Gene Symbol: Aqp1
Description: aquaporin 1
Alias: CHIP28, aquaporin-1, AQP-1, Aquaporin 1 (aquaporin channel forming integral protein 28 (CHIP)), aquaporin-CHIP, water channel protein for red blood cells and kidney proximal tubule
Species: rat
Products:     Aqp1

Top Publications

  1. Jablonski E, Webb A, McConnell N, Riley M, Hughes F. Plasma membrane aquaporin activity can affect the rate of apoptosis but is inhibited after apoptotic volume decrease. Am J Physiol Cell Physiol. 2004;286:C975-85 pubmed
    ..Furthermore, inactivation of AQPs after the AVD does not appear to be through degradation or removal from the cell membrane. ..
  2. Echevarria M, Muñoz Cabello A, Sánchez Silva R, Toledo Aral J, Lopez Barneo J. Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression. J Biol Chem. 2007;282:30207-15 pubmed
    ..Moreover, lung AQP-1 is markedly up-regulated in animals exposed to hypoxia. These data suggest that AQP-1 has O(2) permeability and thus could facilitate O(2) diffusion across the cell membrane. ..
  3. Li J, Nielsen S, Dai Y, Lazowski K, Christensen E, Tabak L, et al. Examination of rat salivary glands for the presence of the aquaporin CHIP. Pflugers Arch. 1994;428:455-60 pubmed
    The aquaporin CHIP, AQP-CHIP, is a 28-kDa integral membrane protein that functions as a water channel in kidney and red blood cells. We have examined rat salivary glands for the presence of this molecule...
  4. Li C, Wang W, Knepper M, Nielsen S, Frøkiaer J. Downregulation of renal aquaporins in response to unilateral ureteral obstruction. Am J Physiol Renal Physiol. 2003;284:F1066-79 pubmed
    ..Therefore, the expression of additional renal aquaporins (AQP1-4) and phosphorylated AQP2 (p-AQP2), known to play a role in urinary concentration, was examined in a Wistar rat ..
  5. Bai C, Fukuda N, Song Y, Ma T, Matthay M, Verkman A. Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. J Clin Invest. 1999;103:555-61 pubmed
    The mammalian lung expresses water channel aquaporin-1 (AQP1) in microvascular endothelia and aquaporin-4 (AQP4) in airway epithelia...
  6. Herrera M, Garvin J. Novel role of AQP-1 in NO-dependent vasorelaxation. Am J Physiol Renal Physiol. 2007;292:F1443-51 pubmed
  7. Chou C, Knepper M, Hoek A, Brown D, Yang B, Ma T, et al. Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice. J Clin Invest. 1999;103:491-6 pubmed
    ..high density of intramembrane particles (IMPs), which were proposed to consist of tetramers of aquaporin-1 (AQP1) water channels...
  8. Pallone T, Edwards A, Ma T, Silldorff E, Verkman A. Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta. J Clin Invest. 2000;105:215-22 pubmed
    Deletion of AQP1 in mice results in diminished urinary concentrating ability, possibly related to reduced NaCl- and urea gradient-driven water transport across the outer medullary descending vasa recta (OMDVR)...
  9. Song Y, Ma T, Matthay M, Verkman A. Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method. J Gen Physiol. 2000;115:17-27 pubmed
    The mammalian peripheral lung contains at least three aquaporin (AQP) water channels: AQP1 in microvascular endothelia, AQP4 in airway epithelia, and AQP5 in alveolar epithelia...

More Information


  1. Iandiev I, Pannicke T, Reichenbach A, Wiedemann P, Bringmann A. Diabetes alters the localization of glial aquaporins in rat retina. Neurosci Lett. 2007;421:132-6 pubmed
    ..We investigated whether the immunolocalization of two water channels, AQP1 and AQP4, alters in the rat retina during experimental diabetes...
  2. Hayashi Y, Edwards N, Proescholdt M, Oldfield E, Merrill M. Regulation and function of aquaporin-1 in glioma cells. Neoplasia. 2007;9:777-87 pubmed
    ..We sought to gain insight into AQP1 function in GBM...
  3. Bouley R, Palomino Z, Tang S, Nunes P, Kobori H, LU H, et al. Angiotensin II and hypertonicity modulate proximal tubular aquaporin 1 expression. Am J Physiol Renal Physiol. 2009;297:F1575-86 pubmed publisher
    b>Aquaporin 1 (AQP1) is the major water channel in the renal proximal tubule (PT) and thin descending limb of Henle, but its regulation remains elusive...
  4. Hoque M, Soria J, Woo J, Lee T, Lee J, Jang S, et al. Aquaporin 1 is overexpressed in lung cancer and stimulates NIH-3T3 cell proliferation and anchorage-independent growth. Am J Pathol. 2006;168:1345-53 pubmed reverse transcriptase-polymerase chain reaction and Western blot analysis and identified clear expression of aquaporin 1 (AQP1) in seven cell lines...
  5. Kim J, Son Y, Yun C, Kim Y, Nam Goong I, Park J, et al. Thyroid transcription factor-1 facilitates cerebrospinal fluid formation by regulating aquaporin-1 synthesis in the brain. J Biol Chem. 2007;282:14923-31 pubmed
    ..These results suggest that TTF-1 is physiologically involved in the transcriptional control of AQP-1, which is required for CSF formation. ..
  6. Ma T, Yang B, Gillespie A, Carlson E, Epstein C, Verkman A. Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. J Biol Chem. 1998;273:4296-9 pubmed
    Water channel aquaporin-1 (AQP1) is strongly expressed in kidney in proximal tubule and descending limb of Henle epithelia and in vasa recta endothelia...
  7. McCoy E, Sontheimer H. MAPK induces AQP1 expression in astrocytes following injury. Glia. 2010;58:209-17 pubmed publisher
    ..In response to injury, two additional aquaporins, AQP1 and AQP9, can be detected in astrocytes, yet neither is found in cultured astrocytes, and therefore their ..
  8. Cao C, Yin Q, Huang L, Zhan Z, Yang J, Xiong H. [Effect of angiotensin II on the expression of aquaporin 1 in lung of rats following acute lung injury]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2010;22:426-9 pubmed
    To investigate the effect of angiotensin II (Ang II) on the expression of aquaporin 1 (AQP1) in lung of rats with acute lung injury (ALI) and the role of Ang II in the formation of lung edema...
  9. Stamer W, Bok D, Hu J, Jaffe G, McKay B. Aquaporin-1 channels in human retinal pigment epithelium: role in transepithelial water movement. Invest Ophthalmol Vis Sci. 2003;44:2803-8 pubmed
    ..Although AQP1 has been cloned from a cDNA library prepared from cultures of retinal pigment epithelial (RPE) cells isolated from ..
  10. Buck T, Wagner J, Grund S, Skach W. A novel tripartite motif involved in aquaporin topogenesis, monomer folding and tetramerization. Nat Struct Mol Biol. 2007;14:762-9 pubmed
    ..We now show that in AQP1 these residues (Asn49 and Lys51) interact with Asp185 at the C terminus of TM5 to form a polar, quaternary ..
  11. Satoh J, Tabunoki H, Yamamura T, Arima K, Konno H. Human astrocytes express aquaporin-1 and aquaporin-4 in vitro and in vivo. Neuropathology. 2007;27:245-56 pubmed
    ..Previous studies indicate that AQP1 is expressed exclusively in the choroid plexus epithelium, while AQP4 is localized on the vascular foot of ..
  12. Cowan C, Yokoyama N, Bianchi L, Henkemeyer M, Fritzsch B. EphB2 guides axons at the midline and is necessary for normal vestibular function. Neuron. 2000;26:417-30 pubmed
    ..This suggests EphB2 may regulate ionic homeostasis and endolymph fluid production through macromolecular associations with membrane channels that transport chloride, bicarbonate, and water. ..
  13. Nesic O, Lee J, Unabia G, Johnson K, Ye Z, Vergara L, et al. Aquaporin 1 - a novel player in spinal cord injury. J Neurochem. 2008;105:628-40 pubmed publisher
    The role of water channel aquaporin 1 (AQP-1) in uninjured or injured spinal cords is unknown...
  14. Kaneko K, Yagui K, Tanaka A, Yoshihara K, Ishikawa K, Takahashi K, et al. Aquaporin 1 is required for hypoxia-inducible angiogenesis in human retinal vascular endothelial cells. Microvasc Res. 2008;75:297-301 pubmed publisher
    b>Aquaporin 1 (AQP1) was first purified from red blood cell membranes and is now known to be an osmolarity-driven water transporter that is widely expressed in many epithelial and endothelial cells outside the brain...
  15. Dolman D, Drndarski S, Abbott N, Rattray M. Induction of aquaporin 1 but not aquaporin 4 messenger RNA in rat primary brain microvessel endothelial cells in culture. J Neurochem. 2005;93:825-33 pubmed
    ..Expression of AQP1 and AQP4 in rat brain microvessel endothelial cells was investigated in order to determine whether these isoforms ..
  16. Shields S, Mazario J, Skinner K, Basbaum A. Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons. Pain. 2007;131:8-20 pubmed
    b>Aquaporin 1 (AQP1) is the archetypal member of a family of water channel proteins that contribute to water homeostasis in kidney, lung, and other tissues...
  17. Murata K, Mitsuoka K, Hirai T, Walz T, Agre P, Heymann J, et al. Structural determinants of water permeation through aquaporin-1. Nature. 2000;407:599-605 pubmed
    Human red cell AQP1 is the first functionally defined member of the aquaporin family of membrane water channels. Here we describe an atomic model of AQP1 at 3.8A resolution from electron crystallographic data...
  18. Yang B, Ma T, Dong J, Verkman A. Partial correction of the urinary concentrating defect in aquaporin-1 null mice by adenovirus-mediated gene delivery. Hum Gene Ther. 2000;11:567-75 pubmed gene delivery to kidney tubules and microvessels was evaluated by delivery of an adenovirus encoding aquaporin 1 (AQP1-Ad5) to transgenic AQP1 null mice...
  19. Kang T, Choi Y, Kim I, Oh S, Chun M. Identification and characterization of an aquaporin 1 immunoreactive amacrine-type cell of the mouse retina. J Comp Neurol. 2005;488:352-67 pubmed
    Using immunocytochemistry, a type of amacrine cell that is immunoreactive for aquaporin 1 was identified in the mouse retina...
  20. Nguyen T, Toussaint J, Xue Y, Raval C, Cancel L, Russell S, et al. Aquaporin-1 facilitates pressure-driven water flow across the aortic endothelium. Am J Physiol Heart Circ Physiol. 2015;308:H1051-64 pubmed publisher
    ..Lower atherogenic precursor solute concentrations may slow their intimal entrainment kinetics. ..
  21. Virkki M, Agrawal N, Edsbäcker E, Cristobal S, Elofsson A, Kauko A. Folding of Aquaporin 1: multiple evidence that helix 3 can shift out of the membrane core. Protein Sci. 2014;23:981-92 pubmed publisher
    ..However, for some proteins, including Aquaporin 1 (AQP1), the folding appears to follow a more complicated path...
  22. Sohara E, Rai T, Miyazaki J, Verkman A, Sasaki S, Uchida S. Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice. Am J Physiol Renal Physiol. 2005;289:F1195-200 pubmed
    ..0 +/- 0.3 x 10(-3) cm/s). Although AQP7 solo-knockout mice did not exhibit a urinary concentrating defect, AQP1/AQP7 double-knockout mice had a reduction in urinary concentrating ability compared with AQP1 solo-knockout mice, ..
  23. Hoshi A, Tsunoda A, Yamamoto T, Tada M, Kakita A, Ugawa Y. Increased neuronal and astroglial aquaporin-1 immunoreactivity in rat striatum by chemical preconditioning with 3-nitropropionic acid. Neurosci Lett. 2016;626:48-53 pubmed publisher
    Aquaporin-1 (AQP1) is a water channel expressed in the choroid plexus and participates in forming cerebrospinal fluid. Interestingly, reactive astrocytes also express AQP1 in the central nervous system under some pathological conditions...
  24. Au C, Butler T, Egan J, Cooper S, Lo H, Compton A, et al. Changes in skeletal muscle expression of AQP1 and AQP4 in dystrophinopathy and dysferlinopathy patients. Acta Neuropathol. 2008;116:235-46 pubmed publisher
    Transmembrane water transport is mediated by aquaporins (AQPs), of which AQP1 and AQP4 are expressed in skeletal muscle...
  25. Jiang J, Bai C, Hong Q, Zhang M, Song Y. Effect of aquaporin-1 deletion on pleural fluid transport. Acta Pharmacol Sin. 2003;24:301-5 pubmed
    To investigate the role of aquaporin-1 (AQP1) and sodium channel on pleural fluid transport. Wild-type and AQP1 null mice were used in this study. After the mice were briefly anesthetized, 0...
  26. Radtke A, O Riordan M. Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation of aquaporin-1. Cell Microbiol. 2008;10:2197-207 pubmed publisher
    ..We found that Aquaporin-1 (AQP1), a water channel that regulates swelling of secretory vesicles, associated with PCV...
  27. Furuya S, Naruse S, Ko S, Ishiguro H, Yoshikawa T, Hayakawa T. Distribution of aquaporin 1 in the rat pancreatic duct system examined with light- and electron-microscopic immunohistochemistry. Cell Tissue Res. 2002;308:75-86 pubmed
    ..Recently, intense signal for mRNA of aquaporin 1 (AQP1) water channels was detected in isolated rat interlobular ducts...
  28. Lazowski K, Li J, Delporte C, Baum B. Evidence for the presence of a Hg-inhibitable water-permeability pathway and aquaporin 1 in A5 salivary epithelial cells. J Cell Physiol. 1995;164:613-9 pubmed
    ..To determine if this activity was associated with the expression of the prototypical water channel (aquaporin, AQP) AQP1, we used three separate experimental approaches; Northern analysis and reverse transcription-polymerase chain ..
  29. Zhu X, Jiang S, Zhu X, Zou S, Wang Y, Hu Y. Expression of aquaporin 1 and aquaporin 3 in fetal membranes and placenta in human term pregnancies with oligohydramnios. Placenta. 2009;30:670-6 pubmed publisher
    To explore the pathophysiology of oligohydramnios, the association between the expression of aquaporin 1 and aquaporin 3 in fetal membranes and placenta and oligohydramnios was investigated...
  30. Zhang L, Li J, Jiang Z, Sun L, Mei X, Yong B, et al. Inhibition of aquaporin-1 expression by RNAi protects against aristolochic acid I-induced apoptosis in human proximal tubular epithelial (HK-2) cells. Biochem Biophys Res Commun. 2011;405:68-73 pubmed publisher
    The aim of this study was to investigate the protective effect of inhibition of aquaporin-1 (AQP1) expression against aristolochic acid I (AA-I)-induced apoptosis...
  31. Zhao W, Shen H, Yuan F, Li G, Sun Y, Shi Z, et al. Induction stage-dependent expression of vascular endothelial growth factor and aquaporin-1 in diethylstilbestrol-treated rat pituitary. Eur J Histochem. 2009;53:53-60 pubmed
  32. Umenishi F, Schrier R. Induction of human aquaporin-1 gene by retinoic acid in human erythroleukemia HEL cells. Biochem Biophys Res Commun. 2002;293:913-7 pubmed
    ..We report here that aquaporin-1 (AQP1) is specifically induced by retinoic acid (RA) in human erythroleukemia HEL cells...
  33. Ishibashi K, Morinaga T, Kuwahara M, Sasaki S, Imai M. Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin. Biochim Biophys Acta. 2002;1576:335-40 pubmed
    ..aquaglyceroporins (50% with AQP9, 48% with AQP3, 42% with AQP7) and lower identity with other aquaporins (32% with AQP1 and AQP8). AQP10 is expressed only in the small intestine with (approximately 2 kb)...
  34. Burghardt B, Elkaer M, Kwon T, Racz G, Varga G, Steward M, et al. Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas. Gut. 2003;52:1008-16 pubmed
    ..Messenger RNAs for AQP1, -3, -4, -5, and -8 were detected in normal pancreas and in pancreatic adenocarcinoma...
  35. Splinter P, Masyuk A, Larusso N. Specific inhibition of AQP1 water channels in isolated rat intrahepatic bile duct units by small interfering RNAs. J Biol Chem. 2003;278:6268-74 pubmed
    ..To address this issue, we designed, synthesized, and utilized small interfering RNAs (siRNAs) selective for AQP1 and investigated their effectiveness in altering AQP1-mediated water transport in intrahepatic bile duct units (..
  36. Yasui M, Kwon T, Knepper M, Nielsen S, Agre P. Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia. Proc Natl Acad Sci U S A. 1999;96:5808-13 pubmed
    ..Moreover, our studies predict that AQP6 participates in distinct physiological functions such as glomerular filtration, tubular endocytosis, and acid-base metabolism. ..
  37. Herak Kramberger C, Breljak D, Ljubojević M, Matokanović M, Lovrić M, Rogić D, et al. Sex-dependent expression of water channel AQP1 along the rat nephron. Am J Physiol Renal Physiol. 2015;308:F809-21 pubmed publisher
    In the mammalian kidney, nonglycosylated and glycosylated forms of aquaporin protein 1 (AQP1) coexist in the luminal and basolateral plasma membranes of proximal tubule and descending thin limb...
  38. Missner A, Kügler P, Saparov S, Sommer K, Mathai J, Zeidel M, et al. Carbon dioxide transport through membranes. J Biol Chem. 2008;283:25340-7 pubmed publisher
    Several membrane channels, like aquaporin-1 (AQP1) and the RhAG protein of the rhesus complex, were hypothesized to be of physiological relevance for CO(2) transport...
  39. Al Ghouleh I, Frazziano G, Rodriguez A, Csanyi G, Maniar S, St Croix C, et al. Aquaporin 1, Nox1, and Ask1 mediate oxidant-induced smooth muscle cell hypertrophy. Cardiovasc Res. 2013;97:134-42 pubmed publisher
    ..We hypothesized that extracellular H(2)O(2) induces smooth muscle cell (SMC) hypertrophy by a mechanism involving Aqp1, Nox1, and Ask1...
  40. Chao G, Zhang S. Aquaporins 1, 3 and 8 expression in irritable bowel syndrome rats' colon via NF-κB pathway. Oncotarget. 2017;8:47175-47183 pubmed publisher
    ..The expression of AQP1, AQP3, and AQP8 of IBS model group was down-regulated while NF-κB p65 was up-regulated comparing with control ..
  41. Zeidel M, Ambudkar S, Smith B, Agre P. Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein. Biochemistry. 1992;31:7436-40 pubmed
    ..b>CHIP28 is an abundant integral membrane protein in RBCs and renal tubules, and Xenopus laevis oocytes injected with ..
  42. Ablimit A, Hasan B, Lu W, Qin W, Wushouer Q, Zhong N, et al. Changes in water channel aquaporin 1 and aquaporin 5 in the small airways and the alveoli in a rat asthma model. Micron. 2013;45:68-73 pubmed publisher
    To examine changes in aquaporin 1 (AQP1) and aquaporin 5 (AQP5) in the small airways and alveoli in a rat asthma model. Forty Wistar rats were randomly divided into a control group and an ovalbumin (OVA) sensitization asthma model group...
  43. Zhao S, Li X. Expression of aquaporin-1 and aquaporin-3 in lung tissue of rat model with ischemia-reperfusion injury. Chin Med J (Engl). 2010;123:3711-3 pubmed
  44. Segura Anaya E, Martínez Gómez A, Dent M. Localization of aquaporin 1 water channel in the Schmidt-Lanterman incisures and the paranodal regions of the rat sciatic nerve. Neuroscience. 2015;285:119-27 pubmed publisher
    b>Aquaporin 1 (AQP1) is a member of a family of small, integral membrane water-transporting proteins, which facilitate water movement across cell membranes in response to osmotic gradients...
  45. Yu H, Sun B, Bai Q, Koide S, Li X. Influence of acetazolamide on AQP1 gene expression in testis and on sperm count/motility in epididymis of rats. Arch Androl. 2002;48:281-94 pubmed
    ..b>AQP1 and CAII or CAIV share many common biological properties...
  46. Kim J, Jung Y. Increased aquaporin-1 and Na+ -K+ -2Cl- cotransporter 1 expression in choroid plexus leads to blood-cerebrospinal fluid barrier disruption and necrosis of hippocampal CA1 cells in acute rat models of hyponatremia. J Neurosci Res. 2012;90:1437-44 pubmed publisher
    ..The present study was undertaken to investigate the possible roles of choroid plexus aquaporin-1 (AQP1) and of cation chloride transporters (Na(+) -K(+) -2Cl(-) cotransporter 1 [NKCC1] and K(+) -Cl(-) cotransporter 4 [..
  47. Iandiev I, Pannicke T, Biedermann B, Wiedemann P, Reichenbach A, Bringmann A. Ischemia-reperfusion alters the immunolocalization of glial aquaporins in rat retina. Neurosci Lett. 2006;408:108-12 pubmed
    ..staining, we investigated whether ischemia-reperfusion of the rat retina causes alterations in the distribution of AQP1 and AQP4 proteins...
  48. Fukuda M, Nakanishi Y, Fuse M, Yokoi N, Hamada Y, Fukagawa M, et al. Altered expression of aquaporins 1 and 4 coincides with neurodegenerative events in retinas of spontaneously diabetic Torii rats. Exp Eye Res. 2010;90:17-25 pubmed publisher
    ..b>AQP1 was expressed in the outer retina, whereas AQP4 was expressed in the perivascular and end feet of Müller cells and ..
  49. Shanahan C, Weissberg P, Metcalfe J. Isolation of gene markers of differentiated and proliferating vascular smooth muscle cells. Circ Res. 1993;73:193-204 pubmed
    ..function of differentiated VSMCs; SM22 alpha, a smooth muscle-specific protein of unknown function, and CHIP28, a putative membrane channel protein that is not highly expressed in other SM tissues and may therefore be a new ..
  50. Yoshii T, Harada F, Saito I, Nozawa Inoue K, Kawano Y, Maeda T. Immunoexpression of aquaporin-1 in the rat periodontal ligament during experimental tooth movement. Biomed Res. 2012;33:225-33 pubmed
    This study examined the immunoexpression pattern of aquaporin-1 (AQP1), first identified as a water channel protein, in the periodontal ligament of rat molars during experimental tooth movement to clarify its role in periodontal responses ..
  51. Wang G, Yuan W, Kwon T, Li Z, Wen J, Topcu S, et al. Age-related changes in expression in renal AQPs in response to congenital, partial, unilateral ureteral obstruction in rats. Pediatr Nephrol. 2012;27:83-94 pubmed publisher
    ..Semiquantitative immunoblotting and immunohistochemistry were used to examine the changes in abundance of AQP1, AQP2, p-S256AQP2 (AQP2 phosphorylated at consensus site Ser(256)) and AQP3 in the kidneys of rats with neonatally ..
  52. Xuli X, Wang J, Li Z, Yi Z, Xiao D. [Effect of early enteral feeding on the expression of aquaporin 1 in edematous small intestinal tissues of rats after severe burn]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:727-30 pubmed
    To investigate the changes in the expression of aquaporin 1 (AQP-1) in edematous small intestinal tissues of rats after severe burn and the effect of early enteral feeding on its expression...
  53. Ishihara E, Nagahama M, Naruse S, Semba R, Miura T, Usami M, et al. Neuropathological alteration of aquaporin 1 immunoreactive enteric neurons in the streptozotocin-induced diabetic rats. Auton Neurosci. 2008;138:31-40 pubmed
    ..In recent years, water channel protein, aquaporin 1 (AQP1) has been identified in the enteric nervous system (ENS)...