during the early development of the baculum
    Tomohiro Yonezawa
    Laboratories of Veterinary Physiology and Veterinary Anatomy, Kitasato University, Aomori, Japan
    Biol Reprod 85:105-12. 2011
    ..These findings suggest that not only androgen but also locally aromatized estrogen is involved in the early growth and development of the baculum...
  97. pmc Gain in transcriptional activity by primate-specific coevolution of melanoma antigen-A11 and its interaction site in androgen receptor
    Qiang Liu
    Laboratories for Reproductive Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7500, USA
    J Biol Chem 286:29951-63. 2011
    Male sex development and growth occur in response to high affinity androgen binding to the androgen receptor (AR)...
  98. pmc Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors
    C S Chang
    Ben May Institute, Chicago, IL
    Proc Natl Acad Sci U S A 85:7211-5. 1988
    ..The human AR has a long stretch of repeated glycines, whereas rat AR has a long stretch of glutamines...
  99. ncbi Correlation between genetic and cytogenetic maps of the rat
    Y Andoh
    Institute of Laboratory Animals, Faculty of Medicine, Kyoto University, Japan
    Mamm Genome 9:287-93. 1998
    ..Thus, we provide here a new base for rat genetic maps...

Research Grants4

  1. Persistent changes in brain expression after withdrawal
    KRISTINE WIREN; Fiscal Year: 2003
    ..e. physical dependence leading to withdrawal seizures) are regulated at the genetic level. This knowledge may help in the development of new strategies for the treatment of alcohol dependence. ..
  2. Androgen Receptor Expression in Developing Rat Forebrain
    Lydia Doncarlos; Fiscal Year: 2005
    ..of the organizational effects of testosterone on the nervous system, and that spatial and temporal shifts in androgen receptor expression and regulation contribute to specific actions of androgens in modulation of brain development...
  3. Exploratory Studies of Androgen Receptors in Axons
    Lydia Doncarlos; Fiscal Year: 2006
    ..Androgens have been thought to exert their effects exclusively through the androgen receptor, traditionally considered to be a ligand dependent nuclear transcription factor...
  4. Androgen action in bone: Overexpression of AR
    Kristine M Wiren; Fiscal Year: 2010
    ..We hypothesize that androgens influence bone formation and bone size through actions mediated by the androgen receptor (AR) in the osteoblastic lineage...