Apobec2

Summary

Gene Symbol: Apobec2
Description: apolipoprotein B mRNA editing enzyme catalytic subunit 2
Alias: C->U-editing enzyme APOBEC-2, apolipoprotein B editing complex 2, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
Species: rat
Products:     Apobec2

Top Publications

  1. Prochnow C, Bransteitter R, Klein M, Goodman M, Chen X. The APOBEC-2 crystal structure and functional implications for the deaminase AID. Nature. 2007;445:447-51 pubmed
    ..The structure suggests how mutations in patients with hyper-IgM-2 syndrome inactivate AID, resulting in defective antibody maturation. ..
  2. Guo J, Su Y, Zhong C, Ming G, Song H. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell. 2011;145:423-34 pubmed publisher
    ..Our study suggests a TET1-induced oxidation-deamination mechanism for active DNA demethylation in mammals. ..
  3. Hirano K, Young S, Farese R, Ng J, Sande E, Warburton C, et al. Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48. J Biol Chem. 1996;271:9887-90 pubmed
    ..The apobec-1-/- mice lacked detectable levels of Apobec-1 mRNA, expressed only unedited apoB mRNA in all tissues, and contained no apoB48 in their serum, demonstrating that there is no functional duplication of this gene. ..
  4. Liao W, Hong S, Chan B, Rudolph F, Clark S, Chan L. APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family. Biochem Biophys Res Commun. 1999;260:398-404 pubmed