Gene Symbol: Aoc1
Description: amine oxidase, copper containing 1
Alias: Abp, Abp1, amiloride-sensitive amine oxidase [copper-containing], DAO, amiloride binding protein 1 (amine oxidase, copper-containing), amiloride-binding protein 1, amiloride-sensitive amine oxidase, amine oxidase copper domain-containing protein 1, diamine oxidase, histaminase
Species: rat
Products:     Aoc1

Top Publications

  1. Befani O, Shiozaki T, Turini P, Gerosa P, Mondovi B. Inhibition of diamine oxidase activity by metronidazole. Biochem Biophys Res Commun. 1995;212:589-94 pubmed
    ..and antiprotozoal drugs, should be given under careful control, especially when administered for long times, because a decrease of intestinal diamine oxidase activity was proven to be a risk factor for several pathologies of this organ.
  2. Disilvestro R, Jones A, Smith D, Wildman R. Plasma diamine oxidase activities in renal dialysis patients, a human with spontaneous copper deficiency and marginally copper deficient rats. Clin Biochem. 1997;30:559-63 pubmed
    Intestine and kidney are generally the most concentrated sources of the copper metalloenzyme diamine oxidase (DAO). Clinically, plasma DAO activities are used to diagnose disruptions in intestinal integrity...
  3. Kojima H, Omoto Y, Hidaka H, Aoki T, Nakamura T, Kawabata T, et al. Increased plasma post-heparin diamine oxidase activity and plant sterol levels in streptozotocin diabetic rat. Biochem Biophys Res Commun. 1992;186:398-404 pubmed
    Plasma post-heparin diamine oxidase (DAO) activity and plasma levels of plant sterols were examined in streptozotocin diabetic rats fed with chow containing plant sterols, to investigate the enzyme activity in relation to the ..
  4. Verity K, Fuller P. Isolation of a rat amiloride-binding protein cDNA clone: tissue distribution and regulation of expression. Am J Physiol. 1994;266:C1505-12 pubmed
    ..gene expression in sodium-transporting epithelia by corticosteroids, we have cloned an amiloride-binding protein (ABP) cDNA from rat descending colon and kidney...
  5. Sun Y, Chen W, Zhang T, Cao H, Zhou J. Effects of cardiopulmonary bypass on tight junction protein expressions in intestinal mucosa of rats. World J Gastroenterol. 2008;14:5868-75 pubmed
    ..Plasma levels of diamine oxidase (DAO) and d-lactate were determined using an enzymatic spectrophotometry...
  6. Novotny W, Chassande O, Baker M, Lazdunski M, Barbry P. Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues. J Biol Chem. 1994;269:9921-5 pubmed
    b>Diamine oxidase (histaminase), an enzyme that oxidatively deaminates putrescine and histamine, was purified from human placenta and from pig kidney...
  7. Elmore B, Bollinger J, Dooley D. Human kidney diamine oxidase: heterologous expression, purification, and characterization. J Biol Inorg Chem. 2002;7:565-79 pubmed
    Human kidney diamine oxidase has been overexpressed as a secreted enzyme under the control of a metallothionein promoter in Drosophila S2 cell culture...
  8. Juda G, Shepard E, Elmore B, Dooley D. A comparative study of the binding and inhibition of four copper-containing amine oxidases by azide: implications for the role of copper during the oxidative half-reaction. Biochemistry. 2006;45:8788-800 pubmed
    ..the reductive and oxidative half-reactions of pea seedling amine oxidase (PSAO), the recombinant human kidney diamine oxidase (rhDAO), Arthrobacter globiformis amine oxidase (AGAO), and Pichia pastoris amine oxidase (PPLO) have been ..
  9. Barbry P, Champe M, Chassande O, Munemitsu S, Champigny G, Lingueglia E, et al. Human kidney amiloride-binding protein: cDNA structure and functional expression. Proc Natl Acad Sci U S A. 1990;87:7347-51 pubmed

More Information


  1. Ippolito J, Merritt M, Backhed F, Moulder K, Mennerick S, Manchester J, et al. Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers. Proc Natl Acad Sci U S A. 2006;103:12505-10 pubmed
    ..Treatment of nude mice containing PNEC tumor xenografts with (i) amiloride, a diuretic that inhibits Abp1, an enzyme involved in NE cell GABA metabolism, (ii) carbidopa, an inhibitor of dopa decarboxylase which functions ..
  2. Lingueglia E, Renard S, Voilley N, Waldmann R, Chassande O, Lazdunski M, et al. Molecular cloning and functional expression of different molecular forms of rat amiloride-binding proteins. Eur J Biochem. 1993;216:679-87 pubmed
    ..from the pore-forming protein of the epithelial Na+ channel, the pharmacological profile of the long form of the ABP is identical to that described previously in pig and human kidney, and similar to that expected for an epithelial ..
  3. Kovacs P, Voigt B, Kloting I. Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18. Biochem Biophys Res Commun. 1997;235:343-8 pubmed
    ..On chromosome 10 there was a QTL for blood pressure found between Ppy and Abp and on chromosome 18 there were three regions (Ttr-Grl, Tilp-Gja1, Olf-D18Mit9) with linkage to blood pressure...
  4. McGrath A, Hilmer K, Collyer C, Shepard E, Elmore B, Brown D, et al. Structure and inhibition of human diamine oxidase. Biochemistry. 2009;48:9810-22 pubmed publisher
    ..The product of the AOC1 gene is a so-called diamine oxidase (hDAO), named for its substrate preference for diamines, particularly histamine...
  5. Ji Y, Sakata Y, Li X, Zhang C, Yang Q, Xu M, et al. Lymphatic diamine oxidase secretion stimulated by fat absorption is linked with histamine release. Am J Physiol Gastrointest Liver Physiol. 2013;304:G732-40 pubmed publisher
    b>Diamine oxidase (DAO) is abundantly expressed in mammalian small intestine catalyzing the oxidative breakdown of polyamines and histamine...
  6. Cai C, Li W, Chen J, Li X, Chen S. Diamine oxidase as a marker for diagnosis of superior mesenteric arterial occlusion. Hepatogastroenterology. 2012;59:155-8 pubmed publisher
    We investigated changes in serum diamine oxidase (DAO) activity during superior mesenteric arterial occlusion. We aimed to evaluate its value in the early diagnosis of superior mesenteric arterial occlusion...