Gene Symbol: Amd1
Description: adenosylmethionine decarboxylase 1
Alias: Amd1a, Amd1b, S-adenosylmethionine decarboxylase proenzyme, S-Adenosylmethionine decarboxylase 1B, S-adenosylmethionine decarboxylase 1, S-adenosylmethionine decarboxylase 1A, SAMDC, adoMetDC
Species: rat
Products:     Amd1

Top Publications

  1. Wada M, Shirahata A. Conformational stabilization of rat s-adenosylmethionine decarboxylase by putrescine. Biol Pharm Bull. 2010;33:1800-5 pubmed
    The activity and processing of mammalian S-adenosylmethionine decarboxylase (AdoMetDC) is stimulated by putrescine...
  2. Wilson J, Corti A, Hawkins M, Williams Ashman H, Pegg A. The decarboxylation of S-adenosylmethionine by detergent-treated extracts of rat liver. Biochem J. 1979;180:515-22 pubmed
  3. Pulkka A, Ihalainen R, Aatsinki J, Pajunen A. Structure and organization of the gene encoding rat S-adenosylmethionine decarboxylase. FEBS Lett. 1991;291:289-95 pubmed
    The gene for S-adenosylmethionine decarboxylase (AdoMetDC) was isolated from a rat genomic library using AdoMetDC cDNA as a probe...
  4. Eloranta T, Khomutov A, Khomutov R, Hyvonen T. Aminooxy analogues of spermidine as inhibitors of spermine synthase and substrates of hepatic polyamine acetylating activity. J Biochem. 1990;108:593-8 pubmed
    ..The results suggest that compounds of this type are valuable tools in unraveling the physiology of polyamines. ..
  5. Pajunen A, Crozat A, Janne O, Ihalainen R, Laitinen P, Stanley B, et al. Structure and regulation of mammalian S-adenosylmethionine decarboxylase. J Biol Chem. 1988;263:17040-9 pubmed
  6. Pulkka A, Ihalainen R, Suorsa A, Riviere M, Szpirer J, Pajunen A. Structures and chromosomal localizations of two rat genes encoding S-adenosylmethionine decarboxylase. Genomics. 1993;16:342-9 pubmed
    S-Adenosylmethionine decarboxylase (AdoMetDC) is a ubiquitous enzyme in eukaryotic cells and responds to a wide variety of stimuli affecting growth...
  7. Raney A, Baron A, Mize G, Law G, Morris D. In vitro translation of the upstream open reading frame in the mammalian mRNA encoding S-adenosylmethionine decarboxylase. J Biol Chem. 2000;275:24444-50 pubmed
  8. Raney A, Law G, Mize G, Morris D. Regulated translation termination at the upstream open reading frame in s-adenosylmethionine decarboxylase mRNA. J Biol Chem. 2002;277:5988-94 pubmed
    ..This regulation may involve an interaction between the peptide, polyamines, and a target in the translational apparatus. ..
  9. Wang J, Viar M, McCormack S, Johnson L. Effect of putrescine on S-adenosylmethionine decarboxylase in a small intestinal crypt cell line. Am J Physiol. 1992;263:G494-501 pubmed
    Two key enzymes in polyamine biosynthesis are ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMDC)...

More Information


  1. Pulkka A, Keränen M, Salmela A, Salmikangas P, Ihalainen R, Pajunen A. Nucleotide sequence of rat S-adenosylmethionine decarboxylase cDNA. Comparison with an intronless rat pseudogene. Gene. 1990;86:193-9 pubmed
    Due to two different polyadenylation signals, two forms of S-adenosylmethionine decarboxylase (AdoMetDC) mRNA (2.1 and 3.4 kb) are present in human and rodent tissues...
  2. Higaki I, Matsui Yuasa I, Hirohashi K, Kinoshita H, Otani S. The role of polyamines in growth factor induced DNA synthesis in cultured rat hepatocytes. Hepatogastroenterology. 1999;46:1874-9 pubmed
    ..The inhibition was reversed by exogenous spermidine or spermine, but not by putrescine. Increased spermidine or spermine levels are essential for hepatocyte proliferation in cultured rat hepatocytes. ..
  3. Nishimura K, Kashiwagi K, Matsuda Y, Janne O, Igarashi K. Gene structure and chromosomal localization of mouse S-adenosylmethionine decarboxylase. Gene. 1999;238:343-50 pubmed
    The structure of the mouse S-adenosylmethionine decarboxylase (AdoMetDC) gene has been determined. The mouse gene (AMD1) consisted of eight exons and seven introns, similar to the rat AdoMetDC gene, and was mapped to chromosome 10...
  4. Bernal Mizrachi C, Gates A, Weng S, Imamura T, Knutsen R, DeSantis P, et al. Vascular respiratory uncoupling increases blood pressure and atherosclerosis. Nature. 2005;435:502-6 pubmed
    ..These results provide proof of principle that inefficient metabolism in blood vessels can cause vascular disease. ..
  5. Ray R, Viar M, Yuan Q, Johnson L. Polyamine depletion delays apoptosis of rat intestinal epithelial cells. Am J Physiol Cell Physiol. 2000;278:C480-9 pubmed
    ..The above results indicate that polyamine depletion delays the onset of apoptosis in IEC-6 cells and confers protection against DNA damaging agents, suggesting that polyamines might be involved in the caspase activating signal cascade...
  6. Wallace H, Fraser A, Hughes A. A perspective of polyamine metabolism. Biochem J. 2003;376:1-14 pubmed
    ..The future will be in adopting a functional genomics approach to identifying polyamine-regulated genes linked to either carcinogenesis or apoptosis. ..
  7. Lu S, Mato J. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012;92:1515-42 pubmed publisher
    ..In experimental models, it is effective as a chemopreventive agent in HCC and perhaps other forms of cancer as well. ..