Gene Symbol: Antxr1
Description: anthrax toxin receptor 1
Alias: anthrax toxin receptor 1, tumor endothelial marker 8
- Yang M, Chaudhary A, Seaman S, Dunty J, Stevens J, Elzarrad M, et al. The cell surface structure of tumor endothelial marker 8 (TEM8) is regulated by the actin cytoskeleton. Biochim Biophys Acta. 2011;1813:39-49 pubmed publisherb>Tumor endothelial marker 8 (TEM8) is an integrin-like cell surface protein upregulated on tumor blood vessels and a potential vascular target for cancer therapy...
- Maurya S, Tewari M, Kumar M, Thakur M, Shukla H. Expression pattern of tumor endothelial marker 8 protein in gallbladder carcinomas. Asian Pac J Cancer Prev. 2011;12:507-12 pubmedb>Tumor endothelial marker 8 protein (TEM8) is highly specific to tumor angiogenesis and is not required for normal adult angiogenesis and hence might prove to be a target for anti-angiogenic therapies in the future...
- Gutwein L, Al Quran S, Fernando S, Fletcher B, Copeland E, Grobmyer S. Tumor endothelial marker 8 expression in triple-negative breast cancer. Anticancer Res. 2011;31:3417-22 pubmedb>Tumor endothelial marker 8 (TEM8) is a tumor endothelial-associated antigen that is having an increasingly recognized role in tumor biology. The expression of TEM8 in triple-negative breast cancer (TNBC) has not yet been characterized...
- Stránecký V, Hoischen A, Hartmannova H, Zaki M, Chaudhary A, Zudaire E, et al. Mutations in ANTXR1 cause GAPO syndrome. Am J Hum Genet. 2013;92:792-9 pubmed publisher..Arg169*]) or splicing mutations (c.1435-12A>G [p.Gly479Phefs*119]) in ANTXR1, which encodes anthrax toxin receptor 1. The nonsense mutations predictably trigger nonsense-mediated mRNA decay, resulting in the loss of ANTXR1...