Gene Symbol: Aqp2
Description: aquaporin 2
Alias: AQP-2, aquaporin-2, aquaporin-2, ADH water channel, AQP-CD, WCH-CD, aquaporin 2 (collecting duct), aquaporin-CD, collecting duct water channel protein, water channel protein for renal collecting duct
Species: rat
Products:     Aqp2

Top Publications

  1. Lu H, Sun T, Matsuzaki T, Yi X, Eswara J, Bouley R, et al. Heat shock protein 70 interacts with aquaporin-2 and regulates its trafficking. J Biol Chem. 2007;282:28721-32 pubmed
    The trafficking of aquaporin-2 (AQP2) involves multiple complex pathways, including regulated, cAMP-, and cGMP-mediated pathways, as well as a constitutive recycling pathway...
  2. Kwon T, Nielsen J, Knepper M, Frøkiaer J, Nielsen S. Angiotensin II AT1 receptor blockade decreases vasopressin-induced water reabsorption and AQP2 levels in NaCl-restricted rats. Am J Physiol Renal Physiol. 2005;288:F673-84 pubmed
    ..05). Semiquantitative immunoblotting revealed significantly decreased expression of medullary aquaporin-2 (AQP2) and AQP2 phosphorylated in the PKA phosphorylation consensus site Ser-256 (p-AQP2) in response to DDAVP and ..
  3. Li C, Wang W, Knepper M, Nielsen S, Frøkiaer J. Downregulation of renal aquaporins in response to unilateral ureteral obstruction. Am J Physiol Renal Physiol. 2003;284:F1066-79 pubmed
    The expression of aquaporin-2 (AQP2) is decreased in rats with bilateral ureteral obstruction (BUO) and unilateral ureteral obstruction (UUO)...
  4. Gattone V, Maser R, Tian C, Rosenberg J, Branden M. Developmental expression of urine concentration-associated genes and their altered expression in murine infantile-type polycystic kidney disease. Dev Genet. 1999;24:309-18 pubmed
    ..arginine vasopressin V2 receptors (AVP-V2R), and 3) the presence of appropriate CD water channels (aquaporins, AQP 2 and 3). An increase in urine osmolarity, normally seen between 1 and 3 weeks of age, was absent in cpk cystic mice...
  5. Yang B, Gillespie A, Carlson E, Epstein C, Verkman A. Neonatal mortality in an aquaporin-2 knock-in mouse model of recessive nephrogenic diabetes insipidus. J Biol Chem. 2001;276:2775-9 pubmed
    Hereditary non-X-linked nephrogenic diabetes insipidus (NDI) is caused by mutations in the aquaporin-2 (AQP2) water channel...
  6. Li C, Wang W, Summer S, Cadnapaphornchai M, Falk S, Umenishi F, et al. Hyperosmolality in vivo upregulates aquaporin 2 water channel and Na-K-2Cl co-transporter in Brattleboro rats. J Am Soc Nephrol. 2006;17:1657-64 pubmed
    ..This study examined the role of hyperosmolality in vivo to modulate aquaporin 2 (AQP2) and Na-K-2Cl co-transporter (NKCC2), pivotal factors in urinary concentration, in AVP-deficient ..
  7. Tamma G, Klussmann E, Oehlke J, Krause E, Rosenthal W, Svelto M, et al. Actin remodeling requires ERM function to facilitate AQP2 apical targeting. J Cell Sci. 2005;118:3623-30 pubmed
    This study provides the first evidence that actin reorganization during AQP2 vesicular trafficking to the plasma membrane requires the functional involvement of ERM (ezrin/radixin/moesin) proteins cross-linking actin filaments with plasma ..
  8. Shi Y, Li C, Thomsen K, Jørgensen T, Knepper M, Nielsen S, et al. Neonatal ureteral obstruction alters expression of renal sodium transporters and aquaporin water channels. Kidney Int. 2004;66:203-15 pubmed
    ..15 +/- 0.02 vs. 0.06 +/- 0.01 micromol/min/100g bw, P < 0.05). AQP2 abundance in the collecting duct was also reduced both at 12 weeks (68 +/- 5%, P < 0...
  9. Jensen A, Bae E, Fenton R, Nørregaard R, Nielsen S, Kim S, et al. Angiotensin II regulates V2 receptor and pAQP2 during ureteral obstruction. Am J Physiol Renal Physiol. 2009;296:F127-34 pubmed publisher
    ..Because angiotensin II type 1 (AT1) receptor blockade attenuates postobstructive polyuria and aquaporin-2 (AQP2) downregulation, we examined the effect of AT1 receptor blockade on AQP2 phosphorylated at serine 256 (pS256-AQP2) ..

More Information


  1. Fushimi K, Uchida S, Hara Y, Hirata Y, Marumo F, Sasaki S. Cloning and expression of apical membrane water channel of rat kidney collecting tubule. Nature. 1993;361:549-52 pubmed
    ..The functional expression and the limited localization of WCH-CD to the apical region of the kidney collecting tubule suggest that WCH-CD is the vasopressin-regulated water channel. ..
  2. Kamsteeg E, Heijnen I, Van Os C, Deen P. The subcellular localization of an aquaporin-2 tetramer depends on the stoichiometry of phosphorylated and nonphosphorylated monomers. J Cell Biol. 2000;151:919-30 pubmed
    ..Vasopressin-induced phosphorylation of AQP2 at serine 256 (S256) by protein kinase A (PKA) is essential for its localization in the membrane...
  3. Lütken S, Kim S, Jonassen T, Marples D, Knepper M, Kwon T, et al. Changes of renal AQP2, ENaC, and NHE3 in experimentally induced heart failure: response to angiotensin II AT1 receptor blockade. Am J Physiol Renal Physiol. 2009;297:F1678-88 pubmed publisher
    ..days after LAD ligation) semiquantitative immunoblotting revealed increased abundance of inner medulla aquaporin-2 (AQP2) and AQP2 phosphorylated at Ser(256) (p-AQP2) in HF...
  4. Henn V, Edemir B, Stefan E, Wiesner B, Lorenz D, Theilig F, et al. Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells. J Biol Chem. 2004;279:26654-65 pubmed
    ..renal collecting duct principal cells by inducing the fusion of vesicles containing the water channel aquaporin-2 (AQP2) with the plasma membrane (AQP2 shuttle)...
  5. Hoffert J, Nielsen J, Yu M, Pisitkun T, Schleicher S, Nielsen S, et al. Dynamics of aquaporin-2 serine-261 phosphorylation in response to short-term vasopressin treatment in collecting duct. Am J Physiol Renal Physiol. 2007;292:F691-700 pubmed, serine-261 (pS261), in the COOH-terminus of the vasopressin-regulated water channel, aquaporin-2 (AQP2)...
  6. Wang W, Li C, Nejsum L, Li H, Kim S, Kwon T, et al. Biphasic effects of ANP infusion in conscious, euvolumic rats: roles of AQP2 and ENaC trafficking. Am J Physiol Renal Physiol. 2006;290:F530-41 pubmed
    ..Renal hemodynamics, water and sodium excretion, and aquaporin-2 (AQP2) and epithelial Na channel (ENaC) subcellular trafficking were determined in response to continuous ANP infusion in ..
  7. Sohara E, Rai T, Yang S, Uchida K, Nitta K, Horita S, et al. Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation. Proc Natl Acad Sci U S A. 2006;103:14217-22 pubmed
    Frame-shift mutations within the C terminus of aquaporin 2 (AQP2) cause autosomal-dominant nephrogenic diabetes insipidus (AD-NDI)...
  8. Noda Y, Horikawa S, Katayama Y, Sasaki S. Identification of a multiprotein "motor" complex binding to water channel aquaporin-2. Biochem Biophys Res Commun. 2005;330:1041-7 pubmed
    Targeted positioning of water channel aquaporin-2 (AQP2) strictly regulates body water homeostasis. Trafficking of AQP2 to the apical membrane is critical to the reabsorption of water in renal collecting ducts...
  9. Yang B, Zhao D, Qian L, Verkman A. Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion. Am J Physiol Renal Physiol. 2006;291:F465-72 pubmed
    ..ability produced by deletion of various membrane transport or receptor proteins, including aquaporin-2 (AQP2), are associated with neonatal mortality from polyuria...
  10. Noda Y, Horikawa S, Furukawa T, Hirai K, Katayama Y, Asai T, et al. Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1. FEBS Lett. 2004;568:139-45 pubmed
    Targeted positioning of water channel aquaporin-2 (AQP2) strictly regulates body water homeostasis. Trafficking of AQP2 to the apical membrane is critical to the reabsorption of water in renal collecting ducts...
  11. Noda Y, Horikawa S, Katayama Y, Sasaki S. Water channel aquaporin-2 directly binds to actin. Biochem Biophys Res Commun. 2004;322:740-5 pubmed
    Water channel aquaporin-2 (AQP2) strictly regulates body water homeostasis in mammals. Trafficking of AQP2 to the apical membrane is critical to the reabsorption of water in renal collecting ducts...
  12. McDill B, Li S, Kovach P, Ding L, Chen F. Congenital progressive hydronephrosis (cph) is caused by an S256L mutation in aquaporin-2 that affects its phosphorylation and apical membrane accumulation. Proc Natl Acad Sci U S A. 2006;103:6952-7 pubmed
    ..Here, we describe the identification of a single base pair change in aquaporin-2 (Aqp2) in cph mutants through genetic linkage mapping...
  13. Marr N, Bichet D, Hoefs S, Savelkoul P, Konings I, de Mattia F, et al. Cell-biologic and functional analyses of five new Aquaporin-2 missense mutations that cause recessive nephrogenic diabetes insipidus. J Am Soc Nephrol. 2002;13:2267-77 pubmed
    ..Most AQP2 missense mutants in recessive NDI are retained in the endoplasmic reticulum (ER), but AQP2-T125M and AQP2-G175R ..
  14. Nejsum L, Zelenina M, Aperia A, Frøkiaer J, Nielsen S. Bidirectional regulation of AQP2 trafficking and recycling: involvement of AQP2-S256 phosphorylation. Am J Physiol Renal Physiol. 2005;288:F930-8 pubmed
    The present study examined the role of PKA and serine256 (S256) phosphorylation for AQP2 trafficking and recycling using cells transfected with wild-type AQP2 (AQP2-WT) or mutant AQP2 and high-resolution confocal microscopic techniques...
  15. Ge Y, Ahn D, Stricklett P, Hughes A, Yanagisawa M, Verbalis J, et al. Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality. Am J Physiol Renal Physiol. 2005;288:F912-20 pubmed
    ..normal water intake, urinary osmolality (Uosm), plasma Na concentration, urine volume, and renal aquaporin-2 (AQP2) levels were unchanged, but plasma AVP concentration was reduced in CD ET-1 KO animals...
  16. Bouley R, Pastor Soler N, Cohen O, McLaughlin M, Breton S, Brown D. Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra). Am J Physiol Renal Physiol. 2005;288:F1103-12 pubmed
    Vasopressin-stimulated insertion of the aquaporin 2 (AQP2) water channel into the plasma membrane of kidney collecting duct principal cells is a key event in the urinary concentrating mechanism...
  17. Lorenz D, Krylov A, Hahm D, Hagen V, Rosenthal W, Pohl P, et al. Cyclic AMP is sufficient for triggering the exocytic recruitment of aquaporin-2 in renal epithelial cells. EMBO Rep. 2003;4:88-93 pubmed
    ..response in primary cultured epithelial cells from renal inner medulla, namely the transport of aquaporin-2 (AQP2)-bearing vesicles to, and their subsequent fusion with, the plasma membrane (AQP2 shuttle)...
  18. Hasler U, Nunes P, Bouley R, Lu H, Matsuzaki T, Brown D. Acute hypertonicity alters aquaporin-2 trafficking and induces a MAPK-dependent accumulation at the plasma membrane of renal epithelial cells. J Biol Chem. 2008;283:26643-61 pubmed publisher
    ..We investigated the effects of acute hypertonic challenge on AQP2 (aquaporin-2) water channel trafficking...
  19. Yip K. Epac-mediated Ca(2+) mobilization and exocytosis in inner medullary collecting duct. Am J Physiol Renal Physiol. 2006;291:F882-90 pubmed
    ..PKA inhibitors (1 microM H-89 or 10 microM KT-5720) at concentrations known to inhibit aquaporin-2 (AQP2) phosphorylation did not prevent AVP-induced Ca(2+) mobilization and oscillations...
  20. LeMaire S, Raghuram V, Grady C, Pickering C, Chou C, Umejiego E, et al. Serine/threonine phosphatases and aquaporin-2 regulation in renal collecting duct. Am J Physiol Renal Physiol. 2017;312:F84-F95 pubmed publisher
    Phosphorylation of the aquaporin-2 (AQP2) water channel at four COOH-terminal serines plays a central role in the regulation of water permeability of the renal collecting duct...
  21. Rai T, Uchida S, Marumo F, Sasaki S. Cloning of rat and mouse aquaporin-2 gene promoters and identification of a negative cis-regulatory element. Am J Physiol. 1997;273:F264-73 pubmed
    ..These results indicate that tissue-specific expression of AQP-2 gene may in part be regulated by this novel negative acting cis-element...
  22. Murata K, Mitsuoka K, Hirai T, Walz T, Agre P, Heymann J, et al. Structural determinants of water permeation through aquaporin-1. Nature. 2000;407:599-605 pubmed
    ..The atomic model provides a possible molecular explanation to a longstanding puzzle in physiology-how membranes can be freely permeable to water but impermeable to protons. ..
  23. Lin Q, Lin R, Ji Q, Zhang J, Wang W, Yang L, et al. Effect of exercise training on renal function and renal aquaporin-2 expression in rats with chronic heart failure. Clin Exp Pharmacol Physiol. 2011;38:179-85 pubmed publisher
    ..4. The results suggest that exercise training can significantly improve the renal dysfunction in CHF rats and that the underlying mechanism may be related to water reabsorption and preventing changes to the cytoskeleton. ..
  24. Kusaka I, Saito T, Nakamura T, Nagasaka S, Ishibashi S, Ishikawa S. Urinary excretion of aquaporin-2 water channel in diabetic ketoacidosis. Nephron. 2002;91:167-9 pubmed
  25. Ranieri M, Tamma G, Di Mise A, Russo A, Centrone M, Svelto M, et al. Negative feedback from CaSR signaling to aquaporin-2 sensitizes vasopressin to extracellular Ca2. J Cell Sci. 2015;128:2350-60 pubmed publisher
    ..that high luminal Ca(2+) in the renal collecting duct attenuates short-term vasopressin-induced aquaporin-2 (AQP2) trafficking through activation of the Ca(2+)-sensing receptor (CaSR)...
  26. Rivarola V, Di Giusto G, Christensen M, Ford P, Capurro C. AQP2-Induced Acceleration of Renal Cell Proliferation Involves the Activation of a Regulatory Volume Increase Mechanism Dependent on NHE2. J Cell Biochem. 2017;118:967-978 pubmed publisher
    We have previously shown in renal cells that expression of the water channel Aquaporin 2 (AQP2) increases the rate of cell proliferation by shortening the transit time through the S and G2 /M phases of the cell cycle...
  27. Yu M, Pisitkun T, Wang G, Shen R, Knepper M. LC-MS/MS analysis of apical and basolateral plasma membranes of rat renal collecting duct cells. Mol Cell Proteomics. 2006;5:2131-45 pubmed
    ..motor proteins, small GTP-binding proteins, and related proteins that may be involved in vasopressin-stimulated AQP2, UT-A1, and ENaC regulation...
  28. Flamenco P, Galizia L, Rivarola V, Fernandez J, Ford P, Capurro C. Role of AQP2 during apoptosis in cortical collecting duct cells. Biol Cell. 2009;101:237-50 pubmed publisher
  29. Ford P, Rivarola V, Chara O, Blot Chabaud M, Cluzeaud F, Farman N, et al. Volume regulation in cortical collecting duct cells: role of AQP2. Biol Cell. 2005;97:687-97 pubmed
    ..This hormone induces an increase in water permeability due to the translocation of AQP2 (aquaporin 2) from the intracellular vesicles to the apical membrane of principal cells...
  30. Ma T, Frigeri A, Skach W, Verkman A. Cloning of a novel rat kidney cDNA homologous to CHIP28 and WCH-CD water channels. Biochem Biophys Res Commun. 1993;197:654-9 pubmed
    ..WCH3 is a new member of the MIP26 family of channel-forming proteins in mammalian kidney. ..
  31. Barone S, Amlal H, Kujala M, Xu J, Karet F, Blanchard A, et al. Regulation of the basolateral chloride/base exchangers AE1 and SLC26A7 in the kidney collecting duct in potassium depletion. Nephrol Dial Transplant. 2007;22:3462-70 pubmed
  32. Liu Q, Li F, Ren Q. [Effect and mechanism of emodin for regulating aquaporin-2 expression in cultured NRK cells]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010;30:871-4 pubmed
    To investigate the effect and mechanism of emodin for regulating aquapoin-2 (AQP2) in NRK cells cultured in vitro. Experiments on NRK cells cultured with alpha-DMEM medium in vitro were conducted in two steps...
  33. da Silva C, de Bragança A, Shimizu M, Sanches T, Fortes M, Giorgi R, et al. Rosiglitazone prevents sirolimus-induced hypomagnesemia, hypokalemia, and downregulation of NKCC2 protein expression. Am J Physiol Renal Physiol. 2009;297:F916-22 pubmed publisher
    ..Protein abundance of NKCC2, aquaporin-2 (AQP2), and TRPM6 was assessed using immunoblotting...
  34. Cha S, Park B, Jung Y, Kim S, Kang K, Kim W, et al. Regional heterogeneity of expression of renal NPRs, TonEBP, and AQP-2 mRNAs in rats with acute kidney injury. Peptides. 2015;69:33-9 pubmed publisher
    ..Therefore, we suggest that there is a regional heterogeneity of regulation of renal NPRs, TonEBP, and APQ-2 mRNA in AKI. ..
  35. Sonalker P, Tofovic S, Bastacky S, Jackson E. Chronic noradrenaline increases renal expression of NHE-3, NBC-1, BSC-1 and aquaporin-2. Clin Exp Pharmacol Physiol. 2008;35:594-600 pubmed publisher
  36. Abreu N, Tardin J, Boim M, Campos R, Bergamaschi C, Schor N. Hemodynamic parameters during normal and hypertensive pregnancy in rats: evaluation of renal salt and water transporters. Hypertens Pregnancy. 2008;27:49-63 pubmed publisher
    ..also analyzed of the sodium transporters (NHE3, Na/K/2Cl and Na/Cl), potassium channel (ROMK2) and water channel (AQP2)...
  37. Shaw S, Marples D. N-ethylmaleimide causes aquaporin-2 trafficking in the renal inner medullary collecting duct by direct activation of protein kinase A. Am J Physiol Renal Physiol. 2005;288:F832-9 pubmed
    ..increases the osmotic water permeability of the renal collecting ducts by inducing the shuttling of aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical plasma membrane of the principal cells...
  38. Guyon C, Lussier Y, Bissonnette P, Leduc Nadeau A, Lonergan M, Arthus M, et al. Characterization of D150E and G196D aquaporin-2 mutations responsible for nephrogenic diabetes insipidus: importance of a mild phenotype. Am J Physiol Renal Physiol. 2009;297:F489-98 pubmed publisher
    Aquaporin-2 (AQP2) is a water channel responsible for the final water reabsorption in renal collecting ducts...
  39. Fenton R, Moeller H, Hoffert J, Yu M, Nielsen S, Knepper M. Acute regulation of aquaporin-2 phosphorylation at Ser-264 by vasopressin. Proc Natl Acad Sci U S A. 2008;105:3134-9 pubmed publisher, serine 264 (pS264), in the COOH terminus of the vasopressin-regulated water channel, aquaporin-2 (AQP2)...
  40. Hasler U, Mordasini D, Bens M, Bianchi M, Cluzeaud F, Rousselot M, et al. Long term regulation of aquaporin-2 expression in vasopressin-responsive renal collecting duct principal cells. J Biol Chem. 2002;277:10379-86 pubmed
    ..AVP) occurs in principal cells of the collecting duct and is largely dependent on regulation of the aquaporin-2 (AQP2) water channel...
  41. Jensen A, Bae E, Nørregaard R, Wang G, Nielsen S, Schweer H, et al. Cyclooxygenase 2 inhibition exacerbates AQP2 and pAQP2 downregulation independently of V2 receptor abundance in the postobstructed kidney. Am J Physiol Renal Physiol. 2010;298:F941-50 pubmed publisher
    Previously we demonstrated that ANG II receptor (AT1R) blockade attenuates V2 receptor (V2R), AQP2, and pS256-AQP2 downregulation in the postobstructed kidney and partially reverses obstruction-induced inhibition of cAMP generation and ..
  42. Ishibashi K, Morinaga T, Kuwahara M, Sasaki S, Imai M. Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin. Biochim Biophys Acta. 2002;1576:335-40 pubmed
    ..The genome structure of AQP10 is similar to those of other aquaglyceroporins (AQP3, AQP7, AQP9) with six exons. We conclude that AQP10 represents a new member of aquaglyceroporins functionally as well as structurally. ..
  43. Chen C, Chen R, Lin H, Zhang W, Huang X, Huang Z. Tolvaptan regulates aquaporin-2 and fecal water in cirrhotic rats with ascites. World J Gastroenterol. 2016;22:3363-71 pubmed publisher
    ..Upregulation of AQP-2 in the distal colon is found in cirrhotic rats with ascites. Tolvaptan inhibits its expression and may decrease water reabsorption and induce diarrhea. ..
  44. Gong H, Wang W, Kwon T, Jonassen T, Frøkiaer J, Nielsen S. Reduced renal expression of AQP2, p-AQP2 and AQP3 in haemorrhagic shock-induced acute renal failure. Nephrol Dial Transplant. 2003;18:2551-9 pubmed
    ..05). Consistent with this, semiquantitative immunoblotting revealed that the abundance of AQP2, phosphorylated (Ser256) AQP2 (p-AQP2) and AQP3 in whole kidney was significantly decreased after 2 days to 33 +/- ..
  45. Savelkoul P, de Mattia F, Li Y, Kamsteeg E, Konings I, van der Sluijs P, et al. p.R254Q mutation in the aquaporin-2 water channel causing dominant nephrogenic diabetes insipidus is due to a lack of arginine vasopressin-induced phosphorylation. Hum Mutat. 2009;30:E891-903 pubmed publisher
    Vasopressin regulates human water homeostasis by re-distributing homotetrameric aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical membrane of renal principal cells, a process in which phosphorylation of AQP2 at ..
  46. Moeller H, Knepper M, Fenton R. Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cells. Kidney Int. 2009;75:295-303 pubmed publisher
    ..We recently identified a novel form of aquaporin-2 that is phosphorylated at serine-269 (pS269-AQP2)...
  47. Zeidel M, Ambudkar S, Smith B, Agre P. Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein. Biochemistry. 1992;31:7436-40 pubmed
    ..These results demonstrate that CHIP28 protein functions as a molecular water channel and also indicate that CHIP28 is responsible for most transmembrane water movement in RBCs. ..
  48. Kamsteeg E, Stoffels M, Tamma G, Konings I, Deen P. Repulsion between Lys258 and upstream arginines explains the missorting of the AQP2 mutant p.Glu258Lys in nephrogenic diabetes insipidus. Hum Mutat. 2009;30:1387-96 pubmed publisher
    Regulation of body water homeostasis occurs by the vasopressin-dependent sorting of aquaporin-2 (AQP2) water channels to and from the apical membrane of renal principal cells...
  49. Yang B, Ma T, Xu Z, Verkman A. cDNA and genomic cloning of mouse aquaporin-2: functional analysis of an orthologous mutant causing nephrogenic diabetes insipidus. Genomics. 1999;57:79-83 pubmed
    ..a transgenic mouse model of nephrogenic diabetes insipidus (NDI), we have analyzed the mouse aquaporin-2 (Aqp2) cDNA and gene and generated a mutated Aqp2 orthologous to NDI-causing human AQP2-T126M...
  50. Gaeggeler H, Guillod Y, Loffing Cueni D, Loffing J, Rossier B. Vasopressin-dependent coupling between sodium transport and water flow in a mouse cortical collecting duct cell line. Kidney Int. 2011;79:843-52 pubmed publisher
    ..The mCCD(c11) cell line is a first example of a mammalian tight epithelium allowing quantitative study of the coupling between sodium and water transport. Our data are consistent with the 'near isoosmotic' fluid transport model. ..
  51. Yasui M, Kwon T, Knepper M, Nielsen S, Agre P. Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia. Proc Natl Acad Sci U S A. 1999;96:5808-13 pubmed
    ..Moreover, our studies predict that AQP6 participates in distinct physiological functions such as glomerular filtration, tubular endocytosis, and acid-base metabolism. ..
  52. Wang G, Yuan W, Kwon T, Li Z, Wen J, Topcu S, et al. Age-related changes in expression in renal AQPs in response to congenital, partial, unilateral ureteral obstruction in rats. Pediatr Nephrol. 2012;27:83-94 pubmed publisher
    ..Semiquantitative immunoblotting and immunohistochemistry were used to examine the changes in abundance of AQP1, AQP2, p-S256AQP2 (AQP2 phosphorylated at consensus site Ser(256)) and AQP3 in the kidneys of rats with neonatally ..
  53. Olesen E, Rützler M, Moeller H, Praetorius H, Fenton R. Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus. Proc Natl Acad Sci U S A. 2011;108:12949-54 pubmed publisher
    ..increased water reabsorption alongside polyphosphorylation and membrane targeting of the water channel aquaporin-2 (AQP2). Loss-of-function mutations in the V2R cause X-linked nephrogenic diabetes insipidus...