Gene Symbol: Antxr2
Description: anthrax toxin receptor 2
Alias: anthrax toxin receptor 2
Hanks S, Adams S, Douglas J, Arbour L, Atherton D, Balci S, et al
. Mutations in the gene encoding capillary morphogenesis protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet. 2003;73:791-800 pubmed
..These data (1) demonstrate that JHF and ISH are allelic conditions and (2) implicate perturbation of basement-membrane matrix assembly as the cause of the characteristic perivascular hyaline deposition seen in these conditions. ..
Scobie H, Wigelsworth D, Marlett J, Thomas D, Rainey G, Lacy D, et al
. Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. PLoS Pathog. 2006;2:e111 pubmed
Anthrax toxin receptors 1 and 2 (ANTXR1 and ANTXR2) have a related integrin-like inserted (I) domain which interacts with a metal cation that is coordinated by residue D683 of the protective antigen (PA) subunit of anthrax toxin...
Liu S, Crown D, Miller Randolph S, Moayeri M, Wang H, Hu H, et al
. Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo. Proc Natl Acad Sci U S A. 2009;106:12424-9 pubmed publisher
..Finally, the CMG2-null mice are also shown to be highly resistant to B. anthracis spore infection, attesting to the importance of both anthrax toxin and CMG2 in anthrax infections. ..
Liu X, Yuan W, Li J, Yang L, Cai J. ANTXR2 Knock-Out Does Not Result in the Development of Hypertension in Rats. Am J Hypertens. 2017;30:182-187 pubmed publisher
..studies (GWASs) have indicated that the single nucleotide polymorphism rs16998073, located near gene anthrax toxin receptor 2 (ANTXR2), was significantly associated with hypertension in Asians and Europeans...