Gene Symbol: Antxr1
Description: anthrax toxin receptor 1
Alias: anthrax toxin receptor 1, tumor endothelial marker 8
Species: rat
Products:     Antxr1

Top Publications

  1. Davies G, Rmali K, Watkins G, Mansel R, Mason M, Jiang W. Elevated levels of tumour endothelial marker-8 in human breast cancer and its clinical significance. Int J Oncol. 2006;29:1311-7 pubmed
    ..We conclude that TEM-8 is a useful marker for identifying tumour associated micro-vessels and that elevated levels are associated with disease progression, which may have some bearing on the prognostic outcome in breast cancer. ..
  2. Liu S, Crown D, Miller Randolph S, Moayeri M, Wang H, Hu H, et al. Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo. Proc Natl Acad Sci U S A. 2009;106:12424-9 pubmed publisher
    ..Finally, the CMG2-null mice are also shown to be highly resistant to B. anthracis spore infection, attesting to the importance of both anthrax toxin and CMG2 in anthrax infections. ..
  3. Raeisossadati R, Farshchian M, Ganji A, Tavassoli A, Velayati A, Dadkhah E, et al. Quantitative analysis of TEM-8 and CEA tumor markers indicating free tumor cells in the peripheral blood of colorectal cancer patients. Int J Colorectal Dis. 2011;26:1265-70 pubmed publisher
    ..The circulating mRNA levels of two CRC tumor markers, tumor endothelial marker 8 (TEM-8) and carcinoembryogenic antigen (CEA) were evaluated using an absolute quantitative real-time PCR ..
  4. Opoku Darko M, Yuen C, Gratton K, Sampson E, Bathe O. Tumor endothelial marker 8 overexpression in breast cancer cells enhances tumor growth and metastasis. Cancer Invest. 2011;29:676-82 pubmed publisher
    Tumor vasculature is known to express high levels of the longest splice variant of tumor endothelial marker 8 (TEM8). Little is known about its expression by tumor cells...
  5. Werner E, Kowalczyk A, Faundez V. Anthrax toxin receptor 1/tumor endothelium marker 8 mediates cell spreading by coupling extracellular ligands to the actin cytoskeleton. J Biol Chem. 2006;281:23227-36 pubmed
    b>Tumor endothelial marker 8 (TEM8) is induced in tumor-associated vasculature and acts as a receptor for Protective Antigen (PA), the cell-binding component of the anthrax toxin determinant for toxin entrance into cells...
  6. Fernando S, Fletcher B. Targeting tumor endothelial marker 8 in the tumor vasculature of colorectal carcinomas in mice. Cancer Res. 2009;69:5126-32 pubmed publisher
    b>Tumor endothelial marker 8 (TEM8) is a recently described protein that is preferentially expressed within tumor endothelium...
  7. Ruan Z, Yang Z, Wang Y, Wang H, Chen Y, Shang X, et al. DNA vaccine against tumor endothelial marker 8 inhibits tumor angiogenesis and growth. J Immunother. 2009;32:486-91 pubmed publisher
    ..Recently, tumor endothelial marker 8 (TEM8) was discovered to be dominantly expressed in tumor endothelium, which presented a new strategy to ..
  8. Cullen M, Seaman S, Chaudhary A, Yang M, Hilton M, Logsdon D, et al. Host-derived tumor endothelial marker 8 promotes the growth of melanoma. Cancer Res. 2009;69:6021-6 pubmed publisher
    b>Tumor endothelial marker 8 (TEM8) was initially identified as a gene overexpressed in the vasculature of human tumors and was subsequently identified as an anthrax toxin receptor...
  9. Yang X, Zhu H, Hu Z. Dendritic cells transduced with TEM8 recombinant adenovirus prevents hepatocellular carcinoma angiogenesis and inhibits cells growth. Vaccine. 2010;28:7130-5 pubmed publisher
    ..b>Tumor endothelial marker 8 (TEM8) is a recently described protein that is preferentially expressed within tumor endothelium...

More Information


  1. Yang M, Chaudhary A, Seaman S, Dunty J, Stevens J, Elzarrad M, et al. The cell surface structure of tumor endothelial marker 8 (TEM8) is regulated by the actin cytoskeleton. Biochim Biophys Acta. 2011;1813:39-49 pubmed publisher
    b>Tumor endothelial marker 8 (TEM8) is an integrin-like cell surface protein upregulated on tumor blood vessels and a potential vascular target for cancer therapy...
  2. Maurya S, Tewari M, Kumar M, Thakur M, Shukla H. Expression pattern of tumor endothelial marker 8 protein in gallbladder carcinomas. Asian Pac J Cancer Prev. 2011;12:507-12 pubmed
    b>Tumor endothelial marker 8 protein (TEM8) is highly specific to tumor angiogenesis and is not required for normal adult angiogenesis and hence might prove to be a target for anti-angiogenic therapies in the future...
  3. Gutwein L, Al Quran S, Fernando S, Fletcher B, Copeland E, Grobmyer S. Tumor endothelial marker 8 expression in triple-negative breast cancer. Anticancer Res. 2011;31:3417-22 pubmed
    b>Tumor endothelial marker 8 (TEM8) is a tumor endothelial-associated antigen that is having an increasingly recognized role in tumor biology. The expression of TEM8 in triple-negative breast cancer (TNBC) has not yet been characterized...
  4. Stránecký V, Hoischen A, Hartmannova H, Zaki M, Chaudhary A, Zudaire E, et al. Mutations in ANTXR1 cause GAPO syndrome. Am J Hum Genet. 2013;92:792-9 pubmed publisher
    ..Arg169*]) or splicing mutations (c.1435-12A>G [p.Gly479Phefs*119]) in ANTXR1, which encodes anthrax toxin receptor 1. The nonsense mutations predictably trigger nonsense-mediated mRNA decay, resulting in the loss of ANTXR1...