Alox5ap

Summary

Gene Symbol: Alox5ap
Description: arachidonate 5-lipoxygenase activating protein
Alias: 5-lipoxygenase-activating protein FLAP, FLAP, MK-886-binding protein, arachidonate 5-lipoxygenase-activating protein
Species: rat

Top Publications

  1. doi Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute
    Daniel S Lorrain
    Amira Pharmaceuticals, San Diego, California 92121, USA
    J Pharmacol Exp Ther 331:1042-50. 2009
  2. doi Increased urinary leukotriene E4 excretion in obstructive sleep apnea: effects of obesity and hypoxia
    Françoise Stanke-Labesque
    Institut National de la Sante et de la Recherche Medicale, Grenoble, France
    J Allergy Clin Immunol 124:364-70, 370.e1-2. 2009
  3. doi Differential gene signatures in rat mammary tumors induced by DMBA and those induced by fractionated gamma radiation
    Hae June Lee
    Division of Radiation Effect, Korea Institute of Radiological and Medical Sciences, Seoul, Korea
    Radiat Res 170:579-90. 2008
  4. pmc Placenta growth factor induces 5-lipoxygenase-activating protein to increase leukotriene formation in sickle cell disease
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Blood 113:1129-38. 2009
  5. doi 5-lipoxygenase and 5-lipoxygenase-activating protein gene polymorphisms, dietary linoleic acid, and risk for breast cancer
    Jun Wang
    Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Cancer Epidemiol Biomarkers Prev 17:2748-54. 2008
  6. ncbi Identification and isolation of a membrane protein necessary for leukotriene production
    D K Miller
    Department of Biochemistry and Molecular Biology, Merck Institute for Therapeutic Research, Rahway, New Jersey 07065
    Nature 343:278-81. 1990
  7. doi Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy
    Baldur Sveinbjörnsson
    Childhood Cancer Research Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    FASEB J 22:3525-36. 2008
  8. doi The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility
    J W Holloway
    Divisios of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton, UK
    Allergy 63:1046-53. 2008
  9. ncbi Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome
    Yoshiji Yamada
    FAHA, Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Mie 514 8507, Japan
    Int J Mol Med 21:801-8. 2008
  10. doi Candidate genes and cerebral palsy: a population-based study
    Catherine S Gibson
    Schools of aPaediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia
    Pediatrics 122:1079-85. 2008

Scientific Experts

  • Daniel S Lorrain
  • Françoise Stanke-Labesque
  • Jun Wang
  • Gayle E Hosford
  • Yoshiji Yamada
  • M Via
  • Magnus Bäck
  • Asim K Mandal
  • I Sayers
  • A P Sampson
  • J W Holloway
  • S T Holgate
  • Alexander K Tsai
  • Rozenn N Lemaitre
  • S M J Torres-Galván
  • Tetsuro Yoshida
  • V S Westergren
  • Junhao Liu
  • Nitin Patel
  • Catherine S Gibson
  • J F Penrose
  • Baldur Sveinbjörnsson
  • Hae June Lee
  • Giuliana Fortunato
  • T Koshino
  • Xiao Wei Xu
  • A J Jame
  • Peter Christmas
  • Jilly F Evans
  • Bradley T Hyman
  • Douglas Wisniewski
  • Douglas Miller
  • Ting ting D Yamin
  • Roy J Soberman
  • M A Kedda
  • Anna Helgadottir
  • Angel Montero
  • Michelle L Seymour
  • W R Henderson
  • L Escoubet-Lozach
  • S J Chu
  • N F Voelkel
  • Hidemi Yoshida
  • Michael Y Tsai
  • Caryn S Gonsalves
  • Vijay K Kalra
  • T Carrillo
  • Norifumi Metoki
  • Joshua C Bis
  • Zhe Liu
  • Yoshinori Nozawa
  • Weili Zhang
  • Jingzhou Chen
  • Thomas S Lumley
  • Susan R Heckbert
  • Kiyoshi Yokoi
  • Kristin Marciante
  • J A Cumplido
  • Kerri L Wiggins
  • Minyang Yang
  • Na Li
  • Kimihiko Kato
  • S J Wilson
  • Kenneth Rice
  • E Hernandez
  • Yibo Wang
  • Ying Xin
  • Hu Wang
  • Takao Suzuki
  • Kei Satoh
  • Rutai Hui
  • A Caballero-Hidalgo
  • Kai Sun
  • Nicholas L Smith
  • N Buset
  • Bruce M Psaty
  • Xiaojian Wang
  • C Blanco
  • Naomi Q Hanson
  • P H Howarth
  • Punam Malik
  • Xiaodong Song
  • Sachiro Watanabe
  • Weihong Tang
  • Yongyi Bai
  • Yutaka Nishigaki
  • Yukitoshi Aoyagi
  • Sangwoo Bae
  • Gustaaf A Dekker
  • Brian Bacskai

Detail Information

Publications39

  1. doi Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute
    Daniel S Lorrain
    Amira Pharmaceuticals, San Diego, California 92121, USA
    J Pharmacol Exp Ther 331:1042-50. 2009
    ..of arachidonic acid (AA) to LTA(4) by the enzyme 5-lipoxygenase (5-LO) in the presence of 5-LO-activating protein (FLAP)...
  2. doi Increased urinary leukotriene E4 excretion in obstructive sleep apnea: effects of obesity and hypoxia
    Françoise Stanke-Labesque
    Institut National de la Sante et de la Recherche Medicale, Grenoble, France
    J Allergy Clin Immunol 124:364-70, 370.e1-2. 2009
    ..However, the respective contribution of intermittent hypoxia and confounders, such as obesity, is still debated...
  3. doi Differential gene signatures in rat mammary tumors induced by DMBA and those induced by fractionated gamma radiation
    Hae June Lee
    Division of Radiation Effect, Korea Institute of Radiological and Medical Sciences, Seoul, Korea
    Radiat Res 170:579-90. 2008
    ..calcium activated 3 (Clca3) were expressed in both, and that arachidonate 5-lipoxygenase activating protein 1 (Alox5ap) and cathepsin S (Ctss) were expressed only in radiation-induced tumors...
  4. pmc Placenta growth factor induces 5-lipoxygenase-activating protein to increase leukotriene formation in sickle cell disease
    Nitin Patel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Blood 113:1129-38. 2009
    ..We show that expression of 5-lipoxygenase and 5-lipoxygenase activating protein (FLAP), key catalytic molecules in the LT pathway, were significantly increased in peripheral blood mononuclear cells (..
  5. doi 5-lipoxygenase and 5-lipoxygenase-activating protein gene polymorphisms, dietary linoleic acid, and risk for breast cancer
    Jun Wang
    Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Cancer Epidemiol Biomarkers Prev 17:2748-54. 2008
    ..area to examine the association of the 5-lipoxygenase gene (ALOX5) and 5-lipoxygenase-activating protein gene (ALOX5AP) with breast cancer risk...
  6. ncbi Identification and isolation of a membrane protein necessary for leukotriene production
    D K Miller
    Department of Biochemistry and Molecular Biology, Merck Institute for Therapeutic Research, Rahway, New Jersey 07065
    Nature 343:278-81. 1990
    ..We have now used these potent agents to identify and isolate a novel membrane protein of relative molecular mass 18,000 which is necessary for cellular leukotriene synthesis...
  7. doi Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy
    Baldur Sveinbjörnsson
    Childhood Cancer Research Unit, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    FASEB J 22:3525-36. 2008
    ..High expression of 5-LO, 5-LO-activating protein (FLAP), leukotriene A(4) hydrolase, leukotriene C(4) synthase, and leukotriene receptors was detected in a majority of ..
  8. doi The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility
    J W Holloway
    Divisios of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton, UK
    Allergy 63:1046-53. 2008
    ..Single nucleotide polymorphism (SNPs) and haplotypes spanning the LTA4H and ALOX5AP genes have been associated with LTB(4) production and myocardial infarction (MI)...
  9. ncbi Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome
    Yoshiji Yamada
    FAHA, Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Mie 514 8507, Japan
    Int J Mol Med 21:801-8. 2008
    ..of ROS1, the -11377C-->G polymorphism (rs266729) of ADIPOQ, the 162A-->C polymorphism (rs4769055) of ALOX5AP, the -786T-->C polymorphism (rs2070744) of NOS3, and the 3279C-->T polymorphism (rs7291467) of LGALS2 were ..
  10. doi Candidate genes and cerebral palsy: a population-based study
    Catherine S Gibson
    Schools of aPaediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia
    Pediatrics 122:1079-85. 2008
    ..The objective of this study was to examine whether selected genetic polymorphisms in the infant are associated with later-diagnosed cerebral palsy...
  11. pmc Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA
    Atherosclerosis 204:e58-63. 2009
    ..TBXAS1), prostacyclin synthase (PTGIS), prostaglandin E synthase (PTGES), 5-lipoxygenase activating protein (ALOX5AP), 12-lipoxygenase (ALOX12) and 15-lipoxygenase (ALOX15) with the risks of myocardial infarction (MI) and ischemic ..
  12. pmc The nuclear membrane organization of leukotriene synthesis
    Asim K Mandal
    Renal Unit, Massachusetts General Hospital, Building 149 The Navy Yard, 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 105:20434-9. 2008
    ..We also identify these complexes in mouse neutrophils isolated from inflamed joints. Our studies reveal the macromolecular organization of LT synthesis...
  13. ncbi Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus
    Tetsuro Yoshida
    Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan
    Int J Mol Med 23:529-37. 2009
    ..for covariates as well as a stepwise forward selection procedure revealed that the 8733T-->C polymorphism of ALOX5AP (rs3803278), the C-->T (Ser532Leu) polymorphism of IRAK1 (rs1059703), and the 2445G-->A (Ala54Thr) ..
  14. doi Nasal mucosal expression of the leukotriene and prostanoid pathways in seasonal and perennial allergic rhinitis
    V S Westergren
    Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton, UK
    Clin Exp Allergy 39:820-8. 2009
    ..Leukotrienes (LTs) and prostanoids are potent pro-inflammatory and vasoactive lipid mediators implicated in airway disease, but their cellular sources in the nasal airway in naturally occurring allergic rhinitis (AR) are unclear...
  15. doi Association of three-gene interaction among MTHFR, ALOX5AP and NOTCH3 with thrombotic stroke: a multicenter case-control study
    Junhao Liu
    Sino German Laboratory, Molecular Medicine, Key Laboratory for Clinical Cardiovascular Genetics of Ministry of Education, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Hum Genet 125:649-56. 2009
    ..A significant gene-gene interaction was found by GMDR. The best model including MTHFR C677T, ALOX5AP T2354A and NOTCH3 C381T scored 10 for Cross-Validation Consistency and 9 for Sign Test (P = 0.0107)...
  16. doi Associations of genetic polymorphisms of arachidonate 5-lipoxygenase-activating protein with risk of coronary artery disease in a European-American population
    Alexander K Tsai
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Atherosclerosis 207:487-91. 2009
    To examine whether genetic polymorphisms in the 5-lipoxygenase activating protein (ALOX5AP) confer an increased risk to angiographically proven coronary artery disease (CAD) in a case-control study of a Midwestern population in the US.
  17. pmc The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos
    M Via
    Lung Biology Center, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Clin Exp Allergy 40:582-9. 2010
    Leukotrienes play an important role in allergic and inflammatory diseases, but reports on the involvement of arachidonate 5-lipoxygenase-activating protein (ALOX5AP) and leukotriene A(4) hydrolase (LTA4H) in asthma have been inconclusive.
  18. ncbi 5-Lipoxygenase pathway gene polymorphisms: lack of association with asthma in a Spanish population
    S M J Torres-Galván
    Research Unit, Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Spain
    J Investig Allergol Clin Immunol 19:453-8. 2009
    ..The promoter polymorphisms LTC4S -444 A/C, ALOX5 -176/-147, and ALOX5AP -169/-146 have been reported to be associated with bronchial asthma.
  19. doi Decreased paraoxonase-2 expression in human carotids during the progression of atherosclerosis
    Giuliana Fortunato
    Dipartimento di Biochimica e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, Via S Pansini 5, 80131 Napoli, Italy
    Arterioscler Thromb Vasc Biol 28:594-600. 2008
    ..We investigated paraoxonase 2 (PON2), 5-lipoxygenase (5-LO), and 5-LO activating protein (FLAP) expression and malondialdehyde (MDA) levels in carotid lesions to assess their involvement in plaque formation.
  20. ncbi [Association between mRNA level of Pde4d and Alox5ap and hypertensive stroke as well as hypertension in rats]
    Xiao Wei Xu
    Department of Neurology, the First Hospital Affiliated, Sun Yat Sen University, Guangzhou, Guangdong, 510080 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 24:491-4. 2007
    To evaluate whether mRNA levels of Pde4d and Alox5ap were associated with hypertensive stroke and hypertension in stroke-prone renovascular hypertensive rats (RHRSP) which could simulate human being's hypertensive cerebral stroke.
  21. ncbi Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4
    A J Jame
    Division of Infection, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK
    Clin Exp Allergy 37:880-92. 2007
    ....
  22. ncbi Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis
    R A Dixon
    Department of Molecular Biology, Merck Sharp and Dohme Research Laboratories, West Point, Pennsylvania 19486
    Nature 343:282-4. 1990
    ..Because the MK-886-binding protein seems to play a part in activating this enzyme in cells, it is termed the five-lipoxygenase activating protein (FLAP).
  23. ncbi Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells
    T G Brock
    Department of Internal Medicine, University of Michigan, Ann Arbor
    J Biol Chem 269:22059-66. 1994
    ..microscopy has identified the nuclear membrane as the site at which 5-LO, as well as 5-LO activating protein (FLAP), are localized in activated cells, the locale of soluble 5-LO in unstimulated cells could not be established by ..
  24. pmc Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats
    N F Voelkel
    Pulmonary Hypertension Center, Department of Pathology, University of Colorado Health Sciences Center, Denver 80262, USA
    J Clin Invest 97:2491-8. 1996
    ..from the cytosol to the membrane fraction and increased levels of lung tissue 5-lipoxygenase-activating protein (FLAP)...
  25. pmc The importance of leukotrienes in airway inflammation in a mouse model of asthma
    W R Henderson
    Department of Medicine, University of Washington, Seattle 98195, USA
    J Exp Med 184:1483-94. 1996
    ..Specific inhibitors of 5-lipoxygenase and 5-lipoxygenase-activating protein (FLAP) blocked airway mucus release and infiltration by eosinophils indicating a key role for leukotrienes in these ..
  26. ncbi 5-Lipoxygenase and 5-lipoxygenase activating protein (FLAP) immunoreactivity in lungs from patients with primary pulmonary hypertension
    L Wright
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Am J Respir Crit Care Med 157:219-29. 1998
    ..5-LO), with translocation of the enzyme to the nuclear membrane, and association with the 5-LO activating protein (FLAP)...
  27. ncbi Expression of 5-lipoxygenase and 5-lipoxygenase-activating protein mRNAs in the peripheral blood leukocytes of asthmatics
    T Koshino
    Faculty of Medicine, University of Tokyo, 7 3 1 Hongou, Bunkyou ku, 113, Japan
    Biochem Biophys Res Commun 247:510-3. 1998
    ..Therefore, we examined the expression of 5-LO and FLAP mRNAs in the peripheral blood leukocytes (PBL) of 10 asthmatics and 10 controls...
  28. ncbi Novel polymorphism of the 5-lipoxygenase activating protein (FLAP) promoter gene associated with asthma
    T Koshino
    Department of Respiratory Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Mol Cell Biol Res Commun 2:32-5. 1999
    The human 5-lipoxygenase activating protein (FLAP) gene is one of the key genes involved in the production of the cysteinyl-leukotrienes...
  29. ncbi In situ amplification of 5-lipoxygenase and 5-lipoxygenase-activating protein in allergic airway inflammation and inhibition by leukotriene blockade
    S J Chu
    Departments of Medicine and Pathology, University of Washington, Seattle, WA 98195, USA
    J Immunol 165:4640-8. 2000
    ..situ PCR in this model of human asthma to detect lung mRNA for 5-lipoxygenase (5-LO) and 5-LO-activating protein (FLAP), key proteins necessary for leukotriene synthesis. Lung tissue was obtained on day 28 from mice treated with i.p...
  30. ncbi Increased expression of cytosolic phospholipase A2, 5-lipoxygenase and 5-lipoxygenase-activating protein in rat peritoneal macrophages during ovalbumin-induced sensitization
    L Escoubet-Lozach
    Université Paul Sabatier UPRES EA 2405, Macrophages, Mediateurs de l Inflammation et Interactions Cellulaires, CHU Rangueil, 1 avenue Jean Poulhes, 31403 Toulouse Cedex 4, France
    Clin Exp Allergy 31:1094-104. 2001
    ..To date it is unknown whether this ability to secrete leukotrienes has been favoured by modifications, occurring during the sensitization phase, of the enzymes involved in leukotriene metabolism...
  31. ncbi Rhinovirus infection increases 5-lipoxygenase and cyclooxygenase-2 in bronchial biopsy specimens from nonatopic subjects
    Michelle L Seymour
    Division of Respiratory Cell and Molecular Biology, University of Southampton School of Medicine, Southampton, United Kingdom
    J Infect Dis 185:540-4. 2002
    ..5-LO-positive cell counts increased 9-fold (from 0.48 to 4.4 cells/mm(2); P <.05), and 5-LO-activating protein (FLAP)-positive cell counts increased 3.6-fold (from 1.8 to 6.5 cells/mm(2); P =.09)...
  32. ncbi Hyperoxia increases protein mass of 5-lipoxygenase and its activating protein, flap, and leukotriene B(4) output in newborn rat lungs
    Gayle E Hosford
    Department of Physiology, The Perinatal Research Centre, The CIHR Group in Perinatal Health and Disease, University of Alberta, Edmonton, Canada
    Exp Lung Res 28:671-84. 2002
    ..in vitro, the protein expression of the LT-synthesizing enzyme, 5-lipoxygenase (5-LO), and its activating protein (FLAP), and the effects of in vivo hyperoxic exposure (>95% O(2)) on these parameters...
  33. ncbi Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population
    I Sayers
    Divisions of Human Genetics Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton General Hospital, Tremona Road, Southampton, UK
    Clin Exp Allergy 33:1103-10. 2003
    5-Lipoxygenase (5-LO) and 5-lipoxygenase-activating protein (FLAP) are essential for cysteinyl-leukotriene (cys-LT) production, critical mediators in asthma.
  34. ncbi Increased 5-lipoxygenase activating protein in immune-mediated experimental nephritis
    Angel Montero
    Renal Division, Emory University School of Medicine, Atlanta, USA
    J Nephrol 16:682-90. 2003
    The binding of 5-lipoxygenase (5-LO) to 5-LO activating protein (FLAP) is a prerequisite for subsequent formation of leukotrienes from arachidonic acid.
  35. ncbi The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke
    Anna Helgadottir
    deCODE Genetics, Sturlugata 8, Reykjavik, Iceland
    Nat Genet 36:233-9. 2004
    ..A four-marker single-nucleotide polymorphism (SNP) haplotype in this locus spanning the gene ALOX5AP encoding 5-lipoxygenase activating protein (FLAP) is associated with a two times greater risk of myocardial ..
  36. pmc The membrane organization of leukotriene synthesis
    Asim K Mandal
    Department of Medicine, Massachusetts General Hospital, 149 The Navy Yard, 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 101:6587-92. 2004
    ..One complex consists of multimers of LTC(4) synthase and the 5-lipoxygenase activating protein (FLAP). The second complex consists of multimers of FLAP...
  37. ncbi Polymorphisms in the 5-lipoxygenase activating protein (ALOX5AP) gene are not associated with asthma in an Australian population
    M A Kedda
    The Co operative Research Centre for Asthma, The Asthma and Allergy Research Institute Inc, Perth, Australia
    Clin Exp Allergy 35:332-8. 2005
    ..Few studies have investigated the role of polymorphisms in the ALOX5AP gene, encoding 5-lipoxygenase activating protein (FLAP), and asthma...
  38. ncbi 5-Lipoxygenase-activating protein: a potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation
    Magnus Bäck
    Department of Medicine, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
    Circ Res 100:946-9. 2007
    ..Gene array analyses identified the 5-lipoxygenase-activating protein (FLAP) among the most upregulated genes in both the aorta and adipose tissue of dnTGFbetaRII transgenic ApoE(-/-) mice ..
  39. doi Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation
    Daniel S Lorrain
    Amira Pharmaceuticals, 9535 Waples Street, Ste 100, San Diego, California 92121, USA
    Eur J Pharmacol 640:211-8. 2010
    ..acid, a selective five-lipoxygenase-activating protein (FLAP) inhibitor, using rat and mouse models of acute inflammation...