Gene Symbol: Aplp2
Description: amyloid beta precursor like protein 2
Alias: APLP-2, Apph, WALPLP2, amyloid-like protein 2, Amyloid protein precursor-like protein 2, amyloid beta (A4) precursor-like protein 2, amyloid beta (A4) precursor-like protein 2-like, sperm membrane protein (YWK-II)
Species: rat
Products:     Aplp2

Top Publications

  1. White A, Reyes R, Mercer J, Camakaris J, Zheng H, Bush A, et al. Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice. Brain Res. 1999;842:439-44 pubmed
    ..precursor protein (APP), a member of a larger gene family including the amyloid precursor-like proteins, APLP1 and APLP2. The APP and APLP2 molecules contain metal binding sites for copper and zinc...
  2. Shen Y, Yu Y, Guo H, Tang Z, Yu F, Zhou J. Identification and comparative analysis of differentially expressed proteins in rat striatum following 6-hydroxydopamine lesions of the nigrostriatal pathway: up-regulation of amyloid precursor-like protein 2 expression. Eur J Neurosci. 2002;16:896-906 pubmed
    ..1-750% compared to control) in response to the lesion: amyloid precursor-like protein 2 (APLP2), kininogen, glucokinase, tropomyosin alpha chain, type brain-1 and calpactin I light chain; whilst four proteins, ..
  3. Zhang Y, Wang R, Liu Q, Zhang H, Liao F, Xu H. Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc Natl Acad Sci U S A. 2007;104:10613-8 pubmed
    ..Our results indicate an important role of PS/gamma-secretase-generated APP metabolite AICD in gene transcription and in EGFR-mediated tumorigenesis. ..
  4. Santha P, Pakaski M, Fazekas O, Szucs S, Fodor E, Kalman S, et al. [Acute and chronic stress induced changes in gene transcriptions related to Alzheimer's disease]. Ideggyogy Sz. 2012;65:195-200 pubmed
    ..These proteins maintain the normal function of the cytoskeleton and the synaptic plasticity. The above changes may lead to cognitive deterioration, and the development of AD. ..
  5. Yan Y, Bai Y, Wang L, Miao S, Koide S. Characterization of cDNA encoding a human sperm membrane protein related to A4 amyloid protein. Proc Natl Acad Sci U S A. 1990;87:2405-8 pubmed
    ..A sequence of basic amino acid residues, Arg-Lys-Arg, was found instead of Lys-Lys-Lys at the probable membrane-cytoplasmic junction that may be a unique property of sperm membrane proteins. ..
  6. Duilio A, Faraonio R, Minopoli G, Zambrano N, Russo T. Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein. Biochem J. 1998;330 ( Pt 1):513-9 pubmed
    ..the case of APP, another two closely related proteins exist, named beta-amyloid precursor-like protein (APLP)1 and APLP2: by using the interaction trap procedure we observed that both Fe65 and Fe65L2 interact with APP, APLP1 or APLP2, ..
  7. Maloney B, Ge Y, Greig N, Lahiri D. Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease. FASEB J. 2004;18:1288-90 pubmed publisher
  8. Wang P, Yang G, Mosier D, Chang P, Zaidi T, Gong Y, et al. Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2. J Neurosci. 2005;25:1219-25 pubmed
    ..Mice deficient in APP and its homolog APP-like protein 2 (APLP2) exhibit aberrant apposition of presynaptic marker proteins with postsynaptic acetylcholine receptors and ..
  9. Liu Q, Zerbinatti C, Zhang J, HOE H, Wang B, Cole S, et al. Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron. 2007;56:66-78 pubmed
    ..We also found that deletion of APP and its homolog APLP2, or components of the gamma-secretase complex, significantly enhanced the expression and function of LRP1, which ..

More Information


  1. Trillaud Doppia E, Paradis Isler N, Boehm J. A single amino acid difference between the intracellular domains of amyloid precursor protein and amyloid-like precursor protein 2 enables induction of synaptic depression and block of long-term potentiation. Neurobiol Dis. 2016;91:94-104 pubmed publisher
    ..induces synaptic depression, while the intracellular domain of its homolog amyloid-like precursor protein 2 (APLP2-ICD) does not. We are able to show that this effect by APP-ICD is due to a single alanine vs...
  2. von Koch C, Zheng H, Chen H, Trumbauer M, Thinakaran G, Van der Ploeg L, et al. Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice. Neurobiol Aging. 1997;18:661-9 pubmed
    ..precursor protein (APP) is a member of a larger gene family including amyloid precursor-like proteins (APLP), APLP2 and APLP1. To examine the function of APLP2 in vivo, we generated APLP2 knockout (KO) mice...
  3. Soba P, Eggert S, Wagner K, Zentgraf H, Siehl K, Kreger S, et al. Homo- and heterodimerization of APP family members promotes intercellular adhesion. EMBO J. 2005;24:3624-34 pubmed
    ..of APP family proteins promotes cell-cell adhesion in a homo- and heterotypic fashion and that endogenous APLP2 is required for cell-cell adhesion in mouse embryonic fibroblasts...
  4. von Der Kammer H, Hanes J, Klaudiny J, Scheit K. A human amyloid precursor-like protein is highly homologous to a mouse sequence-specific DNA-binding protein. DNA Cell Biol. 1994;13:1137-43 pubmed
    From a cDNA sequence, we have deduced the amino acid sequence for a human amyloid precursor-like protein (APPH) with > 92% identity to the CDEI binding protein (CDEBP) of the mouse and the fragmentary rat protein YWK-II of unknown ..
  5. Sandbrink R, Masters C, Beyreuther K. Complete nucleotide and deduced amino acid sequence of rat amyloid protein precursor-like protein 2 (APLP2/APPH): two amino acids length difference to human and murine homologues. Biochim Biophys Acta. 1994;1219:167-70 pubmed
    We present the cDNA sequence of the rat amyloid precursor-like protein 2 (APLP2) comprising the complete coding sequence of 765 amino acid residues...
  6. Herms J, Anliker B, Heber S, Ring S, Fuhrmann M, Kretzschmar H, et al. Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members. EMBO J. 2004;23:4106-15 pubmed
    ..APP) is a member of a larger gene family that includes the amyloid precursor-like proteins, termed APLP1 and APLP2. We previously documented that APLP2-/-APLP1-/- and APLP2-/-APP-/- mice die postnatally, while APLP1-/-APP-/- mice ..
  7. Pluta R, Kocki J, Ułamek Kozioł M, Petniak A, Gil Kulik P, Januszewski S, et al. Discrepancy in Expression of β-Secretase and Amyloid-β Protein Precursor in Alzheimer-Related Genes in the Rat Medial Temporal Lobe Cortex Following Transient Global Brain Ischemia. J Alzheimers Dis. 2016;51:1023-31 pubmed publisher
    ..Finally, the ischemia-induced gene changes may play a key role in a late and slow onset of Alzheimer-type pathology. ..