Gene Symbol: Apoo
Description: apolipoprotein O
Alias: RGD1565289, MICOS complex subunit MIC26
Turkieh A, Caubère C, Barutaut M, Desmoulin F, Harmancey R, Galinier M, et al
. Apolipoprotein O is mitochondrial and promotes lipotoxicity in heart. J Clin Invest. 2014;124:2277-86 pubmed publisher
..obesity-associated cardiac gene expression, we previously identified and cloned the gene encoding apolipoprotein O (APOO), which is overexpressed in hearts from diabetic patients...
Ott C, Dorsch E, Fraunholz M, Straub S, Kozjak Pavlovic V. Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits. PLoS ONE. 2015;10:e0120213 pubmed publisher
..We provide additional proof that ApoO indeed is a subunit of the MICOS and MIB complexes and propose the name Mic23 for this protein...
Guarani V, McNeill E, Paulo J, Huttlin E, FrÃ¶hlich F, Gygi S, et al
. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. elife. 2015;4: pubmed publisher
..Collectively, our work uncovers a previously unrecognized subunit of the MICOS complex, necessary for CJ integrity, cristae morphology, and mitochondrial function and provides a resource for further analysis of MICOS architecture. ..
Zerbes R, van der Klei I, Veenhuis M, Pfanner N, van der Laan M, Bohnert M. Mitofilin complexes: conserved organizers of mitochondrial membrane architecture. Biol Chem. 2012;393:1247-61 pubmed publisher
..MINOS has been conserved in evolution from unicellular eukaryotes to humans, where alterations of MINOS subunits are associated with multiple pathological conditions. ..
Koob S, Barrera M, Anand R, Reichert A. The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions. Biochim Biophys Acta. 2015;1853:1551-63 pubmed publisher
..Here we investigated the functional role of MIC26, a lipoprotein formerly termed APOO. Its levels are increased in diabetic heart tissue and in blood plasma of patients suffering from acute coronary ..