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Genomes and Genes | AplnSummaryGene Symbol: Apln Description: apelin Alias: Apel, APJ endogenous ligand, apelin, AGTRL1 ligand Species: rat Top Publications
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Publications
Apelin levels are increased in morbidly obese subjects with type 2 diabetes mellitusFederico Soriguer
Servicio de Endocrinologia y Nutricion, Hospital Regional Universitario Carlos Haya, Malaga, Spain
Obes Surg 19:1574-80. 2009..We measured the changes in apelin levels in morbidly obese subjects, with and without diabetes, and in the inverse situation of improvement in carbohydrate metabolism as a result of bariatric surgery...- Low plasma apelin levels in newly diagnosed type 2 diabetes mellitusG Erdem
Department of Internal Medicine, Gulhane School of Medicine, Etlik, Ankara, Turkey
Exp Clin Endocrinol Diabetes 116:289-92. 2008.... - A possible role for hypoxia-induced apelin expression in enteric cell proliferationSong Han
Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
Am J Physiol Regul Integr Comp Physiol 294:R1832-9. 2008..Apelin treatment during normoxia was ineffective. Our studies imply that the elevation in apelin expression during hypoxia and inflammation in the GI tract functions in part to stimulate epithelial cell proliferation... 
Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injuryLauren A O'Donnell
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Neurochem 102:1905-17. 2007..Thus, apelin/APJ signaling likely represents an endogenous hippocampal neuronal survival response, and therefore apelin should be further investigated as a potential neuroprotectant against hippocampal injury...- Adiposity dependent apelin gene expression: relationships with oxidative and inflammation markersDiego García-Díaz
Department of Physiology and Nutrition, University of Navarra, C Irunlarrea s n, 31008, Pamplona, Spain
Mol Cell Biochem 305:87-94. 2007..701; r=0.692 and r=0.561, respectively). These associations evidence a possible role for apelin in the excessive weight gain induced by high-fat feeding and increased adiposity, insulin-resistance, liver oxidative stress and inflammation... - Direct effects of apelin on cardiomyocyte contractility and electrophysiologyKlára Farkasfalvi
Heart Science Centre, Laboratory of Cell Electrophysiology, NHLI, Imperial College London, Harefield Hospital, Harefield, Middlesex UB9 6JH, UK
Biochem Biophys Res Commun 357:889-95. 2007..One of the mechanisms involved in the inotropic effect may be an increased myofilament sensitivity to Ca(2+) as apelin enhanced the activity of NHE with consequent intracellular alkalinization... - Increased colonic apelin production in rodents with experimental colitis and in humans with IBDSong Han
Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0725, USA
Regul Pept 142:131-7. 2007.... - Hypoxia inducible factor regulates the cardiac expression and secretion of apelinVeli Pekka Ronkainen
Department of Physiology, University of Oulu and Biocenter Oulu, Finland
FASEB J 21:1821-30. 2007..Because apelin gene expression has been shown to increase in cardiac ischemia, we investigated if apelin (Apln) gene expression was sensitive to hypoxia... - Interactions between apelin and angiotensin II on rat portal veinBogdan Gurzu
Faculty of Medicine, Department of Physiology, University of Medicine and Pharmacy Gr T Popa, 16 Universitatii Str, RO 700115 Iasi, Romania
J Renin Angiotensin Aldosterone Syst 7:212-6. 2006..Our results sustain the hypothesis that AP13 could increase the activity of both constitutive and inducible NO synthase on either endothelium intact or endothelium denuded rat portal vein rings... - Ischemic heart failure enhances endogenous myocardial apelin and APJ receptor expressionPavan Atluri
Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
Cell Mol Biol Lett 12:127-38. 2007..008). Infusion of apelin-13 significantly enhanced myocardial function in sham and failing hearts. We conclude that total myocardial apelin and APJ receptor levels increase in compensation for ischemic cardiomyopathy... - Characterization of the 5'-regulatory regions of the rat and human apelin genes and regulation of breast apelin by USFGuiyun Wang
Department of Surgery, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
FASEB J 20:2639-41. 2006..Together, our findings show that USF exerts a stimulatory role in regulation of breast apelin expression during pregnancy and lactation... - Data supporting a new physiological role for brain apelin in the regulation of hypothalamic oxytocin neurons in lactating ratsLaurence Bodineau
Institut National de la Sante et de la Recherche Medicale, Paris F 75231, France
Endocrinology 152:3492-503. 2011..In conclusion, these findings highlight the inhibitory role of apelin as an autocrine/paracrine peptide acting on OXY neurons during breastfeeding... - Effect of apelin on glomerular hemodynamic function in the rat kidneyAnnette Hus-Citharel
INSERM, U 691, Paris, France
Kidney Int 74:486-94. 2008..These results show that apelin has complex effects on the pre- and post glomerular microvasculature regulating renal hemodynamics. Its role on tubular function (if any) remains to be determined... - The hepatic apelin system: a new therapeutic target for liver diseaseAlessandro Principe
Biochemistry and Molecular Genetics Service, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Hospital Clinic, University of Barcelona, Barcelona, Spain
Hepatology 48:1193-201. 2008.... - Maternal apelin physiology during rat pregnancy: the role of the placentaT Van Mieghem
Department of Obstetrics and Gynecology, Health Campus Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49, Leuven, Belgium
Placenta 31:725-30. 2010..To gain further insight in apelin physiology, we investigated relative tissue expression, plasma clearance and metabolic pathways of apelin in pregnant rats... - Apelin protects against cardiomyocyte apoptosis induced by glucose deprivationZhi Zhang
Department of Cardiology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, China
Chin Med J (Engl) 122:2360-5. 2009..The aim of this study was to investigate the effects of apelin on apoptosis of rat cardiomyocytes induced by glucose deprivation (GD) and study the related signaling pathway... - Correlation between plasma levels of apelin and myocardial hypertrophy in rats and humans: possible target for treatment?Ines Falcao-Pires
University of Porto, Department of Physiology, Cardiovascular R and D Unit, Faculty of Medicine, 4200 319 Porto, Portugal
Expert Opin Ther Targets 14:231-41. 2010..To investigate the effects of left ventricular (LV) pressure overload and diabetes on the apelinergic system... 
Ontogeny of apelin and its receptor in the rodent gastrointestinal tractGuiyun Wang
Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555, USA
Regul Pept 158:32-9. 2009..Together, our data support a role for the apelin-APJ system in the regulation of smooth muscle, epithelial and goblet cell function in the GI tract...- Apelin gene transfer into the rostral ventrolateral medulla induces chronic blood pressure elevation in normotensive ratsQi Zhang
Department of Pharmaceutical Sciences, North Dakota State University, 1401 Albrecht Blvd, Fargo, ND 58105, USA
Circ Res 104:1421-8. 2009..Thus, the apelin system in the RVLM may play a very important role in central blood pressure regulation and in the pathogenesis of hypertension... - Apelin decreases myocardial injury and improves right ventricular function in monocrotaline-induced pulmonary hypertensionInes Falcao-Pires
Department of Physiology, Cardiovascular R and D Unit, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
Am J Physiol Heart Circ Physiol 296:H2007-14. 2009.... - Apelin signaling modulates splanchnic angiogenesis and portosystemic collateral vessel formation in rats with portal hypertensionCarolina Tiani
Hepatic Hemodynamic Laboratory, Liver Unit, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, CIBERehd, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
J Hepatol 50:296-305. 2009..The apelin/APJ signaling pathway plays a crucial role in angiogenesis. Therefore, we determined whether the apelin system modulates angiogenesis-driven processes in portal hypertension... - Reduced apelin levels in stable anginaZhao Li
Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, China
Intern Med 47:1951-5. 2008..To investigate the change in the plasma apelin level in patients with stable angina... - Involvement of a Stat3 binding site in inflammation-induced enteric apelin expressionSong Han
Dept of Surgery, Univ of Texas Medical Branch, Galveston, TX 77555, USA
Am J Physiol Gastrointest Liver Physiol 295:G1068-78. 2008..Together, our findings indicate that binding of phospho-Stat3 to the apelin promoter is the final step underlying proinflammatory cytokine-induced enteric apelin expression during intestinal inflammation... - Apelin increases contractility in failing cardiac muscleTieying Dai
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Tower 711, 600 N Wolfe Street, Baltimore, MD 21287, United States
Eur J Pharmacol 553:222-8. 2006..The increased force development is the result of increased [Ca(2+)](i) transients rather than changes in myofilament calcium responsiveness... - Down-regulation of cardiac apelin system in hypertrophied and failing hearts: Possible role of angiotensin II-angiotensin type 1 receptor systemYoshitaka Iwanaga
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Shogoinn kawahara cho Sakyo ku, Kyoto 606 8507, Japan
J Mol Cell Cardiol 41:798-806. 2006..Inhibition of the renin-angiotensin system may have beneficial effects, at least in part, through restoration of the cardiac apelin system in the treatment of HF... - Cellular localization of apelin and its receptor in the anterior pituitary: evidence for a direct stimulatory action of apelin on ACTH releaseAnnabelle Reaux-Le Goazigo
Institut National de la Sante et de la Recherche Medicale, Unité 691, College de France, 11 place Marcelin Berthelot, Paris, France
Am J Physiol Endocrinol Metab 292:E7-15. 2007.... - Dehydration-induced cross-regulation of apelin and vasopressin immunoreactivity levels in magnocellular hypothalamic neuronsAnnabelle Reaux-Le Goazigo
Department of Neurology and Neurosurgery, Montreal Neurological Institute, Room 896, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
Endocrinology 145:4392-400. 2004.... - Apelin, a new enteric peptide: localization in the gastrointestinal tract, ontogeny, and stimulation of gastric cell proliferation and of cholecystokinin secretionGuiyun Wang
Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555 0725, USA
Endocrinology 145:1342-8. 2004..Together, these data indicate that apelin is an important new stomach peptide with a potential physiological role in the gastrointestinal tract... - Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptorsDennis K Lee
Department of Pharmacology, University of Toronto, Toronto, Ontario M5S 1A8, USA
J Biol Chem 279:7901-8. 2004..This discovery of apelin, AT(1), and B(2) receptors with agonist-independent nuclear translocation suggests major unanticipated roles for these receptors in cell signaling and function... - Intracerebroventricular injection of apelin-13 reduces food intake in the ratDavid Sunter
Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
Neurosci Lett 353:1-4. 2003..In fasted rats, food intake was reduced at 24-h post-injection only. These data provide evidence of a possible role for apelin-13 in the control of food intake... - Venous dilator effect of apelin, an endogenous peptide ligand for the orphan APJ receptor, in conscious ratsXing Cheng
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
Eur J Pharmacol 470:171-5. 2003..These results show that apelin is an arterial and venous dilator in vivo. The depressor effect of apelin is accompanied by tachycardia which is abolished by ganglion blockade... - Regulation of rat APJ receptor messenger ribonucleic acid expression in magnocellular neurones of the paraventricular and supraopric nuclei by osmotic stimuliA M O'Carroll
University Research Centre for Neuroendocrinology, University of Bristol, Bristol, UK
J Neuroendocrinol 15:661-6. 2003..These data verify a role for APJ receptors in body fluid regulation and suggest a role for apelin in the regulation of vasopressin-containing neurones via a local autocrine/paracrine action of the peptide... - Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brainA Reaux
Institut National de la Sante et de la Recherche Medicale, Paris, France Laboratory of Neuromorphology, Faculty of Medicine Semmelweis University, Budapest, Hungary
J Neurochem 77:1085-96. 2001..Together, these results suggest that neuronal apelin plays an important role in the central control of body fluid homeostasis... - Molecular properties of apelin: tissue distribution and receptor bindingY Kawamata
Discovery Research Laboratories 1, Pharmaceutical Discovery Research Division, Takeda Chemical Industries, Ltd, Wadai 10, Tsukuba, 300 4293, Ibaraki, Japan
Biochim Biophys Acta 1538:162-71. 2001..Our results demonstrate that the long and short forms of apelin differently interact with APJ... - Characterization of apelin, the ligand for the APJ receptorD K Lee
Department of Pharmacology, University of Toronto, Ontario, Canada
J Neurochem 74:34-41. 2000..Intraperitoneal apelin injections induced an increase in drinking behavior within the first 30 min after injection, with a return to baseline within 1 h... - Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrumY Habata
Discovery Research Laboratories 1, Pharmaceutical Discovery Research Division, Takeda Chemical Industries, Ltd, Wadai 10, Tsukuba, Ibaraki, Japan
Biochim Biophys Acta 1452:25-35. 1999..Since apelin partially suppressed cytokine production by mouse spleen cells in response to T cell receptor/CD3 cross-linking, the oral intake of apelin in the colostrum and milk might modulate immune responses in neonates... - Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin releaseNadia De Mota
Institut National de la Sante et de la Recherche Medicale, Unite 36, College de France, 75231 Paris, France
Proc Natl Acad Sci U S A 101:10464-9. 2004..The coexistence of apelin and AVP in magnocellular neurons, their opposite biological effects, and regulation are likely to play a key role for maintaining body fluid homeostasis... - Modification of the terminal residue of apelin-13 antagonizes its hypotensive actionDennis K Lee
Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
Endocrinology 146:231-6. 2005..However, concomitant administration of apelin-13(F13A) (30 microg/kg) blocked hypotensive effects of apelin-13 (15 microg/kg), which revealed that apelin-13(F13A) behaved as an apelin-specific antagonist... - Effects of central and peripheral injections of apelin on fluid intake and cardiovascular parameters in ratsAnaya Mitra
Department of Psychology, University of Florida, Gainesville, FL 32611 2250, USA
Physiol Behav 89:221-5. 2006.... - Exercise training promotes expression of apelin and APJ of cardiovascular tissues in spontaneously hypertensive ratsJing Zhang
Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China
Life Sci 79:1153-9. 2006.... - Apelin stimulates myosin light chain phosphorylation in vascular smooth muscle cellsTatsuo Hashimoto
Division of Cellular Pathobiology, Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, 236 0004, Japan
Arterioscler Thromb Vasc Biol 26:1267-72. 2006..The present study determined whether apelin activates myosin light chain (MLC), a major regulatory event in initiating smooth muscle contraction... - Reduced apelin levels in lone atrial fibrillationPatrick T Ellinor
Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Boston, MA, USA
Eur Heart J 27:222-6. 2006..This peptide has been reported to be down-regulated in subjects with acute heart failure, but has not been studied in other cardiovascular conditions. We studied apelin levels in 73 subjects with lone atrial fibrillation (AF)... - Apelin protects myocardial injury induced by isoproterenol in ratsYue Xia Jia
Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China
Regul Pept 133:147-54. 2006..Apelin could have a cardioprotective effect, and the apelin-APJ system may be a new therapeutic target in myocardial injury and heart failure... - Apelin: a new plasma marker of cardiopulmonary diseaseJens Peter Goetze
Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK 2100, Copenhagen, Denmark
Regul Pept 133:134-8. 2006..We therefore examined whether plasma concentrations of apelin, a novel inotropic hormone, is affected in patients with chronic parenchymal lung disease without cardiac dysfunction... - Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric bandingM V Heinonen
Department of Biotechnology Molecular Medicine, A I Virtanen Institute for Molecular Sciences, University of Kuopio, 70211 Kuopio, Finland
Regul Pept 130:7-13. 2005..In addition, we measured in a subgroup of these patients in the same individual orexin-A and leptin plasma levels one year after gastric banding surgery... - Effects of all-trans retinoic acid on orphan receptor APJ signaling in spontaneously hypertensive ratsJiu Chang Zhong
Center for Molecular Biology, Shantou University Medical College, Shantou, Guangdong 515041, China
Cardiovasc Res 65:743-50. 2005..To further validate effects of atRA on the cardiovascular GPCRs, the present study was designed to assess whether atRA will modulate orphan receptor APJ, a homologue of angiotensin II type 1 (AT(1)) receptor... - Central and peripheral cardiovascular actions of apelin in conscious ratsShuntaro Kagiyama
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
Regul Pept 125:55-9. 2005..These results suggest that apelin plays a role in both central and peripheral cardiovascular regulation in conscious rats, and that the cardiovascular effects of apelin are not mediated by the AT1R... - Behavioral, neuroendocrine and thermoregulatory actions of apelin-13M Jászberényi
Department of Pathophysiology, University of Szeged, Neurohumoral Research Group, Hungarian Academy of Sciences, Semmelweis u 1, PO Box 427, H 6701, Szeged, Hungary
Neuroscience 129:811-6. 2004..Since the corticosterone response could be blocked by the CRH antagonist, it is likely to be mediated through the activation of the CRH neurons... - Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptorK Tatemoto
Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, 371 8512, Japan
Biochem Biophys Res Commun 251:471-6. 1998....