Gene Symbol: Ank2
Description: ankyrin 2
Alias: Ank3, ankyrin-2, LOW QUALITY PROTEIN: ankyrin-2, ankyrin 2, brain, ankyrin 2, neuronal, ankyrin 3, epithelial
Species: rat
Products:     Ank2

Top Publications

  1. Harada K, Fukuda S, Kunimoto M, Yoshida K. Distribution of ankyrin isoforms and their proteolysis after ischemia and reperfusion in rat brain. J Neurochem. 1997;69:371-6 pubmed
    ..The reperfusion also significantly decreased the 212-kDa isoform of ankyrinB. Both ischemia-reperfusion and in vitro proteolysis with calpain generated the 160-kDa fragment of ankyrinR, suggesting the involvement of calpain. ..
  2. Yoshida K, Harada K. Proteolysis of erythrocyte-type and brain-type ankyrins in rat heart after postischemic reperfusion. J Biochem. 1997;122:279-85 pubmed
    ..The proteolysis of ankyrin(R) may interfere with force conduction through disruption of the linkage between integral membrane proteins and the myofibril-cytoskeleton. ..
  3. Davis J, Bennett V. Ankyrin binding activity shared by the neurofascin/L1/NrCAM family of nervous system cell adhesion molecules. J Biol Chem. 1994;269:27163-6 pubmed
    ..Linkage of these ankyrin-binding cell adhesion molecules to spectrin-based structures may provide a major class of membrane-cytoskeletal connections in adult brain as well as earlier stages of development. ..
  4. Mohler P, Schott J, Gramolini A, Dilly K, Guatimosim S, duBell W, et al. Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. Nature. 2003;421:634-9 pubmed
    ..We report here that a loss-of-function (E1425G) mutation in ankyrin-B (also known as ankyrin 2), a member of a family of versatile membrane adapters, causes dominantly inherited type 4 long-QT cardiac ..
  5. Lencesova L, O Neill A, Resneck W, Bloch R, Blaustein M. Plasma membrane-cytoskeleton-endoplasmic reticulum complexes in neurons and astrocytes. J Biol Chem. 2004;279:2885-93 pubmed
    ..The adaptor protein, ankyrin 2 (Ank 2), and the cytoskeletal proteins, alpha-fodrin and beta-spectrin, also selectively co-immunoprecipitated ..
  6. Mohler P, Splawski I, Napolitano C, Bottelli G, Sharpe L, Timothy K, et al. A cardiac arrhythmia syndrome caused by loss of ankyrin-B function. Proc Natl Acad Sci U S A. 2004;101:9137-42 pubmed
  7. Gudmundsson H, Hund T, Wright P, Kline C, Snyder J, Qian L, et al. EH domain proteins regulate cardiac membrane protein targeting. Circ Res. 2010;107:84-95 pubmed publisher
    ..Notably, these data provide the first link between EHD proteins and a human disease model. ..
  8. Lopez Santiago L, Meadows L, Ernst S, Chen C, Malhotra J, McEwen D, et al. Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. J Mol Cell Cardiol. 2007;43:636-47 pubmed
    ..Together, these results suggest that beta1 is critical for normal cardiac excitability and loss of beta1 may be associated with a long QT phenotype. ..
  9. Engelhardt M, Vorwald S, Sobotzik J, Bennett V, Schultz C. Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons. Brain Struct Funct. 2013;218:1005-16 pubmed publisher
    ..Instead, we propose that ankyrin-B serves as a major membrane organizer in mechanoreceptive and nociceptive terminals of the PNS. ..

More Information


  1. Garver T, Ren Q, Tuvia S, Bennett V. Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin. J Cell Biol. 1997;137:703-14 pubmed
  2. Cunha S, Bhasin N, Mohler P. Targeting and stability of Na/Ca exchanger 1 in cardiomyocytes requires direct interaction with the membrane adaptor ankyrin-B. J Biol Chem. 2007;282:4875-83 pubmed
    ..These results raise exciting new questions regarding potentially dynamic roles for ankyrin proteins in the biogenesis and maintenance of specialized membrane domains in excitable cells. ..
  3. Cunha S, Hund T, Hashemi S, Voigt N, Li N, Wright P, et al. Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation. Circulation. 2011;124:1212-22 pubmed publisher
    ..b>ANK2 encodes ankyrin-B, a multifunctional adapter molecule implicated in membrane targeting of ion channels, ..
  4. Mohler P, Davis J, Bennett V. Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain. PLoS Biol. 2005;3:e423 pubmed
    ..Ankyrin-B also is not abundantly expressed in smooth muscle. We propose that the ankyrin-B-based complex is a specialized adaptation of cardiomyocytes with a role for cytosolic Ca2+ modulation. ..
  5. Mohler P, Yoon W, Bennett V. Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes. J Biol Chem. 2004;279:40185-93 pubmed
    ..This work also establishes a functional hierarchy in which ankyrin-B determines the localization of beta(2)-spectrin and operates independently of beta(2)-spectrin in its role in organizing membrane-spanning proteins. ..
  6. Sakaue M, Takanaga H, Adachi T, Hara S, Kunimoto M. Selective disappearance of an axonal protein, 440-kDa ankyrinB, associated with neuronal degeneration induced by methylmercury. J Neurosci Res. 2003;73:831-9 pubmed
    ..Therefore, 440-kDa ankyrinB should be useful as a specific and sensitive marker for the neurotoxicity of methylmercury. ..
  7. Dickson T, Mintz C, Benson D, Salton S. Functional binding interaction identified between the axonal CAM L1 and members of the ERM family. J Cell Biol. 2002;157:1105-12 pubmed
    ..Together, our data indicate that L1 binds directly to members of the ERM family and suggest this association may coordinate aspects of axonal morphogenesis. ..
  8. Mohler P, Gramolini A, Bennett V. The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes. J Biol Chem. 2002;277:10599-607 pubmed
    ..C-terminal domains are the most divergent between ankyrin isoforms and are candidates to encode the signal(s) that enable ankyrins to selectively target proteins to diverse cellular sites. ..
  9. Kunimoto M, Adachi T, Ishido M. Expression and localization of brain ankyrin isoforms and related proteins during early developmental stages of rat nervous system. J Neurochem. 1998;71:2585-92 pubmed
  10. Yang M, Ge W, Chowdhury R, Claridge T, Kramer H, Schmierer B, et al. Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor. J Biol Chem. 2011;286:7648-60 pubmed publisher
  11. Li J, Kline C, Hund T, Anderson M, Mohler P. Ankyrin-B regulates Kir6.2 membrane expression and function in heart. J Biol Chem. 2010;285:28723-30 pubmed publisher
    ..Collectively, our new findings define a new role for cardiac ankyrin polypeptides in regulation of ion channel membrane expression in heart...
  12. Wu H, Yamankurt G, Luo J, Subramaniam J, Hashmi S, Hu H, et al. Identification and characterization of two ankyrin-B isoforms in mammalian heart. Cardiovasc Res. 2015;107:466-77 pubmed publisher
    ..The identification and characterization of two functionally distinct ankyrin-B isoforms in heart provide compelling evidence that alternative splicing of the ANK2 gene regulates the fidelity of ankyrin-B interactions with proteins.
  13. Kline C, Kurata H, Hund T, Cunha S, Koval O, Wright P, et al. Dual role of K ATP channel C-terminal motif in membrane targeting and metabolic regulation. Proc Natl Acad Sci U S A. 2009;106:16669-74 pubmed publisher
    ..Thus, the K(ATP) channel ABM serves as a previously unrecognized bifunctional touch-point for grading K(ATP) channel gating and membrane targeting and may play a fundamental role in controlling excitable cell metabolic regulation. ..
  14. Kizhatil K, Sandhu N, Peachey N, Bennett V. Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na/K-ATPase and the Na/Ca exchanger in the inner segment of rod photoreceptors. Exp Eye Res. 2009;88:57-64 pubmed publisher
    ..These results are consistent with a mechanism where ankyrin-B is required to restrict the Na/K-ATPase and Na/Ca exchanger to the inner segment of rod photoreceptors by tethering these membrane proteins to beta-2-spectrin. ..
  15. Le Scouarnec S, Bhasin N, Vieyres C, Hund T, Cunha S, Koval O, et al. Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease. Proc Natl Acad Sci U S A. 2008;105:15617-22 pubmed publisher
    ..We mapped two families with highly penetrant and severe SND to the human ANK2 (ankyrin-B/AnkB) locus...
  16. Cunha S, Mohler P. Obscurin targets ankyrin-B and protein phosphatase 2A to the cardiac M-line. J Biol Chem. 2008;283:31968-80 pubmed publisher
    ..In summary, our new findings demonstrate that ANK2 is subject to alternative splicing that gives rise to unique polypeptides with diverse roles in cardiac function.
  17. Bhasin N, Cunha S, Mudannayake M, Gigena M, Rogers T, Mohler P. Molecular basis for PP2A regulatory subunit B56alpha targeting in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2007;293:H109-19 pubmed
    ..These new data implicate ankyrin-B as a critical targeting component for PP2A in heart and identify a new class of signaling proteins targeted by ankyrin polypeptides. ..
  18. Mohler P, Le Scouarnec S, Denjoy I, Lowe J, Guicheney P, Caron L, et al. Defining the cellular phenotype of "ankyrin-B syndrome" variants: human ANK2 variants associated with clinical phenotypes display a spectrum of activities in cardiomyocytes. Circulation. 2007;115:432-41 pubmed
    Mutations in the ankyrin-B gene (ANK2) cause type 4 long-QT syndrome and have been described in kindreds with other arrhythmias...
  19. Ogawa Y, Schafer D, Horresh I, Bar V, Hales K, Yang Y, et al. Spectrins and ankyrinB constitute a specialized paranodal cytoskeleton. J Neurosci. 2006;26:5230-9 pubmed
    ..Our results demonstrate that the paranodal junction contains specialized cytoskeletal components that may be important to stabilize axon-glia interactions and contribute to the membrane protein diffusion barrier found at paranodes. ..
  20. Lopez C, Metral S, Eladari D, Drevensek S, Gane P, Chambrey R, et al. The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells. J Biol Chem. 2005;280:8221-8 pubmed