Gene Symbol: Ap2s1
Description: adaptor-related protein complex 2, sigma 1 subunit
Alias: Ap17, AP-2 complex subunit sigma, adapter-related protein complex 2 sigma subunit, adapter-related protein complex 2 subunit sigma, adaptor protein complex AP-2 subunit sigma, adaptor-related protein complex 2 subunit sigma, clathrin assembly protein 2 sigma small chain, clathrin assembly protein 2 small chain, clathrin coat assembly protein AP17, clathrin coat-associated protein AP17, clathrin-associated protein 17, plasma membrane adaptor AP-2 17 kDa protein, sigma-adaptin 3b, sigma2-adaptin
Adams L, Lemire J, Schwartz S. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells a. Arterioscler Thromb Vasc Biol. 1999;19:2600-8 pubmed
Zhang Y, Moheban D, Conway B, Bhattacharyya A, Segal R. Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation. J Neurosci. 2000;20:5671-8 pubmed
..Thus, interactions between Trk receptor tyrosine kinases and intracellular signaling molecules are dictated both by phosphotyrosine motifs within the receptors and by the intracellular location of phosphorylated receptors. ..
Tsuchida S, Matsusaka T, Chen X, Okubo S, Niimura F, Nishimura H, et al
. Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J Clin Invest. 1998;101:755-60 pubmed
..Also, unlike Agt-/- mice, some Agtr1a-/-; Agtr1b-/- mice have a large ventricular septum defect, suggesting that another receptor such as AT2 is functionally activated in Agtr1a-/-, Agtr1b-/- mice. ..
Collins B, McCoy A, Kent H, Evans P, Owen D. Molecular architecture and functional model of the endocytic AP2 complex. Cell. 2002;109:523-35 pubmed
..A model for AP2 recruitment and activation is proposed. ..
Kirchhausen T, Davis A, Frucht S, Greco B, Payne G, Tubb B. AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. J Biol Chem. 1991;266:11153-7 pubmed
b>AP17 and AP19 are the smallest polypeptide chain components of AP-2 and AP-1, the clathrin-associated protein complexes found in coated structures of the plasma membrane and Golgi apparatus of mammalian cells...
Page L, Robinson M. Targeting signals and subunit interactions in coated vesicle adaptor complexes. J Cell Biol. 1995;131:619-30 pubmed
..The subunit composition of the plasma membrane adaptor complex is alpha-adaptin, beta-adaptin, AP50, and AP17; while that of the TGN adaptor complex is gamma-adaptin, beta'-adaptin, AP47, and AP19...
Saheki Y, De Camilli P. Synaptic vesicle endocytosis. Cold Spring Harb Perspect Biol. 2012;4:a005645 pubmed publisher