Anxa2

Summary

Gene Symbol: Anxa2
Description: annexin A2
Alias: ANX2, annexin A2, PAP-IV, annexin-2, calpactin I heavy chain, calpactin-1 heavy chain, chromobindin-8, lipocortin II, p36, placental anticoagulant protein IV, protein I
Species: rat
Products:     Anxa2

Top Publications

  1. Benaud C, Gentil B, Assard N, Court M, Garin J, Delphin C, et al. AHNAK interaction with the annexin 2/S100A10 complex regulates cell membrane cytoarchitecture. J Cell Biol. 2004;164:133-44 pubmed
    ..At the plasma membrane, AHNAK associates as a multimeric complex with actin and the annexin 2/S100A10 complex...
  2. Hayes M, Merrifield C, Shao D, Ayala Sanmartin J, Schorey C, Levine T, et al. Annexin 2 binding to phosphatidylinositol 4,5-bisphosphate on endocytic vesicles is regulated by the stress response pathway. J Biol Chem. 2004;279:14157-64 pubmed
    b>Annexin 2 is a Ca(2+)-binding protein that has an essential role in actin-dependent macropinosome motility...
  3. Ling Q, Jacovina A, Deora A, Febbraio M, Simantov R, Silverstein R, et al. Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. J Clin Invest. 2004;113:38-48 pubmed
    ..These data establish annexin II as a regulator of cell surface plasmin generation and reveal that impaired endothelial cell fibrinolytic activity constitutes a barrier to effective neoangiogenesis. ..
  4. Mayer G, Poirier S, Seidah N. Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels. J Biol Chem. 2008;283:31791-801 pubmed publisher
    ..and mass spectrometry analysis, we demonstrated that PCSK9 binds to a approximately 33-kDa protein identified as annexin A2 (AnxA2) but not to the closely related annexin A1...
  5. Liu N, Han S, Lu P, Xu X. Upregulation of annexins I, II, and V after traumatic spinal cord injury in adult rats. J Neurosci Res. 2004;77:391-401 pubmed
    ..The present study thus revealed increased expression of the three annexin isoforms after moderate contusive SCI. The precise role of annexins in posttraumatic inflammation and neuroprotection after SCI remains to be determined. ..
  6. Avenali L, Narayanan P, Rouwette T, Cervellini I, Sereda M, Gomez Varela D, et al. Annexin A2 regulates TRPA1-dependent nociception. J Neurosci. 2014;34:14506-16 pubmed publisher
    ..Using an unbiased proteomics-based approach we uncovered the physical association of Annexin A2 (AnxA2) with native TRPA1 in mouse sensory neurons...
  7. Sarkar S, Kantara C, Singh P. Clathrin mediates endocytosis of progastrin and activates MAPKs: role of cell surface annexin A2. Am J Physiol Gastrointest Liver Physiol. 2012;302:G712-22 pubmed publisher
    Cell-surface-associated annexin A2 (CS-ANXA2) is a nonconventional "receptor" for progastrin; expression levels of both are elevated in colon cancers, and downregulation of either reduces tumorigenic potential of cells...
  8. Blackwood R, Ernst J. Characterization of Ca2(+)-dependent phospholipid binding, vesicle aggregation and membrane fusion by annexins. Biochem J. 1990;266:195-200 pubmed
    ..We compared six members of this family (calpactin I heavy chain, lipocortins I and III, endonexin II, p68 and protein II) to determine their phospholipid-binding ..
  9. Unuma K, Aki T, Noritake K, Funakoshi T, Uemura K. A CO-releasing molecule prevents annexin A2 down-regulation and associated disorders in LPS-administered rat lung. Biochem Biophys Res Commun. 2017;487:748-754 pubmed publisher
    ..Given the established roles of AnxA2 in fibrinolysis as well as intracellular vesicle trafficking, AnxA2 down-regulation should play an important role in the pathogenesis of septic lung injuries. ..

More Information

Publications65

  1. Yamashita K, Nagai H, Toyokuni S. Receptor role of the annexin A2 in the mesothelial endocytosis of crocidolite fibers. Lab Invest. 2015;95:749-64 pubmed publisher
    ..Among the identified proteins, annexin A2 (ANXA2) and transferrin receptor protein 1 (TFRC) were distinguished because of their high score and presence at ..
  2. Nazmi A, Ozorowski G, Pejic M, Whitelegge J, Gerke V, Luecke H. N-terminal acetylation of annexin A2 is required for S100A10 binding. Biol Chem. 2012;393:1141-50 pubmed publisher
    b>Annexin A2 (AnxA2), a Ca2+-regulated phospholipid binding protein involved in membrane-cytoskeleton contacts and membrane transport, exists in two physical states, as a monomer or in a heterotetrameric complex mediated by S100A10...
  3. Kirsch T, Swoboda B, Nah H. Activation of annexin II and V expression, terminal differentiation, mineralization and apoptosis in human osteoarthritic cartilage. Osteoarthritis Cartilage. 2000;8:294-302 pubmed
    ..Thus, these cells resume phenotypic changes similar to terminal differentiation of chondrocytes in growth plate cartilage culminating in the destruction of articular cartilage in osteoarthritis. ..
  4. Esposito I, Penzel R, Chaib Harrireche M, Barcena U, Bergmann F, Riedl S, et al. Tenascin C and annexin II expression in the process of pancreatic carcinogenesis. J Pathol. 2006;208:673-85 pubmed
    ..Pancreatic stellate cells are identified as a source of TNC in pancreatic tissues, possibly under the influence of soluble factors released by the tumour cells. ..
  5. Sun L, Min L, Zhou H, Li M, Shao F, Wang W. Adolescent social isolation affects schizophrenia-like behavior and astrocyte biomarkers in the PFC of adult rats. Behav Brain Res. 2017;333:258-266 pubmed publisher
    ..between the SR group and the IR group, the most remarkable of which were glial fibrillary acidic protein (GFAP), Annexin A2 (ANXA2) and vimentin (VIM), three astrocyte biomarkers...
  6. Chuthapisith S, Bean B, Cowley G, Eremin J, Samphao S, Layfield R, et al. Annexins in human breast cancer: Possible predictors of pathological response to neoadjuvant chemotherapy. Eur J Cancer. 2009;45:1274-81 pubmed publisher
    ..The mechanisms by which annexins confer chemoresistance have not been identified, but may be due to inhibition of apoptosis. Annexin-A1 has been shown to enhance apoptosis, whilst annexin-A2, by contrast, inhibits apoptosis. ..
  7. Ledesma M, Da Silva J, Schevchenko A, Wilm M, Dotti C. Proteomic characterisation of neuronal sphingolipid-cholesterol microdomains: role in plasminogen activation. Brain Res. 2003;987:107-16 pubmed
    ..These observations suggest that neuronal rafts may play, in addition to intracellular signaling, a role in extracellular/membrane protein proteolysis. ..
  8. Ozeki M, Hoshino S, Hiai H, Toyokuni S. Isolation and characterization of annexin 2 pseudogene in Rattus norvegicus. Gene. 2002;289:185-90 pubmed
    b>Annexin 2 is a calcium-regulated, phospholipid-binding protein present in endothelial cells, macrophages and some tumor cells...
  9. Nezi L, Greco D, Nitsch L, Garbi C. The role of proteases in fibronectin matrix remodeling in thyroid epithelial cell monolayer cultures. Biol Chem. 2002;383:167-76 pubmed
    ..These results indicate that in the FN remodeling process, occurring during FRT epithelium maturation, both plasmin-dependent (tPA activated) and plasmin-independent proteolytic activities are involved. ..
  10. Yonglitthipagon P, Pairojkul C, Chamgramol Y, Mulvenna J, Sripa B. Up-regulation of annexin A2 in cholangiocarcinoma caused by Opisthorchis viverrini and its implication as a prognostic marker. Int J Parasitol. 2010;40:1203-12 pubmed publisher
    ..Among 20 up-regulated membrane proteins identified in the CCA cell lines was ANXA2, a participant in tumor invasion and metastasis in other cancers...
  11. Aitkenhead M, Wang S, Nakatsu M, Mestas J, Heard C, Hughes C. Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM. Microvasc Res. 2002;63:159-71 pubmed
    ..These data expand the suite of genes implicated in vascular remodeling and angiogenesis. ..
  12. Zhao S, Pan D, Zhang Y, Wu J, Liu X, Xu Y. Annexin A2 promotes choroidal neovascularization by increasing vascular endothelial growth factor expression in a rat model of argon laser coagulation-induced choroidal neovascularization. Chin Med J (Engl). 2010;123:713-21 pubmed
    ..This study aimed to investigate the relationship between annexin A2 (ANXA2) and vascular endothelial growth factor (VEGF) in CNV...
  13. Pons V, Luyet P, Morel E, Abrami L, van der Goot F, Parton R, et al. Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies. PLoS Biol. 2008;6:e214 pubmed publisher
    ..PtdIns3P thus controls the complementary functions of Hrs and SNX3 in sorting and multivesicular body biogenesis. ..
  14. Zacharias U, Purfürst B, Schöwel V, Morano I, Spuler S, Haase H. Ahnak1 abnormally localizes in muscular dystrophies and contributes to muscle vesicle release. J Muscle Res Cell Motil. 2011;32:271-80 pubmed publisher
    ..Taken together, our results define ahnak1 in muscle connective tissue as a novel feature of two genetically distinct muscular dystrophies that might contribute to disease pathology...
  15. Zhang L, Peng X, Zhang Z, Feng Y, Jia X, Shi Y, et al. Subcellular proteome analysis unraveled annexin A2 related to immune liver fibrosis. J Cell Biochem. 2010;110:219-28 pubmed publisher
    ..PM with 149-fold purification was obtained and 22 differentially expressed proteins were identified. Of which, annexin A2 (ANXA2) was detected to be increased obviously in S4 compared with S0-1, and verified by Western blotting of rat ..
  16. Baldwin C, Nolan V, Wyszynski D, Ma Q, Sebastiani P, Embury S, et al. Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis. Blood. 2005;106:372-5 pubmed
    ..studies showed that individual SNPs and haplotypes composed of several SNPs in bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis...
  17. Liao L, Zheng B, Yi B, Liu C, Chen L, Zeng Z, et al. Annexin A2-modulated proliferation of pulmonary arterial smooth muscle cells depends on caveolae and caveolin-1 in hepatopulmonary syndrome. Exp Cell Res. 2017;359:266-274 pubmed publisher
    We have established that annexin A2 (ANXA2) is an important factor in the experimental hepatopulmonary syndrome (HPS) serum-induced proliferation of pulmonary arterial smooth muscle cells (PASMCs)...
  18. El Btaouri H, Claisse D, Bellon G, Antonicelli F, Haye B. In vivo modulation of annexins I, II and V expression by thyroxine and methylthiouracil. Eur J Biochem. 1996;242:506-11 pubmed
    ..These results suggest that, in thyroid tissue, an indirect mechanism links thyroid hormones to annexin expressions via the TSH feed-back loop, and excludes autocrine regulation. ..
  19. Ghitescu L, Gugliucci A, Dumas F. Actin and annexins I and II are among the main endothelial plasmalemma-associated proteins forming early glucose adducts in experimental diabetes. Diabetes. 2001;50:1666-74 pubmed
  20. Ozaki T, Sakiyama S. Molecular cloning of rat calpactin I heavy-chain cDNA whose expression is induced in v-src-transformed rat culture cell lines. Oncogene. 1993;8:1707-10 pubmed
    ..Sequence analysis revealed that N02 cDNA encodes a p36 calpactin I heavy chain. In addition, the amount of a p11 calpactin I light-chain mRNA was also increased in v-src-transformed ..
  21. Upton A, Moss S. Molecular cloning of a novel N-terminal variant of annexin II from rat basophilic leukaemia cells. Biochem J. 1994;302 ( Pt 2):425-8 pubmed
    ..The discovery of this novel annexin II variant may have important implications both for p11 binding and for regulation of annexin II function by phosphorylation. ..
  22. Gou D, Mishra A, Weng T, Su L, Chintagari N, Wang Z, et al. Annexin A2 interactions with Rab14 in alveolar type II cells. J Biol Chem. 2008;283:13156-64 pubmed publisher
    b>Annexin A2, a calcium-dependent phospholipid-binding protein, is abundantly expressed in alveolar type II cells where it plays a role in lung surfactant secretion. Nevertheless, little is known about the details of its cellular pathways...
  23. Yamanaka H, Kobayashi K, Okubo M, Noguchi K. Annexin A2 in primary afferents contributes to neuropathic pain associated with tissue type plasminogen activator. Neuroscience. 2016;314:189-99 pubmed publisher
    b>Annexin A2 (ANX2) is a calcium (Ca(2+))-binding protein that binds to acidic phospholipids and is known to play a crucial role in many cellular regulatory processes...
  24. Hayes M, Moss S. Annexin 2 has a dual role as regulator and effector of v-Src in cell transformation. J Biol Chem. 2009;284:10202-10 pubmed publisher
    ..Here, we report that this is dependent on annexin 2, a v-Src substrate and calcium-dependent regulator of actin dynamics...
  25. Seidah N, Poirier S, Denis M, Parker R, Miao B, Mapelli C, et al. Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation. PLoS ONE. 2012;7:e41865 pubmed publisher
    ..Accordingly, the quest for PCSK9 inhibitors has major clinical implications. We have previously identified annexin A2 (AnxA2) as an endogenous binding partner and functional inhibitor of PCSK9...
  26. Lei H, Romeo G, Kazlauskas A. Heat shock protein 90alpha-dependent translocation of annexin II to the surface of endothelial cells modulates plasmin activity in the diabetic rat aorta. Circ Res. 2004;94:902-9 pubmed
  27. Das R, Burke T, Plow E. Histone H2B as a functionally important plasminogen receptor on macrophages. Blood. 2007;110:3763-72 pubmed
    ..Three previously characterized Plg-Rs (alpha-enolase, annexin 2, and p11) and a recently identified Plg-R (histone H2B [H2B]) were assessed for their contribution to Plg ..
  28. te Vruchte D, Lloyd Evans E, Veldman R, Neville D, Dwek R, Platt F, et al. Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport. J Biol Chem. 2004;279:26167-75 pubmed
    ..Both annexin 2 and 6, membrane-associated proteins that are important in endocytic trafficking, show distorted distributions in ..
  29. Yuan S, Qu L, Shou C. N-Terminal Polypeptide of Annexin A2 Decreases Infection of Mycoplasma hyorhinis to Gastric Cancer Cells. PLoS ONE. 2016;11:e0147776 pubmed publisher
    ..hyorhinis) infection was mediated by the interaction between p37 of M. hyorhinis and Annexin A2 (ANXA2) of host cells, however the translational value of this mechanism was unknown...
  30. Somarajan S, Al Asadi F, Ramasamy K, Pandranki L, Baseman J, Kannan T. Annexin A2 mediates Mycoplasma pneumoniae community-acquired respiratory distress syndrome toxin binding to eukaryotic cells. MBio. 2014;5: pubmed publisher
    ..A549 cell membrane protein bound to CARDS toxin and was identified by time of flight (TOF) mass spectroscopy as annexin A2 (AnxA2) and verified by immunoblotting with anti-AnxA2 monoclonal antibody...
  31. Dathe C, Daigeler A, Seifert W, Jankowski V, Mrowka R, Kalis R, et al. Annexin A2 mediates apical trafficking of renal Na?-K?-2Cl? cotransporter. J Biol Chem. 2014;289:9983-97 pubmed publisher
    ..Yeast two-hybrid screening identified an interaction between NKCC2 and the cytosolic protein, annexin A2 (AnxA2)...
  32. Domon M, Besson F, Tylki Szymanska A, Bandorowicz Pikula J, Pikula S. Interaction of AnxA6 with isolated and artificial lipid microdomains; importance of lipid composition and calcium content. Mol Biosyst. 2013;9:668-76 pubmed publisher
  33. Di Marco G, König M, Stock C, Wiesinger A, Hillebrand U, Reiermann S, et al. High phosphate directly affects endothelial function by downregulating annexin II. Kidney Int. 2013;83:213-22 pubmed publisher
    ..In addition, high phosphate stiffened endothelial cells in vitro and in rats in vivo. Thus, our results link phosphate and adverse clinical outcomes involving the endothelium in both healthy individuals and patients with renal disease. ..
  34. Noda Y, Horikawa S, Katayama Y, Sasaki S. Identification of a multiprotein "motor" complex binding to water channel aquaporin-2. Biochem Biophys Res Commun. 2005;330:1041-7 pubmed
    ..adapter molecule 2, myosin regulatory light chain smooth muscle isoforms 2-A and 2-B, alpha-tropomyosin 5b, annexin A2 and A6, scinderin, gelsolin, alpha-actinin 4, alpha-II spectrin, and myosin heavy chain nonmuscle type A...
  35. Grindheim A, Hollås H, Raddum A, Saraste J, Vedeler A. Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of annexin A2. J Cell Sci. 2016;129:314-28 pubmed publisher
    b>Annexin A2 (AnxA2) is a multi-functional and -compartmental protein whose subcellular localisation and functions are tightly regulated by its post-translational modifications...
  36. Mizutani A, Usuda N, Tokumitsu H, Minami H, Yasui K, Kobayashi R, et al. CAP-50, a newly identified annexin, localizes in nuclei of cultured fibroblast 3Y1 cells. J Biol Chem. 1992;267:13498-504 pubmed
    ..CAP-50 was found in isolated 3Y1 nuclei lacking outer nuclear membranes, and approximately 50% of CAP-50 was extracted from the nuclei by chelating calcium. Thus, CAP-50, a unique annexin, localizes in nuclei. ..
  37. Takahashi S, Reddy S, Chirgwin J, Devlin R, Haipek C, Anderson J, et al. Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone resorption. J Biol Chem. 1994;269:28696-701 pubmed
    ..These data suggest that the AXII is an autocrine factor that enhances osteoclast formation and bone resorption and demonstrate a previous unknown function for AXII. ..
  38. Huang K, Wallner B, Mattaliano R, Tizard R, Burne C, Frey A, et al. Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase. Cell. 1986;46:191-9 pubmed
    ..By similar criteria, we determine that lipocortin II is the human analogue of pp36, a major substrate for pp60src, which has been characterized in chicken embryo ..
  39. Moraru I, Syrbu S, Michaels K, Kim D, Malchoff D, Watras J. Pressure overload induces overexpression of annexins II and V in aortic-banded rats. Ann N Y Acad Sci. 1998;853:329-32 pubmed
  40. Hayashi T, Morishita E, Ohtake H, Oda Y, Asakura H, Nakao S. Expression of annexin II in experimental abdominal aortic aneurysms. Int J Hematol. 2009;90:336-342 pubmed publisher
    ..It has been suggested that alteration of fibrinolytic activity regulated by annexin II within the aortic wall may be associated with aneurysm formation. ..
  41. Ishii H, Yoshida M, Hiraoka M, Hajjar K, Tanaka A, Yasukochi Y, et al. Recombinant annexin II modulates impaired fibrinolytic activity in vitro and in rat carotid artery. Circ Res. 2001;89:1240-5 pubmed
    ..Further study of rAN II in vitro and in vivo may lead to the establishment of novel therapeutic approaches to thrombogenic vascular disease. ..
  42. Rodrigo J, García Pedrero J, Llorente J, Fresno M, Allonca E, Suarez C, et al. Down-regulation of annexin A1 and A2 protein expression in intestinal-type sinonasal adenocarcinomas. Hum Pathol. 2011;42:88-94 pubmed publisher
    ..In this study the expression of annexin A1 and annexin A2 was studied by immunohistochemistry in intestinal-type sinonasal adenocarcinoma using a study set of 57 ..
  43. Ma K, Simantov R, Zhang J, Silverstein R, Hajjar K, McCrae K. High affinity binding of beta 2-glycoprotein I to human endothelial cells is mediated by annexin II. J Biol Chem. 2000;275:15541-8 pubmed
    ..Finally, surface plasmon resonance studies revealed high affinity binding between annexin II and beta(2)GPI. These results demonstrate that annexin II mediates the binding of beta(2)GPI to endothelial cells. ..
  44. Ning L, Wang C, Ding X, Zhang Y, Wang X, Yue S. Functional interaction of TRPV4 channel protein with annexin A2 in DRG. Neurol Res. 2012;34:685-93 pubmed publisher
    ..b>Annexin A2 belongs to a class of membrane-binding proteins that plays an important role in the regulation of ion channels...
  45. Badea L, Herlea V, Dima S, Dumitrascu T, Popescu I. Combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identifies genes specifically overexpressed in tumor epithelia. Hepatogastroenterology. 2008;55:2016-27 pubmed
    ..inversely correlated with patient survival: keratin 7, laminin gamma 2, stratifin, platelet phosphofructokinase, annexin A2, MAP4K4 and OACT2 (MBOAT2), which are all specifically upregulated in the neoplastic epithelia, rather than the ..
  46. Patel S, Ma N, Monks T, Lau S. Changes in gene expression during chemical-induced nephrocarcinogenicity in the Eker rat. Mol Carcinog. 2003;38:141-54 pubmed
    ..Histopathological analysis further indicated that the tumors were composed of neoplastic cells, resembling renal carcinoma cells with varying degrees of atypia, with the presence of apoptotic and mitotic figures. ..
  47. Dai F, Zhang Y, Kang Y, Wang Q, Gaisano H, Braunewell K, et al. The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion. J Biol Chem. 2006;281:21942-53 pubmed
    ..Increased VILIP-1 enhanced insulin secretion in a cAMP-associated manner. Down-regulation of VILIP-1 was accompanied by decreased cAMP accumulation but increased insulin gene transcription. ..
  48. Alvares K, Stern P, Veis A. Dentin phosphoprotein binds annexin 2 and is involved in calcium transport in rat kidney ureteric bud cells. J Biol Chem. 2013;288:13036-45 pubmed publisher
    ..In this report, we show that DPP binds to annexin 2 and 6 present in a rat ureteric bud cell line (RUB1)...
  49. Drücker P, Pejic M, Galla H, Gerke V. Lipid segregation and membrane budding induced by the peripheral membrane binding protein annexin A2. J Biol Chem. 2013;288:24764-76 pubmed publisher
    ..Here we analyzed the ability of one peripherally associated membrane protein, annexin A2 (AnxA2), to induce the formation of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-rich domains in giant ..
  50. Chattopadhyay S, Sun P, Wang P, Abonyo B, Cross N, Liu L. Fusion of lamellar body with plasma membrane is driven by the dual action of annexin II tetramer and arachidonic acid. J Biol Chem. 2003;278:39675-83 pubmed
    ..Our results suggest that the fusion between lamellar bodies with the plasma membrane is driven by the synergistic action of AIIt and arachidonic acid. ..
  51. Zhu H, Fan X, Yu Z, Liu J, Murata Y, Lu J, et al. Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke. J Cereb Blood Flow Metab. 2010;30:1137-46 pubmed publisher
    Recent studies showed that soluble annexin A2 dramatically increases tissue plasminogen activator (tPA)-mediated plasmin generation in vitro, and reduces thrombus formation in vivo...
  52. Chojnacka K, Bilinska B, Mruk D. Annexin A2 is critical for blood-testis barrier integrity and spermatid disengagement in the mammalian testis. Biochim Biophys Acta Mol Cell Res. 2017;1864:527-545 pubmed publisher
    ..We aimed to determine whether annexin A2 (ANXA2), a Ca2+-dependent and phospholipid-binding protein, participates in cell junction dynamics...
  53. Wang P, Chintagari N, Gou D, Su L, Liu L. Physical and functional interactions of SNAP-23 with annexin A2. Am J Respir Cell Mol Biol. 2007;37:467-76 pubmed
    ..b>Annexin A2, a Ca(2+)- and phospholipid-binding protein, promotes the fusion of lamellar bodies with the plasma membrane...
  54. Lennon N, Kho A, Bacskai B, Perlmutter S, Hyman B, Brown R. Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. J Biol Chem. 2003;278:50466-73 pubmed
    ..We propose a model of muscle membrane healing mediated by dysferlin that is relevant to both normal and dystrophic muscle and defines the annexins as potential muscular dystrophy genes. ..
  55. Chen J, Cui Z, Yang S, Wu C, Li W, Bao G, et al. The upregulation of annexin A2 after spinal cord injury in rats may have implication for astrocyte proliferation. Neuropeptides. 2017;61:67-76 pubmed publisher
    b>Annexin A2 (ANXA2), is a member of the annexin family of proteins that exhibit Ca2+-dependent binding to phospholipids. One attractive biological function of ANXA2 is participating in DNA synthesis and cell proliferation...
  56. Ling T, Chen C, Huang Y, Liu I, Huang S, Huang J. Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1. J Biol Chem. 2004;279:38736-48 pubmed
    ..These results suggest that cell surface annexin VI may function as an acidic pH binding site or receptor and may also function as a co-receptor with LRP-1 at neutral pH. ..