Apc

Summary

Gene Symbol: Apc
Description: APC, WNT signaling pathway regulator
Alias: RATAPC, adenomatous polyposis coli protein, WNT signaling pathway regulator, adenomatosis polyposis coli
Species: rat
Products:     Apc

Top Publications

  1. Holmen S, Zylstra C, Mukherjee A, Sigler R, Faugere M, Bouxsein M, et al. Essential role of beta-catenin in postnatal bone acquisition. J Biol Chem. 2005;280:21162-8 pubmed
    ..Wnt signaling pathway in osteogenesis, we generated mice lacking the beta-catenin or adenomatous polyposis coli (Apc) genes in osteoblasts...
  2. Fodde R, Edelmann W, Yang K, van Leeuwen C, Carlson C, Renault B, et al. A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc Natl Acad Sci U S A. 1994;91:8969-73 pubmed
    Germ-line mutations in the human adenomatous polyposis coli (APC) gene result in familial adenomatous polyposis, an autosomal dominant disorder characterized by the early onset of multiple adenomatous polyps in the large bowel with a ..
  3. Etienne Manneville S, Hall A. Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. Nature. 2003;421:753-6 pubmed
    ..specifically at the leading edge of migrating cells, and induces the interaction of adenomatous polyposis coli (Apc) protein with the plus ends of microtubules...
  4. Sansom O, Reed K, Hayes A, Ireland H, Brinkmann H, Newton I, et al. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev. 2004;18:1385-90 pubmed
    Although Apc is well characterized as a tumor-suppressor gene in the intestine, the precise mechanism of this suppression remains to be defined...
  5. Kaplan K, Burds A, Swedlow J, Bekir S, Sorger P, Nathke I. A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat Cell Biol. 2001;3:429-32 pubmed
    Mutations in the Adenomatous Polyposis Coli (APC) gene are responsible for familial colon cancer and also occur in the early stages of sporadic colon cancer...
  6. Qian C, Knol J, Igarashi P, Lin F, Zylstra U, Teh B, et al. Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium. J Biol Chem. 2005;280:3938-45 pubmed
    ..To gain more insights into the effects of these alterations, we created mice carrying a conditional deletion of the Apc tumor suppressor gene specifically in the renal epithelium...
  7. Hasegawa S, Sato T, Akazawa H, Okada H, Maeno A, Ito M, et al. Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene. Proc Natl Acad Sci U S A. 2002;99:297-302 pubmed
    b>Apc is a gene associated with familial adenomatous polyposis coli (FAP) and its inactivation is a critical step in colorectal tumor formation...
  8. Baeg G, Matsumine A, Kuroda T, Bhattacharjee R, Miyashiro I, Toyoshima K, et al. The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase. EMBO J. 1995;14:5618-25 pubmed
    The APC gene is mutated in familial adenomatous polyposis (FAP) as well as in sporadic colorectal tumours. The product of the APC gene is a 300 kDa cytoplasmic protein associated with the adherence junction protein catenin...
  9. Liu J, Xing Y, Hinds T, Zheng J, Xu W. The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin. J Mol Biol. 2006;360:133-44 pubmed
    Adenomatous polyposis coli (APC) plays a critical role in the Wnt signaling pathway by tightly regulating beta-catenin turnover and localization...

More Information

Publications98

  1. Zumbrunn J, Kinoshita K, Hyman A, Nathke I. Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation. Curr Biol. 2001;11:44-9 pubmed
    Truncation mutations in the adenomatous polyposis coli protein (APC) are responsible for familial polyposis, a form of inherited colon cancer...
  2. Sansom O, Griffiths D, Reed K, Winton D, Clarke A. Apc deficiency predisposes to renal carcinoma in the mouse. Oncogene. 2005;24:8205-10 pubmed
    ..Here, we directly test this association by using a Cre-LoxP strategy to inactivate the Adenomatous Polyposis Coli (Apc) gene in the murine renal epithelium...
  3. Ishikawa T, Tamai Y, Li Q, Oshima M, Taketo M. Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo. Dev Biol. 2003;253:230-46 pubmed
    Tumor suppressor Apc (adenomatous polyposis coli) is implicated in the Wnt signaling pathway that is involved in the early embryonic development and tumorigenesis in vertebrates...
  4. Hart M, de los Santos R, Albert I, Rubinfeld B, Polakis P. Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr Biol. 1998;8:573-81 pubmed
    Inactivation of the adenomatous polyposis coli (APC) tumor suppressor protein is responsible for both inherited and sporadic forms of colon cancer...
  5. Smits R, Kielman M, Breukel C, Zurcher C, Neufeld K, Jagmohan Changur S, et al. Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development. Genes Dev. 1999;13:1309-21 pubmed
    The adenomatous polyposis coli (APC) gene is considered as the true gatekeeper of colonic epithelial proliferation: It is mutated in the majority of colorectal tumors, and mutations occur at early stages of tumor development in mouse and ..
  6. Gounari F, Chang R, Cowan J, Guo Z, Dose M, Gounaris E, et al. Loss of adenomatous polyposis coli gene function disrupts thymic development. Nat Immunol. 2005;6:800-9 pubmed
    Loss of the adenomatous polyposis coli (APC) protein is a common initiating event in colon cancer. Here we show that thymocyte-specific loss of APC deregulated beta-catenin signaling and suppressed Notch-dependent transcription...
  7. Rubinfeld B, Albert I, Porfiri E, Fiol C, Munemitsu S, Polakis P. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science. 1996;272:1023-6 pubmed
    The adenomatous polyposis coli gene (APC) is mutated in most colon cancers...
  8. Amos Landgraf J, Kwong L, Kendziorski C, Reichelderfer M, Torrealba J, Weichert J, et al. A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer. Proc Natl Acad Sci U S A. 2007;104:4036-41 pubmed
    ..have investigated whether a rat model carrying a knockout allele in the gatekeeper gene Adenomatous polyposis coli (Apc) recapitulates familial colon cancer of the human more closely than existing murine models...
  9. You S, Ohmori M, Pena M, Nassri B, Quiton J, Al Assad Z, et al. Developmental abnormalities in multiple proliferative tissues of Apc(Min/+) mice. Int J Exp Pathol. 2006;87:227-36 pubmed
    Germ-line mutation of the Apc gene has been linked to familial adenomatous polyposis (FAP) that predisposes to colon cancer...
  10. Sohn K, Shah S, Reid S, Choi M, Carrier J, Comiskey M, et al. Molecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and beta(2)-microglobulin-deficient mouse. Cancer Res. 2001;61:6912-7 pubmed
    ..We investigated mutations of the Apc and p53 genes and microsatellite instability in colonic adenocarcinomas arising in this model...
  11. Levy D, Smith K, Beazer Barclay Y, Hamilton S, Vogelstein B, Kinzler K. Inactivation of both APC alleles in human and mouse tumors. Cancer Res. 1994;54:5953-8 pubmed
    Germline mutations of the adenomatous polyposis coli (APC) gene lead to multiple intestinal tumors in familial adenomatous polyposis patients and in multiple intestinal neoplasia (Min) mice...
  12. Yu C, Whiteley L, Carryl O, Basson M. Differential dietary effects on colonic and small bowel neoplasia in C57BL/6J Apc Min/+ mice. Dig Dis Sci. 2001;46:1367-80 pubmed
    The effects of fiber on colon cancer are controversial. Twenty 5-week old C57BL/6J Apc Min/+ mice were fed for 60 days with a commercial mouse diet (Teklad LM-485) and eight semidefined diets containing 5-10% various fibers and 20% ..
  13. Oshima M, Dinchuk J, Kargman S, Oshima H, Hancock B, Kwong E, et al. Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell. 1996;87:803-9 pubmed
    ..colorectal tumorigenisis, we determined the effects of COX-2 gene (Ptgs2) knockouts and a novel COX-2 inhibitor on Apc delta716 knockout mice, a model of human familial adenomatous polyposis...
  14. Rudolph K, Millard M, Bosenberg M, DePinho R. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet. 2001;28:155-9 pubmed
    ..We propose that early and transient telomere dysfunction is a major mechanism underlying chromosomal instability of human cancer. ..
  15. Takahashi T, Shivapurkar N, Riquelme E, Shigematsu H, Reddy J, Suzuki M, et al. Aberrant promoter hypermethylation of multiple genes in gallbladder carcinoma and chronic cholecystitis. Clin Cancer Res. 2004;10:6126-33 pubmed
    ..There is limited information about the molecular changes involved in the pathogenesis of gallbladder carcinoma (GBC), including methylation status...
  16. Tran H, Hamada F, Schwarz Romond T, Bienz M. Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. Genes Dev. 2008;22:528-42 pubmed publisher
    ..We further show that Trabid can bind to and deubiquitylate the APC tumor suppressor protein, a negative regulator of Wnt-mediated transcription...
  17. Shi S, Cheng T, Jan L, Jan Y. APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity. Curr Biol. 2004;14:2025-32 pubmed
    ..Here, we report that mPar3 forms a complex with adenomatous polyposis coli (APC) and kinesin superfamily (KIF) 3A, proteins that move along microtubules...
  18. Collin L, Schlessinger K, Hall A. APC nuclear membrane association and microtubule polarity. Biol Cell. 2008;100:243-52 pubmed
    ..using primary fibroblasts and astrocytes in in vitro scratch-induced migration assays, that the accumulation of APC (adenomatous polyposis coli; the APC tumour suppressor protein) at microtubule plus-ends promotes their association ..
  19. Yoshimi K, Tanaka T, Serikawa T, Kuramoto T. Tumor suppressor APC protein is essential in mucosal repair from colonic inflammation through angiogenesis. Am J Pathol. 2013;182:1263-74 pubmed publisher
    ..The adenomatous polyposis coli (APC) tumor suppressor gene regulates the Wnt signaling pathway, which is essential for epithelial development, and ..
  20. Onouchi T, Takamori N, Senda T. Colocalization of APC and PSD-95 in the nerve fiber as well as in the post-synapse of matured neurons. Med Mol Morphol. 2012;45:152-60 pubmed
    b>Adenomatous polyposis coli protein (APC) is highly expressed in the nervous tissue, but its function there is not yet known...
  21. Zaoui K, Benseddik K, Daou P, Salaün D, Badache A. ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. Proc Natl Acad Sci U S A. 2010;107:18517-22 pubmed publisher
    ..Memo-dependent inhibition of GSK3 allows the relocalization of APC (adenomatous polyposis coli) and cytoplasmic linker-associated protein 2 (CLASP2), known MT-associated proteins, to ..
  22. Votin V, Nelson W, Barth A. Neurite outgrowth involves adenomatous polyposis coli protein and beta-catenin. J Cell Sci. 2005;118:5699-708 pubmed
    ..A candidate protein for controlling neurite extension is the adenomatous polyposis coli (APC) protein, which regulates membrane extensions, microtubules and beta-catenin-mediated transcription downstream of ..
  23. Halberg R, Katzung D, Hoff P, Moser A, Cole C, Lubet R, et al. Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers. Proc Natl Acad Sci U S A. 2000;97:3461-6 pubmed
    The interaction between mutations in the tumor-suppressor genes Apc and p53 was studied in congenic mouse strains to minimize the influence of polymorphic modifiers...
  24. Blum C, Tanaka T, Zhong X, Li Q, Dashwood W, Pereira C, et al. Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun. Mol Carcinog. 2003;36:195-203 pubmed
    ..02). More than 50 of the colon tumors with wild-type beta-catenin were examined further for their Apc status; the overall frequency of Apc mutations was <10%, and these genetic changes occurred exclusively in the '..
  25. Farías G, Vallés A, Colombres M, Godoy J, Toledo E, Lukas R, et al. Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons. J Neurosci. 2007;27:5313-25 pubmed
    ..a ligand active in the canonical Wnt signaling pathway, induces dissociation of the adenomatous polyposis coli (APC) protein from the beta-catenin cytoplasmic complex and the interaction of APC with alpha7-nAChRs in hippocampal ..
  26. Gould K, Dietrich W, Borenstein N, Lander E, Dove W. Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice. Genetics. 1996;144:1769-76 pubmed
    ..The application and efficiency of this method are discussed. We used this strain to determine that Mom1 affects both tumor multiplicity and tumor size in a semi-dominant fashion. ..
  27. Topol L, Jiang X, Choi H, Garrett Beal L, Carolan P, Yang Y. Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J Cell Biol. 2003;162:899-908 pubmed
    ..This pathway is Siah2 and APC dependent, but GSK-3 and beta-TrCP independent...
  28. Islam M, Nautiyal M, Wynn R, Mobley J, Chuang D, Hutson S. Branched-chain amino acid metabolon: interaction of glutamate dehydrogenase with the mitochondrial branched-chain aminotransferase (BCATm). J Biol Chem. 2010;285:265-76 pubmed publisher
    ..Kinetic results suggest that GDH1 facilitates regeneration of the form of BCATm that binds to E1 decarboxylase of the BCKDC, promotes metabolon formation, branched-chain amino acid oxidation, and cycling of nitrogen through glutamate. ..
  29. Bareiss S, Kim K, Lu Q. Delta-catenin/NPRAP: A new member of the glycogen synthase kinase-3beta signaling complex that promotes beta-catenin turnover in neurons. J Neurosci Res. 2010;88:2350-63 pubmed publisher
  30. Clarke A, Cummings M, Harrison D. Interaction between murine germline mutations in p53 and APC predisposes to pancreatic neoplasia but not to increased intestinal malignancy. Oncogene. 1995;11:1913-20 pubmed
    Murine strains which bear constitutive inactivating mutations of either the APC or the p53 tumor suppressor genes are characterised by spontaneous tumors...
  31. Yoshimizu T, Miroglio A, Ripoche M, Gabory A, Vernucci M, Riccio A, et al. The H19 locus acts in vivo as a tumor suppressor. Proc Natl Acad Sci U S A. 2008;105:12417-22 pubmed publisher
    ..tumorigenesis, that the H19 locus controls the size of experimental teratocarcinomas, the number of polyps in the Apc murine model of colorectal cancer and the timing of appearance of SV40-induced hepatocarcinomas...
  32. Giroux V, Lemay F, Bernatchez G, Robitaille Y, Carrier J. Estrogen receptor beta deficiency enhances small intestinal tumorigenesis in ApcMin/+ mice. Int J Cancer. 2008;123:303-311 pubmed publisher
    ..first aim of this study was to investigate the consequence of ERbeta deficiency on intestinal tumorigenesis in the Apc(Min/+) mouse model...
  33. Leitges M. Functional PKC in vivo analysis using deficient mouse models. Biochem Soc Trans. 2007;35:1018-20 pubmed
    ..Exemplary of this approach, recent data generated with PKCalpha-deficient APC(Min) (adenomatous polyposis coli) mice identify PKCalpha in this system acting as a tumour suppressor instead of ..
  34. Pecina Slaus N, Pavelic K, Pavelic J. Loss of heterozygosity and protein expression of APC gene in renal cell carcinomas. J Mol Med (Berl). 1999;77:446-53 pubmed
    This study evaluated the potential contribution of the APC gene to malignant transformation in patients with renal cell carcinoma...
  35. Ploplis V, Tipton H, Menchen H, Castellino F. A urokinase-type plasminogen activator deficiency diminishes the frequency of intestinal adenomas in ApcMin/+ mice. J Pathol. 2007;213:266-74 pubmed
    ..In the current study, a mouse model of colon cancer, Apc(Min/+), with an additional deficiency of uPA (Apc(Min/+)/Plau-/-) was used to determine the effects of uPA on ..
  36. Shimomura A, Kohu K, Akiyama T, Senda T. Subcellular localization of the tumor suppressor protein APC in developing cultured neurons. Neurosci Lett. 2005;375:81-6 pubmed
    We examined the subcellular distribution of tumor suppressor adenomatous polyposis coli (APC) in developing cultured rat hippocampal neurons using both immunofluorescent microscopy and immunoelectron microscopy...
  37. Hargreaves G, Quinn H, Kashem M, Matsumoto I, McGregor I. Proteomic analysis demonstrates adolescent vulnerability to lasting hippocampal changes following chronic alcohol consumption. Alcohol Clin Exp Res. 2009;33:86-94 pubmed publisher
    ..The proteins most affected include those related to glycolysis, glutamate metabolism, neurodegeneration, synaptic function, and cytoskeletal structure. ..
  38. Li P, Schulz S, Bombonati A, Palazzo J, Hyslop T, Xu Y, et al. Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity. Gastroenterology. 2007;133:599-607 pubmed
    ..tumorigenesis was examined in wild-type (Gcc(+/+)) and GCC-deficient (Gcc(-/-)) mice carrying mutations in Apc (Apc(Min/+)) or exposed to the carcinogen azoxymethane...
  39. Veas Pérez de Tudela M, Maestre C, Delgado Esteban M, Bolaños J, Almeida A. Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons. Sci Rep. 2015;5:18180 pubmed publisher
    The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that regulates cell cycle progression in proliferating cells. To enter the S-phase, APC/C must be inactivated by phosphorylation of its cofactor, Cdh1...
  40. Sansom O, Mansergh F, Evans M, Wilkins J, Clarke A. Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice. Gut. 2007;56:1410-4 pubmed
    ..SPARC upregulation was determined in intestinal adenomas of tumour-prone Apc(Min/+) mice at both the RNA and the protein level...
  41. Wang Q, Zhang Y, Yang K, Zhou H, Yang H. Wnt/beta-catenin signaling pathway is active in pancreatic development of rat embryo. World J Gastroenterol. 2006;12:2615-9 pubmed
    ..The mRNAs of beta-catenin, APC, cyclin D1 genes were amplified by means of semiquantitative reverse transcription polymerase chain reaction (RT-..
  42. Ellender M, Harrison J, Kozlowski R, Szłuińska M, Bouffler S, Cox R. In utero and neonatal sensitivity of ApcMin/+ mice to radiation-induced intestinal neoplasia. Int J Radiat Biol. 2006;82:141-51 pubmed
    To assess the sensitivity of ApcMin/+ mice (adenomatous polyposis coli Apc, multiple intestinal neoplasia, Min) to the development of intestinal adenomas after x-irradiation in utero, as neonates, or as young adults...
  43. Neufeld K, Nix D, Bogerd H, Kang Y, Beckerle M, Cullen B, et al. Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. Proc Natl Acad Sci U S A. 2000;97:12085-90 pubmed
    Mutational inactivation of the adenomatous polyposis coli (APC) tumor suppressor initiates most hereditary and sporadic colon carcinomas...
  44. Erdmann K, Kuhlmann J, Lessmann V, Herrmann L, Eulenburg V, Muller O, et al. The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain. Oncogene. 2000;19:3894-901 pubmed
    Mutations of the tumor suppressor protein APC (Adenomatous Polyposis Coli) are linked to familiar and sporadic human colon cancer...
  45. Pierre F, Perrin P, Bassonga E, Bornet F, Meflah K, Menanteau J. T cell status influences colon tumor occurrence in min mice fed short chain fructo-oligosaccharides as a diet supplement. Carcinogenesis. 1999;20:1953-6 pubmed
    ..of short chain fructo-oligosaccharides (indigestible carbohydrates) to food prevented colon tumors in C57BL/6-Apc(Min/+) mice, a model for human colon cancer...
  46. Purro S, Ciani L, Hoyos Flight M, Stamatakou E, Siomou E, Salinas P. Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli. J Neurosci. 2008;28:8644-54 pubmed publisher
    ..Wnt signaling directly affects the microtubule cytoskeleton by unexpectedly inducing adenomatous polyposis coli (APC) loss from microtubule plus-ends. Consistently, short hairpin RNA knockdown of APC mimics Wnt3a function...
  47. Schoonjans K, Dubuquoy L, Mebis J, Fayard E, Wendling O, Haby C, et al. Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation. Proc Natl Acad Sci U S A. 2005;102:2058-62 pubmed
    ..In combination, these data suggest a role of LRH-1 in the initiation of intestinal tumorigenesis both by affecting cell cycle control as well as through its impact on inflammatory pathways. ..
  48. Tucker J, Murphy J, Kisiel N, Diegelman P, Barbour K, Davis C, et al. Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase. Cancer Res. 2005;65:5390-8 pubmed
    ..Herein, we examined the effects of differential SSAT expression on intestinal tumorigenesis in the Apc(Min/+) (MIN) mouse...
  49. Chulada P, Thompson M, Mahler J, Doyle C, Gaul B, Lee C, et al. Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res. 2000;60:4705-8 pubmed
    ..The results indicate that COX-1, as well as COX-2, plays a key role in intestinal tumorigenesis and that COX-1 may also be a chemotherapeutic target for nonsteroidal anti-inflammatory drugs. ..
  50. Takaku K, Sonoshita M, Sasaki N, Uozumi N, Doi Y, Shimizu T, et al. Suppression of intestinal polyposis in Apc(delta 716) knockout mice by an additional mutation in the cytosolic phospholipase A(2) gene. J Biol Chem. 2000;275:34013-6 pubmed
    ..cPLA(2) mRNA was markedly elevated in the polyps and correlated with the polyp size in the small intestine of the Apc(delta)(716) knockout mouse, a model for human familial adenomatous polyposis...
  51. Marcus D, Rustgi A, Defoe D, Kucherlapati R, Edelmann W, Hamasaki D, et al. Ultrastructural and ERG findings in mice with adenomatous polyposis coli gene disruption. Mol Vis. 2000;6:169-77 pubmed
    In order to continue the previous morphological studies of eyes from mice with adenomatous polyposis coli (APC) gene mutation at codon 1638, we determined the ultrastructural and electrophysiologic characteristics of these eyes...
  52. Abraham S, Wu T, Hruban R, Lee J, Yeo C, Conlon K, et al. Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway. Am J Pathol. 2002;160:953-62 pubmed
    ..We have recently demonstrated a high frequency of allelic loss on chromosome arm 11p and mutations in the APC/beta-catenin pathway in pancreatoblastomas, suggesting that similar alterations might also play a role in the ..
  53. Stanton J, Green D. Meta-analysis of gene expression in mouse preimplantation embryo development. Mol Hum Reprod. 2001;7:545-52 pubmed
    ..By anchoring the analysis of mouse preimplantation development in UniGene, it will be possible to identify homologous genes that are likely to be involved in human preimplantation embryo development. ..
  54. Yang K, Edelmann W, Fan K, Lau K, Leung D, Newmark H, et al. Dietary modulation of carcinoma development in a mouse model for human familial adenomatous polyposis. Cancer Res. 1998;58:5713-7 pubmed
    Familial adenomatous polyposis (FAP) is caused by a dominant mutation in the adenomatous polyposis coli (APC) gene. Individuals with FAP progressively develop adenomas and carcinomas of the colon and rectum...
  55. Oshima M, Murai N, Kargman S, Arguello M, Luk P, Kwong E, et al. Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor. Cancer Res. 2001;61:1733-40 pubmed
    Mutations in the human adenomatous polyposis (APC) gene are causative for familial adenomatous polyposis (FAP), a rare condition in which numerous colonic polyps arise during puberty and, if left untreated, lead to colon cancer...
  56. Tanaka S, Akiyoshi T, Mori M, Wands J, Sugimachi K. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. Proc Natl Acad Sci U S A. 1998;95:10164-9 pubmed
    ..of the FzE3 cDNA in esophageal carcinoma cells stimulates complex formation between adenomatous polyposis coli (APC) and beta-catenin followed by nuclear translocation of beta-catenin...
  57. Askham J, Moncur P, Markham A, Morrison E. Regulation and function of the interaction between the APC tumour suppressor protein and EB1. Oncogene. 2000;19:1950-8 pubmed
    The interaction between the adenomatous polyposis coli (APC) tumour suppressor and the microtubule-associated protein EB1 was examined...
  58. Brenman J, Topinka J, Cooper E, McGee A, Rosen J, Milroy T, et al. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. J Neurosci. 1998;18:8805-13 pubmed
    ..restored by a variety of PDZ ligands, including the C termini of NMDA receptor 2B, adenomatous polyposis coli (APC), and CRIPT...
  59. Kroboth K, Newton I, Kita K, Dikovskaya D, Zumbrunn J, Waterman Storer C, et al. Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. Mol Biol Cell. 2007;18:910-8 pubmed
    Most sporadic colorectal tumors carry truncation mutations in the adenomatous polyposis coli (APC) gene. The APC protein is involved in many processes that govern gut tissue...
  60. Ohshima R, Ohta T, Wu W, Koike A, Iwatani T, Henderson M, et al. Putative tumor suppressor EDD interacts with and up-regulates APC. Genes Cells. 2007;12:1339-45 pubmed
    Adenomatous polyposis coli (APC), whose mutation causes colorectal cancers, is a key player in the Wnt signaling pathway...
  61. Rubinfeld B, Souza B, Albert I, Munemitsu S, Polakis P. The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin. J Biol Chem. 1995;270:5549-55 pubmed
    The tumor suppressor APC protein associates with the cadherin-binding proteins alpha- and beta-catenin...
  62. Nateri A, Spencer Dene B, Behrens A. Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature. 2005;437:281-5 pubmed
    ..In the Apc(Min) mouse model of intestinal cancer, genetic abrogation of c-Jun N-terminal phosphorylation or gut-specific ..
  63. Kanamori M, Sandy P, Marzinotto S, Benetti R, Kai C, Hayashizaki Y, et al. The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. J Biol Chem. 2003;278:38758-64 pubmed
    ..These data suggest that TIP-1 may represent a novel regulatory element in the Wnt/beta-catenin signaling pathway. ..
  64. Mahmoud N, Boolbol S, Bilinski R, Martucci C, Chadburn A, Bertagnolli M. Apc gene mutation is associated with a dominant-negative effect upon intestinal cell migration. Cancer Res. 1997;57:5045-50 pubmed
    b>Apc-associated intestinal tumor formation appears to require functional loss of both Apc alleles. Apc has, therefore, been classified as a tumor suppressor gene...
  65. Moser A, Hegge L, Cardiff R. Genetic background affects susceptibility to mammary hyperplasias and carcinomas in Apc(min)/+ mice. Cancer Res. 2001;61:3480-5 pubmed
    Treatment of female C57BL/6J (B6) mice carrying the mutant Min allele of the adenomatous polyposis coli (Apc) gene with ethylnitrosourea (ENU) results in approximately 90% of mice developing an average of three mammary tumors within 65 ..
  66. Taketo M, Takaku K. Gastrointestinal tumorigenesis in Smad4 (Dpc4) mutant mice. Hum Cell. 2000;13:85-95 pubmed
    ..We then introduced the Smad4 mutation into the Apc delta 716 knockout mice, a model for human familial adenomatous polyposis...
  67. Hulit J, Wang C, Li Z, Albanese C, Rao M, Di Vizio D, et al. Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice. Mol Cell Biol. 2004;24:7598-611 pubmed
    ..activity, the primary transforming events in colorectal carcinoma, occurs through induction of the Wnt pathway or APC gene mutations that cause familial adenomatous polyposis...
  68. Yang Y, Zhou L, Lu L, Wang L, Li X, Jiang P, et al. A novel miR-193a-5p-YY1-APC regulatory axis in human endometrioid endometrial adenocarcinoma. Oncogene. 2013;32:3432-42 pubmed publisher
    ..analysis revealed a significant effect of YY1 on critical aspects of EEC tumorigenesis through inhibition of APC expression...
  69. Hülsken J, Birchmeier W, Behrens J. E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J Cell Biol. 1994;127:2061-9 pubmed
    ..It interacts with the cell adhesion molecule E-cadherin and also with the tumor suppressor gene product APC, and the Drosophila homologue of beta-catenin, armadillo, mediates morphogenetic signals...
  70. Sansom O, Meniel V, Muncan V, Phesse T, Wilkins J, Reed K, et al. Myc deletion rescues Apc deficiency in the small intestine. Nature. 2007;446:676-9 pubmed
    The APC gene encodes the adenomatous polyposis coli tumour suppressor protein, germline mutation of which characterizes familial adenomatous polyposis (FAP), an autosomal intestinal cancer syndrome...
  71. Pecina Slaus N, Gall Troselj K, Slaus M, Radic K, Nikuseva Martic T, Pavelic K. Genetic changes of the E-cadherin and APC tumour suppressor genes in clear cell renal cell carcinoma. Pathology. 2004;36:145-51 pubmed
    The roles of tumour suppressor genes: adenomatous polyposis coli (APC) and E-cadherin (CDH1) were investigated in clear cell renal cell carcinoma...
  72. Berger F, Kramer D, Porter C. Polyamine metabolism and tumorigenesis in the Apc(Min/+) mouse. Biochem Soc Trans. 2007;35:336-9 pubmed
    ..In attempts to clarify the function of SSAT in tumour development, we have utilized the Apc(Min/+) mouse, which carries a mutant allele of the Apc (adenomatous polyposis coli) gene, rendering it susceptible ..
  73. Zhou F, Zhou J, Dedhar S, Wu Y, Snider W. NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC. Neuron. 2004;42:897-912 pubmed
    ..kinases control axon growth via regulation of a microtubule plus end binding protein, adenomatous polyposis coli (APC)...
  74. Blanc V, Henderson J, Newberry R, Xie Y, Cho S, Newberry E, et al. Deletion of the AU-rich RNA binding protein Apobec-1 reduces intestinal tumor burden in Apc(min) mice. Cancer Res. 2007;67:8565-73 pubmed
    ..Here, we show that small intestinal adenoma formation is dramatically reduced in compound Apc(min/+) apobec-1(-/-) mice when compared with the parental Apc(min/+) strain...
  75. Wang D, Wang H, Shi Q, Katkuri S, Walhi W, Desvergne B, et al. Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. Cancer Cell. 2004;6:285-95 pubmed
    ..We also found that PGE(2) treatment of Apc(min) mice dramatically increased intestinal adenoma burden, which was negated in Apc(min) mice lacking PPARdelta...
  76. Arif M, Pandey R, Alam P, Jiang S, Sadayappan S, Paul A, et al. MicroRNA-210-mediated proliferation, survival, and angiogenesis promote cardiac repair post myocardial infarction in rodents. J Mol Med (Berl). 2017;95:1369-1385 pubmed publisher
    ..When compared to control, ?-catenin and Bcl-2 were upregulated while APC (adenomatous polyposis coli), p16, and caspase-3 were downregulated in miR-210 group...
  77. Novelli M, Wasan H, Rosewell I, Bee J, Tomlinson I, Wright N, et al. Tumor burden and clonality in multiple intestinal neoplasia mouse/normal mouse aggregation chimeras. Proc Natl Acad Sci U S A. 1999;96:12553-8 pubmed
    Aggregation chimeras were formed between C57BL/6 mice heterozygous for the Apc(min) (Min) mutation and wild-type SWR mice, that differ in their Pla2g2a status, a modifier of Apc(min), and also in their resistance to intestinal polyp ..
  78. Abal M, Obrador Hevia A, Janssen K, Casadome L, Menendez M, Carpentier S, et al. APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation. Gastroenterology. 2007;132:2448-58 pubmed
    ..A role for the tumor suppressor gene APC has been proposed in colorectal cancer that leads to compromised chromosome segregation even though the molecular ..
  79. Moreno Bueno G, Hardisson D, Sanchez C, Sarrio D, Cassia R, Garcia Rostan G, et al. Abnormalities of the APC/beta-catenin pathway in endometrial cancer. Oncogene. 2002;21:7981-90 pubmed
    The activation of the APC/beta-catenin signalling pathway due to beta-catenin mutations has been implicated in the development of a subset of endometrial carcinomas (ECs)...
  80. Penman G, Leung L, Nathke I. The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions. J Cell Sci. 2005;118:4741-50 pubmed
    Mutations resulting in the truncation of the adenomatous polyposis coli (APC) protein are common to most colonic tumours...
  81. Elander N, Ungerbäck J, Olsson H, Uematsu S, Akira S, Soderkvist P. Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice. Biochem Biophys Res Commun. 2008;372:249-53 pubmed publisher
    ..Here we demonstrate that APC(Min/+) mice with genetic deletion of microsomal prostaglandin E synthase-1 (mPGES-1), which catalyses the terminal ..
  82. Benhamouche S, Decaens T, Godard C, Chambrey R, Rickman D, Moinard C, et al. Apc tumor suppressor gene is the "zonation-keeper" of mouse liver. Dev Cell. 2006;10:759-70 pubmed
    ..we show the complementary localization of activated beta-catenin in the perivenous area and the negative regulator Apc in periportal hepatocytes...
  83. Kita K, Wittmann T, Nathke I, Waterman Storer C. Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1. Mol Biol Cell. 2006;17:2331-45 pubmed
    In interphase cells, the adenomatous polyposis coli (APC) protein accumulates on a small subset of microtubules (MTs) in cell protrusions, suggesting that APC may regulate the dynamics of these MTs...
  84. Dahlhoff M, Horst D, Gerhard M, Kolligs F, Wolf E, Schneider M. Betacellulin stimulates growth of the mouse intestinal epithelium and increases adenoma multiplicity in Apc+/Min mice. FEBS Lett. 2008;582:2911-5 pubmed publisher
    ..increased polyp multiplicity but did not change the mean size or the histological quality of intestinal polyps in Apc(+/Min) mice...
  85. Sansom O, Meniel V, Wilkins J, Cole A, Oien K, Marsh V, et al. Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proc Natl Acad Sci U S A. 2006;103:14122-7 pubmed
    ..expressed an oncogenic K-ras(V12) allele in the small intestine of adult mice either alone or in the context of Apc deficiency...
  86. Sakamoto Y, Boëda B, Etienne Manneville S. APC binds intermediate filaments and is required for their reorganization during cell migration. J Cell Biol. 2013;200:249-58 pubmed publisher
    ..We found that the tumor suppressor adenomatous polyposis coli (APC) was required for microtubule interaction with IFs and for microtubule-dependent rearrangements of IFs during ..
  87. Ghaleb A, McConnell B, Nandan M, Katz J, Kaestner K, Yang V. Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Res. 2007;67:7147-54 pubmed
    ..that the expression of KLF4 was activated by the colorectal cancer tumor suppressor adenomatous polyposis coli (APC) and that KLF4 repressed the Wnt/beta-catenin pathway...
  88. Baker S, Harris A, Tsao J, Flath T, Bronner C, Gordon M, et al. Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice. Cancer Res. 1998;58:1087-9 pubmed
    ..that mutations in either one of four DNA mismatch repair gene homologues or the adenomatous polyposis coli (APC) gene, respectively, are important for the development of colorectal cancer...
  89. Park K, Jeon S, Kim S, Bahk Y, Holmen S, Williams B, et al. APC inhibits ERK pathway activation and cellular proliferation induced by RAS. J Cell Sci. 2006;119:819-27 pubmed
    Inactivating mutations in the adenomatous polyposis coli gene (APC), and activating mutations in RAS, occur in a majority of colorectal carcinomas. However, the relationship between these changes and tumorigenesis is poorly understood...