Gene Symbol: Amy1a
Description: amylase, alpha 1A
Alias: Amy1, alpha-amylase 1, amylase 1, salivary, amylase, alpha 1A (salivary)
Bloor J, Meisler M. Additional evidence for the close linkage of amy-1 and amy-2 in the mouse. J Hered. 1980;71:449-51 pubmed
..Among 343 potentially recombinant chromosomes examined, no recombinants were found. Our data sets an upper limit of 0.87 cM (P = 0.95) for the distance between the salivary and pancreatic loci. ..
Imai A, Yoshie S, Ishibashi K, Haga Tsujimura M, Nashida T, Shimomura H, et al
. EPI64 protein functions as a physiological GTPase-activating protein for Rab27 protein and regulates amylase release in rat parotid acinar cells. J Biol Chem. 2011;286:33854-62 pubmed publisher
..Our findings indicated that EPI64 acted as a physiological Rab27-GAP that enhanced GTPase activity of Rab27 in response to IPR stimulation, and that this activity is required for IPR-induced amylase release. ..
Chen L, Yang Z, Chen W. Parallel increase in secretory activity between N-glycosylated and nonglycosylated Î±-amylase without protein synthesis after short-term Î²-adrenergic receptor activation in isolated rat parotid acinar cells. Anal Quant Cytopathol Histpathol. 2014;36:279-84 pubmed
..There seems to be a dissociation of Î±-amylase synthesis from secretion within 30 minutes. ..
MacDonald R, Crerar M, Swain W, Pictet R, Thomas G, Rutter W. Structure of a family of rat amylase genes. Nature. 1980;287:117-22 pubmed
Chang M, Alsaigh T, Kistler E, Schmid Schonbein G. Breakdown of mucin as barrier to digestive enzymes in the ischemic rat small intestine. PLoS ONE. 2012;7:e40087 pubmed publisher
Youssef R, Malaisse W, Courtois P, Sener A. Alteration of alpha-amylase secretion from rat parotid cells in the absence of extracellular bicarbonate. Int J Mol Med. 2003;12:199-200 pubmed
..It is proposed, therefore, that the HCO3-anion participates in the secretory sequence at sites distal to the identification of secretagogues in both endocrine and exocrine cells. ..
Sierra F, Pittet A, Schibler U. Different tissue-specific expression of the amylase gene Amy-1 in mice and rats. Mol Cell Biol. 1986;6:4067-76 pubmed
Venkatesh S, Tan J, Gorr S, Darling D. Isoproterenol increases sorting of parotid gland cargo proteins to the basolateral pathway. Am J Physiol Cell Physiol. 2007;293:C558-65 pubmed
..These studies demonstrate that shifts of endogenous proteins can modulate regulated secretion and sorting of cargo proteins. ..
Merigo F, Benati D, Cecchini M, Cristofoletti M, Osculati F, Sbarbati A. Amylase expression in taste receptor cells of rat circumvallate papillae. Cell Tissue Res. 2009;336:411-21 pubmed publisher
..The data suggest that amylase-positive cells constitute an additional subset of taste receptor cells also associated with chemoreceptorial and/or secretory molecules, confirming the occurrence of various pathways in taste buds. ..